Putative epsin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative epsin

Gene product:

epsin, putative

Species:

Leishmania major

UniProt:

Q4QA28_LEIMA

TriTrypDb:

LmjF.25.0670 , LMJLV39_250012600 , LMJSD75_250012500

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0030117	membrane coat	3	2
GO:0030118	clathrin coat	4	2
GO:0030120	vesicle coat	4	2
GO:0030125	clathrin vesicle coat	5	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA28

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0016192	vesicle-mediated transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005543	phospholipid binding	3	2
GO:0008289	lipid binding	2	2
GO:0030276	clathrin binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.696
CLV_NRD_NRD_1	237	239	PF00675	0.559
CLV_NRD_NRD_1	287	289	PF00675	0.647
CLV_PCSK_FUR_1	285	289	PF00082	0.544
CLV_PCSK_KEX2_1	237	239	PF00082	0.559
CLV_PCSK_KEX2_1	287	289	PF00082	0.647
CLV_PCSK_PC7_1	233	239	PF00082	0.541
CLV_PCSK_SKI1_1	77	81	PF00082	0.357
DEG_APCC_DBOX_1	573	581	PF00400	0.599
DEG_Nend_UBRbox_3	1	3	PF02207	0.513
DOC_CKS1_1	402	407	PF01111	0.577
DOC_CKS1_1	467	472	PF01111	0.657
DOC_CYCLIN_RxL_1	73	83	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.537
DOC_MAPK_gen_1	285	293	PF00069	0.708
DOC_MAPK_MEF2A_6	222	231	PF00069	0.526
DOC_PP2B_LxvP_1	322	325	PF13499	0.590
DOC_PP4_FxxP_1	328	331	PF00568	0.706
DOC_USP7_MATH_1	18	22	PF00917	0.581
DOC_USP7_MATH_1	197	201	PF00917	0.667
DOC_USP7_MATH_1	342	346	PF00917	0.685
DOC_USP7_MATH_1	391	395	PF00917	0.672
DOC_USP7_MATH_1	410	414	PF00917	0.663
DOC_USP7_MATH_1	559	563	PF00917	0.653
DOC_USP7_MATH_2	354	360	PF00917	0.588
DOC_WW_Pin1_4	201	206	PF00397	0.781
DOC_WW_Pin1_4	301	306	PF00397	0.696
DOC_WW_Pin1_4	307	312	PF00397	0.687
DOC_WW_Pin1_4	336	341	PF00397	0.572
DOC_WW_Pin1_4	401	406	PF00397	0.578
DOC_WW_Pin1_4	466	471	PF00397	0.670
LIG_14-3-3_CanoR_1	105	113	PF00244	0.344
LIG_14-3-3_CanoR_1	186	191	PF00244	0.642
LIG_14-3-3_CanoR_1	238	246	PF00244	0.541
LIG_14-3-3_CanoR_1	453	459	PF00244	0.594
LIG_14-3-3_CanoR_1	479	484	PF00244	0.623
LIG_14-3-3_CanoR_1	491	496	PF00244	0.522
LIG_14-3-3_CanoR_1	503	508	PF00244	0.583
LIG_14-3-3_CanoR_1	521	530	PF00244	0.554
LIG_AP2alpha_2	461	463	PF02296	0.699
LIG_APCC_Cbox_2	91	97	PF00515	0.322
LIG_BIR_III_4	382	386	PF00653	0.739
LIG_BRCT_BRCA1_1	107	111	PF00533	0.344
LIG_Clathr_ClatBox_1	79	83	PF01394	0.344
LIG_FHA_1	2	8	PF00498	0.484
LIG_FHA_1	314	320	PF00498	0.691
LIG_FHA_2	17	23	PF00498	0.442
LIG_FHA_2	214	220	PF00498	0.542
LIG_FHA_2	265	271	PF00498	0.546
LIG_FHA_2	29	35	PF00498	0.371
LIG_FHA_2	377	383	PF00498	0.690
LIG_GBD_Chelix_1	132	140	PF00786	0.344
LIG_GBD_Chelix_1	148	156	PF00786	0.484
LIG_LIR_Apic_2	110	116	PF02991	0.344
LIG_LIR_Apic_2	359	363	PF02991	0.695
LIG_LIR_Apic_2	373	377	PF02991	0.594
LIG_LIR_Apic_2	382	387	PF02991	0.650
LIG_LIR_Apic_2	415	421	PF02991	0.730
LIG_LIR_Apic_2	426	432	PF02991	0.609
LIG_LIR_Apic_2	461	466	PF02991	0.646
LIG_LIR_Apic_2	553	559	PF02991	0.634
LIG_LIR_Gen_1	21	30	PF02991	0.349
LIG_LIR_Gen_1	527	537	PF02991	0.623
LIG_LIR_Nem_3	12	16	PF02991	0.445
LIG_LIR_Nem_3	185	190	PF02991	0.625
LIG_LIR_Nem_3	21	26	PF02991	0.351
LIG_LIR_Nem_3	450	454	PF02991	0.611
LIG_LIR_Nem_3	527	533	PF02991	0.798
LIG_LIR_Nem_3	579	584	PF02991	0.639
LIG_Pex14_1	72	76	PF04695	0.344
LIG_SH2_CRK	113	117	PF00017	0.344
LIG_SH2_CRK	76	80	PF00017	0.344
LIG_SH2_GRB2like	113	116	PF00017	0.344
LIG_SH2_PTP2	23	26	PF00017	0.344
LIG_SH2_STAP1	250	254	PF00017	0.528
LIG_SH2_STAT5	113	116	PF00017	0.353
LIG_SH2_STAT5	190	193	PF00017	0.550
LIG_SH2_STAT5	23	26	PF00017	0.344
LIG_SH2_STAT5	84	87	PF00017	0.334
LIG_SH2_STAT5	93	96	PF00017	0.334
LIG_SH3_1	35	41	PF00018	0.462
LIG_SH3_3	288	294	PF00018	0.692
LIG_SH3_3	303	309	PF00018	0.677
LIG_SH3_3	330	336	PF00018	0.701
LIG_SH3_3	35	41	PF00018	0.462
LIG_SH3_3	456	462	PF00018	0.642
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.344
LIG_SUMO_SIM_par_1	78	83	PF11976	0.344
LIG_TRAF2_1	216	219	PF00917	0.549
LIG_TRAF2_2	549	554	PF00917	0.677
LIG_WRC_WIRS_1	343	348	PF05994	0.732
MOD_CDK_SPxK_1	301	307	PF00069	0.791
MOD_CK1_1	200	206	PF00069	0.641
MOD_CK1_1	239	245	PF00069	0.656
MOD_CK1_1	292	298	PF00069	0.643
MOD_CK1_1	447	453	PF00069	0.768
MOD_CK1_1	524	530	PF00069	0.740
MOD_CK1_1	570	576	PF00069	0.694
MOD_CK2_1	121	127	PF00069	0.344
MOD_CK2_1	16	22	PF00069	0.452
MOD_CK2_1	213	219	PF00069	0.580
MOD_CK2_1	256	262	PF00069	0.506
MOD_CK2_1	28	34	PF00069	0.344
MOD_CK2_1	6	12	PF00069	0.467
MOD_GlcNHglycan	172	175	PF01048	0.704
MOD_GlcNHglycan	207	210	PF01048	0.657
MOD_GlcNHglycan	238	241	PF01048	0.563
MOD_GlcNHglycan	350	353	PF01048	0.729
MOD_GlcNHglycan	408	411	PF01048	0.664
MOD_GlcNHglycan	446	449	PF01048	0.679
MOD_GlcNHglycan	545	548	PF01048	0.709
MOD_GlcNHglycan	96	100	PF01048	0.271
MOD_GSK3_1	103	110	PF00069	0.344
MOD_GSK3_1	154	161	PF00069	0.511
MOD_GSK3_1	170	177	PF00069	0.612
MOD_GSK3_1	197	204	PF00069	0.636
MOD_GSK3_1	205	212	PF00069	0.659
MOD_GSK3_1	295	302	PF00069	0.750
MOD_GSK3_1	342	349	PF00069	0.726
MOD_GSK3_1	406	413	PF00069	0.740
MOD_GSK3_1	524	531	PF00069	0.617
MOD_GSK3_1	564	571	PF00069	0.700
MOD_N-GLC_1	1	6	PF02516	0.513
MOD_N-GLC_1	158	163	PF02516	0.571
MOD_N-GLC_1	444	449	PF02516	0.821
MOD_NEK2_1	1	6	PF00069	0.495
MOD_NEK2_1	111	116	PF00069	0.427
MOD_NEK2_1	249	254	PF00069	0.583
MOD_NEK2_1	346	351	PF00069	0.693
MOD_NEK2_1	552	557	PF00069	0.728
MOD_NEK2_1	568	573	PF00069	0.681
MOD_PIKK_1	1	7	PF00454	0.492
MOD_PIKK_1	326	332	PF00454	0.690
MOD_PIKK_1	434	440	PF00454	0.755
MOD_PIKK_1	454	460	PF00454	0.583
MOD_PIKK_1	473	479	PF00454	0.611
MOD_PIKK_1	485	491	PF00454	0.606
MOD_PIKK_1	497	503	PF00454	0.601
MOD_PIKK_1	509	515	PF00454	0.615
MOD_PIKK_1	521	527	PF00454	0.700
MOD_PKA_2	236	242	PF00069	0.673
MOD_PKA_2	256	262	PF00069	0.506
MOD_Plk_1	68	74	PF00069	0.462
MOD_Plk_1	95	101	PF00069	0.271
MOD_Plk_4	107	113	PF00069	0.344
MOD_Plk_4	342	348	PF00069	0.774
MOD_Plk_4	356	362	PF00069	0.615
MOD_Plk_4	576	582	PF00069	0.595
MOD_Plk_4	75	81	PF00069	0.344
MOD_ProDKin_1	201	207	PF00069	0.783
MOD_ProDKin_1	301	307	PF00069	0.696
MOD_ProDKin_1	336	342	PF00069	0.571
MOD_ProDKin_1	401	407	PF00069	0.577
MOD_ProDKin_1	466	472	PF00069	0.670
TRG_DiLeu_BaEn_1	96	101	PF01217	0.344
TRG_ENDOCYTIC_2	23	26	PF00928	0.344
TRG_ENDOCYTIC_2	76	79	PF00928	0.344
TRG_ER_diArg_1	254	257	PF00400	0.575
TRG_ER_diArg_1	285	288	PF00400	0.606
TRG_ER_diArg_1	61	64	PF00400	0.362
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI1	Leptomonas seymouri	54%	100%
A0A3Q8IDD0	Leishmania donovani	75%	100%
A4HDZ7	Leishmania braziliensis	62%	100%
A4I1A8	Leishmania infantum	75%	100%
E9AXE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	93%
O95208	Homo sapiens	26%	93%
Q8CHU3	Mus musculus	28%	100%
Q9Z1Z3	Rattus norvegicus	24%	100%