SCAMP family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SCAMP family, putative

Species:

Leishmania major

UniProt:

Q4QA24_LEIMA

TriTrypDb:

LmjF.25.0710 , LMJLV39_250013000 , LMJSD75_250012900

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0010008	endosome membrane	5	2
GO:0012506	vesicle membrane	4	2
GO:0016020	membrane	2	11
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0032588	trans-Golgi network membrane	4	2
GO:0055038	recycling endosome membrane	6	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QA24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA24

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.746
CLV_C14_Caspase3-7	87	91	PF00656	0.683
CLV_NRD_NRD_1	112	114	PF00675	0.542
CLV_NRD_NRD_1	343	345	PF00675	0.318
CLV_NRD_NRD_1	349	351	PF00675	0.332
CLV_NRD_NRD_1	353	355	PF00675	0.335
CLV_PCSK_KEX2_1	343	345	PF00082	0.316
CLV_PCSK_KEX2_1	349	351	PF00082	0.336
CLV_PCSK_KEX2_1	353	355	PF00082	0.341
CLV_PCSK_PC7_1	349	355	PF00082	0.407
CLV_PCSK_SKI1_1	106	110	PF00082	0.412
CLV_PCSK_SKI1_1	117	121	PF00082	0.393
CLV_PCSK_SKI1_1	188	192	PF00082	0.232
CLV_PCSK_SKI1_1	193	197	PF00082	0.301
DEG_Nend_Nbox_1	1	3	PF02207	0.668
DOC_MAPK_gen_1	349	359	PF00069	0.609
DOC_MAPK_RevD_3	336	350	PF00069	0.517
DOC_PIKK_1	139	146	PF02985	0.637
DOC_USP7_MATH_1	220	224	PF00917	0.307
DOC_USP7_MATH_1	84	88	PF00917	0.665
DOC_USP7_MATH_2	58	64	PF00917	0.730
DOC_USP7_UBL2_3	94	98	PF12436	0.681
DOC_WW_Pin1_4	160	165	PF00397	0.624
DOC_WW_Pin1_4	31	36	PF00397	0.745
DOC_WW_Pin1_4	54	59	PF00397	0.712
DOC_WW_Pin1_4	66	71	PF00397	0.635
LIG_14-3-3_CanoR_1	113	119	PF00244	0.671
LIG_APCC_ABBA_1	225	230	PF00400	0.345
LIG_FHA_1	100	106	PF00498	0.687
LIG_FHA_1	124	130	PF00498	0.644
LIG_FHA_1	155	161	PF00498	0.668
LIG_FHA_1	6	12	PF00498	0.733
LIG_FHA_2	181	187	PF00498	0.488
LIG_FHA_2	73	79	PF00498	0.724
LIG_Integrin_isoDGR_2	24	26	PF01839	0.581
LIG_LIR_Apic_2	61	67	PF02991	0.731
LIG_LIR_Gen_1	198	207	PF02991	0.418
LIG_LIR_Gen_1	331	341	PF02991	0.393
LIG_LIR_Nem_3	198	202	PF02991	0.411
LIG_LIR_Nem_3	331	336	PF02991	0.345
LIG_NRBOX	273	279	PF00104	0.349
LIG_Pex14_2	166	170	PF04695	0.472
LIG_RPA_C_Fungi	339	351	PF08784	0.480
LIG_SH2_NCK_1	64	68	PF00017	0.697
LIG_SH3_1	64	70	PF00018	0.653
LIG_SH3_2	164	169	PF14604	0.331
LIG_SH3_3	161	167	PF00018	0.331
LIG_SH3_3	310	316	PF00018	0.423
LIG_SH3_3	64	70	PF00018	0.746
LIG_SUMO_SIM_par_1	270	275	PF11976	0.357
LIG_TRAF2_1	151	154	PF00917	0.505
LIG_TRAF2_1	58	61	PF00917	0.656
LIG_TRAF2_2	35	40	PF00917	0.545
LIG_TYR_ITIM	253	258	PF00017	0.331
LIG_UBA3_1	285	292	PF00899	0.352
MOD_CDK_SPK_2	54	59	PF00069	0.710
MOD_CK1_1	180	186	PF00069	0.393
MOD_CK1_1	5	11	PF00069	0.599
MOD_CK2_1	148	154	PF00069	0.562
MOD_CK2_1	180	186	PF00069	0.413
MOD_CK2_1	54	60	PF00069	0.650
MOD_GlcNHglycan	20	23	PF01048	0.712
MOD_GlcNHglycan	217	220	PF01048	0.423
MOD_GlcNHglycan	274	277	PF01048	0.378
MOD_GlcNHglycan	296	299	PF01048	0.379
MOD_GlcNHglycan	310	313	PF01048	0.447
MOD_GlcNHglycan	50	53	PF01048	0.590
MOD_GlcNHglycan	86	89	PF01048	0.671
MOD_GSK3_1	113	120	PF00069	0.506
MOD_GSK3_1	79	86	PF00069	0.621
MOD_GSK3_1	90	97	PF00069	0.648
MOD_N-GLC_1	26	31	PF02516	0.618
MOD_NEK2_1	242	247	PF00069	0.405
MOD_NEK2_1	272	277	PF00069	0.321
MOD_PIKK_1	5	11	PF00454	0.609
MOD_PKA_1	113	119	PF00069	0.553
MOD_PKA_2	112	118	PF00069	0.621
MOD_PKA_2	148	154	PF00069	0.564
MOD_PKA_2	308	314	PF00069	0.455
MOD_Plk_1	60	66	PF00069	0.710
MOD_Plk_1	77	83	PF00069	0.679
MOD_Plk_2-3	60	66	PF00069	0.696
MOD_Plk_4	247	253	PF00069	0.355
MOD_ProDKin_1	160	166	PF00069	0.542
MOD_ProDKin_1	31	37	PF00069	0.714
MOD_ProDKin_1	54	60	PF00069	0.665
MOD_ProDKin_1	66	72	PF00069	0.557
MOD_SUMO_rev_2	121	126	PF00179	0.590
TRG_ENDOCYTIC_2	255	258	PF00928	0.331
TRG_ER_diArg_1	342	344	PF00400	0.392
TRG_ER_diArg_1	353	355	PF00400	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M1	Leptomonas seymouri	51%	98%
A0A1X0P5U6	Trypanosomatidae	41%	96%
A0A3Q8IBN8	Leishmania donovani	93%	100%
A0A3R7KLV8	Trypanosoma rangeli	35%	97%
A4HE02	Leishmania braziliensis	78%	100%
A4I1B2	Leishmania infantum	93%	100%
D0A5K3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	90%
E9AXE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q9M5P2	Arabidopsis thaliana	23%	100%
V5B7L0	Trypanosoma cruzi	39%	97%