LeishMANIAdb
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Putative RNA-binding protein, UPB2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative RNA-binding protein, UPB2
Gene product:
RNA-binding protein UBP2, putative
Species:
Leishmania major
UniProt:
Q4QA45_LEIMA
TriTrypDb:
LmjF.25.0500 * , LMJLV39_250010700 , LMJSD75_250010600
Length:
167

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 24
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 3
GO:0005737 cytoplasm 2 2
GO:0016020 membrane 2 1
GO:0032991 protein-containing complex 1 11
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 4
GO:1990904 ribonucleoprotein complex 2 11
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Expansion

Sequence features

Q4QA45
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA45

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003676 nucleic acid binding 3 19
GO:0003723 RNA binding 4 19
GO:0003729 mRNA binding 5 3
GO:0003730 mRNA 3'-UTR binding 6 1
GO:0005488 binding 1 19
GO:0097159 organic cyclic compound binding 2 19
GO:1901363 heterocyclic compound binding 2 19
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_MEL_PAP_1 48 54 PF00089 0.276
CLV_PCSK_KEX2_1 98 100 PF00082 0.269
CLV_PCSK_PC1ET2_1 98 100 PF00082 0.267
CLV_PCSK_SKI1_1 46 50 PF00082 0.269
CLV_PCSK_SKI1_1 98 102 PF00082 0.290
DOC_CYCLIN_RxL_1 43 50 PF00134 0.469
DOC_MAPK_gen_1 98 104 PF00069 0.467
LIG_BIR_II_1 1 5 PF00653 0.648
LIG_FHA_2 36 42 PF00498 0.467
LIG_IBAR_NPY_1 142 144 PF08397 0.535
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Homologs

ProteinTaxonomySequence identityCoverage
A0A1X0P4G4 Trypanosomatidae 66% 80%
A0A1X0P4M7 Trypanosomatidae 68% 96%
A0A3Q8IBN4 Leishmania donovani 45% 70%
A0A3Q8ID53 Leishmania donovani 97% 100%
A0A3S7WYY4 Leishmania donovani 99% 100%
A0A422NWY7 Trypanosoma rangeli 73% 100%
A4HDZ1 Leishmania braziliensis 90% 99%
A4HDZ2 Leishmania braziliensis 86% 99%
A4HDZ4 Leishmania braziliensis 44% 70%
A4I191 Leishmania infantum 97% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS