J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA39_LEIMA

TriTrypDb:

LmjF.25.0560 , LMJLV39_250011300 , LMJSD75_250011200

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QA39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.595
CLV_NRD_NRD_1	159	161	PF00675	0.400
CLV_NRD_NRD_1	32	34	PF00675	0.527
CLV_NRD_NRD_1	58	60	PF00675	0.474
CLV_PCSK_KEX2_1	158	160	PF00082	0.380
CLV_PCSK_KEX2_1	32	34	PF00082	0.527
CLV_PCSK_KEX2_1	58	60	PF00082	0.440
CLV_PCSK_KEX2_1	68	70	PF00082	0.368
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.380
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.393
CLV_PCSK_SKI1_1	18	22	PF00082	0.536
CLV_PCSK_SKI1_1	182	186	PF00082	0.317
CLV_PCSK_SKI1_1	193	197	PF00082	0.586
DEG_APCC_DBOX_1	181	189	PF00400	0.438
DEG_Nend_UBRbox_1	1	4	PF02207	0.670
DOC_MAPK_gen_1	156	164	PF00069	0.555
DOC_MAPK_MEF2A_6	10	17	PF00069	0.707
DOC_PP1_RVXF_1	146	152	PF00149	0.600
DOC_PP1_RVXF_1	158	165	PF00149	0.568
DOC_PP1_RVXF_1	31	38	PF00149	0.627
DOC_PP2B_LxvP_1	84	87	PF13499	0.602
DOC_USP7_MATH_1	139	143	PF00917	0.594
DOC_USP7_MATH_1	25	29	PF00917	0.733
DOC_USP7_MATH_1	87	91	PF00917	0.656
DOC_USP7_UBL2_3	101	105	PF12436	0.674
DOC_WW_Pin1_4	130	135	PF00397	0.573
LIG_14-3-3_CanoR_1	10	16	PF00244	0.615
LIG_14-3-3_CanoR_1	27	35	PF00244	0.674
LIG_14-3-3_CanoR_1	58	66	PF00244	0.696
LIG_14-3-3_CterR_2	193	197	PF00244	0.404
LIG_EH1_1	163	171	PF00400	0.536
LIG_EH1_1	173	181	PF00400	0.422
LIG_FHA_1	39	45	PF00498	0.640
LIG_FHA_2	89	95	PF00498	0.563
LIG_LIR_Gen_1	60	66	PF02991	0.701
LIG_LIR_Nem_3	119	125	PF02991	0.544
LIG_LIR_Nem_3	76	81	PF02991	0.549
LIG_Pex14_2	74	78	PF04695	0.563
LIG_SH2_STAT5	136	139	PF00017	0.615
LIG_SH3_3	128	134	PF00018	0.569
LIG_SH3_3	181	187	PF00018	0.415
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.562
LIG_SUMO_SIM_par_1	79	85	PF11976	0.597
LIG_TRFH_1	151	155	PF08558	0.539
MOD_CK1_1	141	147	PF00069	0.528
MOD_CK1_1	28	34	PF00069	0.691
MOD_CK1_1	88	94	PF00069	0.543
MOD_CK2_1	87	93	PF00069	0.570
MOD_Cter_Amidation	66	69	PF01082	0.507
MOD_GlcNHglycan	51	54	PF01048	0.630
MOD_N-GLC_1	188	193	PF02516	0.601
MOD_NEK2_1	188	193	PF00069	0.456
MOD_NEK2_1	37	42	PF00069	0.541
MOD_PIKK_1	139	145	PF00454	0.611
MOD_PIKK_1	57	63	PF00454	0.553
MOD_PIKK_1	73	79	PF00454	0.446
MOD_PKA_2	57	63	PF00069	0.639
MOD_Plk_1	188	194	PF00069	0.572
MOD_Plk_1	88	94	PF00069	0.561
MOD_ProDKin_1	130	136	PF00069	0.466
TRG_DiLeu_BaEn_2	69	75	PF01217	0.479
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.527
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.608
TRG_ENDOCYTIC_2	125	128	PF00928	0.406
TRG_ENDOCYTIC_2	62	65	PF00928	0.727
TRG_ER_diArg_1	146	149	PF00400	0.490
TRG_ER_diArg_1	15	18	PF00400	0.486
TRG_ER_diArg_1	159	161	PF00400	0.487
TRG_NLS_MonoExtC_3	157	163	PF00514	0.480
TRG_NLS_MonoExtN_4	155	162	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXP6	Leptomonas seymouri	65%	100%
A0A0S4IQD4	Bodo saltans	46%	100%
A0A1X0P4F3	Trypanosomatidae	60%	100%
A0A3S7WYX1	Leishmania donovani	95%	100%
A0A422NX26	Trypanosoma rangeli	68%	100%
A4HEG2	Leishmania braziliensis	81%	100%
A4I197	Leishmania infantum	95%	100%
D0A5I8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AXD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%