DNL-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNL zinc finger, putative

Species:

Leishmania major

UniProt:

Q4QA14_LEIMA

TriTrypDb:

LmjF.25.0800 , LMJLV39_250014200 , LMJSD75_250014100

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA14

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0030150	protein import into mitochondrial matrix	4	2
GO:0031647	regulation of protein stability	3	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0044743	protein transmembrane import into intracellular organelle	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0050821	protein stabilization	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0055085	transmembrane transport	2	2
GO:0065002	intracellular protein transmembrane transport	4	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071806	protein transmembrane transport	3	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2
GO:1990542	mitochondrial transmembrane transport	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005515	protein binding	2	2
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6
GO:0051087	protein-folding chaperone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.575
CLV_NRD_NRD_1	57	59	PF00675	0.741
CLV_PCSK_KEX2_1	12	14	PF00082	0.575
CLV_PCSK_KEX2_1	162	164	PF00082	0.438
CLV_PCSK_KEX2_1	57	59	PF00082	0.741
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.405
CLV_PCSK_SKI1_1	159	163	PF00082	0.405
CLV_PCSK_SKI1_1	184	188	PF00082	0.405
CLV_PCSK_SKI1_1	4	8	PF00082	0.692
DEG_APCC_DBOX_1	3	11	PF00400	0.589
DEG_Nend_Nbox_1	1	3	PF02207	0.607
DEG_SPOP_SBC_1	100	104	PF00917	0.595
DEG_SPOP_SBC_1	231	235	PF00917	0.542
DOC_CKS1_1	77	82	PF01111	0.556
DOC_CYCLIN_RxL_1	181	189	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.577
DOC_MAPK_gen_1	206	215	PF00069	0.589
DOC_MAPK_JIP1_4	4	10	PF00069	0.584
DOC_PP2B_LxvP_1	124	127	PF13499	0.603
DOC_USP7_MATH_1	230	234	PF00917	0.511
DOC_USP7_MATH_1	43	47	PF00917	0.678
DOC_USP7_MATH_1	98	102	PF00917	0.609
DOC_USP7_UBL2_3	162	166	PF12436	0.405
DOC_WW_Pin1_4	110	115	PF00397	0.598
DOC_WW_Pin1_4	66	71	PF00397	0.575
DOC_WW_Pin1_4	76	81	PF00397	0.708
LIG_14-3-3_CanoR_1	44	53	PF00244	0.537
LIG_BRCT_BRCA1_1	233	237	PF00533	0.624
LIG_FHA_1	100	106	PF00498	0.575
LIG_FHA_1	168	174	PF00498	0.435
LIG_FHA_2	102	108	PF00498	0.622
LIG_FHA_2	197	203	PF00498	0.405
LIG_FHA_2	216	222	PF00498	0.444
LIG_LIR_Gen_1	210	219	PF02991	0.611
LIG_LIR_Gen_1	221	230	PF02991	0.541
LIG_LIR_Nem_3	157	161	PF02991	0.405
LIG_LIR_Nem_3	210	215	PF02991	0.659
LIG_LIR_Nem_3	219	225	PF02991	0.678
LIG_MYND_1	32	36	PF01753	0.617
LIG_SH2_CRK	158	162	PF00017	0.405
LIG_SH2_CRK	222	226	PF00017	0.769
LIG_SH2_STAT5	169	172	PF00017	0.405
LIG_SH3_3	173	179	PF00018	0.405
LIG_SH3_3	222	228	PF00018	0.651
LIG_SH3_3	74	80	PF00018	0.654
LIG_SUMO_SIM_par_1	172	177	PF11976	0.405
LIG_SUMO_SIM_par_1	6	11	PF11976	0.514
LIG_UBA3_1	120	129	PF00899	0.521
MOD_CDK_SPxK_1	66	72	PF00069	0.579
MOD_CK1_1	101	107	PF00069	0.618
MOD_CK1_1	233	239	PF00069	0.582
MOD_CK1_1	48	54	PF00069	0.628
MOD_CK1_1	66	72	PF00069	0.688
MOD_CK2_1	101	107	PF00069	0.616
MOD_CK2_1	196	202	PF00069	0.405
MOD_GlcNHglycan	137	140	PF01048	0.625
MOD_GlcNHglycan	47	50	PF01048	0.641
MOD_GSK3_1	17	24	PF00069	0.698
MOD_GSK3_1	233	240	PF00069	0.608
MOD_GSK3_1	48	55	PF00069	0.610
MOD_GSK3_1	58	65	PF00069	0.565
MOD_GSK3_1	68	75	PF00069	0.653
MOD_GSK3_1	96	103	PF00069	0.628
MOD_N-GLC_1	96	101	PF02516	0.547
MOD_NEK2_1	135	140	PF00069	0.607
MOD_NEK2_1	194	199	PF00069	0.398
MOD_NEK2_1	237	242	PF00069	0.622
MOD_NEK2_1	52	57	PF00069	0.697
MOD_NEK2_1	8	13	PF00069	0.525
MOD_NEK2_1	81	86	PF00069	0.630
MOD_PIKK_1	237	243	PF00454	0.621
MOD_PKA_1	162	168	PF00069	0.405
MOD_PKA_2	162	168	PF00069	0.405
MOD_PKA_2	17	23	PF00069	0.615
MOD_PKA_2	43	49	PF00069	0.537
MOD_Plk_1	129	135	PF00069	0.661
MOD_Plk_1	82	88	PF00069	0.532
MOD_Plk_4	130	136	PF00069	0.668
MOD_Plk_4	208	214	PF00069	0.602
MOD_Plk_4	48	54	PF00069	0.579
MOD_ProDKin_1	110	116	PF00069	0.596
MOD_ProDKin_1	66	72	PF00069	0.579
MOD_ProDKin_1	76	82	PF00069	0.705
MOD_SUMO_for_1	207	210	PF00179	0.405
MOD_SUMO_rev_2	71	80	PF00179	0.641
TRG_ENDOCYTIC_2	158	161	PF00928	0.405
TRG_ENDOCYTIC_2	222	225	PF00928	0.769
TRG_ER_diArg_1	12	14	PF00400	0.604
TRG_ER_diArg_1	57	59	PF00400	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDE1	Leishmania donovani	87%	100%
A4HE15	Leishmania braziliensis	77%	100%
A4I1C2	Leishmania infantum	87%	100%
E9AXF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%