Scd6-like Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein SCD6.10

Species:

Leishmania major

UniProt:

Q4QA41_LEIMA

TriTrypDb:

LmjF.25.0540 , LMJLV39_250011100 , LMJSD75_250011000

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	2
GO:0032991	protein-containing complex	1	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2
GO:1990124	messenger ribonucleoprotein complex	3	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QA41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA41

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0033962	P-body assembly	7	2
GO:0034063	stress granule assembly	7	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0140694	non-membrane-bounded organelle assembly	6	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.607
CLV_NRD_NRD_1	182	184	PF00675	0.599
CLV_NRD_NRD_1	263	265	PF00675	0.580
CLV_NRD_NRD_1	283	285	PF00675	0.436
CLV_NRD_NRD_1	45	47	PF00675	0.324
CLV_PCSK_KEX2_1	142	144	PF00082	0.624
CLV_PCSK_KEX2_1	182	184	PF00082	0.587
CLV_PCSK_KEX2_1	283	285	PF00082	0.680
CLV_PCSK_SKI1_1	72	76	PF00082	0.308
DEG_Nend_UBRbox_3	1	3	PF02207	0.534
DOC_USP7_MATH_1	109	113	PF00917	0.617
DOC_USP7_MATH_1	115	119	PF00917	0.552
DOC_USP7_UBL2_3	229	233	PF12436	0.505
DOC_USP7_UBL2_3	237	241	PF12436	0.496
DOC_WW_Pin1_4	79	84	PF00397	0.666
LIG_14-3-3_CanoR_1	122	128	PF00244	0.693
LIG_APCC_ABBA_1	74	79	PF00400	0.524
LIG_BRCT_BRCA1_1	123	127	PF00533	0.641
LIG_BRCT_BRCA1_1	241	245	PF00533	0.520
LIG_FHA_1	30	36	PF00498	0.457
LIG_FHA_1	55	61	PF00498	0.537
LIG_FHA_2	188	194	PF00498	0.568
LIG_LIR_Gen_1	242	251	PF02991	0.502
LIG_LIR_Gen_1	58	66	PF02991	0.457
LIG_LIR_Nem_3	242	248	PF02991	0.525
LIG_LIR_Nem_3	58	64	PF02991	0.457
LIG_MLH1_MIPbox_1	241	245	PF16413	0.520
LIG_PCNA_yPIPBox_3	2	14	PF02747	0.318
LIG_Pex14_2	205	209	PF04695	0.499
LIG_SH2_NCK_1	128	132	PF00017	0.619
LIG_SH2_SRC	128	131	PF00017	0.689
LIG_SH3_3	90	96	PF00018	0.651
LIG_SUMO_SIM_par_1	28	36	PF11976	0.463
MOD_CDK_SPxxK_3	79	86	PF00069	0.636
MOD_CK1_1	118	124	PF00069	0.750
MOD_CK1_1	159	165	PF00069	0.537
MOD_CK1_1	25	31	PF00069	0.496
MOD_CK2_1	10	16	PF00069	0.524
MOD_CK2_1	220	226	PF00069	0.537
MOD_Cter_Amidation	140	143	PF01082	0.534
MOD_Cter_Amidation	44	47	PF01082	0.324
MOD_GlcNHglycan	111	114	PF01048	0.624
MOD_GlcNHglycan	117	120	PF01048	0.627
MOD_GlcNHglycan	177	180	PF01048	0.656
MOD_GSK3_1	111	118	PF00069	0.722
MOD_GSK3_1	240	247	PF00069	0.575
MOD_GSK3_1	25	32	PF00069	0.461
MOD_N-GLC_1	159	164	PF02516	0.720
MOD_NEK2_1	1	6	PF00069	0.509
MOD_NEK2_1	244	249	PF00069	0.539
MOD_NEK2_1	275	280	PF00069	0.529
MOD_NEK2_1	77	82	PF00069	0.576
MOD_NEK2_2	123	128	PF00069	0.659
MOD_PK_1	22	28	PF00069	0.408
MOD_PKA_1	220	226	PF00069	0.485
MOD_PKA_2	121	127	PF00069	0.775
MOD_PKA_2	66	72	PF00069	0.468
MOD_PKA_2	77	83	PF00069	0.523
MOD_Plk_1	239	245	PF00069	0.655
MOD_Plk_1	29	35	PF00069	0.524
MOD_Plk_1	72	78	PF00069	0.496
MOD_Plk_2-3	240	246	PF00069	0.573
MOD_Plk_4	240	246	PF00069	0.576
MOD_Plk_4	72	78	PF00069	0.490
MOD_ProDKin_1	79	85	PF00069	0.667
MOD_SUMO_rev_2	15	23	PF00179	0.408
MOD_SUMO_rev_2	187	197	PF00179	0.610
MOD_SUMO_rev_2	216	223	PF00179	0.471
MOD_SUMO_rev_2	226	234	PF00179	0.478
MOD_SUMO_rev_2	69	74	PF00179	0.508
TRG_ER_diArg_1	181	183	PF00400	0.592
TRG_ER_diArg_1	282	284	PF00400	0.563
TRG_ER_diArg_1	289	292	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC4	Leptomonas seymouri	70%	100%
A0A1X0P4R0	Trypanosomatidae	47%	100%
A0A3Q8IGG5	Leishmania donovani	88%	99%
A4HEG4	Leishmania braziliensis	86%	100%
A4I195	Leishmania infantum	88%	99%
D0A5I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AXD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P45978	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	85%
Q9BX40	Homo sapiens	31%	77%