Protein TSSC4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein TSSC4

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA23_LEIMA

TriTrypDb:

LmjF.25.0715 , LMJLV39_250013200 , LMJSD75_250013100

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.490
CLV_NRD_NRD_1	217	219	PF00675	0.497
CLV_NRD_NRD_1	259	261	PF00675	0.663
CLV_PCSK_KEX2_1	209	211	PF00082	0.490
CLV_PCSK_KEX2_1	217	219	PF00082	0.497
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.490
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.497
CLV_PCSK_SKI1_1	262	266	PF00082	0.659
CLV_PCSK_SKI1_1	275	279	PF00082	0.755
DOC_ANK_TNKS_1	181	188	PF00023	0.614
DOC_CKS1_1	143	148	PF01111	0.565
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.606
DOC_MAPK_MEF2A_6	157	166	PF00069	0.517
DOC_PP2B_LxvP_1	166	169	PF13499	0.522
DOC_USP7_MATH_1	221	225	PF00917	0.573
DOC_USP7_MATH_1	269	273	PF00917	0.573
DOC_USP7_UBL2_3	262	266	PF12436	0.579
DOC_USP7_UBL2_3	271	275	PF12436	0.583
DOC_USP7_UBL2_3	276	280	PF12436	0.586
DOC_WW_Pin1_4	142	147	PF00397	0.616
LIG_14-3-3_CanoR_1	127	132	PF00244	0.530
LIG_14-3-3_CanoR_1	240	247	PF00244	0.553
LIG_FHA_1	128	134	PF00498	0.366
LIG_FHA_1	14	20	PF00498	0.569
LIG_FHA_1	196	202	PF00498	0.547
LIG_FHA_2	150	156	PF00498	0.550
LIG_LIR_Apic_2	224	228	PF02991	0.641
LIG_LIR_Gen_1	110	119	PF02991	0.488
LIG_LIR_Gen_1	120	128	PF02991	0.499
LIG_LIR_Gen_1	15	25	PF02991	0.678
LIG_LIR_Gen_1	186	194	PF02991	0.540
LIG_LIR_Gen_1	73	83	PF02991	0.509
LIG_LIR_Nem_3	110	115	PF02991	0.478
LIG_LIR_Nem_3	186	192	PF02991	0.518
LIG_LIR_Nem_3	73	79	PF02991	0.503
LIG_PTB_Apo_2	188	195	PF02174	0.642
LIG_PTB_Phospho_1	188	194	PF10480	0.638
LIG_SH2_CRK	189	193	PF00017	0.505
LIG_SH2_CRK	225	229	PF00017	0.585
LIG_SH2_CRK	76	80	PF00017	0.526
LIG_SH2_GRB2like	189	192	PF00017	0.526
LIG_SH2_PTP2	159	162	PF00017	0.614
LIG_SH2_SRC	159	162	PF00017	0.614
LIG_SH2_STAT5	118	121	PF00017	0.482
LIG_SH2_STAT5	159	162	PF00017	0.614
LIG_SH2_STAT5	229	232	PF00017	0.574
LIG_SH3_1	159	165	PF00018	0.607
LIG_SH3_2	146	151	PF14604	0.558
LIG_SH3_3	143	149	PF00018	0.647
LIG_SH3_3	159	165	PF00018	0.483
LIG_SH3_3	227	233	PF00018	0.588
LIG_SH3_3	23	29	PF00018	0.640
LIG_SH3_3	8	14	PF00018	0.574
LIG_SH3_4	262	269	PF00018	0.683
LIG_TRAF2_1	152	155	PF00917	0.634
LIG_TRAF2_1	39	42	PF00917	0.756
LIG_TRAF2_1	89	92	PF00917	0.641
LIG_WW_3	148	152	PF00397	0.550
MOD_CK1_1	110	116	PF00069	0.536
MOD_CK1_1	117	123	PF00069	0.493
MOD_CK2_1	149	155	PF00069	0.636
MOD_CK2_1	245	251	PF00069	0.593
MOD_CK2_1	43	49	PF00069	0.709
MOD_GlcNHglycan	170	173	PF01048	0.639
MOD_GlcNHglycan	204	207	PF01048	0.622
MOD_GlcNHglycan	33	36	PF01048	0.682
MOD_GlcNHglycan	45	48	PF01048	0.708
MOD_GlcNHglycan	83	86	PF01048	0.559
MOD_GSK3_1	110	117	PF00069	0.506
MOD_NEK2_1	107	112	PF00069	0.550
MOD_PIKK_1	195	201	PF00454	0.545
MOD_PIKK_1	269	275	PF00454	0.741
MOD_Plk_1	107	113	PF00069	0.555
MOD_Plk_4	107	113	PF00069	0.514
MOD_Plk_4	114	120	PF00069	0.479
MOD_Plk_4	127	133	PF00069	0.511
MOD_Plk_4	13	19	PF00069	0.638
MOD_Plk_4	75	81	PF00069	0.531
MOD_ProDKin_1	142	148	PF00069	0.612
MOD_SUMO_for_1	175	178	PF00179	0.530
MOD_SUMO_for_1	267	270	PF00179	0.634
TRG_ENDOCYTIC_2	122	125	PF00928	0.401
TRG_ENDOCYTIC_2	189	192	PF00928	0.456
TRG_ENDOCYTIC_2	76	79	PF00928	0.528
TRG_ER_diArg_1	254	257	PF00400	0.545
TRG_NLS_Bipartite_1	260	278	PF00514	0.656
TRG_NLS_MonoExtC_3	208	214	PF00514	0.616
TRG_NLS_MonoExtN_4	271	278	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P685	Leptomonas seymouri	54%	94%
A0A1X0P5H5	Trypanosomatidae	34%	100%
A0A3Q8IC96	Leishmania donovani	94%	100%
A0A422NX50	Trypanosoma rangeli	35%	100%
A4HE03	Leishmania braziliensis	69%	100%
A4I1B3	Leishmania infantum	94%	100%
D0A5K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AXE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BN56	Trypanosoma cruzi	30%	100%