ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QA15_LEIMA

TriTrypDb:

LmjF.25.0790 , LMJLV39_250014100 , LMJSD75_250014000

Length:

1032

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QA15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.663
CLV_C14_Caspase3-7	796	800	PF00656	0.768
CLV_NRD_NRD_1	1024	1026	PF00675	0.535
CLV_NRD_NRD_1	241	243	PF00675	0.551
CLV_NRD_NRD_1	526	528	PF00675	0.373
CLV_NRD_NRD_1	58	60	PF00675	0.430
CLV_NRD_NRD_1	650	652	PF00675	0.429
CLV_NRD_NRD_1	697	699	PF00675	0.512
CLV_NRD_NRD_1	751	753	PF00675	0.535
CLV_NRD_NRD_1	762	764	PF00675	0.484
CLV_NRD_NRD_1	823	825	PF00675	0.481
CLV_PCSK_FUR_1	524	528	PF00082	0.374
CLV_PCSK_FUR_1	648	652	PF00082	0.423
CLV_PCSK_FUR_1	695	699	PF00082	0.498
CLV_PCSK_FUR_1	749	753	PF00082	0.516
CLV_PCSK_KEX2_1	1024	1026	PF00082	0.535
CLV_PCSK_KEX2_1	106	108	PF00082	0.381
CLV_PCSK_KEX2_1	457	459	PF00082	0.289
CLV_PCSK_KEX2_1	526	528	PF00082	0.370
CLV_PCSK_KEX2_1	58	60	PF00082	0.430
CLV_PCSK_KEX2_1	650	652	PF00082	0.429
CLV_PCSK_KEX2_1	697	699	PF00082	0.512
CLV_PCSK_KEX2_1	751	753	PF00082	0.543
CLV_PCSK_KEX2_1	762	764	PF00082	0.488
CLV_PCSK_KEX2_1	822	824	PF00082	0.509
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.346
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.289
CLV_PCSK_PC7_1	54	60	PF00082	0.310
CLV_PCSK_SKI1_1	100	104	PF00082	0.315
CLV_PCSK_SKI1_1	215	219	PF00082	0.308
CLV_PCSK_SKI1_1	246	250	PF00082	0.518
CLV_PCSK_SKI1_1	331	335	PF00082	0.456
CLV_PCSK_SKI1_1	383	387	PF00082	0.332
CLV_PCSK_SKI1_1	58	62	PF00082	0.362
CLV_PCSK_SKI1_1	744	748	PF00082	0.503
CLV_PCSK_SKI1_1	752	756	PF00082	0.469
CLV_PCSK_SKI1_1	865	869	PF00082	0.438
CLV_PCSK_SKI1_1	987	991	PF00082	0.427
CLV_Separin_Metazoa	97	101	PF03568	0.506
DEG_APCC_DBOX_1	57	65	PF00400	0.547
DEG_APCC_DBOX_1	864	872	PF00400	0.388
DEG_APCC_DBOX_1	94	102	PF00400	0.502
DEG_APCC_KENBOX_2	736	740	PF00400	0.630
DEG_SCF_FBW7_1	248	253	PF00400	0.650
DEG_SPOP_SBC_1	886	890	PF00917	0.491
DEG_SPOP_SBC_1	910	914	PF00917	0.492
DOC_CDC14_PxL_1	860	868	PF14671	0.340
DOC_CKS1_1	402	407	PF01111	0.503
DOC_CKS1_1	460	465	PF01111	0.552
DOC_CYCLIN_RxL_1	862	869	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.574
DOC_MAPK_gen_1	484	491	PF00069	0.525
DOC_MAPK_gen_1	524	532	PF00069	0.571
DOC_MAPK_gen_1	695	703	PF00069	0.695
DOC_MAPK_MEF2A_6	484	493	PF00069	0.529
DOC_MAPK_MEF2A_6	597	605	PF00069	0.426
DOC_MAPK_MEF2A_6	95	103	PF00069	0.503
DOC_MAPK_RevD_3	92	107	PF00069	0.568
DOC_PP1_RVXF_1	495	501	PF00149	0.582
DOC_PP2B_LxvP_1	861	864	PF13499	0.291
DOC_PP2B_PxIxI_1	392	398	PF00149	0.513
DOC_PP4_FxxP_1	740	743	PF00568	0.698
DOC_PP4_FxxP_1	995	998	PF00568	0.642
DOC_SPAK_OSR1_1	835	839	PF12202	0.679
DOC_USP7_MATH_1	1026	1030	PF00917	0.686
DOC_USP7_MATH_1	23	27	PF00917	0.665
DOC_USP7_MATH_1	238	242	PF00917	0.708
DOC_USP7_MATH_1	254	258	PF00917	0.738
DOC_USP7_MATH_1	294	298	PF00917	0.683
DOC_USP7_MATH_1	314	318	PF00917	0.587
DOC_USP7_MATH_1	541	545	PF00917	0.356
DOC_USP7_MATH_1	586	590	PF00917	0.606
DOC_USP7_MATH_1	591	595	PF00917	0.615
DOC_USP7_MATH_1	675	679	PF00917	0.653
DOC_USP7_MATH_1	795	799	PF00917	0.614
DOC_USP7_MATH_1	886	890	PF00917	0.484
DOC_USP7_MATH_1	910	914	PF00917	0.450
DOC_USP7_MATH_1	921	925	PF00917	0.451
DOC_WW_Pin1_4	15	20	PF00397	0.681
DOC_WW_Pin1_4	228	233	PF00397	0.565
DOC_WW_Pin1_4	246	251	PF00397	0.739
DOC_WW_Pin1_4	264	269	PF00397	0.786
DOC_WW_Pin1_4	401	406	PF00397	0.513
DOC_WW_Pin1_4	44	49	PF00397	0.625
DOC_WW_Pin1_4	459	464	PF00397	0.557
DOC_WW_Pin1_4	664	669	PF00397	0.663
DOC_WW_Pin1_4	767	772	PF00397	0.758
DOC_WW_Pin1_4	805	810	PF00397	0.650
DOC_WW_Pin1_4	815	820	PF00397	0.686
DOC_WW_Pin1_4	881	886	PF00397	0.456
DOC_WW_Pin1_4	887	892	PF00397	0.477
DOC_WW_Pin1_4	905	910	PF00397	0.379
DOC_WW_Pin1_4	994	999	PF00397	0.678
LIG_14-3-3_CanoR_1	107	113	PF00244	0.542
LIG_14-3-3_CanoR_1	130	135	PF00244	0.526
LIG_14-3-3_CanoR_1	29	37	PF00244	0.700
LIG_14-3-3_CanoR_1	375	382	PF00244	0.512
LIG_14-3-3_CanoR_1	448	456	PF00244	0.599
LIG_14-3-3_CanoR_1	490	494	PF00244	0.508
LIG_14-3-3_CanoR_1	497	507	PF00244	0.516
LIG_14-3-3_CanoR_1	617	626	PF00244	0.359
LIG_14-3-3_CanoR_1	651	661	PF00244	0.652
LIG_14-3-3_CanoR_1	697	702	PF00244	0.719
LIG_14-3-3_CanoR_1	744	749	PF00244	0.665
LIG_14-3-3_CanoR_1	835	845	PF00244	0.657
LIG_14-3-3_CanoR_1	911	916	PF00244	0.450
LIG_14-3-3_CanoR_1	987	995	PF00244	0.638
LIG_Actin_WH2_2	971	989	PF00022	0.388
LIG_AP2alpha_2	825	827	PF02296	0.697
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BIR_III_4	293	297	PF00653	0.696
LIG_BRCT_BRCA1_1	699	703	PF00533	0.692
LIG_BRCT_BRCA1_1	813	817	PF00533	0.691
LIG_Clathr_ClatBox_1	131	135	PF01394	0.577
LIG_CtBP_PxDLS_1	463	467	PF00389	0.543
LIG_deltaCOP1_diTrp_1	517	523	PF00928	0.596
LIG_FHA_1	127	133	PF00498	0.531
LIG_FHA_1	191	197	PF00498	0.559
LIG_FHA_1	205	211	PF00498	0.489
LIG_FHA_1	371	377	PF00498	0.580
LIG_FHA_1	401	407	PF00498	0.529
LIG_FHA_1	48	54	PF00498	0.582
LIG_FHA_1	490	496	PF00498	0.486
LIG_FHA_1	563	569	PF00498	0.291
LIG_FHA_1	810	816	PF00498	0.778
LIG_FHA_1	875	881	PF00498	0.466
LIG_FHA_1	920	926	PF00498	0.475
LIG_FHA_2	460	466	PF00498	0.550
LIG_FHA_2	794	800	PF00498	0.681
LIG_LIR_Apic_2	1019	1023	PF02991	0.687
LIG_LIR_Apic_2	738	743	PF02991	0.698
LIG_LIR_Apic_2	825	830	PF02991	0.749
LIG_LIR_Apic_2	839	845	PF02991	0.604
LIG_LIR_Apic_2	993	998	PF02991	0.673
LIG_LIR_Gen_1	173	184	PF02991	0.518
LIG_LIR_Gen_1	474	480	PF02991	0.451
LIG_LIR_Gen_1	856	867	PF02991	0.478
LIG_LIR_Nem_3	173	179	PF02991	0.511
LIG_LIR_Nem_3	474	479	PF02991	0.502
LIG_LIR_Nem_3	801	807	PF02991	0.767
LIG_LIR_Nem_3	856	862	PF02991	0.478
LIG_MYND_1	425	429	PF01753	0.523
LIG_NRBOX	127	133	PF00104	0.511
LIG_NRBOX	385	391	PF00104	0.513
LIG_NRBOX	97	103	PF00104	0.504
LIG_Pex14_1	548	552	PF04695	0.450
LIG_SH2_CRK	176	180	PF00017	0.479
LIG_SH2_CRK	402	406	PF00017	0.492
LIG_SH2_CRK	552	556	PF00017	0.432
LIG_SH2_CRK	931	935	PF00017	0.463
LIG_SH2_NCK_1	302	306	PF00017	0.637
LIG_SH2_STAP1	176	180	PF00017	0.479
LIG_SH2_STAP1	302	306	PF00017	0.631
LIG_SH2_STAP1	564	568	PF00017	0.330
LIG_SH2_STAP1	857	861	PF00017	0.529
LIG_SH2_STAT3	566	569	PF00017	0.388
LIG_SH2_STAT5	188	191	PF00017	0.486
LIG_SH2_STAT5	388	391	PF00017	0.506
LIG_SH2_STAT5	402	405	PF00017	0.511
LIG_SH2_STAT5	507	510	PF00017	0.556
LIG_SH2_STAT5	52	55	PF00017	0.629
LIG_SH2_STAT5	564	567	PF00017	0.315
LIG_SH2_STAT5	854	857	PF00017	0.731
LIG_SH3_2	830	835	PF14604	0.675
LIG_SH3_3	16	22	PF00018	0.619
LIG_SH3_3	248	254	PF00018	0.791
LIG_SH3_3	482	488	PF00018	0.562
LIG_SH3_3	57	63	PF00018	0.599
LIG_SH3_3	658	664	PF00018	0.672
LIG_SH3_3	669	675	PF00018	0.690
LIG_SH3_3	7	13	PF00018	0.689
LIG_SH3_3	827	833	PF00018	0.704
LIG_SH3_3	84	90	PF00018	0.524
LIG_SH3_3	879	885	PF00018	0.665
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.388
LIG_SUMO_SIM_par_1	129	136	PF11976	0.610
LIG_SUMO_SIM_par_1	537	544	PF11976	0.361
LIG_SUMO_SIM_par_1	559	565	PF11976	0.295
LIG_TRAF2_1	133	136	PF00917	0.597
LIG_TYR_ITIM	505	510	PF00017	0.565
LIG_TYR_ITIM	855	860	PF00017	0.666
LIG_UBA3_1	101	106	PF00899	0.518
LIG_WRC_WIRS_1	198	203	PF05994	0.478
LIG_WW_2	13	16	PF00397	0.627
LIG_WW_3	908	912	PF00397	0.430
MOD_CDK_SPK_2	994	999	PF00069	0.678
MOD_CDK_SPxK_1	905	911	PF00069	0.432
MOD_CDK_SPxxK_3	664	671	PF00069	0.704
MOD_CDK_SPxxK_3	815	822	PF00069	0.627
MOD_CDK_SPxxK_3	994	1001	PF00069	0.679
MOD_CK1_1	204	210	PF00069	0.549
MOD_CK1_1	231	237	PF00069	0.742
MOD_CK1_1	317	323	PF00069	0.717
MOD_CK1_1	33	39	PF00069	0.673
MOD_CK1_1	335	341	PF00069	0.602
MOD_CK1_1	43	49	PF00069	0.601
MOD_CK1_1	678	684	PF00069	0.678
MOD_CK1_1	686	692	PF00069	0.681
MOD_CK1_1	714	720	PF00069	0.735
MOD_CK1_1	770	776	PF00069	0.706
MOD_CK1_1	917	923	PF00069	0.459
MOD_CK1_1	924	930	PF00069	0.433
MOD_CK1_1	985	991	PF00069	0.592
MOD_CK2_1	130	136	PF00069	0.581
MOD_CK2_1	254	260	PF00069	0.737
MOD_CK2_1	447	453	PF00069	0.618
MOD_CK2_1	459	465	PF00069	0.490
MOD_CK2_1	721	727	PF00069	0.660
MOD_CK2_1	732	738	PF00069	0.770
MOD_CK2_1	795	801	PF00069	0.665
MOD_CMANNOS	518	521	PF00535	0.392
MOD_CMANNOS	545	548	PF00535	0.388
MOD_GlcNHglycan	1002	1005	PF01048	0.505
MOD_GlcNHglycan	172	175	PF01048	0.316
MOD_GlcNHglycan	207	210	PF01048	0.304
MOD_GlcNHglycan	235	238	PF01048	0.532
MOD_GlcNHglycan	274	277	PF01048	0.591
MOD_GlcNHglycan	290	293	PF01048	0.458
MOD_GlcNHglycan	295	299	PF01048	0.506
MOD_GlcNHglycan	310	313	PF01048	0.398
MOD_GlcNHglycan	314	317	PF01048	0.393
MOD_GlcNHglycan	32	35	PF01048	0.454
MOD_GlcNHglycan	337	340	PF01048	0.486
MOD_GlcNHglycan	500	503	PF01048	0.332
MOD_GlcNHglycan	588	591	PF01048	0.472
MOD_GlcNHglycan	593	596	PF01048	0.455
MOD_GlcNHglycan	613	616	PF01048	0.527
MOD_GlcNHglycan	619	622	PF01048	0.619
MOD_GlcNHglycan	704	707	PF01048	0.516
MOD_GlcNHglycan	719	722	PF01048	0.448
MOD_GlcNHglycan	772	775	PF01048	0.616
MOD_GlcNHglycan	782	785	PF01048	0.428
MOD_GlcNHglycan	935	938	PF01048	0.699
MOD_GSK3_1	126	133	PF00069	0.535
MOD_GSK3_1	197	204	PF00069	0.540
MOD_GSK3_1	246	253	PF00069	0.669
MOD_GSK3_1	28	35	PF00069	0.719
MOD_GSK3_1	294	301	PF00069	0.720
MOD_GSK3_1	308	315	PF00069	0.634
MOD_GSK3_1	40	47	PF00069	0.628
MOD_GSK3_1	66	73	PF00069	0.498
MOD_GSK3_1	673	680	PF00069	0.686
MOD_GSK3_1	693	700	PF00069	0.632
MOD_GSK3_1	717	724	PF00069	0.795
MOD_GSK3_1	728	735	PF00069	0.722
MOD_GSK3_1	805	812	PF00069	0.794
MOD_GSK3_1	813	820	PF00069	0.679
MOD_GSK3_1	881	888	PF00069	0.451
MOD_GSK3_1	905	912	PF00069	0.547
MOD_GSK3_1	917	924	PF00069	0.447
MOD_GSK3_1	933	940	PF00069	0.439
MOD_GSK3_1	981	988	PF00069	0.587
MOD_GSK3_1	990	997	PF00069	0.634
MOD_N-GLC_1	108	113	PF02516	0.378
MOD_N-GLC_1	335	340	PF02516	0.503
MOD_N-GLC_1	717	722	PF02516	0.463
MOD_N-GLC_1	732	737	PF02516	0.594
MOD_N-GLC_1	738	743	PF02516	0.478
MOD_N-GLC_1	897	902	PF02516	0.639
MOD_NEK2_1	160	165	PF00069	0.536
MOD_NEK2_1	190	195	PF00069	0.474
MOD_NEK2_1	218	223	PF00069	0.551
MOD_NEK2_1	28	33	PF00069	0.744
MOD_NEK2_1	439	444	PF00069	0.567
MOD_NEK2_1	531	536	PF00069	0.505
MOD_NEK2_1	562	567	PF00069	0.368
MOD_NEK2_1	701	706	PF00069	0.692
MOD_NEK2_1	866	871	PF00069	0.436
MOD_NEK2_1	874	879	PF00069	0.235
MOD_NEK2_1	969	974	PF00069	0.312
MOD_NEK2_1	982	987	PF00069	0.618
MOD_NEK2_2	329	334	PF00069	0.588
MOD_NEK2_2	639	644	PF00069	0.304
MOD_NEK2_2	732	737	PF00069	0.696
MOD_NEK2_2	845	850	PF00069	0.678
MOD_NEK2_2	921	926	PF00069	0.475
MOD_PIKK_1	66	72	PF00454	0.600
MOD_PIKK_1	988	994	PF00454	0.655
MOD_PK_1	130	136	PF00069	0.529
MOD_PK_1	434	440	PF00069	0.604
MOD_PKA_1	697	703	PF00069	0.693
MOD_PKA_2	28	34	PF00069	0.622
MOD_PKA_2	447	453	PF00069	0.603
MOD_PKA_2	489	495	PF00069	0.475
MOD_PKA_2	584	590	PF00069	0.585
MOD_PKA_2	697	703	PF00069	0.716
MOD_PKA_2	831	837	PF00069	0.671
MOD_PKA_2	910	916	PF00069	0.432
MOD_PKB_1	695	703	PF00069	0.695
MOD_Plk_1	108	114	PF00069	0.521
MOD_Plk_1	329	335	PF00069	0.639
MOD_Plk_1	732	738	PF00069	0.792
MOD_Plk_1	845	851	PF00069	0.677
MOD_Plk_4	197	203	PF00069	0.479
MOD_Plk_4	329	335	PF00069	0.639
MOD_Plk_4	434	440	PF00069	0.663
MOD_Plk_4	506	512	PF00069	0.508
MOD_Plk_4	697	703	PF00069	0.728
MOD_Plk_4	78	84	PF00069	0.586
MOD_Plk_4	866	872	PF00069	0.412
MOD_Plk_4	897	903	PF00069	0.492
MOD_Plk_4	911	917	PF00069	0.414
MOD_Plk_4	921	927	PF00069	0.455
MOD_Plk_4	956	962	PF00069	0.474
MOD_Plk_4	969	975	PF00069	0.242
MOD_Plk_4	990	996	PF00069	0.664
MOD_ProDKin_1	15	21	PF00069	0.681
MOD_ProDKin_1	228	234	PF00069	0.573
MOD_ProDKin_1	246	252	PF00069	0.741
MOD_ProDKin_1	264	270	PF00069	0.787
MOD_ProDKin_1	401	407	PF00069	0.510
MOD_ProDKin_1	44	50	PF00069	0.617
MOD_ProDKin_1	459	465	PF00069	0.557
MOD_ProDKin_1	664	670	PF00069	0.667
MOD_ProDKin_1	767	773	PF00069	0.758
MOD_ProDKin_1	805	811	PF00069	0.649
MOD_ProDKin_1	815	821	PF00069	0.686
MOD_ProDKin_1	881	887	PF00069	0.459
MOD_ProDKin_1	905	911	PF00069	0.489
MOD_ProDKin_1	994	1000	PF00069	0.677
TRG_DiLeu_BaEn_1	474	479	PF01217	0.557
TRG_DiLeu_BaEn_1	97	102	PF01217	0.503
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.507
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.660
TRG_DiLeu_BaLyEn_6	783	788	PF01217	0.617
TRG_DiLeu_BaLyEn_6	862	867	PF01217	0.312
TRG_DiLeu_LyEn_5	97	102	PF01217	0.503
TRG_ENDOCYTIC_2	176	179	PF00928	0.489
TRG_ENDOCYTIC_2	507	510	PF00928	0.556
TRG_ENDOCYTIC_2	552	555	PF00928	0.408
TRG_ENDOCYTIC_2	857	860	PF00928	0.624
TRG_ER_diArg_1	1023	1025	PF00400	0.729
TRG_ER_diArg_1	484	487	PF00400	0.512
TRG_ER_diArg_1	523	526	PF00400	0.585
TRG_ER_diArg_1	58	60	PF00400	0.515
TRG_ER_diArg_1	648	651	PF00400	0.624
TRG_ER_diArg_1	695	698	PF00400	0.707
TRG_ER_diArg_1	748	751	PF00400	0.687
TRG_ER_diArg_1	762	764	PF00400	0.708
TRG_ER_diArg_1	821	824	PF00400	0.631
TRG_NES_CRM1_1	124	138	PF08389	0.503
TRG_NES_CRM1_1	469	482	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P736	Leptomonas seymouri	41%	87%
A0A3S5H7E4	Leishmania donovani	89%	88%
A4HE14	Leishmania braziliensis	65%	98%
A4I1C1	Leishmania infantum	89%	88%
E9AXF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	88%