Protein-tyrosine-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lipid-like atypical dual specificity phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QA38_LEIMA

TriTrypDb:

LmjF.25.0570 , LMJLV39_250011400 , LMJSD75_250011300

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA38

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.634
CLV_C14_Caspase3-7	308	312	PF00656	0.469
CLV_C14_Caspase3-7	327	331	PF00656	0.395
CLV_NRD_NRD_1	285	287	PF00675	0.269
CLV_NRD_NRD_1	301	303	PF00675	0.269
CLV_NRD_NRD_1	332	334	PF00675	0.405
CLV_PCSK_KEX2_1	301	303	PF00082	0.269
CLV_PCSK_KEX2_1	332	334	PF00082	0.413
DEG_Nend_UBRbox_1	1	4	PF02207	0.417
DEG_SPOP_SBC_1	173	177	PF00917	0.621
DOC_CYCLIN_yClb5_NLxxxL_5	288	297	PF00134	0.469
DOC_USP7_MATH_1	105	109	PF00917	0.576
DOC_USP7_MATH_1	123	127	PF00917	0.636
DOC_USP7_MATH_1	173	177	PF00917	0.733
DOC_USP7_MATH_1	182	186	PF00917	0.593
DOC_USP7_MATH_1	233	237	PF00917	0.653
DOC_USP7_MATH_1	62	66	PF00917	0.425
DOC_WW_Pin1_4	202	207	PF00397	0.589
LIG_APCC_ABBA_1	316	321	PF00400	0.469
LIG_BRCT_BRCA1_1	226	230	PF00533	0.630
LIG_Clathr_ClatBox_1	323	327	PF01394	0.469
LIG_FHA_1	34	40	PF00498	0.329
LIG_FHA_1	92	98	PF00498	0.586
LIG_FHA_2	244	250	PF00498	0.469
LIG_FHA_2	82	88	PF00498	0.555
LIG_GBD_Chelix_1	251	259	PF00786	0.269
LIG_LIR_Gen_1	313	323	PF02991	0.469
LIG_LIR_Nem_3	202	207	PF02991	0.576
LIG_LIR_Nem_3	261	267	PF02991	0.469
LIG_LIR_Nem_3	298	303	PF02991	0.487
LIG_LIR_Nem_3	313	318	PF02991	0.469
LIG_LIR_Nem_3	58	63	PF02991	0.430
LIG_LYPXL_yS_3	265	268	PF13949	0.469
LIG_NRBOX	255	261	PF00104	0.469
LIG_PDZ_Class_2	335	340	PF00595	0.464
LIG_Pex14_2	315	319	PF04695	0.469
LIG_SH2_CRK	26	30	PF00017	0.354
LIG_SH2_CRK	80	84	PF00017	0.577
LIG_SH2_NCK_1	80	84	PF00017	0.533
LIG_SH2_STAT5	10	13	PF00017	0.384
LIG_SH2_STAT5	214	217	PF00017	0.587
LIG_SH2_STAT5	80	83	PF00017	0.570
LIG_SH3_3	204	210	PF00018	0.580
LIG_SUMO_SIM_par_1	265	270	PF11976	0.469
LIG_SUMO_SIM_par_1	292	299	PF11976	0.469
LIG_SUMO_SIM_par_1	320	327	PF11976	0.516
MOD_CK1_1	176	182	PF00069	0.754
MOD_CK1_1	202	208	PF00069	0.622
MOD_CK1_1	55	61	PF00069	0.430
MOD_CK2_1	141	147	PF00069	0.649
MOD_CK2_1	243	249	PF00069	0.457
MOD_CK2_1	292	298	PF00069	0.490
MOD_Cter_Amidation	330	333	PF01082	0.428
MOD_GlcNHglycan	125	128	PF01048	0.599
MOD_GlcNHglycan	226	229	PF01048	0.704
MOD_GlcNHglycan	277	280	PF01048	0.269
MOD_GlcNHglycan	54	57	PF01048	0.384
MOD_GlcNHglycan	99	102	PF01048	0.587
MOD_GSK3_1	119	126	PF00069	0.728
MOD_GSK3_1	164	171	PF00069	0.727
MOD_GSK3_1	172	179	PF00069	0.611
MOD_GSK3_1	322	329	PF00069	0.587
MOD_GSK3_1	64	71	PF00069	0.488
MOD_GSK3_1	87	94	PF00069	0.606
MOD_N-GLC_1	105	110	PF02516	0.608
MOD_N-GLC_1	141	146	PF02516	0.662
MOD_N-GLC_1	199	204	PF02516	0.606
MOD_N-GLC_1	305	310	PF02516	0.269
MOD_NEK2_1	267	272	PF00069	0.469
MOD_NEK2_1	28	33	PF00069	0.360
MOD_NEK2_1	52	57	PF00069	0.376
MOD_NEK2_2	69	74	PF00069	0.452
MOD_PIKK_1	141	147	PF00454	0.627
MOD_PIKK_1	64	70	PF00454	0.500
MOD_PKA_1	332	338	PF00069	0.399
MOD_PKA_2	332	338	PF00069	0.399
MOD_Plk_1	141	147	PF00069	0.642
MOD_Plk_2-3	322	328	PF00069	0.516
MOD_Plk_4	251	257	PF00069	0.469
MOD_Plk_4	292	298	PF00069	0.469
MOD_Plk_4	332	338	PF00069	0.399
MOD_Plk_4	55	61	PF00069	0.433
MOD_Plk_4	78	84	PF00069	0.535
MOD_ProDKin_1	202	208	PF00069	0.589
MOD_SUMO_for_1	113	116	PF00179	0.629
MOD_SUMO_for_1	159	162	PF00179	0.573
MOD_SUMO_rev_2	236	241	PF00179	0.614
TRG_DiLeu_BaEn_4	321	327	PF01217	0.469
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.469
TRG_ENDOCYTIC_2	26	29	PF00928	0.346
TRG_ENDOCYTIC_2	264	267	PF00928	0.504
TRG_ENDOCYTIC_2	300	303	PF00928	0.469
TRG_ENDOCYTIC_2	80	83	PF00928	0.570
TRG_ER_diArg_1	300	302	PF00400	0.469
TRG_ER_diArg_1	332	334	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKW7	Leptomonas seymouri	57%	90%
A0A3S7WYV2	Leishmania donovani	93%	100%
A4HEG1	Leishmania braziliensis	79%	100%
A4I198	Leishmania infantum	93%	100%
E9AXD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%