Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA18_LEIMA

TriTrypDb:

LmjF.25.0760 , LMJLV39_250013800 , LMJSD75_250013700

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA18

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006511	ubiquitin-dependent protein catabolic process	7	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009057	macromolecule catabolic process	4	3
GO:0009987	cellular process	1	3
GO:0019538	protein metabolic process	3	3
GO:0019941	modification-dependent protein catabolic process	6	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043632	modification-dependent macromolecule catabolic process	5	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044248	cellular catabolic process	3	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0044265	obsolete cellular macromolecule catabolic process	4	3
GO:0051603	proteolysis involved in protein catabolic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901575	organic substance catabolic process	3	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.449
CLV_NRD_NRD_1	15	17	PF00675	0.487
CLV_NRD_NRD_1	270	272	PF00675	0.521
CLV_PCSK_KEX2_1	15	17	PF00082	0.487
CLV_PCSK_KEX2_1	269	271	PF00082	0.522
CLV_PCSK_SKI1_1	134	138	PF00082	0.481
CLV_PCSK_SKI1_1	246	250	PF00082	0.699
CLV_PCSK_SKI1_1	88	92	PF00082	0.600
DEG_SPOP_SBC_1	59	63	PF00917	0.548
DOC_CYCLIN_RxL_1	179	188	PF00134	0.571
DOC_CYCLIN_RxL_1	85	93	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.442
DOC_MAPK_HePTP_8	117	129	PF00069	0.625
DOC_MAPK_MEF2A_6	120	129	PF00069	0.490
DOC_PP1_RVXF_1	180	187	PF00149	0.582
DOC_PP2B_LxvP_1	286	289	PF13499	0.406
DOC_USP7_MATH_1	118	122	PF00917	0.604
DOC_USP7_MATH_1	58	62	PF00917	0.697
DOC_WW_Pin1_4	120	125	PF00397	0.664
DOC_WW_Pin1_4	163	168	PF00397	0.728
DOC_WW_Pin1_4	169	174	PF00397	0.603
DOC_WW_Pin1_4	343	348	PF00397	0.639
DOC_WW_Pin1_4	64	69	PF00397	0.670
LIG_14-3-3_CanoR_1	120	124	PF00244	0.452
LIG_14-3-3_CanoR_1	175	181	PF00244	0.600
LIG_14-3-3_CanoR_1	246	251	PF00244	0.531
LIG_Actin_WH2_2	200	218	PF00022	0.427
LIG_APCC_ABBA_1	140	145	PF00400	0.314
LIG_BIR_II_1	1	5	PF00653	0.489
LIG_BRCT_BRCA1_1	165	169	PF00533	0.586
LIG_CaM_NSCaTE_8	223	230	PF13499	0.476
LIG_Clathr_ClatBox_1	204	208	PF01394	0.422
LIG_Clathr_ClatBox_1	303	307	PF01394	0.435
LIG_eIF4E_1	199	205	PF01652	0.396
LIG_FHA_1	114	120	PF00498	0.673
LIG_FHA_1	288	294	PF00498	0.468
LIG_FHA_1	41	47	PF00498	0.662
LIG_HCF-1_HBM_1	196	199	PF13415	0.403
LIG_LIR_Gen_1	135	144	PF02991	0.367
LIG_LIR_Gen_1	145	152	PF02991	0.424
LIG_LIR_Gen_1	44	54	PF02991	0.552
LIG_LIR_Nem_3	135	140	PF02991	0.346
LIG_LIR_Nem_3	145	150	PF02991	0.386
LIG_LIR_Nem_3	193	198	PF02991	0.533
LIG_LIR_Nem_3	340	345	PF02991	0.472
LIG_LIR_Nem_3	44	50	PF02991	0.555
LIG_MYND_1	343	347	PF01753	0.526
LIG_NRBOX	200	206	PF00104	0.440
LIG_NRBOX	86	92	PF00104	0.499
LIG_Pex14_1	195	199	PF04695	0.326
LIG_SH2_CRK	73	77	PF00017	0.495
LIG_SH2_SRC	143	146	PF00017	0.348
LIG_SH2_STAP1	152	156	PF00017	0.529
LIG_SH2_STAP1	42	46	PF00017	0.631
LIG_SH2_STAT3	78	81	PF00017	0.498
LIG_SH2_STAT5	143	146	PF00017	0.370
LIG_SH2_STAT5	152	155	PF00017	0.518
LIG_SH2_STAT5	199	202	PF00017	0.511
LIG_SH2_STAT5	42	45	PF00017	0.653
LIG_SH2_STAT5	78	81	PF00017	0.498
LIG_SH3_3	122	128	PF00018	0.484
LIG_SH3_3	230	236	PF00018	0.530
LIG_SH3_3	47	53	PF00018	0.621
LIG_SUMO_SIM_par_1	115	123	PF11976	0.459
LIG_SUMO_SIM_par_1	301	308	PF11976	0.424
MOD_CDC14_SPxK_1	172	175	PF00782	0.547
MOD_CDK_SPK_2	343	348	PF00069	0.465
MOD_CDK_SPxK_1	169	175	PF00069	0.557
MOD_CK1_1	113	119	PF00069	0.656
MOD_CK1_1	26	32	PF00069	0.674
MOD_CK1_1	38	44	PF00069	0.655
MOD_CK1_1	5	11	PF00069	0.473
MOD_CK1_1	62	68	PF00069	0.604
MOD_CK2_1	190	196	PF00069	0.363
MOD_DYRK1A_RPxSP_1	120	124	PF00069	0.452
MOD_GlcNHglycan	112	115	PF01048	0.698
MOD_GlcNHglycan	154	157	PF01048	0.600
MOD_GlcNHglycan	317	320	PF01048	0.597
MOD_GlcNHglycan	322	325	PF01048	0.599
MOD_GlcNHglycan	62	65	PF01048	0.685
MOD_GSK3_1	150	157	PF00069	0.546
MOD_GSK3_1	165	172	PF00069	0.542
MOD_GSK3_1	207	214	PF00069	0.447
MOD_GSK3_1	22	29	PF00069	0.701
MOD_GSK3_1	30	37	PF00069	0.743
MOD_GSK3_1	58	65	PF00069	0.635
MOD_NEK2_1	119	124	PF00069	0.456
MOD_NEK2_1	150	155	PF00069	0.648
MOD_NEK2_1	207	212	PF00069	0.483
MOD_NEK2_1	294	299	PF00069	0.376
MOD_PIKK_1	207	213	PF00454	0.443
MOD_PIKK_1	23	29	PF00454	0.621
MOD_PIKK_1	237	243	PF00454	0.641
MOD_PIKK_1	254	260	PF00454	0.279
MOD_PIKK_1	281	287	PF00454	0.297
MOD_PKA_2	119	125	PF00069	0.446
MOD_PKA_2	22	28	PF00069	0.619
MOD_PKB_1	269	277	PF00069	0.467
MOD_Plk_1	207	213	PF00069	0.458
MOD_Plk_1	38	44	PF00069	0.588
MOD_Plk_4	165	171	PF00069	0.705
MOD_Plk_4	5	11	PF00069	0.546
MOD_Plk_4	52	58	PF00069	0.659
MOD_ProDKin_1	120	126	PF00069	0.657
MOD_ProDKin_1	163	169	PF00069	0.729
MOD_ProDKin_1	64	70	PF00069	0.661
MOD_SUMO_for_1	236	239	PF00179	0.597
TRG_DiLeu_BaEn_1	6	11	PF01217	0.452
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.463
TRG_ENDOCYTIC_2	198	201	PF00928	0.396
TRG_ER_diArg_1	14	16	PF00400	0.466
TRG_ER_diArg_1	269	271	PF00400	0.479
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T2	Leptomonas seymouri	36%	98%
A0A1X0P4E3	Trypanosomatidae	27%	100%
A0A3Q8IF78	Leishmania donovani	90%	98%
A0A3R7K7C7	Trypanosoma rangeli	30%	100%
A4HE11	Leishmania braziliensis	71%	99%
A4I1B8	Leishmania infantum	92%	100%
D0A5L2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AXF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%