HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA40_LEIMA

TriTrypDb:

LmjF.25.0550 , LMJLV39_250011200 , LMJSD75_250011100

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.312
CLV_C14_Caspase3-7	359	363	PF00656	0.616
CLV_C14_Caspase3-7	43	47	PF00656	0.596
CLV_NRD_NRD_1	16	18	PF00675	0.734
CLV_NRD_NRD_1	276	278	PF00675	0.405
CLV_NRD_NRD_1	370	372	PF00675	0.572
CLV_NRD_NRD_1	524	526	PF00675	0.462
CLV_NRD_NRD_1	549	551	PF00675	0.442
CLV_NRD_NRD_1	55	57	PF00675	0.499
CLV_NRD_NRD_1	73	75	PF00675	0.312
CLV_PCSK_FUR_1	522	526	PF00082	0.574
CLV_PCSK_FUR_1	547	551	PF00082	0.337
CLV_PCSK_FUR_1	71	75	PF00082	0.402
CLV_PCSK_KEX2_1	16	18	PF00082	0.734
CLV_PCSK_KEX2_1	276	278	PF00082	0.405
CLV_PCSK_KEX2_1	370	372	PF00082	0.572
CLV_PCSK_KEX2_1	524	526	PF00082	0.462
CLV_PCSK_KEX2_1	549	551	PF00082	0.441
CLV_PCSK_KEX2_1	55	57	PF00082	0.498
CLV_PCSK_KEX2_1	73	75	PF00082	0.312
CLV_PCSK_SKI1_1	221	225	PF00082	0.426
CLV_PCSK_SKI1_1	277	281	PF00082	0.471
CLV_PCSK_SKI1_1	543	547	PF00082	0.466
CLV_PCSK_SKI1_1	550	554	PF00082	0.388
DEG_APCC_DBOX_1	220	228	PF00400	0.473
DEG_APCC_DBOX_1	549	557	PF00400	0.422
DEG_SPOP_SBC_1	174	178	PF00917	0.633
DEG_SPOP_SBC_1	439	443	PF00917	0.474
DOC_CKS1_1	249	254	PF01111	0.514
DOC_CYCLIN_RxL_1	379	392	PF00134	0.512
DOC_CYCLIN_RxL_1	483	493	PF00134	0.489
DOC_CYCLIN_RxL_1	547	558	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.512
DOC_MAPK_gen_1	218	226	PF00069	0.505
DOC_MAPK_gen_1	276	284	PF00069	0.394
DOC_MAPK_gen_1	370	378	PF00069	0.501
DOC_MAPK_gen_1	547	556	PF00069	0.457
DOC_MAPK_gen_1	662	671	PF00069	0.594
DOC_MAPK_gen_1	71	81	PF00069	0.328
DOC_MAPK_MEF2A_6	276	283	PF00069	0.372
DOC_MAPK_MEF2A_6	547	556	PF00069	0.463
DOC_MAPK_NFAT4_5	276	284	PF00069	0.389
DOC_MAPK_NFAT4_5	549	557	PF00069	0.471
DOC_PP1_RVXF_1	484	491	PF00149	0.483
DOC_USP7_MATH_1	12	16	PF00917	0.763
DOC_USP7_MATH_1	139	143	PF00917	0.620
DOC_USP7_MATH_1	144	148	PF00917	0.573
DOC_USP7_MATH_1	164	168	PF00917	0.754
DOC_USP7_MATH_1	188	192	PF00917	0.751
DOC_USP7_MATH_1	194	198	PF00917	0.531
DOC_USP7_MATH_1	200	204	PF00917	0.507
DOC_USP7_MATH_1	262	266	PF00917	0.634
DOC_USP7_MATH_1	355	359	PF00917	0.599
DOC_USP7_MATH_1	363	367	PF00917	0.605
DOC_USP7_MATH_1	439	443	PF00917	0.720
DOC_USP7_MATH_1	99	103	PF00917	0.445
DOC_USP7_UBL2_3	162	166	PF12436	0.649
DOC_WW_Pin1_4	241	246	PF00397	0.578
DOC_WW_Pin1_4	248	253	PF00397	0.684
DOC_WW_Pin1_4	263	268	PF00397	0.695
DOC_WW_Pin1_4	27	32	PF00397	0.624
LIG_14-3-3_CanoR_1	123	128	PF00244	0.335
LIG_14-3-3_CanoR_1	22	31	PF00244	0.705
LIG_14-3-3_CanoR_1	276	282	PF00244	0.466
LIG_14-3-3_CanoR_1	370	378	PF00244	0.525
LIG_14-3-3_CanoR_1	534	541	PF00244	0.390
LIG_14-3-3_CanoR_1	555	564	PF00244	0.377
LIG_14-3-3_CanoR_1	665	671	PF00244	0.425
LIG_14-3-3_CanoR_1	90	94	PF00244	0.308
LIG_Actin_WH2_2	117	133	PF00022	0.447
LIG_Actin_WH2_2	203	220	PF00022	0.527
LIG_BIR_III_2	115	119	PF00653	0.434
LIG_CaM_IQ_9	585	601	PF13499	0.382
LIG_FHA_1	175	181	PF00498	0.543
LIG_FHA_1	212	218	PF00498	0.437
LIG_FHA_1	234	240	PF00498	0.463
LIG_FHA_1	278	284	PF00498	0.474
LIG_FHA_1	312	318	PF00498	0.535
LIG_FHA_1	321	327	PF00498	0.403
LIG_FHA_1	340	346	PF00498	0.187
LIG_FHA_1	489	495	PF00498	0.373
LIG_FHA_1	533	539	PF00498	0.487
LIG_FHA_1	576	582	PF00498	0.421
LIG_FHA_1	630	636	PF00498	0.477
LIG_FHA_2	176	182	PF00498	0.685
LIG_FHA_2	357	363	PF00498	0.607
LIG_FHA_2	41	47	PF00498	0.644
LIG_FHA_2	432	438	PF00498	0.610
LIG_FHA_2	578	584	PF00498	0.482
LIG_GBD_Chelix_1	336	344	PF00786	0.457
LIG_LIR_Gen_1	641	652	PF02991	0.396
LIG_LIR_Nem_3	125	130	PF02991	0.335
LIG_LIR_Nem_3	414	418	PF02991	0.494
LIG_LIR_Nem_3	604	608	PF02991	0.527
LIG_LIR_Nem_3	641	647	PF02991	0.379
LIG_MAD2	346	354	PF02301	0.514
LIG_PCNA_yPIPBox_3	335	348	PF02747	0.464
LIG_PDZ_Class_3	672	677	PF00595	0.708
LIG_Pex14_1	128	132	PF04695	0.447
LIG_Pex14_2	222	226	PF04695	0.520
LIG_SH2_PTP2	415	418	PF00017	0.519
LIG_SH2_SRC	415	418	PF00017	0.519
LIG_SH2_SRC	507	510	PF00017	0.612
LIG_SH2_STAP1	396	400	PF00017	0.449
LIG_SH2_STAT5	400	403	PF00017	0.514
LIG_SH2_STAT5	415	418	PF00017	0.519
LIG_SH2_STAT5	457	460	PF00017	0.505
LIG_SH2_STAT5	507	510	PF00017	0.651
LIG_SH3_3	242	248	PF00018	0.552
LIG_SH3_3	315	321	PF00018	0.504
LIG_SH3_3	36	42	PF00018	0.508
LIG_SUMO_SIM_anti_2	280	285	PF11976	0.396
LIG_SUMO_SIM_anti_2	323	330	PF11976	0.417
LIG_SUMO_SIM_anti_2	373	380	PF11976	0.508
LIG_SUMO_SIM_anti_2	535	542	PF11976	0.371
LIG_SUMO_SIM_par_1	117	122	PF11976	0.480
LIG_SUMO_SIM_par_1	373	380	PF11976	0.486
LIG_SUMO_SIM_par_1	535	542	PF11976	0.430
LIG_TRAF2_1	108	111	PF00917	0.447
LIG_TRAF2_1	354	357	PF00917	0.638
LIG_TRAF2_1	511	514	PF00917	0.464
LIG_TYR_ITIM	413	418	PF00017	0.520
LIG_UBA3_1	120	129	PF00899	0.447
LIG_UBA3_1	344	353	PF00899	0.467
LIG_UBA3_1	480	486	PF00899	0.353
LIG_UBA3_1	643	651	PF00899	0.453
LIG_UBA3_1	93	98	PF00899	0.402
LIG_WW_2	245	248	PF00397	0.462
MOD_CK1_1	20	26	PF00069	0.637
MOD_CK1_1	30	36	PF00069	0.615
MOD_CK1_1	358	364	PF00069	0.645
MOD_CK1_1	366	372	PF00069	0.554
MOD_CK1_1	558	564	PF00069	0.544
MOD_CK2_1	431	437	PF00069	0.487
MOD_CK2_1	450	456	PF00069	0.509
MOD_CK2_1	508	514	PF00069	0.455
MOD_CK2_1	89	95	PF00069	0.246
MOD_Cter_Amidation	71	74	PF01082	0.327
MOD_GlcNHglycan	101	104	PF01048	0.264
MOD_GlcNHglycan	141	144	PF01048	0.608
MOD_GlcNHglycan	157	160	PF01048	0.681
MOD_GlcNHglycan	166	169	PF01048	0.743
MOD_GlcNHglycan	170	173	PF01048	0.706
MOD_GlcNHglycan	186	189	PF01048	0.719
MOD_GlcNHglycan	196	199	PF01048	0.708
MOD_GlcNHglycan	255	258	PF01048	0.701
MOD_GlcNHglycan	365	368	PF01048	0.693
MOD_GlcNHglycan	442	445	PF01048	0.691
MOD_GlcNHglycan	560	563	PF01048	0.409
MOD_GlcNHglycan	614	617	PF01048	0.625
MOD_GlcNHglycan	623	626	PF01048	0.511
MOD_GSK3_1	119	126	PF00069	0.227
MOD_GSK3_1	134	141	PF00069	0.557
MOD_GSK3_1	160	167	PF00069	0.740
MOD_GSK3_1	17	24	PF00069	0.667
MOD_GSK3_1	180	187	PF00069	0.679
MOD_GSK3_1	189	196	PF00069	0.749
MOD_GSK3_1	247	254	PF00069	0.676
MOD_GSK3_1	335	342	PF00069	0.448
MOD_GSK3_1	358	365	PF00069	0.652
MOD_GSK3_1	366	373	PF00069	0.649
MOD_GSK3_1	448	455	PF00069	0.512
MOD_GSK3_1	528	535	PF00069	0.422
MOD_GSK3_1	539	546	PF00069	0.404
MOD_GSK3_1	558	565	PF00069	0.227
MOD_GSK3_1	77	84	PF00069	0.488
MOD_GSK3_1	99	106	PF00069	0.318
MOD_LATS_1	333	339	PF00433	0.497
MOD_N-GLC_1	184	189	PF02516	0.686
MOD_NEK2_1	1	6	PF00069	0.745
MOD_NEK2_1	119	124	PF00069	0.438
MOD_NEK2_1	160	165	PF00069	0.550
MOD_NEK2_1	175	180	PF00069	0.466
MOD_NEK2_1	217	222	PF00069	0.507
MOD_NEK2_1	239	244	PF00069	0.470
MOD_NEK2_1	253	258	PF00069	0.696
MOD_NEK2_1	448	453	PF00069	0.436
MOD_NEK2_1	539	544	PF00069	0.438
MOD_NEK2_1	639	644	PF00069	0.526
MOD_NEK2_2	144	149	PF00069	0.605
MOD_NEK2_2	457	462	PF00069	0.514
MOD_OFUCOSY	423	428	PF10250	0.439
MOD_PIKK_1	1	7	PF00454	0.712
MOD_PIKK_1	17	23	PF00454	0.697
MOD_PIKK_1	488	494	PF00454	0.528
MOD_PIKK_1	555	561	PF00454	0.542
MOD_PKA_1	370	376	PF00069	0.480
MOD_PKA_2	122	128	PF00069	0.335
MOD_PKA_2	21	27	PF00069	0.745
MOD_PKA_2	217	223	PF00069	0.499
MOD_PKA_2	311	317	PF00069	0.446
MOD_PKA_2	370	376	PF00069	0.558
MOD_PKA_2	533	539	PF00069	0.513
MOD_PKA_2	629	635	PF00069	0.546
MOD_PKA_2	664	670	PF00069	0.359
MOD_PKA_2	89	95	PF00069	0.283
MOD_Plk_2-3	577	583	PF00069	0.531
MOD_Plk_4	123	129	PF00069	0.373
MOD_Plk_4	131	137	PF00069	0.408
MOD_Plk_4	457	463	PF00069	0.448
MOD_Plk_4	562	568	PF00069	0.446
MOD_Plk_4	577	583	PF00069	0.308
MOD_Plk_4	639	645	PF00069	0.407
MOD_Plk_4	77	83	PF00069	0.427
MOD_Plk_4	89	95	PF00069	0.299
MOD_ProDKin_1	241	247	PF00069	0.593
MOD_ProDKin_1	248	254	PF00069	0.685
MOD_ProDKin_1	263	269	PF00069	0.687
MOD_ProDKin_1	27	33	PF00069	0.621
TRG_DiLeu_BaEn_1	313	318	PF01217	0.521
TRG_DiLeu_BaEn_1	476	481	PF01217	0.361
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.447
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.557
TRG_ENDOCYTIC_2	293	296	PF00928	0.393
TRG_ENDOCYTIC_2	396	399	PF00928	0.544
TRG_ENDOCYTIC_2	415	418	PF00928	0.519
TRG_ER_diArg_1	370	372	PF00400	0.572
TRG_ER_diArg_1	522	525	PF00400	0.475
TRG_ER_diArg_1	547	550	PF00400	0.371
TRG_ER_diArg_1	55	58	PF00400	0.483
TRG_ER_diArg_1	70	73	PF00400	0.448
TRG_NES_CRM1_1	456	470	PF08389	0.431
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	385	390	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P679	Leptomonas seymouri	51%	94%
A0A1X0P4F4	Trypanosomatidae	31%	100%
A0A3R7MYK8	Trypanosoma rangeli	29%	100%
A0A3S7WYU6	Leishmania donovani	90%	100%
A4HEG3	Leishmania braziliensis	74%	100%
A4I196	Leishmania infantum	90%	100%
D0A5I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AXD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BXH6	Trypanosoma cruzi	29%	100%