Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

Q4QA43_LEIMA

TriTrypDb:

LmjF.25.0520 , LMJLV39_250010900 , LMJSD75_250010800

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

Q4QA43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA43

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	113	117	PF00082	0.289
CLV_PCSK_SKI1_1	229	233	PF00082	0.487
CLV_PCSK_SKI1_1	35	39	PF00082	0.434
DOC_CKS1_1	10	15	PF01111	0.546
DOC_CKS1_1	230	235	PF01111	0.449
DOC_MAPK_MEF2A_6	133	141	PF00069	0.411
DOC_SPAK_OSR1_1	107	111	PF12202	0.450
DOC_USP7_MATH_1	14	18	PF00917	0.639
DOC_USP7_MATH_1	146	150	PF00917	0.353
DOC_USP7_MATH_1	166	170	PF00917	0.429
DOC_USP7_MATH_1	214	218	PF00917	0.607
DOC_USP7_MATH_1	223	227	PF00917	0.503
DOC_WW_Pin1_4	21	26	PF00397	0.596
DOC_WW_Pin1_4	229	234	PF00397	0.502
DOC_WW_Pin1_4	9	14	PF00397	0.599
LIG_14-3-3_CanoR_1	133	141	PF00244	0.403
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_BIR_III_2	22	26	PF00653	0.505
LIG_FHA_1	230	236	PF00498	0.573
LIG_FHA_1	97	103	PF00498	0.457
LIG_LIR_Gen_1	127	137	PF02991	0.406
LIG_LIR_Gen_1	149	158	PF02991	0.383
LIG_LIR_Nem_3	127	132	PF02991	0.399
LIG_LIR_Nem_3	181	185	PF02991	0.585
LIG_LIR_Nem_3	62	67	PF02991	0.484
LIG_LIR_Nem_3	84	90	PF02991	0.453
LIG_LYPXL_S_1	208	212	PF13949	0.532
LIG_LYPXL_yS_3	209	212	PF13949	0.528
LIG_MAD2	229	237	PF02301	0.428
LIG_PDZ_Class_2	235	240	PF00595	0.475
LIG_SH2_CRK	129	133	PF00017	0.392
LIG_SH2_CRK	77	81	PF00017	0.472
LIG_SH2_CRK	87	91	PF00017	0.514
LIG_SH2_GRB2like	119	122	PF00017	0.405
LIG_SH2_GRB2like	185	188	PF00017	0.529
LIG_SH2_NCK_1	119	123	PF00017	0.386
LIG_SH2_NCK_1	77	81	PF00017	0.450
LIG_SH2_SRC	119	122	PF00017	0.405
LIG_SH2_SRC	50	53	PF00017	0.450
LIG_SH2_STAT3	151	154	PF00017	0.425
LIG_SH2_STAT5	219	222	PF00017	0.505
LIG_SH2_STAT5	50	53	PF00017	0.489
LIG_SH2_STAT5	93	96	PF00017	0.464
LIG_SH3_3	7	13	PF00018	0.543
LIG_TYR_ITIM	75	80	PF00017	0.450
MOD_CK1_1	165	171	PF00069	0.467
MOD_CK2_1	14	20	PF00069	0.594
MOD_Cter_Amidation	111	114	PF01082	0.250
MOD_GlcNHglycan	134	137	PF01048	0.528
MOD_GlcNHglycan	164	167	PF01048	0.536
MOD_GlcNHglycan	172	175	PF01048	0.509
MOD_GlcNHglycan	199	202	PF01048	0.499
MOD_GlcNHglycan	225	228	PF01048	0.524
MOD_GlcNHglycan	32	35	PF01048	0.528
MOD_GlcNHglycan	96	99	PF01048	0.284
MOD_GSK3_1	162	169	PF00069	0.495
MOD_GSK3_1	225	232	PF00069	0.522
MOD_GSK3_1	5	12	PF00069	0.586
MOD_GSK3_1	96	103	PF00069	0.453
MOD_N-GLC_1	5	10	PF02516	0.544
MOD_NEK2_1	132	137	PF00069	0.410
MOD_NEK2_1	94	99	PF00069	0.450
MOD_NEK2_2	146	151	PF00069	0.373
MOD_NEK2_2	214	219	PF00069	0.485
MOD_PK_1	69	75	PF00069	0.450
MOD_PKA_2	132	138	PF00069	0.399
MOD_PKA_2	197	203	PF00069	0.519
MOD_Plk_4	146	152	PF00069	0.376
MOD_Plk_4	214	220	PF00069	0.577
MOD_ProDKin_1	21	27	PF00069	0.597
MOD_ProDKin_1	229	235	PF00069	0.503
MOD_ProDKin_1	9	15	PF00069	0.605
TRG_ENDOCYTIC_2	129	132	PF00928	0.363
TRG_ENDOCYTIC_2	152	155	PF00928	0.491
TRG_ENDOCYTIC_2	209	212	PF00928	0.528
TRG_ENDOCYTIC_2	61	64	PF00928	0.572
TRG_ENDOCYTIC_2	77	80	PF00928	0.451
TRG_ENDOCYTIC_2	87	90	PF00928	0.494
TRG_ENDOCYTIC_2	92	95	PF00928	0.532
TRG_ER_diArg_1	195	198	PF00400	0.550
TRG_NES_CRM1_1	130	143	PF08389	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P674	Leptomonas seymouri	58%	100%
A0A3Q8IBN4	Leishmania donovani	93%	100%
A4HDZ4	Leishmania braziliensis	68%	100%
A4I193	Leishmania infantum	93%	100%
E9AXC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AXC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%