Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QA44_LEIMA

TriTrypDb:

LmjF.25.0510 , LMJLV39_250010800 , LMJSD75_250010700

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.650
CLV_C14_Caspase3-7	404	408	PF00656	0.629
CLV_C14_Caspase3-7	45	49	PF00656	0.600
CLV_NRD_NRD_1	192	194	PF00675	0.763
CLV_NRD_NRD_1	197	199	PF00675	0.644
CLV_NRD_NRD_1	365	367	PF00675	0.572
CLV_NRD_NRD_1	374	376	PF00675	0.404
CLV_NRD_NRD_1	93	95	PF00675	0.680
CLV_PCSK_KEX2_1	192	194	PF00082	0.763
CLV_PCSK_KEX2_1	197	199	PF00082	0.644
CLV_PCSK_KEX2_1	365	367	PF00082	0.572
CLV_PCSK_KEX2_1	374	376	PF00082	0.404
CLV_PCSK_KEX2_1	93	95	PF00082	0.674
CLV_PCSK_PC7_1	193	199	PF00082	0.602
CLV_PCSK_PC7_1	370	376	PF00082	0.577
CLV_PCSK_SKI1_1	122	126	PF00082	0.538
CLV_PCSK_SKI1_1	137	141	PF00082	0.413
CLV_PCSK_SKI1_1	22	26	PF00082	0.667
CLV_PCSK_SKI1_1	251	255	PF00082	0.499
CLV_PCSK_SKI1_1	325	329	PF00082	0.558
CLV_PCSK_SKI1_1	365	369	PF00082	0.684
CLV_PCSK_SKI1_1	370	374	PF00082	0.476
CLV_PCSK_SKI1_1	93	97	PF00082	0.559
CLV_Separin_Metazoa	462	466	PF03568	0.448
DEG_APCC_DBOX_1	121	129	PF00400	0.618
DEG_APCC_DBOX_1	250	258	PF00400	0.517
DEG_APCC_DBOX_1	324	332	PF00400	0.551
DEG_APCC_DBOX_1	369	377	PF00400	0.574
DEG_SPOP_SBC_1	434	438	PF00917	0.548
DOC_CDC14_PxL_1	527	535	PF14671	0.565
DOC_CKS1_1	25	30	PF01111	0.562
DOC_CKS1_1	319	324	PF01111	0.507
DOC_CYCLIN_RxL_1	169	178	PF00134	0.559
DOC_CYCLIN_RxL_1	19	29	PF00134	0.664
DOC_CYCLIN_RxL_1	362	369	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	522	525	PF00134	0.508
DOC_MAPK_gen_1	374	381	PF00069	0.452
DOC_MAPK_gen_1	385	393	PF00069	0.569
DOC_PP1_RVXF_1	135	142	PF00149	0.619
DOC_PP1_RVXF_1	238	245	PF00149	0.559
DOC_PP2B_LxvP_1	174	177	PF13499	0.657
DOC_PP2B_LxvP_1	424	427	PF13499	0.623
DOC_PP2B_LxvP_1	522	525	PF13499	0.594
DOC_PP4_FxxP_1	244	247	PF00568	0.596
DOC_PP4_FxxP_1	380	383	PF00568	0.587
DOC_USP7_MATH_1	10	14	PF00917	0.637
DOC_USP7_MATH_1	313	317	PF00917	0.672
DOC_USP7_MATH_1	320	324	PF00917	0.534
DOC_USP7_MATH_1	532	536	PF00917	0.686
DOC_WW_Pin1_4	183	188	PF00397	0.753
DOC_WW_Pin1_4	224	229	PF00397	0.627
DOC_WW_Pin1_4	230	235	PF00397	0.727
DOC_WW_Pin1_4	24	29	PF00397	0.563
DOC_WW_Pin1_4	303	308	PF00397	0.610
DOC_WW_Pin1_4	311	316	PF00397	0.600
DOC_WW_Pin1_4	318	323	PF00397	0.542
DOC_WW_Pin1_4	475	480	PF00397	0.696
DOC_WW_Pin1_4	74	79	PF00397	0.619
LIG_14-3-3_CanoR_1	137	142	PF00244	0.559
LIG_14-3-3_CanoR_1	14	21	PF00244	0.660
LIG_14-3-3_CanoR_1	143	148	PF00244	0.544
LIG_14-3-3_CanoR_1	192	201	PF00244	0.718
LIG_14-3-3_CanoR_1	251	257	PF00244	0.518
LIG_14-3-3_CanoR_1	501	510	PF00244	0.685
LIG_BIR_III_2	359	363	PF00653	0.622
LIG_BRCT_BRCA1_1	437	441	PF00533	0.741
LIG_DLG_GKlike_1	197	204	PF00625	0.538
LIG_eIF4E_1	119	125	PF01652	0.636
LIG_FHA_1	171	177	PF00498	0.593
LIG_FHA_1	260	266	PF00498	0.441
LIG_FHA_1	268	274	PF00498	0.466
LIG_FHA_1	319	325	PF00498	0.587
LIG_FHA_1	367	373	PF00498	0.462
LIG_FHA_1	395	401	PF00498	0.689
LIG_FHA_1	83	89	PF00498	0.553
LIG_FHA_2	212	218	PF00498	0.489
LIG_FHA_2	427	433	PF00498	0.636
LIG_FHA_2	43	49	PF00498	0.695
LIG_FHA_2	547	553	PF00498	0.403
LIG_GBD_Chelix_1	120	128	PF00786	0.621
LIG_Integrin_RGD_1	385	387	PF01839	0.589
LIG_LIR_Apic_2	241	247	PF02991	0.622
LIG_LIR_Gen_1	199	209	PF02991	0.625
LIG_LIR_Nem_3	199	204	PF02991	0.642
LIG_LIR_Nem_3	255	261	PF02991	0.573
LIG_LIR_Nem_3	51	57	PF02991	0.690
LIG_NRBOX	338	344	PF00104	0.453
LIG_NRBOX	459	465	PF00104	0.445
LIG_SH2_CRK	201	205	PF00017	0.622
LIG_SH2_CRK	329	333	PF00017	0.510
LIG_SH2_SRC	210	213	PF00017	0.606
LIG_SH2_STAP1	201	205	PF00017	0.622
LIG_SH2_STAT5	119	122	PF00017	0.653
LIG_SH2_STAT5	259	262	PF00017	0.564
LIG_SH2_STAT5	317	320	PF00017	0.553
LIG_SH2_STAT5	329	332	PF00017	0.462
LIG_SH3_3	182	188	PF00018	0.744
LIG_SH3_3	222	228	PF00018	0.683
LIG_SH3_3	242	248	PF00018	0.485
LIG_SH3_3	289	295	PF00018	0.685
LIG_SH3_3	316	322	PF00018	0.541
LIG_SH3_3	518	524	PF00018	0.589
LIG_SUMO_SIM_anti_2	264	271	PF11976	0.574
LIG_SUMO_SIM_par_1	259	264	PF11976	0.446
LIG_SUMO_SIM_par_1	508	514	PF11976	0.536
LIG_TRAF2_1	111	114	PF00917	0.698
LIG_TRAF2_1	446	449	PF00917	0.648
LIG_TYR_ITIM	256	261	PF00017	0.567
LIG_TYR_ITIM	327	332	PF00017	0.576
LIG_WRC_WIRS_1	212	217	PF05994	0.481
MOD_CDK_SPxxK_3	318	325	PF00069	0.599
MOD_CK1_1	103	109	PF00069	0.721
MOD_CK1_1	13	19	PF00069	0.630
MOD_CK1_1	196	202	PF00069	0.682
MOD_CK1_1	302	308	PF00069	0.649
MOD_CK1_1	403	409	PF00069	0.658
MOD_CK1_1	43	49	PF00069	0.708
MOD_CK1_1	495	501	PF00069	0.576
MOD_CK2_1	108	114	PF00069	0.608
MOD_CK2_1	211	217	PF00069	0.633
MOD_CK2_1	280	286	PF00069	0.622
MOD_CK2_1	426	432	PF00069	0.630
MOD_CK2_1	546	552	PF00069	0.410
MOD_CK2_1	81	87	PF00069	0.631
MOD_GlcNHglycan	105	108	PF01048	0.602
MOD_GlcNHglycan	205	208	PF01048	0.553
MOD_GlcNHglycan	234	237	PF01048	0.538
MOD_GlcNHglycan	300	304	PF01048	0.573
MOD_GlcNHglycan	40	43	PF01048	0.729
MOD_GlcNHglycan	424	427	PF01048	0.515
MOD_GlcNHglycan	479	482	PF01048	0.636
MOD_GlcNHglycan	495	498	PF01048	0.527
MOD_GlcNHglycan	501	504	PF01048	0.681
MOD_GlcNHglycan	534	537	PF01048	0.633
MOD_GlcNHglycan	7	10	PF01048	0.639
MOD_GSK3_1	137	144	PF00069	0.572
MOD_GSK3_1	166	173	PF00069	0.541
MOD_GSK3_1	179	186	PF00069	0.592
MOD_GSK3_1	192	199	PF00069	0.723
MOD_GSK3_1	230	237	PF00069	0.668
MOD_GSK3_1	299	306	PF00069	0.587
MOD_GSK3_1	309	316	PF00069	0.720
MOD_GSK3_1	38	45	PF00069	0.663
MOD_GSK3_1	391	398	PF00069	0.697
MOD_GSK3_1	422	429	PF00069	0.585
MOD_GSK3_1	495	502	PF00069	0.656
MOD_GSK3_1	532	539	PF00069	0.676
MOD_GSK3_1	98	105	PF00069	0.606
MOD_LATS_1	135	141	PF00433	0.556
MOD_LATS_1	364	370	PF00433	0.566
MOD_NEK2_1	170	175	PF00069	0.642
MOD_NEK2_1	559	564	PF00069	0.538
MOD_NEK2_1	88	93	PF00069	0.619
MOD_NEK2_1	98	103	PF00069	0.593
MOD_NEK2_2	234	239	PF00069	0.549
MOD_OFUCOSY	390	396	PF10250	0.522
MOD_OFUCOSY	97	104	PF10250	0.604
MOD_PIKK_1	511	517	PF00454	0.476
MOD_PKA_1	192	198	PF00069	0.601
MOD_PKA_2	13	19	PF00069	0.654
MOD_PKA_2	192	198	PF00069	0.702
MOD_PKA_2	543	549	PF00069	0.511
MOD_Plk_1	268	274	PF00069	0.594
MOD_Plk_1	386	392	PF00069	0.487
MOD_Plk_4	137	143	PF00069	0.567
MOD_Plk_4	166	172	PF00069	0.565
MOD_Plk_4	211	217	PF00069	0.492
MOD_Plk_4	252	258	PF00069	0.647
MOD_Plk_4	268	274	PF00069	0.390
MOD_Plk_4	327	333	PF00069	0.544
MOD_Plk_4	409	415	PF00069	0.574
MOD_Plk_4	543	549	PF00069	0.448
MOD_Plk_4	55	61	PF00069	0.650
MOD_ProDKin_1	183	189	PF00069	0.755
MOD_ProDKin_1	224	230	PF00069	0.629
MOD_ProDKin_1	24	30	PF00069	0.563
MOD_ProDKin_1	303	309	PF00069	0.609
MOD_ProDKin_1	311	317	PF00069	0.601
MOD_ProDKin_1	318	324	PF00069	0.534
MOD_ProDKin_1	475	481	PF00069	0.699
MOD_ProDKin_1	74	80	PF00069	0.615
TRG_DiLeu_BaEn_1	335	340	PF01217	0.580
TRG_DiLeu_BaEn_1	462	467	PF01217	0.562
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.653
TRG_DiLeu_LyEn_5	462	467	PF01217	0.562
TRG_ENDOCYTIC_2	201	204	PF00928	0.629
TRG_ENDOCYTIC_2	258	261	PF00928	0.628
TRG_ENDOCYTIC_2	329	332	PF00928	0.573
TRG_ER_diArg_1	142	145	PF00400	0.649
TRG_ER_diArg_1	365	367	PF00400	0.576
TRG_ER_diArg_1	373	375	PF00400	0.438
TRG_ER_diArg_1	92	94	PF00400	0.672
TRG_NES_CRM1_1	458	472	PF08389	0.571
TRG_NES_CRM1_1	87	100	PF08389	0.547
TRG_Pf-PMV_PEXEL_1	465	470	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4J4	Leptomonas seymouri	30%	100%
A0A3Q8ID76	Leishmania donovani	87%	100%
A4HDZ3	Leishmania braziliensis	65%	100%
A4I192	Leishmania infantum	86%	100%
E9AXC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%