PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA56_LEIMA

TriTrypDb:

LmjF.25.0390 , LMJLV39_250009500 , LMJSD75_250009500

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0008180	COP9 signalosome	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4QA56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.307
CLV_C14_Caspase3-7	56	60	PF00656	0.460
CLV_NRD_NRD_1	87	89	PF00675	0.472
CLV_PCSK_SKI1_1	107	111	PF00082	0.432
CLV_PCSK_SKI1_1	125	129	PF00082	0.477
CLV_PCSK_SKI1_1	178	182	PF00082	0.429
CLV_PCSK_SKI1_1	208	212	PF00082	0.653
DEG_APCC_DBOX_1	177	185	PF00400	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.511
DOC_CKS1_1	151	156	PF01111	0.419
DOC_CYCLIN_RxL_1	104	113	PF00134	0.487
DOC_CYCLIN_RxL_1	136	145	PF00134	0.347
DOC_MAPK_DCC_7	29	37	PF00069	0.467
DOC_MAPK_FxFP_2	24	27	PF00069	0.488
DOC_MAPK_gen_1	137	146	PF00069	0.296
DOC_MAPK_MEF2A_6	29	37	PF00069	0.467
DOC_PP1_RVXF_1	105	112	PF00149	0.485
DOC_PP1_RVXF_1	137	144	PF00149	0.273
DOC_PP1_RVXF_1	219	226	PF00149	0.411
DOC_PP4_FxxP_1	24	27	PF00568	0.517
DOC_USP7_MATH_1	27	31	PF00917	0.618
DOC_USP7_MATH_1	63	67	PF00917	0.465
DOC_USP7_MATH_1	69	73	PF00917	0.514
DOC_USP7_MATH_1	97	101	PF00917	0.541
DOC_WW_Pin1_4	150	155	PF00397	0.551
DOC_WW_Pin1_4	208	213	PF00397	0.559
DOC_WW_Pin1_4	28	33	PF00397	0.536
LIG_14-3-3_CanoR_1	139	144	PF00244	0.259
LIG_14-3-3_CanoR_1	201	206	PF00244	0.546
LIG_14-3-3_CanoR_1	98	106	PF00244	0.402
LIG_BRCT_BRCA1_1	71	75	PF00533	0.485
LIG_DLG_GKlike_1	139	146	PF00625	0.277
LIG_FHA_1	100	106	PF00498	0.497
LIG_FHA_1	171	177	PF00498	0.596
LIG_FHA_2	111	117	PF00498	0.462
LIG_FHA_2	209	215	PF00498	0.569
LIG_FHA_2	54	60	PF00498	0.514
LIG_LIR_Apic_2	22	27	PF02991	0.520
LIG_LIR_Gen_1	110	119	PF02991	0.505
LIG_LIR_Gen_1	142	151	PF02991	0.476
LIG_LIR_Nem_3	110	114	PF02991	0.424
LIG_LIR_Nem_3	142	146	PF02991	0.524
LIG_MLH1_MIPbox_1	71	75	PF16413	0.485
LIG_NRBOX	104	110	PF00104	0.476
LIG_SH2_CRK	76	80	PF00017	0.365
LIG_SH2_STAT5	47	50	PF00017	0.508
LIG_SH3_3	148	154	PF00018	0.419
LIG_SUMO_SIM_anti_2	99	107	PF11976	0.489
LIG_WRC_WIRS_1	108	113	PF05994	0.407
LIG_WRC_WIRS_1	140	145	PF05994	0.462
MOD_CK1_1	142	148	PF00069	0.408
MOD_CK1_1	204	210	PF00069	0.569
MOD_CK1_1	22	28	PF00069	0.537
MOD_CK1_1	5	11	PF00069	0.480
MOD_GlcNHglycan	65	68	PF01048	0.466
MOD_GlcNHglycan	80	83	PF01048	0.320
MOD_GSK3_1	172	179	PF00069	0.454
MOD_GSK3_1	204	211	PF00069	0.544
MOD_GSK3_1	78	85	PF00069	0.422
MOD_N-GLC_1	208	213	PF02516	0.559
MOD_NEK2_1	2	7	PF00069	0.474
MOD_NEK2_2	69	74	PF00069	0.493
MOD_PIKK_1	145	151	PF00454	0.377
MOD_PKA_2	97	103	PF00069	0.427
MOD_Plk_1	69	75	PF00069	0.491
MOD_Plk_4	139	145	PF00069	0.378
MOD_Plk_4	19	25	PF00069	0.542
MOD_Plk_4	69	75	PF00069	0.499
MOD_ProDKin_1	150	156	PF00069	0.542
MOD_ProDKin_1	208	214	PF00069	0.559
MOD_ProDKin_1	28	34	PF00069	0.536
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.283
TRG_ENDOCYTIC_2	76	79	PF00928	0.370
TRG_ER_diArg_1	11	14	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8M2	Leptomonas seymouri	47%	100%
A0A3Q8IF59	Leishmania donovani	93%	100%
A4H4A3	Leishmania braziliensis	82%	100%
A4I182	Leishmania infantum	93%	100%
D0A5G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AXB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%