Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA35_LEIMA

TriTrypDb:

LmjF.25.0600 , LMJLV39_250011800 , LMJSD75_250011700

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.335
CLV_C14_Caspase3-7	341	345	PF00656	0.651
CLV_C14_Caspase3-7	401	405	PF00656	0.616
CLV_NRD_NRD_1	107	109	PF00675	0.390
CLV_NRD_NRD_1	320	322	PF00675	0.691
CLV_NRD_NRD_1	332	334	PF00675	0.667
CLV_NRD_NRD_1	4	6	PF00675	0.541
CLV_PCSK_FUR_1	105	109	PF00082	0.542
CLV_PCSK_KEX2_1	105	107	PF00082	0.473
CLV_PCSK_KEX2_1	332	334	PF00082	0.643
CLV_PCSK_KEX2_1	4	6	PF00082	0.541
CLV_PCSK_SKI1_1	115	119	PF00082	0.429
CLV_PCSK_SKI1_1	192	196	PF00082	0.398
CLV_PCSK_SKI1_1	5	9	PF00082	0.567
DEG_APCC_DBOX_1	191	199	PF00400	0.463
DEG_APCC_DBOX_1	4	12	PF00400	0.497
DOC_ANK_TNKS_1	107	114	PF00023	0.508
DOC_PP2B_LxvP_1	179	182	PF13499	0.506
DOC_PP4_FxxP_1	70	73	PF00568	0.593
DOC_USP7_MATH_1	270	274	PF00917	0.459
DOC_USP7_MATH_1	53	57	PF00917	0.517
DOC_WW_Pin1_4	283	288	PF00397	0.535
DOC_WW_Pin1_4	291	296	PF00397	0.627
LIG_14-3-3_CanoR_1	271	276	PF00244	0.412
LIG_14-3-3_CanoR_1	346	350	PF00244	0.596
LIG_14-3-3_CanoR_1	5	15	PF00244	0.472
LIG_Actin_WH2_2	20	35	PF00022	0.369
LIG_BRCT_BRCA1_1	172	176	PF00533	0.415
LIG_BRCT_BRCA1_1	195	199	PF00533	0.462
LIG_FHA_1	162	168	PF00498	0.490
LIG_FHA_1	176	182	PF00498	0.388
LIG_FHA_1	233	239	PF00498	0.435
LIG_FHA_1	249	255	PF00498	0.487
LIG_FHA_1	26	32	PF00498	0.450
LIG_FHA_1	368	374	PF00498	0.633
LIG_FHA_1	75	81	PF00498	0.742
LIG_FHA_1	99	105	PF00498	0.740
LIG_FHA_2	124	130	PF00498	0.342
LIG_FHA_2	213	219	PF00498	0.424
LIG_FHA_2	7	13	PF00498	0.448
LIG_GBD_Chelix_1	145	153	PF00786	0.465
LIG_LIR_Apic_2	394	398	PF02991	0.626
LIG_LIR_Apic_2	67	73	PF02991	0.597
LIG_LIR_Gen_1	173	184	PF02991	0.541
LIG_LIR_Gen_1	251	258	PF02991	0.498
LIG_LIR_Gen_1	370	379	PF02991	0.602
LIG_LIR_Gen_1	38	47	PF02991	0.438
LIG_LIR_LC3C_4	221	225	PF02991	0.337
LIG_LIR_Nem_3	173	179	PF02991	0.504
LIG_LIR_Nem_3	251	256	PF02991	0.505
LIG_LIR_Nem_3	370	374	PF02991	0.526
LIG_LIR_Nem_3	38	42	PF02991	0.429
LIG_MLH1_MIPbox_1	172	176	PF16413	0.353
LIG_MYND_1	386	390	PF01753	0.647
LIG_Pex14_2	367	371	PF04695	0.547
LIG_SH2_SRC	239	242	PF00017	0.546
LIG_SH2_SRC	363	366	PF00017	0.593
LIG_SH2_STAP1	130	134	PF00017	0.516
LIG_SH2_STAT5	39	42	PF00017	0.364
LIG_SH3_3	279	285	PF00018	0.538
LIG_SH3_3	381	387	PF00018	0.662
LIG_SH3_3	66	72	PF00018	0.676
LIG_TRAF2_1	204	207	PF00917	0.436
LIG_WRC_WIRS_1	172	177	PF05994	0.296
LIG_WRC_WIRS_1	250	255	PF05994	0.371
MOD_CK1_1	25	31	PF00069	0.288
MOD_CK1_1	299	305	PF00069	0.557
MOD_CK1_1	84	90	PF00069	0.695
MOD_CK1_1	94	100	PF00069	0.688
MOD_CK2_1	163	169	PF00069	0.558
MOD_CK2_1	201	207	PF00069	0.396
MOD_CK2_1	6	12	PF00069	0.438
MOD_GlcNHglycan	120	123	PF01048	0.398
MOD_GlcNHglycan	195	198	PF01048	0.399
MOD_GlcNHglycan	206	211	PF01048	0.356
MOD_GlcNHglycan	220	223	PF01048	0.327
MOD_GlcNHglycan	264	267	PF01048	0.496
MOD_GlcNHglycan	301	304	PF01048	0.663
MOD_GlcNHglycan	55	58	PF01048	0.545
MOD_GlcNHglycan	83	86	PF01048	0.705
MOD_GlcNHglycan	97	100	PF01048	0.618
MOD_GSK3_1	161	168	PF00069	0.540
MOD_GSK3_1	170	177	PF00069	0.409
MOD_GSK3_1	230	237	PF00069	0.520
MOD_GSK3_1	271	278	PF00069	0.467
MOD_GSK3_1	297	304	PF00069	0.554
MOD_GSK3_1	308	315	PF00069	0.607
MOD_GSK3_1	53	60	PF00069	0.598
MOD_GSK3_1	91	98	PF00069	0.705
MOD_NEK2_1	118	123	PF00069	0.385
MOD_NEK2_1	163	168	PF00069	0.500
MOD_NEK2_1	175	180	PF00069	0.476
MOD_NEK2_1	234	239	PF00069	0.423
MOD_NEK2_1	367	372	PF00069	0.568
MOD_NEK2_1	402	407	PF00069	0.549
MOD_NEK2_1	93	98	PF00069	0.525
MOD_NEK2_2	308	313	PF00069	0.675
MOD_PIKK_1	161	167	PF00454	0.493
MOD_PIKK_1	316	322	PF00454	0.580
MOD_PIKK_1	98	104	PF00454	0.769
MOD_PK_1	271	277	PF00069	0.419
MOD_PKA_2	270	276	PF00069	0.396
MOD_PKA_2	312	318	PF00069	0.710
MOD_PKA_2	345	351	PF00069	0.595
MOD_Plk_1	206	212	PF00069	0.418
MOD_Plk_1	248	254	PF00069	0.499
MOD_Plk_4	130	136	PF00069	0.385
MOD_Plk_4	171	177	PF00069	0.507
MOD_Plk_4	234	240	PF00069	0.474
MOD_Plk_4	249	255	PF00069	0.416
MOD_Plk_4	345	351	PF00069	0.721
MOD_ProDKin_1	283	289	PF00069	0.535
MOD_ProDKin_1	291	297	PF00069	0.627
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.469
TRG_ENDOCYTIC_2	39	42	PF00928	0.432
TRG_ER_diArg_1	104	107	PF00400	0.502
TRG_ER_diArg_1	3	5	PF00400	0.552
TRG_ER_diArg_1	337	340	PF00400	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5X9	Leptomonas seymouri	53%	98%
A0A1X0P4Q1	Trypanosomatidae	29%	100%
A0A3S5IS63	Trypanosoma rangeli	30%	100%
A0A3S7WZ17	Leishmania donovani	89%	100%
A4HEF8	Leishmania braziliensis	72%	100%
A4I1A1	Leishmania infantum	89%	100%
D0A5J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AXD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5B7R1	Trypanosoma cruzi	33%	100%