Protein-tyrosine-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lipid-like atypical dual specificity phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QA38_LEIMA

TriTrypDb:

LmjF.25.0570 , LMJLV39_250011400 , LMJSD75_250011300

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA38

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.634
CLV_C14_Caspase3-7	308	312	PF00656	0.469
CLV_C14_Caspase3-7	327	331	PF00656	0.395
CLV_NRD_NRD_1	285	287	PF00675	0.269
CLV_NRD_NRD_1	301	303	PF00675	0.269
CLV_NRD_NRD_1	332	334	PF00675	0.405
CLV_PCSK_KEX2_1	301	303	PF00082	0.269
CLV_PCSK_KEX2_1	332	334	PF00082	0.413
DEG_Nend_UBRbox_1	1	4	PF02207	0.417
DEG_SPOP_SBC_1	173	177	PF00917	0.621

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKW7	Leptomonas seymouri	57%	90%
A0A3S7WYV2	Leishmania donovani	93%	100%
A4HEG1	Leishmania braziliensis	79%	100%
A4I198	Leishmania infantum	93%	100%
E9AXD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%

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