SUI1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor SUI1, putative

Species:

Leishmania major

UniProt:

Q4QA54_LEIMA

TriTrypDb:

LmjF.25.0410 , LMJLV39_250009700 , LMJSD75_250009700

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA54

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	2
GO:0002183	cytoplasmic translational initiation	4	2
GO:0002188	translation reinitiation	5	2
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0003743	translation initiation factor activity	4	8
GO:0005488	binding	1	8
GO:0008135	translation factor activity, RNA binding	3	8
GO:0045182	translation regulator activity	1	8
GO:0090079	translation regulator activity, nucleic acid binding	2	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.490
CLV_NRD_NRD_1	173	175	PF00675	0.450
CLV_NRD_NRD_1	176	178	PF00675	0.482
CLV_NRD_NRD_1	212	214	PF00675	0.313
CLV_NRD_NRD_1	235	237	PF00675	0.334
CLV_NRD_NRD_1	94	96	PF00675	0.775
CLV_PCSK_FUR_1	174	178	PF00082	0.471
CLV_PCSK_KEX2_1	175	177	PF00082	0.524
CLV_PCSK_KEX2_1	208	210	PF00082	0.313
CLV_PCSK_KEX2_1	212	214	PF00082	0.286
CLV_PCSK_KEX2_1	237	239	PF00082	0.331
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.513
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.313
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.300
CLV_PCSK_PC7_1	172	178	PF00082	0.465
CLV_PCSK_PC7_1	233	239	PF00082	0.283
CLV_PCSK_SKI1_1	176	180	PF00082	0.478
CLV_PCSK_SKI1_1	192	196	PF00082	0.507
CLV_PCSK_SKI1_1	213	217	PF00082	0.280
DEG_SPOP_SBC_1	28	32	PF00917	0.612
DOC_CKS1_1	55	60	PF01111	0.680
DOC_MAPK_gen_1	195	203	PF00069	0.514
DOC_MAPK_gen_1	276	284	PF00069	0.554
DOC_MAPK_gen_1	84	93	PF00069	0.573
DOC_USP7_MATH_1	278	282	PF00917	0.485
DOC_USP7_UBL2_3	97	101	PF12436	0.790
DOC_WW_Pin1_4	54	59	PF00397	0.696
LIG_14-3-3_CanoR_1	176	185	PF00244	0.472
LIG_14-3-3_CanoR_1	212	221	PF00244	0.503
LIG_14-3-3_CanoR_1	236	245	PF00244	0.513
LIG_Actin_RPEL_3	185	204	PF02755	0.523
LIG_Actin_WH2_2	214	231	PF00022	0.504
LIG_deltaCOP1_diTrp_1	234	239	PF00928	0.457
LIG_FHA_1	28	34	PF00498	0.567
LIG_FHA_2	178	184	PF00498	0.469
LIG_FHA_2	77	83	PF00498	0.544
LIG_GBD_Chelix_1	263	271	PF00786	0.257
LIG_LIR_Apic_2	273	278	PF02991	0.500
LIG_LIR_LC3C_4	120	125	PF02991	0.476
LIG_LIR_Nem_3	132	138	PF02991	0.459
LIG_LIR_Nem_3	147	151	PF02991	0.452
LIG_Pex14_1	235	239	PF04695	0.457
LIG_SH2_CRK	135	139	PF00017	0.438
LIG_SH2_CRK	275	279	PF00017	0.457
LIG_SH2_STAT5	135	138	PF00017	0.394
LIG_SH2_STAT5	283	286	PF00017	0.422
LIG_SH3_3	288	294	PF00018	0.513
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.292
LIG_SUMO_SIM_par_1	120	126	PF11976	0.573
LIG_SUMO_SIM_par_1	199	205	PF11976	0.351
LIG_TRAF2_1	118	121	PF00917	0.574
LIG_TRAF2_1	247	250	PF00917	0.457
LIG_TYR_ITIM	133	138	PF00017	0.453
MOD_CK1_1	7	13	PF00069	0.612
MOD_CK2_1	14	20	PF00069	0.724
MOD_CK2_1	76	82	PF00069	0.661
MOD_Cter_Amidation	172	175	PF01082	0.454
MOD_Cter_Amidation	210	213	PF01082	0.300
MOD_Cter_Amidation	286	289	PF01082	0.546
MOD_GlcNHglycan	147	151	PF01048	0.470
MOD_GlcNHglycan	46	49	PF01048	0.619
MOD_GlcNHglycan	61	64	PF01048	0.708
MOD_GSK3_1	59	66	PF00069	0.756
MOD_NEK2_1	123	128	PF00069	0.556
MOD_NEK2_1	214	219	PF00069	0.500
MOD_NEK2_1	270	275	PF00069	0.500
MOD_NEK2_2	278	283	PF00069	0.478
MOD_PKA_1	237	243	PF00069	0.514
MOD_PKA_2	237	243	PF00069	0.515
MOD_PKA_2	63	69	PF00069	0.679
MOD_Plk_4	214	220	PF00069	0.505
MOD_Plk_4	278	284	PF00069	0.472
MOD_ProDKin_1	54	60	PF00069	0.696
MOD_SUMO_rev_2	105	109	PF00179	0.662
TRG_DiLeu_BaEn_1	280	285	PF01217	0.549
TRG_ENDOCYTIC_2	135	138	PF00928	0.490
TRG_ER_diArg_1	174	177	PF00400	0.471
TRG_ER_diArg_1	212	214	PF00400	0.504
TRG_ER_diArg_1	235	238	PF00400	0.534
TRG_NLS_Bipartite_1	80	100	PF00514	0.609
TRG_NLS_MonoCore_2	173	178	PF00514	0.446
TRG_NLS_MonoExtC_3	287	292	PF00514	0.525
TRG_NLS_MonoExtC_3	94	99	PF00514	0.580
TRG_NLS_MonoExtN_4	172	179	PF00514	0.446
TRG_NLS_MonoExtN_4	233	240	PF00514	0.500
TRG_NLS_MonoExtN_4	3	9	PF00514	0.605
TRG_NLS_MonoExtN_4	95	100	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAD2	Leptomonas seymouri	59%	100%
A0A3Q8ICD2	Leishmania donovani	92%	100%
A4HDY3	Leishmania braziliensis	79%	99%
A4I184	Leishmania infantum	91%	100%
D0A5G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AXB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%