Tetratricopeptide repeat (TPR)-like superfamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA32_LEIMA

TriTrypDb:

LmjF.25.0630 , LMJLV39_250012200 , LMJSD75_250012100

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QA32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	274	276	PF00675	0.282
CLV_NRD_NRD_1	56	58	PF00675	0.428
CLV_NRD_NRD_1	65	67	PF00675	0.439
CLV_PCSK_FUR_1	288	292	PF00082	0.330
CLV_PCSK_KEX2_1	274	276	PF00082	0.278
CLV_PCSK_KEX2_1	290	292	PF00082	0.292
CLV_PCSK_KEX2_1	56	58	PF00082	0.427
CLV_PCSK_KEX2_1	65	67	PF00082	0.440
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.319
CLV_PCSK_SKI1_1	313	317	PF00082	0.364
DEG_Nend_UBRbox_1	1	4	PF02207	0.546
DEG_SPOP_SBC_1	20	24	PF00917	0.554
DOC_CYCLIN_RxL_1	310	318	PF00134	0.600
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.632
DOC_MAPK_gen_1	310	319	PF00069	0.542
DOC_MAPK_gen_1	65	71	PF00069	0.622
DOC_MAPK_MEF2A_6	116	123	PF00069	0.643
DOC_MAPK_MEF2A_6	140	149	PF00069	0.597
DOC_MAPK_MEF2A_6	310	319	PF00069	0.560
DOC_MAPK_MEF2A_6	331	339	PF00069	0.531
DOC_PP4_FxxP_1	102	105	PF00568	0.691
LIG_14-3-3_CanoR_1	214	220	PF00244	0.506
LIG_14-3-3_CanoR_1	274	278	PF00244	0.486
LIG_Actin_WH2_2	96	112	PF00022	0.692
LIG_ActinCP_TwfCPI_2	102	110	PF01115	0.696
LIG_BRCT_BRCA1_1	40	44	PF00533	0.500
LIG_eIF4E_1	80	86	PF01652	0.635
LIG_EVH1_2	119	123	PF00568	0.668
LIG_LIR_Gen_1	223	234	PF02991	0.494
LIG_LIR_Nem_3	223	229	PF02991	0.478
LIG_LIR_Nem_3	276	280	PF02991	0.476
LIG_LIR_Nem_3	349	355	PF02991	0.412
LIG_LIR_Nem_3	72	77	PF02991	0.625
LIG_PCNA_yPIPBox_3	290	303	PF02747	0.552
LIG_RPA_C_Fungi	52	64	PF08784	0.409
LIG_SH2_CRK	280	284	PF00017	0.328
LIG_SH2_GRB2like	352	355	PF00017	0.507
LIG_SH2_PTP2	39	42	PF00017	0.361
LIG_SH2_SRC	37	40	PF00017	0.477
LIG_SH2_STAP1	226	230	PF00017	0.318
LIG_SH2_STAT5	252	255	PF00017	0.336
LIG_SH2_STAT5	37	40	PF00017	0.349
LIG_SH3_2	105	110	PF14604	0.524
LIG_SH3_3	102	108	PF00018	0.507
LIG_SH3_3	114	120	PF00018	0.461
LIG_SH3_3	231	237	PF00018	0.443
LIG_SH3_3	78	84	PF00018	0.504
LIG_SUMO_SIM_anti_2	127	133	PF11976	0.476
LIG_SUMO_SIM_anti_2	31	37	PF11976	0.361
LIG_SUMO_SIM_par_1	127	133	PF11976	0.531
LIG_TYR_ITIM	278	283	PF00017	0.331
LIG_TYR_ITIM	35	40	PF00017	0.356
LIG_UBA3_1	283	290	PF00899	0.390
LIG_UBA3_1	299	305	PF00899	0.369
MOD_CK1_1	175	181	PF00069	0.358
MOD_CK1_1	206	212	PF00069	0.423
MOD_Cter_Amidation	288	291	PF01082	0.402
MOD_GlcNHglycan	193	196	PF01048	0.460
MOD_GSK3_1	143	150	PF00069	0.538
MOD_GSK3_1	19	26	PF00069	0.430
MOD_GSK3_1	339	346	PF00069	0.276
MOD_GSK3_1	48	55	PF00069	0.398
MOD_N-GLC_2	338	340	PF02516	0.335
MOD_NEK2_1	230	235	PF00069	0.391
MOD_NEK2_1	38	43	PF00069	0.440
MOD_NEK2_1	75	80	PF00069	0.610
MOD_NEK2_2	215	220	PF00069	0.389
MOD_PIKK_1	147	153	PF00454	0.464
MOD_PIKK_1	23	29	PF00454	0.403
MOD_PKA_2	172	178	PF00069	0.356
MOD_PKA_2	273	279	PF00069	0.327
MOD_PKA_2	48	54	PF00069	0.419
MOD_Plk_1	230	236	PF00069	0.405
MOD_Plk_4	175	181	PF00069	0.358
MOD_Plk_4	215	221	PF00069	0.422
MOD_Plk_4	298	304	PF00069	0.450
MOD_Plk_4	48	54	PF00069	0.476
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.548
TRG_ENDOCYTIC_2	226	229	PF00928	0.326
TRG_ENDOCYTIC_2	280	283	PF00928	0.306
TRG_ENDOCYTIC_2	332	335	PF00928	0.350
TRG_ENDOCYTIC_2	37	40	PF00928	0.349
TRG_ENDOCYTIC_2	97	100	PF00928	0.487
TRG_ER_diArg_1	1	4	PF00400	0.424
TRG_ER_diArg_1	273	275	PF00400	0.315
TRG_ER_diArg_1	47	50	PF00400	0.559
TRG_ER_diArg_1	56	59	PF00400	0.547
TRG_ER_diArg_1	64	66	PF00400	0.543
TRG_NES_CRM1_1	127	142	PF08389	0.544
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZB7	Leptomonas seymouri	82%	100%
A0A0S4JI71	Bodo saltans	65%	75%
A0A1X0P4P9	Trypanosomatidae	70%	100%
A0A3S7WYX0	Leishmania donovani	98%	100%
A4HEF5	Leishmania braziliensis	94%	100%
A4I1A4	Leishmania infantum	98%	100%
D0A5J6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AXE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BN61	Trypanosoma cruzi	69%	100%