Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA25_LEIMA

TriTrypDb:

LmjF.25.0700 , LMJLV39_250012900 , LMJSD75_250012800

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.488
CLV_NRD_NRD_1	273	275	PF00675	0.546
CLV_NRD_NRD_1	366	368	PF00675	0.614
CLV_NRD_NRD_1	38	40	PF00675	0.632
CLV_NRD_NRD_1	97	99	PF00675	0.415
CLV_PCSK_FUR_1	364	368	PF00082	0.677
CLV_PCSK_FUR_1	506	510	PF00082	0.613
CLV_PCSK_KEX2_1	185	187	PF00082	0.496
CLV_PCSK_KEX2_1	273	275	PF00082	0.542
CLV_PCSK_KEX2_1	366	368	PF00082	0.686
CLV_PCSK_KEX2_1	508	510	PF00082	0.610
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.496
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.610
CLV_PCSK_SKI1_1	14	18	PF00082	0.611
CLV_PCSK_SKI1_1	173	177	PF00082	0.440
CLV_PCSK_SKI1_1	203	207	PF00082	0.557
CLV_PCSK_SKI1_1	248	252	PF00082	0.514
CLV_PCSK_SKI1_1	387	391	PF00082	0.600
CLV_PCSK_SKI1_1	78	82	PF00082	0.382
CLV_PCSK_SKI1_1	98	102	PF00082	0.268
DEG_APCC_DBOX_1	172	180	PF00400	0.432
DEG_APCC_DBOX_1	247	255	PF00400	0.513
DEG_SPOP_SBC_1	308	312	PF00917	0.532
DEG_SPOP_SBC_1	65	69	PF00917	0.588
DOC_CDC14_PxL_1	333	341	PF14671	0.446
DOC_CKS1_1	458	463	PF01111	0.611
DOC_MAPK_MEF2A_6	387	394	PF00069	0.506
DOC_USP7_MATH_1	111	115	PF00917	0.428
DOC_USP7_MATH_1	197	201	PF00917	0.614
DOC_USP7_MATH_1	205	209	PF00917	0.532
DOC_USP7_MATH_1	269	273	PF00917	0.542
DOC_USP7_MATH_1	291	295	PF00917	0.675
DOC_USP7_MATH_1	309	313	PF00917	0.441
DOC_USP7_MATH_1	349	353	PF00917	0.552
DOC_USP7_MATH_1	484	488	PF00917	0.620
DOC_USP7_MATH_1	49	53	PF00917	0.485
DOC_USP7_MATH_1	496	500	PF00917	0.547
DOC_USP7_MATH_1	65	69	PF00917	0.555
DOC_USP7_UBL2_3	181	185	PF12436	0.555
DOC_WW_Pin1_4	261	266	PF00397	0.552
DOC_WW_Pin1_4	28	33	PF00397	0.604
DOC_WW_Pin1_4	312	317	PF00397	0.550
DOC_WW_Pin1_4	394	399	PF00397	0.461
DOC_WW_Pin1_4	448	453	PF00397	0.626
DOC_WW_Pin1_4	457	462	PF00397	0.600
DOC_WW_Pin1_4	463	468	PF00397	0.606
LIG_14-3-3_CanoR_1	287	293	PF00244	0.546
LIG_14-3-3_CanoR_1	359	363	PF00244	0.565
LIG_14-3-3_CanoR_1	453	457	PF00244	0.589
LIG_14-3-3_CanoR_1	509	515	PF00244	0.541
LIG_14-3-3_CanoR_1	78	84	PF00244	0.450
LIG_14-3-3_CanoR_1	98	104	PF00244	0.255
LIG_Actin_WH2_2	136	152	PF00022	0.478
LIG_Actin_WH2_2	319	334	PF00022	0.447
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BIR_III_2	290	294	PF00653	0.611
LIG_BRCT_BRCA1_1	231	235	PF00533	0.565
LIG_BRCT_BRCA1_1	293	297	PF00533	0.548
LIG_BRCT_BRCA1_1	497	501	PF00533	0.581
LIG_FHA_1	158	164	PF00498	0.390
LIG_FHA_1	24	30	PF00498	0.545
LIG_FHA_1	279	285	PF00498	0.512
LIG_FHA_1	345	351	PF00498	0.553
LIG_FHA_1	453	459	PF00498	0.625
LIG_FHA_1	509	515	PF00498	0.586
LIG_FHA_1	533	539	PF00498	0.493
LIG_FHA_2	262	268	PF00498	0.726
LIG_FHA_2	395	401	PF00498	0.527
LIG_FHA_2	49	55	PF00498	0.593
LIG_LIR_Gen_1	101	112	PF02991	0.364
LIG_LIR_Gen_1	232	243	PF02991	0.549
LIG_LIR_Gen_1	54	63	PF02991	0.384
LIG_LIR_Nem_3	101	107	PF02991	0.375
LIG_LIR_Nem_3	232	238	PF02991	0.587
LIG_LIR_Nem_3	499	505	PF02991	0.574
LIG_LIR_Nem_3	54	59	PF02991	0.393
LIG_MLH1_MIPbox_1	498	502	PF16413	0.574
LIG_Pex14_2	401	405	PF04695	0.515
LIG_Pex14_2	497	501	PF04695	0.653
LIG_SH2_CRK	431	435	PF00017	0.597
LIG_SH2_NCK_1	431	435	PF00017	0.571
LIG_SH2_SRC	167	170	PF00017	0.384
LIG_SH2_STAT3	249	252	PF00017	0.451
LIG_SH2_STAT5	104	107	PF00017	0.355
LIG_SH2_STAT5	155	158	PF00017	0.405
LIG_SH2_STAT5	167	170	PF00017	0.423
LIG_SH2_STAT5	356	359	PF00017	0.590
LIG_SH2_STAT5	517	520	PF00017	0.702
LIG_SH2_STAT5	532	535	PF00017	0.447
LIG_SH3_3	424	430	PF00018	0.661
LIG_SH3_3	474	480	PF00018	0.682
LIG_TRAF2_1	52	55	PF00917	0.508
MOD_CDK_SPK_2	448	453	PF00069	0.626
MOD_CK1_1	102	108	PF00069	0.297
MOD_CK1_1	189	195	PF00069	0.556
MOD_CK1_1	196	202	PF00069	0.576
MOD_CK1_1	312	318	PF00069	0.583
MOD_CK1_1	373	379	PF00069	0.546
MOD_CK1_1	451	457	PF00069	0.590
MOD_CK1_1	466	472	PF00069	0.608
MOD_CK1_1	495	501	PF00069	0.607
MOD_CK1_1	513	519	PF00069	0.476
MOD_CK1_1	67	73	PF00069	0.572
MOD_CK1_1	82	88	PF00069	0.310
MOD_CK2_1	171	177	PF00069	0.463
MOD_CK2_1	332	338	PF00069	0.441
MOD_CK2_1	394	400	PF00069	0.482
MOD_CK2_1	48	54	PF00069	0.522
MOD_CK2_1	525	531	PF00069	0.532
MOD_GlcNHglycan	109	112	PF01048	0.356
MOD_GlcNHglycan	160	163	PF01048	0.439
MOD_GlcNHglycan	173	176	PF01048	0.455
MOD_GlcNHglycan	193	196	PF01048	0.457
MOD_GlcNHglycan	199	202	PF01048	0.595
MOD_GlcNHglycan	293	296	PF01048	0.536
MOD_GlcNHglycan	305	308	PF01048	0.475
MOD_GlcNHglycan	311	314	PF01048	0.391
MOD_GlcNHglycan	352	355	PF01048	0.500
MOD_GlcNHglycan	379	382	PF01048	0.734
MOD_GlcNHglycan	438	441	PF01048	0.658
MOD_GlcNHglycan	486	489	PF01048	0.665
MOD_GlcNHglycan	494	497	PF01048	0.758
MOD_GlcNHglycan	498	501	PF01048	0.557
MOD_GlcNHglycan	51	54	PF01048	0.541
MOD_GlcNHglycan	69	72	PF01048	0.471
MOD_GlcNHglycan	84	87	PF01048	0.336
MOD_GSK3_1	107	114	PF00069	0.348
MOD_GSK3_1	187	194	PF00069	0.540
MOD_GSK3_1	23	30	PF00069	0.603
MOD_GSK3_1	230	237	PF00069	0.588
MOD_GSK3_1	257	264	PF00069	0.521
MOD_GSK3_1	303	310	PF00069	0.686
MOD_GSK3_1	369	376	PF00069	0.621
MOD_GSK3_1	43	50	PF00069	0.695
MOD_GSK3_1	444	451	PF00069	0.639
MOD_GSK3_1	452	459	PF00069	0.581
MOD_GSK3_1	479	486	PF00069	0.572
MOD_GSK3_1	492	499	PF00069	0.543
MOD_GSK3_1	509	516	PF00069	0.459
MOD_GSK3_1	532	539	PF00069	0.583
MOD_GSK3_1	67	74	PF00069	0.556
MOD_GSK3_1	98	105	PF00069	0.512
MOD_LATS_1	330	336	PF00433	0.467
MOD_N-GLC_1	318	323	PF02516	0.523
MOD_N-GLC_1	369	374	PF02516	0.684
MOD_N-GLC_1	520	525	PF02516	0.611
MOD_NEK2_1	107	112	PF00069	0.377
MOD_NEK2_1	158	163	PF00069	0.349
MOD_NEK2_1	229	234	PF00069	0.616
MOD_NEK2_1	279	284	PF00069	0.529
MOD_NEK2_1	331	336	PF00069	0.431
MOD_NEK2_1	536	541	PF00069	0.600
MOD_NEK2_1	79	84	PF00069	0.409
MOD_NEK2_2	243	248	PF00069	0.510
MOD_PIKK_1	279	285	PF00454	0.536
MOD_PIKK_1	93	99	PF00454	0.417
MOD_PK_1	332	338	PF00069	0.441
MOD_PKA_1	508	514	PF00069	0.593
MOD_PKA_1	98	104	PF00069	0.384
MOD_PKA_2	187	193	PF00069	0.509
MOD_PKA_2	286	292	PF00069	0.612
MOD_PKA_2	358	364	PF00069	0.560
MOD_PKA_2	452	458	PF00069	0.611
MOD_PKA_2	484	490	PF00069	0.678
MOD_PKA_2	508	514	PF00069	0.604
MOD_PKA_2	91	97	PF00069	0.423
MOD_PKB_1	184	192	PF00069	0.517
MOD_Plk_1	520	526	PF00069	0.600
MOD_Plk_2-3	358	364	PF00069	0.560
MOD_Plk_4	429	435	PF00069	0.545
MOD_Plk_4	513	519	PF00069	0.605
MOD_Plk_4	71	77	PF00069	0.508
MOD_Plk_4	79	85	PF00069	0.417
MOD_Plk_4	99	105	PF00069	0.334
MOD_ProDKin_1	261	267	PF00069	0.554
MOD_ProDKin_1	28	34	PF00069	0.605
MOD_ProDKin_1	312	318	PF00069	0.557
MOD_ProDKin_1	394	400	PF00069	0.461
MOD_ProDKin_1	448	454	PF00069	0.625
MOD_ProDKin_1	457	463	PF00069	0.604
MOD_SUMO_rev_2	33	42	PF00179	0.527
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.369
TRG_ENDOCYTIC_2	104	107	PF00928	0.362
TRG_ENDOCYTIC_2	155	158	PF00928	0.408
TRG_ENDOCYTIC_2	431	434	PF00928	0.603
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEM3	Leptomonas seymouri	47%	98%
A0A3Q8ID86	Leishmania donovani	94%	100%
A4HE00	Leishmania braziliensis	79%	100%
A4I1B1	Leishmania infantum	95%	100%
E9AXE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%