Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA49_LEIMA

TriTrypDb:

LmjF.25.0460 , LMJLV39_250010200 , LMJSD75_250010200

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QA49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.440
CLV_PCSK_KEX2_1	109	111	PF00082	0.619
CLV_PCSK_KEX2_1	6	8	PF00082	0.440
CLV_PCSK_KEX2_1	70	72	PF00082	0.410
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.619
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.440
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.410
CLV_PCSK_SKI1_1	79	83	PF00082	0.352
DEG_APCC_DBOX_1	78	86	PF00400	0.529
DOC_CKS1_1	54	59	PF01111	0.632
DOC_MAPK_gen_1	6	14	PF00069	0.636
DOC_MAPK_HePTP_8	4	16	PF00069	0.636
DOC_MAPK_MEF2A_6	7	16	PF00069	0.635
DOC_MAPK_MEF2A_6	79	87	PF00069	0.321
DOC_USP7_MATH_1	117	121	PF00917	0.412
DOC_WW_Pin1_4	17	22	PF00397	0.724
DOC_WW_Pin1_4	53	58	PF00397	0.675
LIG_APCC_ABBA_1	22	27	PF00400	0.645
LIG_FHA_1	86	92	PF00498	0.407
LIG_FHA_2	37	43	PF00498	0.639
LIG_FHA_2	99	105	PF00498	0.396
LIG_LIR_Gen_1	78	87	PF02991	0.475
LIG_SH2_CRK	72	76	PF00017	0.596
LIG_SH2_STAT5	80	83	PF00017	0.341
LIG_SH3_3	30	36	PF00018	0.673
LIG_SH3_3	51	57	PF00018	0.671
LIG_SUMO_SIM_par_1	27	35	PF11976	0.625
LIG_SUMO_SIM_par_1	83	88	PF11976	0.332
LIG_TRAF2_1	38	41	PF00917	0.628
MOD_CK1_1	52	58	PF00069	0.725
MOD_CK2_1	117	123	PF00069	0.418
MOD_CK2_1	36	42	PF00069	0.655
MOD_CK2_1	44	50	PF00069	0.598
MOD_CK2_1	98	104	PF00069	0.395
MOD_DYRK1A_RPxSP_1	53	57	PF00069	0.674
MOD_GSK3_1	49	56	PF00069	0.696
MOD_NEK2_1	49	54	PF00069	0.724
MOD_NEK2_1	85	90	PF00069	0.326
MOD_NEK2_1	92	97	PF00069	0.334
MOD_PK_1	8	14	PF00069	0.654
MOD_PKA_2	52	58	PF00069	0.721
MOD_Plk_1	8	14	PF00069	0.622
MOD_Plk_2-3	100	106	PF00069	0.400
MOD_Plk_4	85	91	PF00069	0.326
MOD_ProDKin_1	17	23	PF00069	0.725
MOD_ProDKin_1	53	59	PF00069	0.677
MOD_SUMO_rev_2	104	111	PF00179	0.345
MOD_SUMO_rev_2	95	103	PF00179	0.568
TRG_DiLeu_BaEn_1	78	83	PF01217	0.529
TRG_ENDOCYTIC_2	72	75	PF00928	0.599
TRG_ENDOCYTIC_2	80	83	PF00928	0.341
TRG_ER_diLys_1	129	133	PF00400	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0C5	Leptomonas seymouri	50%	100%
A0A3S7WYV4	Leishmania donovani	88%	100%
A4HDY8	Leishmania braziliensis	69%	100%
A4I189	Leishmania infantum	88%	100%
E9AXC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%