G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania major

UniProt:

Q4QA50_LEIMA

TriTrypDb:

LmjF.25.0450 , LMJLV39_250010100 , LMJSD75_250010100

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA50

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	2
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0030488	tRNA methylation	5	2
GO:0032259	methylation	2	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.622
CLV_NRD_NRD_1	111	113	PF00675	0.565
CLV_NRD_NRD_1	219	221	PF00675	0.278
CLV_NRD_NRD_1	263	265	PF00675	0.424
CLV_NRD_NRD_1	339	341	PF00675	0.600
CLV_NRD_NRD_1	379	381	PF00675	0.526
CLV_NRD_NRD_1	79	81	PF00675	0.547
CLV_PCSK_FUR_1	217	221	PF00082	0.362
CLV_PCSK_KEX2_1	102	104	PF00082	0.571
CLV_PCSK_KEX2_1	111	113	PF00082	0.500
CLV_PCSK_KEX2_1	219	221	PF00082	0.272
CLV_PCSK_KEX2_1	263	265	PF00082	0.479
CLV_PCSK_KEX2_1	339	341	PF00082	0.600
CLV_PCSK_KEX2_1	78	80	PF00082	0.553
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.630
CLV_PCSK_SKI1_1	154	158	PF00082	0.310
CLV_PCSK_SKI1_1	340	344	PF00082	0.528
CLV_PCSK_SKI1_1	428	432	PF00082	0.406
CLV_PCSK_SKI1_1	63	67	PF00082	0.615
CLV_Separin_Metazoa	260	264	PF03568	0.528
CLV_Separin_Metazoa	353	357	PF03568	0.408
DEG_APCC_DBOX_1	294	302	PF00400	0.509
DOC_CKS1_1	205	210	PF01111	0.476
DOC_CKS1_1	282	287	PF01111	0.451
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.401
DOC_MAPK_MEF2A_6	268	276	PF00069	0.389
DOC_PP1_RVXF_1	152	158	PF00149	0.359
DOC_PP1_RVXF_1	286	293	PF00149	0.428
DOC_PP1_RVXF_1	372	379	PF00149	0.428
DOC_PP2B_LxvP_1	241	244	PF13499	0.363
DOC_PP2B_LxvP_1	301	304	PF13499	0.503
DOC_PP2B_LxvP_1	345	348	PF13499	0.566
DOC_PP4_FxxP_1	157	160	PF00568	0.537
DOC_PP4_FxxP_1	394	397	PF00568	0.427
DOC_PP4_FxxP_1	434	437	PF00568	0.437
DOC_USP7_MATH_1	137	141	PF00917	0.656
DOC_USP7_UBL2_3	188	192	PF12436	0.501
DOC_WW_Pin1_4	10	15	PF00397	0.496
DOC_WW_Pin1_4	111	116	PF00397	0.529
DOC_WW_Pin1_4	204	209	PF00397	0.476
DOC_WW_Pin1_4	281	286	PF00397	0.453
LIG_14-3-3_CanoR_1	133	141	PF00244	0.676
LIG_14-3-3_CanoR_1	356	360	PF00244	0.502
LIG_14-3-3_CanoR_1	72	76	PF00244	0.587
LIG_14-3-3_CanoR_1	84	89	PF00244	0.545
LIG_Clathr_ClatBox_1	202	206	PF01394	0.487
LIG_FHA_1	10	16	PF00498	0.495
LIG_FHA_1	164	170	PF00498	0.496
LIG_FHA_1	189	195	PF00498	0.494
LIG_FHA_1	198	204	PF00498	0.457
LIG_FHA_1	205	211	PF00498	0.435
LIG_FHA_1	213	219	PF00498	0.463
LIG_FHA_1	257	263	PF00498	0.559
LIG_FHA_1	306	312	PF00498	0.518
LIG_FHA_1	38	44	PF00498	0.550
LIG_FHA_1	383	389	PF00498	0.420
LIG_FHA_1	64	70	PF00498	0.656
LIG_FHA_2	112	118	PF00498	0.530
LIG_FHA_2	194	200	PF00498	0.560
LIG_FHA_2	275	281	PF00498	0.396
LIG_FHA_2	294	300	PF00498	0.417
LIG_FHA_2	356	362	PF00498	0.482
LIG_FHA_2	377	383	PF00498	0.446
LIG_FHA_2	416	422	PF00498	0.521
LIG_LIR_Apic_2	391	397	PF02991	0.413
LIG_LIR_Gen_1	358	367	PF02991	0.522
LIG_LIR_LC3C_4	236	240	PF02991	0.536
LIG_LIR_Nem_3	110	116	PF02991	0.520
LIG_LIR_Nem_3	117	123	PF02991	0.518
LIG_LIR_Nem_3	358	362	PF02991	0.510
LIG_LIR_Nem_3	402	407	PF02991	0.416
LIG_LIR_Nem_3	61	65	PF02991	0.604
LIG_Pex14_2	427	431	PF04695	0.469
LIG_REV1ctd_RIR_1	391	396	PF16727	0.408
LIG_SH2_CRK	230	234	PF00017	0.562
LIG_SH2_CRK	329	333	PF00017	0.421
LIG_SH2_CRK	62	66	PF00017	0.477
LIG_SH2_NCK_1	113	117	PF00017	0.538
LIG_SH2_NCK_1	329	333	PF00017	0.421
LIG_SH2_STAP1	230	234	PF00017	0.562
LIG_SH2_STAP1	35	39	PF00017	0.512
LIG_SH2_STAT5	113	116	PF00017	0.513
LIG_SH2_STAT5	291	294	PF00017	0.403
LIG_SH2_STAT5	35	38	PF00017	0.513
LIG_SH2_STAT5	39	42	PF00017	0.500
LIG_SH3_3	141	147	PF00018	0.508
LIG_SH3_3	279	285	PF00018	0.440
LIG_SH3_3	48	54	PF00018	0.471
LIG_SUMO_SIM_anti_2	199	207	PF11976	0.503
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.487
LIG_SUMO_SIM_par_1	199	207	PF11976	0.490
LIG_SUMO_SIM_par_1	317	324	PF11976	0.408
LIG_SUMO_SIM_par_1	84	91	PF11976	0.682
LIG_TRAF2_1	115	118	PF00917	0.534
LIG_WRC_WIRS_1	400	405	PF05994	0.412
MOD_CDK_SPxxK_3	281	288	PF00069	0.454
MOD_CK1_1	10	16	PF00069	0.523
MOD_CK1_1	140	146	PF00069	0.593
MOD_CK1_1	383	389	PF00069	0.439
MOD_CK1_1	74	80	PF00069	0.560
MOD_CK1_1	87	93	PF00069	0.525
MOD_CK2_1	111	117	PF00069	0.516
MOD_CK2_1	193	199	PF00069	0.588
MOD_CK2_1	293	299	PF00069	0.411
MOD_CK2_1	355	361	PF00069	0.508
MOD_CK2_1	376	382	PF00069	0.529
MOD_CK2_1	415	421	PF00069	0.513
MOD_GlcNHglycan	134	137	PF01048	0.668
MOD_GlcNHglycan	223	226	PF01048	0.305
MOD_GlcNHglycan	316	319	PF01048	0.507
MOD_GlcNHglycan	382	385	PF01048	0.471
MOD_GSK3_1	164	171	PF00069	0.501
MOD_GSK3_1	17	24	PF00069	0.484
MOD_GSK3_1	184	191	PF00069	0.345
MOD_GSK3_1	193	200	PF00069	0.449
MOD_GSK3_1	25	32	PF00069	0.475
MOD_GSK3_1	293	300	PF00069	0.416
MOD_GSK3_1	3	10	PF00069	0.514
MOD_GSK3_1	305	312	PF00069	0.421
MOD_GSK3_1	33	40	PF00069	0.463
MOD_GSK3_1	376	383	PF00069	0.463
MOD_NEK2_1	132	137	PF00069	0.711
MOD_NEK2_1	168	173	PF00069	0.494
MOD_NEK2_1	355	360	PF00069	0.472
MOD_NEK2_1	376	381	PF00069	0.548
MOD_NEK2_1	58	63	PF00069	0.562
MOD_NEK2_1	65	70	PF00069	0.539
MOD_NEK2_1	9	14	PF00069	0.458
MOD_NEK2_2	193	198	PF00069	0.476
MOD_NEK2_2	399	404	PF00069	0.400
MOD_PIKK_1	197	203	PF00454	0.476
MOD_PIKK_1	212	218	PF00454	0.476
MOD_PK_1	84	90	PF00069	0.575
MOD_PKA_1	380	386	PF00069	0.458
MOD_PKA_2	132	138	PF00069	0.640
MOD_PKA_2	212	218	PF00069	0.538
MOD_PKA_2	355	361	PF00069	0.434
MOD_PKA_2	71	77	PF00069	0.632
MOD_Plk_1	309	315	PF00069	0.446
MOD_Plk_4	164	170	PF00069	0.488
MOD_Plk_4	274	280	PF00069	0.507
MOD_Plk_4	355	361	PF00069	0.508
MOD_Plk_4	84	90	PF00069	0.601
MOD_ProDKin_1	10	16	PF00069	0.495
MOD_ProDKin_1	111	117	PF00069	0.531
MOD_ProDKin_1	204	210	PF00069	0.476
MOD_ProDKin_1	281	287	PF00069	0.452
MOD_SUMO_rev_2	251	257	PF00179	0.426
TRG_DiLeu_BaEn_1	199	204	PF01217	0.414
TRG_ENDOCYTIC_2	113	116	PF00928	0.521
TRG_ENDOCYTIC_2	230	233	PF00928	0.562
TRG_ENDOCYTIC_2	291	294	PF00928	0.403
TRG_ENDOCYTIC_2	404	407	PF00928	0.411
TRG_ENDOCYTIC_2	62	65	PF00928	0.483
TRG_ER_diArg_1	111	113	PF00400	0.565
TRG_ER_diArg_1	217	220	PF00400	0.481
TRG_ER_diArg_1	262	264	PF00400	0.537
TRG_ER_diArg_1	338	340	PF00400	0.601
TRG_ER_diArg_1	371	374	PF00400	0.421
TRG_ER_diArg_1	78	80	PF00400	0.557
TRG_NES_CRM1_1	269	280	PF08389	0.511
TRG_Pf-PMV_PEXEL_1	420	425	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PER9	Leptomonas seymouri	82%	100%
A0A0S4IU66	Bodo saltans	49%	100%
A0A1X0P4I4	Trypanosomatidae	64%	100%
A0A3R7NZ49	Trypanosoma rangeli	66%	100%
A0A3S5H7E2	Leishmania donovani	98%	100%
A4HDY7	Leishmania braziliensis	91%	100%
A4I188	Leishmania infantum	94%	91%
D0A5H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AXC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	84%
V5B7N0	Trypanosoma cruzi	64%	100%