Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QA17_LEIMA

TriTrypDb:

LmjF.25.0770 , LMJLV39_250013900 , LMJSD75_250013800

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.605
CLV_NRD_NRD_1	123	125	PF00675	0.691
CLV_NRD_NRD_1	210	212	PF00675	0.707
CLV_NRD_NRD_1	259	261	PF00675	0.425
CLV_NRD_NRD_1	339	341	PF00675	0.618
CLV_NRD_NRD_1	364	366	PF00675	0.549
CLV_PCSK_KEX2_1	123	125	PF00082	0.665
CLV_PCSK_KEX2_1	259	261	PF00082	0.425
CLV_PCSK_KEX2_1	339	341	PF00082	0.617
CLV_PCSK_KEX2_1	364	366	PF00082	0.549
CLV_PCSK_KEX2_1	94	96	PF00082	0.526
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.526
CLV_PCSK_PC7_1	90	96	PF00082	0.511
CLV_PCSK_SKI1_1	189	193	PF00082	0.530
CLV_PCSK_SKI1_1	230	234	PF00082	0.650
CLV_PCSK_SKI1_1	260	264	PF00082	0.485
CLV_PCSK_SKI1_1	364	368	PF00082	0.524
DEG_APCC_DBOX_1	258	266	PF00400	0.551
DEG_APCC_DBOX_1	363	371	PF00400	0.514
DEG_Kelch_Keap1_1	106	111	PF01344	0.554
DEG_Nend_Nbox_1	1	3	PF02207	0.443
DEG_SCF_FBW7_1	42	49	PF00400	0.523
DEG_SCF_TRCP1_1	247	252	PF00400	0.544
DEG_SPOP_SBC_1	53	57	PF00917	0.496
DEG_SPOP_SBC_1	69	73	PF00917	0.406
DOC_CKS1_1	43	48	PF01111	0.519
DOC_CYCLIN_RxL_1	254	267	PF00134	0.435
DOC_CYCLIN_RxL_1	362	372	PF00134	0.567
DOC_MAPK_FxFP_2	306	309	PF00069	0.506
DOC_MAPK_gen_1	211	218	PF00069	0.681
DOC_MAPK_gen_1	259	265	PF00069	0.461
DOC_MAPK_gen_1	364	370	PF00069	0.510
DOC_PP1_RVXF_1	35	41	PF00149	0.481
DOC_PP2B_LxvP_1	195	198	PF13499	0.595
DOC_PP2B_LxvP_1	218	221	PF13499	0.548
DOC_PP2B_LxvP_1	239	242	PF13499	0.495
DOC_PP4_FxxP_1	306	309	PF00568	0.554
DOC_PP4_FxxP_1	40	43	PF00568	0.505
DOC_USP7_MATH_1	100	104	PF00917	0.699
DOC_USP7_MATH_1	146	150	PF00917	0.649
DOC_USP7_MATH_1	222	226	PF00917	0.533
DOC_USP7_MATH_1	280	284	PF00917	0.634
DOC_USP7_MATH_1	330	334	PF00917	0.671
DOC_USP7_MATH_1	349	353	PF00917	0.502
DOC_USP7_MATH_1	500	504	PF00917	0.649
DOC_USP7_MATH_1	51	55	PF00917	0.513
DOC_WW_Pin1_4	127	132	PF00397	0.681
DOC_WW_Pin1_4	155	160	PF00397	0.644
DOC_WW_Pin1_4	271	276	PF00397	0.679
DOC_WW_Pin1_4	42	47	PF00397	0.516
DOC_WW_Pin1_4	49	54	PF00397	0.521
LIG_14-3-3_CanoR_1	90	94	PF00244	0.503
LIG_BRCT_BRCA1_1	10	14	PF00533	0.412
LIG_BRCT_BRCA1_1	157	161	PF00533	0.542
LIG_BRCT_BRCA1_1	56	60	PF00533	0.466
LIG_FHA_1	250	256	PF00498	0.565
LIG_FHA_1	5	11	PF00498	0.414
LIG_FHA_1	71	77	PF00498	0.432
LIG_FHA_2	116	122	PF00498	0.558
LIG_FHA_2	222	228	PF00498	0.455
LIG_GBD_Chelix_1	397	405	PF00786	0.570
LIG_LIR_Apic_2	154	160	PF02991	0.550
LIG_LIR_Gen_1	332	343	PF02991	0.593
LIG_LIR_Nem_3	11	17	PF02991	0.412
LIG_LIR_Nem_3	332	338	PF02991	0.595
LIG_LIR_Nem_3	57	63	PF02991	0.458
LIG_Pex14_2	36	40	PF04695	0.478
LIG_Pex14_2	60	64	PF04695	0.452
LIG_PTAP_UEV_1	507	512	PF05743	0.615
LIG_PTB_Apo_2	300	307	PF02174	0.501
LIG_SH2_CRK	157	161	PF00017	0.542
LIG_SH2_CRK	458	462	PF00017	0.709
LIG_SH2_CRK	67	71	PF00017	0.430
LIG_SH2_GRB2like	433	436	PF00017	0.675
LIG_SH2_GRB2like	450	453	PF00017	0.581
LIG_SH2_GRB2like	465	468	PF00017	0.540
LIG_SH2_NCK_1	157	161	PF00017	0.542
LIG_SH2_NCK_1	451	455	PF00017	0.590
LIG_SH2_NCK_1	67	71	PF00017	0.430
LIG_SH2_SRC	506	509	PF00017	0.621
LIG_SH2_STAT3	441	444	PF00017	0.644
LIG_SH2_STAT3	487	490	PF00017	0.736
LIG_SH2_STAT3	83	86	PF00017	0.459
LIG_SH2_STAT5	371	374	PF00017	0.498
LIG_SH2_STAT5	506	509	PF00017	0.621
LIG_SH3_1	41	47	PF00018	0.516
LIG_SH3_3	153	159	PF00018	0.654
LIG_SH3_3	40	46	PF00018	0.511
LIG_SH3_3	469	475	PF00018	0.697
LIG_SH3_3	505	511	PF00018	0.621
LIG_SUMO_SIM_anti_2	224	230	PF11976	0.384
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.624
LIG_SUMO_SIM_par_1	261	267	PF11976	0.616
LIG_SUMO_SIM_par_1	286	293	PF11976	0.575
LIG_SUMO_SIM_par_1	366	372	PF11976	0.530
LIG_SUMO_SIM_par_1	6	11	PF11976	0.412
LIG_TRAF2_1	102	105	PF00917	0.663
LIG_TRAF2_1	205	208	PF00917	0.668
LIG_TYR_ITIM	65	70	PF00017	0.440
MOD_CK1_1	18	24	PF00069	0.401
MOD_CK1_1	235	241	PF00069	0.569
MOD_CK1_1	276	282	PF00069	0.649
MOD_CK1_1	283	289	PF00069	0.554
MOD_CK1_1	297	303	PF00069	0.408
MOD_CK1_1	3	9	PF00069	0.422
MOD_CK1_1	313	319	PF00069	0.496
MOD_CK1_1	52	58	PF00069	0.497
MOD_CK1_1	68	74	PF00069	0.407
MOD_CK1_1	99	105	PF00069	0.712
MOD_CK2_1	115	121	PF00069	0.558
MOD_CK2_1	99	105	PF00069	0.698
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.662
MOD_GlcNHglycan	115	118	PF01048	0.525
MOD_GlcNHglycan	146	149	PF01048	0.678
MOD_GlcNHglycan	164	167	PF01048	0.621
MOD_GlcNHglycan	182	186	PF01048	0.403
MOD_GlcNHglycan	213	216	PF01048	0.571
MOD_GlcNHglycan	239	242	PF01048	0.662
MOD_GlcNHglycan	247	250	PF01048	0.611
MOD_GlcNHglycan	452	455	PF01048	0.651
MOD_GlcNHglycan	502	505	PF01048	0.620
MOD_GlcNHglycan	508	511	PF01048	0.556
MOD_GlcNHglycan	98	101	PF01048	0.666
MOD_GSK3_1	134	141	PF00069	0.682
MOD_GSK3_1	15	22	PF00069	0.404
MOD_GSK3_1	155	162	PF00069	0.693
MOD_GSK3_1	207	214	PF00069	0.639
MOD_GSK3_1	23	30	PF00069	0.394
MOD_GSK3_1	245	252	PF00069	0.584
MOD_GSK3_1	276	283	PF00069	0.604
MOD_GSK3_1	290	297	PF00069	0.453
MOD_GSK3_1	4	11	PF00069	0.419
MOD_GSK3_1	42	49	PF00069	0.500
MOD_GSK3_1	502	509	PF00069	0.672
MOD_GSK3_1	51	58	PF00069	0.486
MOD_GSK3_1	65	72	PF00069	0.418
MOD_GSK3_1	96	103	PF00069	0.711
MOD_N-GLC_1	222	227	PF02516	0.473
MOD_NEK2_1	113	118	PF00069	0.535
MOD_NEK2_1	138	143	PF00069	0.612
MOD_NEK2_1	15	20	PF00069	0.410
MOD_NEK2_1	161	166	PF00069	0.538
MOD_NEK2_1	181	186	PF00069	0.442
MOD_NEK2_1	232	237	PF00069	0.496
MOD_NEK2_1	65	70	PF00069	0.440
MOD_NEK2_1	8	13	PF00069	0.411
MOD_NEK2_1	96	101	PF00069	0.712
MOD_NEK2_2	249	254	PF00069	0.499
MOD_PIKK_1	100	106	PF00454	0.713
MOD_PIKK_1	232	238	PF00454	0.405
MOD_PKA_1	211	217	PF00069	0.571
MOD_PKA_2	89	95	PF00069	0.504
MOD_Plk_1	181	187	PF00069	0.626
MOD_Plk_1	222	228	PF00069	0.478
MOD_Plk_1	297	303	PF00069	0.493
MOD_Plk_4	10	16	PF00069	0.411
MOD_Plk_4	134	140	PF00069	0.624
MOD_Plk_4	283	289	PF00069	0.601
MOD_Plk_4	330	336	PF00069	0.620
MOD_Plk_4	502	508	PF00069	0.622
MOD_Plk_4	65	71	PF00069	0.436
MOD_ProDKin_1	127	133	PF00069	0.678
MOD_ProDKin_1	155	161	PF00069	0.644
MOD_ProDKin_1	271	277	PF00069	0.680
MOD_ProDKin_1	42	48	PF00069	0.517
MOD_ProDKin_1	49	55	PF00069	0.518
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.527
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.524
TRG_ENDOCYTIC_2	67	70	PF00928	0.433
TRG_ER_diArg_1	122	124	PF00400	0.552
TRG_ER_diArg_1	258	260	PF00400	0.399
TRG_ER_diArg_1	338	340	PF00400	0.620
TRG_NES_CRM1_1	187	201	PF08389	0.541
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICF2	Leishmania donovani	91%	100%
A4HE12	Leishmania braziliensis	58%	100%
A4I1B9	Leishmania infantum	91%	100%
E9AXF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%