C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania major

UniProt:

Q4QA30_LEIMA

TriTrypDb:

LmjF.25.0650 , LMJLV39_250012400 , LMJSD75_250012300

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.592
CLV_NRD_NRD_1	145	147	PF00675	0.569
CLV_NRD_NRD_1	191	193	PF00675	0.462
CLV_NRD_NRD_1	322	324	PF00675	0.487
CLV_NRD_NRD_1	408	410	PF00675	0.592
CLV_PCSK_FUR_1	189	193	PF00082	0.473
CLV_PCSK_KEX2_1	145	147	PF00082	0.560
CLV_PCSK_KEX2_1	191	193	PF00082	0.462
CLV_PCSK_KEX2_1	408	410	PF00082	0.592
CLV_PCSK_SKI1_1	250	254	PF00082	0.429
CLV_PCSK_SKI1_1	350	354	PF00082	0.549
CLV_PCSK_SKI1_1	570	574	PF00082	0.497
CLV_PCSK_SKI1_1	645	649	PF00082	0.539
CLV_PCSK_SKI1_1	652	656	PF00082	0.475
DEG_APCC_DBOX_1	349	357	PF00400	0.510
DEG_SCF_FBW7_1	462	467	PF00400	0.604
DEG_SCF_FBW7_2	73	80	PF00400	0.591
DEG_SIAH_1	479	487	PF03145	0.523
DEG_SPOP_SBC_1	370	374	PF00917	0.657
DEG_SPOP_SBC_1	377	381	PF00917	0.597
DEG_SPOP_SBC_1	464	468	PF00917	0.535
DOC_CDC14_PxL_1	305	313	PF14671	0.493
DOC_CDC14_PxL_1	487	495	PF14671	0.472
DOC_CKS1_1	174	179	PF01111	0.482
DOC_CKS1_1	74	79	PF01111	0.590
DOC_CYCLIN_yCln2_LP_2	624	630	PF00134	0.451
DOC_MAPK_DCC_7	304	313	PF00069	0.436
DOC_MAPK_gen_1	189	198	PF00069	0.453
DOC_MAPK_gen_1	304	313	PF00069	0.501
DOC_MAPK_HePTP_8	301	313	PF00069	0.452
DOC_MAPK_MEF2A_6	191	200	PF00069	0.439
DOC_MAPK_MEF2A_6	304	313	PF00069	0.505
DOC_MAPK_MEF2A_6	518	525	PF00069	0.415
DOC_PP1_RVXF_1	148	155	PF00149	0.629
DOC_PP1_RVXF_1	242	249	PF00149	0.502
DOC_PP4_FxxP_1	171	174	PF00568	0.378
DOC_USP7_MATH_1	294	298	PF00917	0.605
DOC_USP7_MATH_1	300	304	PF00917	0.636
DOC_USP7_MATH_1	371	375	PF00917	0.669
DOC_USP7_MATH_1	376	380	PF00917	0.606
DOC_USP7_MATH_1	382	386	PF00917	0.529
DOC_USP7_MATH_1	441	445	PF00917	0.671
DOC_USP7_MATH_1	480	484	PF00917	0.600
DOC_USP7_MATH_1	492	496	PF00917	0.403
DOC_USP7_MATH_1	51	55	PF00917	0.677
DOC_USP7_MATH_1	588	592	PF00917	0.490
DOC_USP7_MATH_1	66	70	PF00917	0.579
DOC_USP7_UBL2_3	652	656	PF12436	0.471
DOC_WW_Pin1_4	173	178	PF00397	0.480
DOC_WW_Pin1_4	460	465	PF00397	0.603
DOC_WW_Pin1_4	474	479	PF00397	0.516
DOC_WW_Pin1_4	501	506	PF00397	0.542
DOC_WW_Pin1_4	73	78	PF00397	0.601
LIG_14-3-3_CanoR_1	150	155	PF00244	0.640
LIG_14-3-3_CanoR_1	159	168	PF00244	0.524
LIG_14-3-3_CanoR_1	268	277	PF00244	0.515
LIG_14-3-3_CanoR_1	355	361	PF00244	0.534
LIG_14-3-3_CanoR_1	440	446	PF00244	0.653
LIG_14-3-3_CanoR_1	52	58	PF00244	0.527
LIG_14-3-3_CanoR_1	605	615	PF00244	0.515
LIG_Actin_WH2_2	234	252	PF00022	0.517
LIG_Actin_WH2_2	307	325	PF00022	0.492
LIG_Actin_WH2_2	392	410	PF00022	0.556
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BIR_III_4	457	461	PF00653	0.666
LIG_BRCT_BRCA1_1	494	498	PF00533	0.466
LIG_BRCT_BRCA1_1	53	57	PF00533	0.551
LIG_FHA_1	191	197	PF00498	0.466
LIG_FHA_1	206	212	PF00498	0.431
LIG_FHA_1	220	226	PF00498	0.534
LIG_FHA_1	329	335	PF00498	0.453
LIG_FHA_1	446	452	PF00498	0.625
LIG_FHA_1	465	471	PF00498	0.615
LIG_FHA_1	54	60	PF00498	0.612
LIG_FHA_1	573	579	PF00498	0.462
LIG_FHA_2	161	167	PF00498	0.580
LIG_FHA_2	291	297	PF00498	0.593
LIG_FHA_2	343	349	PF00498	0.601
LIG_FHA_2	466	472	PF00498	0.601
LIG_FHA_2	592	598	PF00498	0.443
LIG_FHA_2	82	88	PF00498	0.644
LIG_GBD_Chelix_1	245	253	PF00786	0.382
LIG_LIR_Gen_1	17	26	PF02991	0.466
LIG_LIR_Gen_1	495	503	PF02991	0.475
LIG_LIR_Nem_3	17	23	PF02991	0.473
LIG_LIR_Nem_3	495	499	PF02991	0.455
LIG_LIR_Nem_3	575	579	PF02991	0.426
LIG_PCNA_PIPBox_1	354	363	PF02747	0.434
LIG_PCNA_yPIPBox_3	350	361	PF02747	0.502
LIG_Pex14_2	171	175	PF04695	0.372
LIG_PTAP_UEV_1	367	372	PF05743	0.542
LIG_PTAP_UEV_1	47	52	PF05743	0.593
LIG_REV1ctd_RIR_1	496	504	PF16727	0.500
LIG_SH2_CRK	23	27	PF00017	0.423
LIG_SH2_STAT5	125	128	PF00017	0.500
LIG_SH2_STAT5	223	226	PF00017	0.489
LIG_SH2_STAT5	400	403	PF00017	0.519
LIG_SH3_3	171	177	PF00018	0.490
LIG_SH3_3	179	185	PF00018	0.440
LIG_SH3_3	197	203	PF00018	0.327
LIG_SH3_3	311	317	PF00018	0.477
LIG_SH3_3	365	371	PF00018	0.528
LIG_SH3_3	45	51	PF00018	0.563
LIG_SH3_CIN85_PxpxPR_1	22	27	PF14604	0.402
LIG_SUMO_SIM_anti_2	621	626	PF11976	0.397
LIG_SUMO_SIM_par_1	330	335	PF11976	0.621
LIG_SUMO_SIM_par_1	80	87	PF11976	0.595
LIG_TRAF2_1	346	349	PF00917	0.550
LIG_TRAF2_1	77	80	PF00917	0.589
LIG_UBA3_1	357	364	PF00899	0.437
LIG_WRC_WIRS_1	357	362	PF05994	0.426
LIG_WRC_WIRS_1	493	498	PF05994	0.460
LIG_WRC_WIRS_1	573	578	PF05994	0.397
MOD_CAAXbox	663	666	PF01239	0.557
MOD_CK1_1	190	196	PF00069	0.643
MOD_CK1_1	263	269	PF00069	0.609
MOD_CK1_1	272	278	PF00069	0.617
MOD_CK1_1	369	375	PF00069	0.624
MOD_CK1_1	381	387	PF00069	0.532
MOD_CK1_1	465	471	PF00069	0.629
MOD_CK1_1	591	597	PF00069	0.509
MOD_CK1_1	603	609	PF00069	0.424
MOD_CK1_1	94	100	PF00069	0.578
MOD_CK2_1	342	348	PF00069	0.554
MOD_CK2_1	441	447	PF00069	0.665
MOD_CK2_1	591	597	PF00069	0.472
MOD_CK2_1	81	87	PF00069	0.639
MOD_CMANNOS	274	277	PF00535	0.636
MOD_GlcNHglycan	212	215	PF01048	0.584
MOD_GlcNHglycan	271	274	PF01048	0.556
MOD_GlcNHglycan	279	282	PF01048	0.598
MOD_GlcNHglycan	296	299	PF01048	0.623
MOD_GlcNHglycan	368	371	PF01048	0.652
MOD_GlcNHglycan	380	383	PF01048	0.555
MOD_GlcNHglycan	384	387	PF01048	0.532
MOD_GlcNHglycan	443	446	PF01048	0.688
MOD_GlcNHglycan	508	511	PF01048	0.529
MOD_GlcNHglycan	582	585	PF01048	0.628
MOD_GlcNHglycan	590	593	PF01048	0.554
MOD_GlcNHglycan	602	605	PF01048	0.339
MOD_GlcNHglycan	611	614	PF01048	0.501
MOD_GlcNHglycan	652	655	PF01048	0.433
MOD_GlcNHglycan	70	73	PF01048	0.604
MOD_GlcNHglycan	97	100	PF01048	0.599
MOD_GSK3_1	201	208	PF00069	0.466
MOD_GSK3_1	215	222	PF00069	0.608
MOD_GSK3_1	268	275	PF00069	0.657
MOD_GSK3_1	277	284	PF00069	0.541
MOD_GSK3_1	290	297	PF00069	0.525
MOD_GSK3_1	328	335	PF00069	0.514
MOD_GSK3_1	338	345	PF00069	0.495
MOD_GSK3_1	366	373	PF00069	0.653
MOD_GSK3_1	377	384	PF00069	0.570
MOD_GSK3_1	407	414	PF00069	0.557
MOD_GSK3_1	441	448	PF00069	0.657
MOD_GSK3_1	460	467	PF00069	0.596
MOD_GSK3_1	600	607	PF00069	0.422
MOD_GSK3_1	609	616	PF00069	0.517
MOD_GSK3_1	90	97	PF00069	0.571
MOD_N-GLC_1	328	333	PF02516	0.445
MOD_N-GLC_1	337	342	PF02516	0.484
MOD_N-GLC_1	474	479	PF02516	0.568
MOD_N-GLC_1	94	99	PF02516	0.497
MOD_NEK2_1	210	215	PF00069	0.591
MOD_NEK2_1	269	274	PF00069	0.538
MOD_NEK2_1	356	361	PF00069	0.540
MOD_NEK2_1	407	412	PF00069	0.590
MOD_NEK2_1	498	503	PF00069	0.505
MOD_NEK2_1	572	577	PF00069	0.342
MOD_NEK2_1	68	73	PF00069	0.596
MOD_NEK2_2	281	286	PF00069	0.592
MOD_NEK2_2	35	40	PF00069	0.470
MOD_OFUCOSY	33	39	PF10250	0.469
MOD_PIKK_1	431	437	PF00454	0.626
MOD_PKA_2	190	196	PF00069	0.532
MOD_PKA_2	382	388	PF00069	0.590
MOD_PKA_2	407	413	PF00069	0.579
MOD_PKA_2	51	57	PF00069	0.525
MOD_PKA_2	604	610	PF00069	0.452
MOD_PKB_1	643	651	PF00069	0.551
MOD_Plk_1	234	240	PF00069	0.453
MOD_Plk_1	328	334	PF00069	0.439
MOD_Plk_4	107	113	PF00069	0.524
MOD_Plk_4	226	232	PF00069	0.404
MOD_Plk_4	281	287	PF00069	0.551
MOD_Plk_4	309	315	PF00069	0.474
MOD_Plk_4	328	334	PF00069	0.471
MOD_Plk_4	480	486	PF00069	0.463
MOD_Plk_4	530	536	PF00069	0.406
MOD_ProDKin_1	173	179	PF00069	0.484
MOD_ProDKin_1	460	466	PF00069	0.602
MOD_ProDKin_1	474	480	PF00069	0.516
MOD_ProDKin_1	501	507	PF00069	0.538
MOD_ProDKin_1	73	79	PF00069	0.601
MOD_SUMO_for_1	637	640	PF00179	0.502
TRG_DiLeu_BaEn_4	348	354	PF01217	0.550
TRG_ER_diArg_1	188	191	PF00400	0.475
TRG_ER_diArg_1	407	409	PF00400	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP2	Leptomonas seymouri	43%	100%
A0A3S7WYX9	Leishmania donovani	86%	100%
A4HEF3	Leishmania braziliensis	68%	100%
A4I1A6	Leishmania infantum	87%	100%
E9AXE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%