Putative RNA-binding protein, UPB1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein UBP2, putative

Species:

Leishmania major

UniProt:

Q4QA46_LEIMA

TriTrypDb:

LmjF.25.0500 , LMJLV39_250010500 , LMJSD75_250010500

Length:

177

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:1990904	ribonucleoprotein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QA46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA46

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003723	RNA binding	4	15
GO:0003729	mRNA binding	5	3
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0005488	binding	1	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	58	64	PF00089	0.376
CLV_PCSK_KEX2_1	108	110	PF00082	0.326
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.326
CLV_PCSK_SKI1_1	108	112	PF00082	0.326
CLV_PCSK_SKI1_1	56	60	PF00082	0.326
DOC_CKS1_1	4	9	PF01111	0.639
DOC_CYCLIN_RxL_1	53	60	PF00134	0.526
DOC_MAPK_gen_1	108	114	PF00069	0.526
DOC_PP4_MxPP_1	5	8	PF00568	0.668
DOC_WW_Pin1_4	3	8	PF00397	0.637
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_FHA_2	46	52	PF00498	0.526
LIG_IBAR_NPY_1	152	154	PF08397	0.611
LIG_LIR_Nem_3	60	65	PF02991	0.526
LIG_LIR_Nem_3	79	85	PF02991	0.526
LIG_SH2_CRK	82	86	PF00017	0.568
LIG_SH2_STAT3	154	157	PF00017	0.572
LIG_SH2_STAT3	166	169	PF00017	0.633
LIG_SH2_STAT5	45	48	PF00017	0.526
LIG_SH3_3	27	33	PF00018	0.760
MOD_CK1_1	89	95	PF00069	0.526
MOD_CK2_1	46	52	PF00069	0.526
MOD_GlcNHglycan	116	119	PF01048	0.670
MOD_GlcNHglycan	88	91	PF01048	0.326
MOD_NEK2_1	114	119	PF00069	0.637
MOD_PKA_2	73	79	PF00069	0.526
MOD_ProDKin_1	3	9	PF00069	0.640
TRG_ENDOCYTIC_2	82	85	PF00928	0.576
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P4G4	Trypanosomatidae	66%	85%
A0A1X0P4M7	Trypanosomatidae	68%	100%
A0A3Q8ID53	Leishmania donovani	98%	100%
A0A3S7WYY4	Leishmania donovani	99%	100%
A0A422NWY7	Trypanosoma rangeli	73%	100%
A4HDZ1	Leishmania braziliensis	90%	100%
A4HDZ2	Leishmania braziliensis	90%	100%
A4I191	Leishmania infantum	98%	100%
E9AH94	Leishmania infantum	99%	76%
E9AXC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9AXC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4QA45	Leishmania major	98%	100%
V5BNA6	Trypanosoma cruzi	71%	100%