Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QA16_LEIMA

TriTrypDb:

LmjF.25.0780 , LMJLV39_250014000 , LMJSD75_250013900

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QA16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.664
CLV_NRD_NRD_1	214	216	PF00675	0.535
CLV_NRD_NRD_1	57	59	PF00675	0.632
CLV_NRD_NRD_1	93	95	PF00675	0.644
CLV_PCSK_FUR_1	209	213	PF00082	0.480
CLV_PCSK_KEX2_1	211	213	PF00082	0.524
CLV_PCSK_KEX2_1	214	216	PF00082	0.517
CLV_PCSK_KEX2_1	93	95	PF00082	0.644
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.491
CLV_PCSK_SKI1_1	142	146	PF00082	0.589
CLV_PCSK_SKI1_1	77	81	PF00082	0.668
DEG_SPOP_SBC_1	87	91	PF00917	0.429
DOC_CKS1_1	69	74	PF01111	0.398
DOC_CYCLIN_yCln2_LP_2	117	120	PF00134	0.400
DOC_MAPK_gen_1	58	65	PF00069	0.398
DOC_MAPK_MEF2A_6	58	67	PF00069	0.394
DOC_PP2B_LxvP_1	117	120	PF13499	0.434
DOC_USP7_MATH_1	120	124	PF00917	0.486
DOC_USP7_MATH_1	19	23	PF00917	0.479
DOC_USP7_MATH_1	204	208	PF00917	0.651
DOC_USP7_MATH_1	47	51	PF00917	0.437
DOC_USP7_MATH_1	87	91	PF00917	0.477
DOC_WW_Pin1_4	235	240	PF00397	0.648
DOC_WW_Pin1_4	293	298	PF00397	0.780
DOC_WW_Pin1_4	65	70	PF00397	0.442
LIG_Actin_WH2_2	126	144	PF00022	0.421
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_FHA_1	103	109	PF00498	0.432
LIG_FHA_1	136	142	PF00498	0.416
LIG_FHA_1	30	36	PF00498	0.370
LIG_FHA_1	52	58	PF00498	0.446
LIG_FHA_2	138	144	PF00498	0.431
LIG_FHA_2	297	303	PF00498	0.662
LIG_LIR_Apic_2	256	260	PF02991	0.740
LIG_LIR_Apic_2	262	266	PF02991	0.584
LIG_LIR_Nem_3	130	135	PF02991	0.449
LIG_PTB_Apo_2	107	114	PF02174	0.391
LIG_SH2_CRK	257	261	PF00017	0.747
LIG_SH2_GRB2like	232	235	PF00017	0.657
LIG_SH2_GRB2like	270	273	PF00017	0.755
LIG_SH2_STAP1	232	236	PF00017	0.655
LIG_SH2_STAT3	226	229	PF00017	0.726
LIG_SH2_STAT3	273	276	PF00017	0.710
LIG_SH2_STAT3	287	290	PF00017	0.634
LIG_SH2_STAT3	33	36	PF00017	0.426
LIG_SH3_3	221	227	PF00018	0.712
LIG_SH3_3	233	239	PF00018	0.703
LIG_SH3_3	258	264	PF00018	0.728
LIG_SH3_3	66	72	PF00018	0.371
LIG_SUMO_SIM_anti_2	21	28	PF11976	0.390
LIG_TRAF2_1	277	280	PF00917	0.650
LIG_TRAF2_1	53	56	PF00917	0.411
LIG_WW_1	260	263	PF00397	0.695
MOD_CK1_1	22	28	PF00069	0.466
MOD_CK1_1	296	302	PF00069	0.740
MOD_CK1_1	68	74	PF00069	0.404
MOD_CK2_1	204	210	PF00069	0.588
MOD_GlcNHglycan	12	15	PF01048	0.739
MOD_GlcNHglycan	146	149	PF01048	0.651
MOD_GlcNHglycan	155	160	PF01048	0.606
MOD_GlcNHglycan	201	204	PF01048	0.405
MOD_GlcNHglycan	273	276	PF01048	0.581
MOD_GlcNHglycan	43	46	PF01048	0.659
MOD_GlcNHglycan	49	52	PF01048	0.639
MOD_GSK3_1	151	158	PF00069	0.359
MOD_GSK3_1	41	48	PF00069	0.391
MOD_N-GLC_1	271	276	PF02516	0.572
MOD_NEK2_1	135	140	PF00069	0.417
MOD_NEK2_1	199	204	PF00069	0.459
MOD_PKA_2	151	157	PF00069	0.372
MOD_PKA_2	171	177	PF00069	0.399
MOD_PKA_2	205	211	PF00069	0.645
MOD_Plk_1	29	35	PF00069	0.463
MOD_Plk_4	19	25	PF00069	0.468
MOD_ProDKin_1	235	241	PF00069	0.651
MOD_ProDKin_1	293	299	PF00069	0.779
MOD_ProDKin_1	65	71	PF00069	0.439
TRG_DiLeu_BaEn_1	163	168	PF01217	0.374
TRG_DiLeu_BaEn_4	55	61	PF01217	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IN96	Leishmania donovani	91%	100%
A4HE13	Leishmania braziliensis	57%	90%
A4I1C0	Leishmania infantum	92%	100%
E9AXF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%