Putative RNA-binding protein, UPB2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein UBP2, putative

Species:

Leishmania major

UniProt:

Q4QA45_LEIMA

TriTrypDb:

LmjF.25.0500 , LMJLV39_250010700 , LMJSD75_250010600

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:1990904	ribonucleoprotein complex	2	11
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QA45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA45

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	19
GO:0003723	RNA binding	4	19
GO:0003729	mRNA binding	5	3
GO:0005488	binding	1	19
GO:0097159	organic cyclic compound binding	2	19
GO:1901363	heterocyclic compound binding	2	19
GO:0003730	mRNA 3'-UTR binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	48	54	PF00089	0.276
CLV_PCSK_KEX2_1	98	100	PF00082	0.269
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.267
CLV_PCSK_SKI1_1	46	50	PF00082	0.269
CLV_PCSK_SKI1_1	98	102	PF00082	0.290
DOC_CYCLIN_RxL_1	43	50	PF00134	0.469
DOC_MAPK_gen_1	98	104	PF00069	0.467
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_FHA_2	36	42	PF00498	0.467
LIG_IBAR_NPY_1	142	144	PF08397	0.535
LIG_LIR_Nem_3	50	55	PF02991	0.487
LIG_LIR_Nem_3	69	75	PF02991	0.490
LIG_SH2_CRK	72	76	PF00017	0.533
LIG_SH2_STAT3	144	147	PF00017	0.519
LIG_SH2_STAT3	156	159	PF00017	0.608
LIG_SH2_STAT5	35	38	PF00017	0.490
LIG_SH3_3	17	23	PF00018	0.587
MOD_CK1_1	79	85	PF00069	0.468
MOD_CK2_1	36	42	PF00069	0.467
MOD_GlcNHglycan	106	109	PF01048	0.589
MOD_GlcNHglycan	78	81	PF01048	0.294
MOD_NEK2_1	104	109	PF00069	0.547
MOD_PKA_2	63	69	PF00069	0.467
TRG_ENDOCYTIC_2	72	75	PF00928	0.533
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.267

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P4G4	Trypanosomatidae	66%	80%
A0A1X0P4M7	Trypanosomatidae	68%	96%
A0A3Q8IBN4	Leishmania donovani	45%	70%
A0A3Q8ID53	Leishmania donovani	97%	100%
A0A3S7WYY4	Leishmania donovani	99%	100%
A0A422NWY7	Trypanosoma rangeli	73%	100%
A4HDZ1	Leishmania braziliensis	90%	99%
A4HDZ2	Leishmania braziliensis	86%	99%
A4HDZ4	Leishmania braziliensis	44%	70%
A4I191	Leishmania infantum	97%	100%
A4I193	Leishmania infantum	45%	70%
E9AH94	Leishmania infantum	99%	72%
E9AXC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	96%
E9AXC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AXC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	70%
Q4QA46	Leishmania major	98%	94%
Q76LC6	Danio rerio	29%	73%
V5BNA6	Trypanosoma cruzi	71%	100%