Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA37_LEIMA

TriTrypDb:

LmjF.25.0580 , LMJLV39_250011500 , LMJSD75_250011400

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.596
CLV_NRD_NRD_1	178	180	PF00675	0.714
CLV_NRD_NRD_1	18	20	PF00675	0.414
CLV_NRD_NRD_1	2	4	PF00675	0.627
CLV_NRD_NRD_1	43	45	PF00675	0.640
CLV_PCSK_FUR_1	153	157	PF00082	0.578
CLV_PCSK_KEX2_1	155	157	PF00082	0.581
CLV_PCSK_KEX2_1	18	20	PF00082	0.414
CLV_PCSK_KEX2_1	2	4	PF00082	0.643
CLV_PCSK_KEX2_1	43	45	PF00082	0.641
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.602
CLV_PCSK_PC7_1	151	157	PF00082	0.571
CLV_PCSK_SKI1_1	112	116	PF00082	0.739
DEG_Nend_UBRbox_1	1	4	PF02207	0.649
DEG_SCF_FBW7_1	54	60	PF00400	0.727
DOC_CKS1_1	5	10	PF01111	0.715
DOC_CKS1_1	54	59	PF01111	0.708
DOC_MAPK_gen_1	131	140	PF00069	0.609
DOC_MAPK_gen_1	2	11	PF00069	0.672
DOC_MAPK_MEF2A_6	133	142	PF00069	0.594
DOC_MAPK_RevD_3	140	156	PF00069	0.568
DOC_USP7_MATH_1	171	175	PF00917	0.733
DOC_USP7_UBL2_3	127	131	PF12436	0.615
DOC_USP7_UBL2_3	133	137	PF12436	0.663
DOC_USP7_UBL2_3	176	180	PF12436	0.706
DOC_WW_Pin1_4	4	9	PF00397	0.689
DOC_WW_Pin1_4	53	58	PF00397	0.615
LIG_FHA_1	113	119	PF00498	0.429
LIG_FHA_1	93	99	PF00498	0.670
LIG_FHA_2	91	97	PF00498	0.679
LIG_LIR_Gen_1	170	177	PF02991	0.735
LIG_LIR_Nem_3	147	152	PF02991	0.532
LIG_LIR_Nem_3	170	175	PF02991	0.618
LIG_LIR_Nem_3	94	100	PF02991	0.679
LIG_SH2_CRK	172	176	PF00017	0.625
LIG_SH2_GRB2like	97	100	PF00017	0.676
LIG_SH2_PTP2	149	152	PF00017	0.486
LIG_SH2_STAT3	100	103	PF00017	0.689
LIG_SH2_STAT5	149	152	PF00017	0.545
LIG_SH2_STAT5	172	175	PF00017	0.663
LIG_SH2_STAT5	97	100	PF00017	0.637
LIG_SxIP_EBH_1	18	28	PF03271	0.668
LIG_TRAF2_1	144	147	PF00917	0.483
LIG_TYR_ITIM	70	75	PF00017	0.605
MOD_CDK_SPxK_1	4	10	PF00069	0.712
MOD_CDK_SPxK_1	53	59	PF00069	0.719
MOD_CK2_1	90	96	PF00069	0.617
MOD_GSK3_1	171	178	PF00069	0.692
MOD_GSK3_1	53	60	PF00069	0.608
MOD_NEK2_1	138	143	PF00069	0.579
MOD_NEK2_1	14	19	PF00069	0.660
MOD_NEK2_1	158	163	PF00069	0.621
MOD_NEK2_1	175	180	PF00069	0.628
MOD_NEK2_1	48	53	PF00069	0.585
MOD_NEK2_2	171	176	PF00069	0.701
MOD_PIKK_1	158	164	PF00454	0.629
MOD_PIKK_1	182	188	PF00454	0.710
MOD_PKA_2	17	23	PF00069	0.679
MOD_Plk_2-3	90	96	PF00069	0.643
MOD_Plk_4	145	151	PF00069	0.632
MOD_ProDKin_1	4	10	PF00069	0.690
MOD_ProDKin_1	53	59	PF00069	0.617
MOD_SUMO_rev_2	130	139	PF00179	0.620
TRG_ENDOCYTIC_2	149	152	PF00928	0.536
TRG_ENDOCYTIC_2	172	175	PF00928	0.616
TRG_ENDOCYTIC_2	71	74	PF00928	0.548
TRG_ER_diArg_1	1	3	PF00400	0.657
TRG_ER_diArg_1	150	153	PF00400	0.591
TRG_ER_diArg_1	42	44	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.739
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.714
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.615
TRG_PTS1	187	190	PF00515	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM8	Leptomonas seymouri	79%	100%
A0A0S4IKU3	Bodo saltans	51%	100%
A0A1X0P4E1	Trypanosomatidae	60%	93%
A0A3Q8IC88	Leishmania donovani	94%	100%
A0A422NWZ6	Trypanosoma rangeli	62%	100%
A4HEG0	Leishmania braziliensis	88%	100%
A4I199	Leishmania infantum	94%	100%
D0A5J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	95%
E9AXD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%