Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA13_LEIMA

TriTrypDb:

LmjF.25.0810 , LMJLV39_250014300 , LMJSD75_250014200

Length:

1022

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.549
CLV_C14_Caspase3-7	204	208	PF00656	0.618
CLV_C14_Caspase3-7	460	464	PF00656	0.376
CLV_C14_Caspase3-7	542	546	PF00656	0.551
CLV_C14_Caspase3-7	734	738	PF00656	0.660
CLV_NRD_NRD_1	220	222	PF00675	0.490
CLV_NRD_NRD_1	426	428	PF00675	0.466
CLV_NRD_NRD_1	443	445	PF00675	0.396
CLV_NRD_NRD_1	644	646	PF00675	0.552
CLV_NRD_NRD_1	696	698	PF00675	0.495
CLV_NRD_NRD_1	835	837	PF00675	0.630
CLV_NRD_NRD_1	964	966	PF00675	0.725
CLV_PCSK_KEX2_1	220	222	PF00082	0.490
CLV_PCSK_KEX2_1	426	428	PF00082	0.466
CLV_PCSK_KEX2_1	443	445	PF00082	0.396
CLV_PCSK_KEX2_1	501	503	PF00082	0.440
CLV_PCSK_KEX2_1	644	646	PF00082	0.552
CLV_PCSK_KEX2_1	696	698	PF00082	0.544
CLV_PCSK_KEX2_1	834	836	PF00082	0.633
CLV_PCSK_KEX2_1	964	966	PF00082	0.725
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.487
CLV_PCSK_SKI1_1	179	183	PF00082	0.496
CLV_PCSK_SKI1_1	201	205	PF00082	0.489
CLV_PCSK_SKI1_1	377	381	PF00082	0.774
CLV_PCSK_SKI1_1	426	430	PF00082	0.467
CLV_PCSK_SKI1_1	473	477	PF00082	0.349
CLV_PCSK_SKI1_1	644	648	PF00082	0.522
CLV_PCSK_SKI1_1	706	710	PF00082	0.382
DEG_ODPH_VHL_1	251	264	PF01847	0.579
DEG_SPOP_SBC_1	725	729	PF00917	0.602
DEG_SPOP_SBC_1	79	83	PF00917	0.633
DOC_CKS1_1	182	187	PF01111	0.577
DOC_CKS1_1	372	377	PF01111	0.686
DOC_CYCLIN_RxL_1	176	187	PF00134	0.581
DOC_CYCLIN_RxL_1	421	432	PF00134	0.464
DOC_CYCLIN_RxL_1	641	649	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.364
DOC_CYCLIN_yCln2_LP_2	608	614	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	786	792	PF00134	0.527
DOC_MAPK_gen_1	339	348	PF00069	0.623
DOC_MAPK_gen_1	48	54	PF00069	0.662
DOC_MAPK_MEF2A_6	1003	1011	PF00069	0.534
DOC_MAPK_MEF2A_6	882	891	PF00069	0.504
DOC_PP1_RVXF_1	299	305	PF00149	0.619
DOC_PP1_RVXF_1	47	54	PF00149	0.536
DOC_PP1_RVXF_1	471	477	PF00149	0.356
DOC_PP2B_LxvP_1	183	186	PF13499	0.530
DOC_PP2B_LxvP_1	251	254	PF13499	0.661
DOC_PP2B_LxvP_1	574	577	PF13499	0.408
DOC_PP2B_LxvP_1	786	789	PF13499	0.470
DOC_PP2B_LxvP_1	790	793	PF13499	0.448
DOC_PP4_FxxP_1	54	57	PF00568	0.535
DOC_PP4_MxPP_1	29	32	PF00568	0.693
DOC_USP7_MATH_1	205	209	PF00917	0.739
DOC_USP7_MATH_1	317	321	PF00917	0.691
DOC_USP7_MATH_1	335	339	PF00917	0.505
DOC_USP7_MATH_1	721	725	PF00917	0.534
DOC_USP7_MATH_1	726	730	PF00917	0.602
DOC_USP7_MATH_1	735	739	PF00917	0.621
DOC_USP7_MATH_1	79	83	PF00917	0.638
DOC_USP7_MATH_1	811	815	PF00917	0.595
DOC_USP7_MATH_1	909	913	PF00917	0.740
DOC_USP7_MATH_1	968	972	PF00917	0.622
DOC_WW_Pin1_4	100	105	PF00397	0.720
DOC_WW_Pin1_4	181	186	PF00397	0.566
DOC_WW_Pin1_4	371	376	PF00397	0.607
DOC_WW_Pin1_4	689	694	PF00397	0.528
DOC_WW_Pin1_4	736	741	PF00397	0.611
DOC_WW_Pin1_4	767	772	PF00397	0.410
DOC_WW_Pin1_4	916	921	PF00397	0.618
DOC_WW_Pin1_4	943	948	PF00397	0.553
DOC_WW_Pin1_4	971	976	PF00397	0.754
LIG_14-3-3_CanoR_1	22	31	PF00244	0.551
LIG_14-3-3_CanoR_1	288	293	PF00244	0.650
LIG_14-3-3_CanoR_1	341	349	PF00244	0.662
LIG_14-3-3_CanoR_1	446	453	PF00244	0.377
LIG_14-3-3_CanoR_1	578	583	PF00244	0.443
LIG_14-3-3_CanoR_1	897	905	PF00244	0.649
LIG_14-3-3_CanoR_1	978	987	PF00244	0.606
LIG_Actin_WH2_2	791	809	PF00022	0.510
LIG_AP2alpha_1	482	486	PF02296	0.333
LIG_APCC_Cbox_2	484	490	PF00515	0.345
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BRCT_BRCA1_1	23	27	PF00533	0.568
LIG_deltaCOP1_diTrp_1	128	133	PF00928	0.563
LIG_deltaCOP1_diTrp_1	701	708	PF00928	0.434
LIG_eIF4E_1	177	183	PF01652	0.492
LIG_FHA_1	124	130	PF00498	0.654
LIG_FHA_1	171	177	PF00498	0.489
LIG_FHA_1	276	282	PF00498	0.531
LIG_FHA_1	341	347	PF00498	0.637
LIG_FHA_1	556	562	PF00498	0.364
LIG_FHA_1	569	575	PF00498	0.401
LIG_FHA_1	587	593	PF00498	0.563
LIG_FHA_1	641	647	PF00498	0.511
LIG_FHA_1	707	713	PF00498	0.412
LIG_FHA_1	84	90	PF00498	0.785
LIG_FHA_1	840	846	PF00498	0.751
LIG_FHA_1	952	958	PF00498	0.635
LIG_FHA_1	980	986	PF00498	0.450
LIG_FHA_2	112	118	PF00498	0.627
LIG_FHA_2	14	20	PF00498	0.509
LIG_FHA_2	202	208	PF00498	0.627
LIG_FHA_2	328	334	PF00498	0.710
LIG_FHA_2	36	42	PF00498	0.578
LIG_FHA_2	614	620	PF00498	0.367
LIG_FHA_2	627	633	PF00498	0.418
LIG_Integrin_RGD_1	389	391	PF01839	0.555
LIG_LIR_Apic_2	902	908	PF02991	0.560
LIG_LIR_Gen_1	166	176	PF02991	0.468
LIG_LIR_Gen_1	178	186	PF02991	0.506
LIG_LIR_Gen_1	3	13	PF02991	0.606
LIG_LIR_Gen_1	484	494	PF02991	0.436
LIG_LIR_Gen_1	594	605	PF02991	0.363
LIG_LIR_Gen_1	616	625	PF02991	0.372
LIG_LIR_Gen_1	701	708	PF02991	0.401
LIG_LIR_Gen_1	761	772	PF02991	0.479
LIG_LIR_Nem_3	166	171	PF02991	0.494
LIG_LIR_Nem_3	174	180	PF02991	0.583
LIG_LIR_Nem_3	3	9	PF02991	0.595
LIG_LIR_Nem_3	484	489	PF02991	0.423
LIG_LIR_Nem_3	594	600	PF02991	0.372
LIG_LIR_Nem_3	601	605	PF02991	0.352
LIG_LIR_Nem_3	616	621	PF02991	0.303
LIG_LIR_Nem_3	631	637	PF02991	0.458
LIG_LIR_Nem_3	701	705	PF02991	0.405
LIG_LIR_Nem_3	761	767	PF02991	0.514
LIG_LIR_Nem_3	878	884	PF02991	0.540
LIG_LIR_Nem_3	986	991	PF02991	0.486
LIG_NRBOX	424	430	PF00104	0.513
LIG_NRBOX	886	892	PF00104	0.470
LIG_PDZ_Class_3	1017	1022	PF00595	0.549
LIG_Pex14_2	482	486	PF04695	0.333
LIG_REV1ctd_RIR_1	495	506	PF16727	0.469
LIG_RPA_C_Fungi	334	346	PF08784	0.646
LIG_SH2_CRK	1014	1018	PF00017	0.523
LIG_SH2_CRK	477	481	PF00017	0.330
LIG_SH2_CRK	634	638	PF00017	0.521
LIG_SH2_CRK	881	885	PF00017	0.602
LIG_SH2_CRK	905	909	PF00017	0.533
LIG_SH2_NCK_1	168	172	PF00017	0.466
LIG_SH2_NCK_1	477	481	PF00017	0.330
LIG_SH2_SRC	468	471	PF00017	0.397
LIG_SH2_STAP1	177	181	PF00017	0.488
LIG_SH2_STAP1	271	275	PF00017	0.537
LIG_SH2_STAP1	434	438	PF00017	0.396
LIG_SH2_STAP1	477	481	PF00017	0.330
LIG_SH2_STAT3	434	437	PF00017	0.473
LIG_SH2_STAT3	500	503	PF00017	0.397
LIG_SH2_STAT5	162	165	PF00017	0.474
LIG_SH2_STAT5	180	183	PF00017	0.635
LIG_SH2_STAT5	260	263	PF00017	0.672
LIG_SH2_STAT5	271	274	PF00017	0.522
LIG_SH2_STAT5	331	334	PF00017	0.706
LIG_SH2_STAT5	468	471	PF00017	0.420
LIG_SH2_STAT5	477	480	PF00017	0.392
LIG_SH2_STAT5	953	956	PF00017	0.645
LIG_SH3_1	369	375	PF00018	0.638
LIG_SH3_2	372	377	PF14604	0.638
LIG_SH3_3	250	256	PF00018	0.582
LIG_SH3_3	369	375	PF00018	0.686
LIG_SH3_3	522	528	PF00018	0.601
LIG_SH3_3	608	614	PF00018	0.404
LIG_SH3_3	785	791	PF00018	0.461
LIG_SH3_3	795	801	PF00018	0.604
LIG_SH3_3	939	945	PF00018	0.656
LIG_SH3_3	946	952	PF00018	0.604
LIG_SH3_5	256	260	PF00018	0.602
LIG_Sin3_3	277	284	PF02671	0.723
LIG_Sin3_3	776	783	PF02671	0.453
LIG_SUMO_SIM_anti_2	558	564	PF11976	0.333
LIG_SUMO_SIM_anti_2	886	892	PF11976	0.495
LIG_SUMO_SIM_par_1	455	461	PF11976	0.375
LIG_SUMO_SIM_par_1	613	619	PF11976	0.377
LIG_SUMO_SIM_par_1	883	888	PF11976	0.434
LIG_TRAF2_1	125	128	PF00917	0.659
LIG_TRAF2_1	284	287	PF00917	0.553
LIG_TRAF2_1	38	41	PF00917	0.594
LIG_TRAF2_1	509	512	PF00917	0.456
LIG_TRAF2_1	668	671	PF00917	0.707
LIG_TRAF2_1	752	755	PF00917	0.686
LIG_UBA3_1	987	996	PF00899	0.439
LIG_WRC_WIRS_1	553	558	PF05994	0.422
LIG_WRC_WIRS_1	624	629	PF05994	0.347
LIG_WW_3	575	579	PF00397	0.406
MOD_CDK_SPK_2	736	741	PF00069	0.655
MOD_CDK_SPK_2	971	976	PF00069	0.646
MOD_CDK_SPxK_1	371	377	PF00069	0.611
MOD_CDK_SPxxK_3	181	188	PF00069	0.577
MOD_CDK_SPxxK_3	689	696	PF00069	0.513
MOD_CDK_SPxxK_3	736	743	PF00069	0.560
MOD_CDK_SPxxK_3	971	978	PF00069	0.642
MOD_CK1_1	1002	1008	PF00069	0.549
MOD_CK1_1	103	109	PF00069	0.687
MOD_CK1_1	187	193	PF00069	0.640
MOD_CK1_1	247	253	PF00069	0.535
MOD_CK1_1	310	316	PF00069	0.608
MOD_CK1_1	370	376	PF00069	0.628
MOD_CK1_1	555	561	PF00069	0.433
MOD_CK1_1	640	646	PF00069	0.511
MOD_CK1_1	724	730	PF00069	0.604
MOD_CK1_1	731	737	PF00069	0.665
MOD_CK1_1	821	827	PF00069	0.628
MOD_CK1_1	83	89	PF00069	0.594
MOD_CK1_1	839	845	PF00069	0.538
MOD_CK1_1	899	905	PF00069	0.648
MOD_CK1_1	971	977	PF00069	0.756
MOD_CK2_1	111	117	PF00069	0.657
MOD_CK2_1	122	128	PF00069	0.747
MOD_CK2_1	163	169	PF00069	0.450
MOD_CK2_1	209	215	PF00069	0.529
MOD_CK2_1	22	28	PF00069	0.696
MOD_CK2_1	229	235	PF00069	0.398
MOD_CK2_1	309	315	PF00069	0.697
MOD_CK2_1	327	333	PF00069	0.703
MOD_CK2_1	35	41	PF00069	0.515
MOD_CK2_1	405	411	PF00069	0.599
MOD_CK2_1	506	512	PF00069	0.446
MOD_CK2_1	613	619	PF00069	0.382
MOD_CK2_1	838	844	PF00069	0.543
MOD_CMANNOS	130	133	PF00535	0.553
MOD_CMANNOS	442	445	PF00535	0.383
MOD_Cter_Amidation	694	697	PF01082	0.383
MOD_GlcNHglycan	173	176	PF01048	0.631
MOD_GlcNHglycan	189	192	PF01048	0.565
MOD_GlcNHglycan	207	210	PF01048	0.451
MOD_GlcNHglycan	231	234	PF01048	0.670
MOD_GlcNHglycan	24	27	PF01048	0.610
MOD_GlcNHglycan	281	284	PF01048	0.579
MOD_GlcNHglycan	319	322	PF01048	0.615
MOD_GlcNHglycan	333	336	PF01048	0.648
MOD_GlcNHglycan	343	346	PF01048	0.625
MOD_GlcNHglycan	357	360	PF01048	0.687
MOD_GlcNHglycan	369	372	PF01048	0.611
MOD_GlcNHglycan	393	396	PF01048	0.620
MOD_GlcNHglycan	449	452	PF01048	0.425
MOD_GlcNHglycan	541	544	PF01048	0.663
MOD_GlcNHglycan	64	67	PF01048	0.727
MOD_GlcNHglycan	678	681	PF01048	0.550
MOD_GlcNHglycan	71	74	PF01048	0.674
MOD_GlcNHglycan	723	726	PF01048	0.572
MOD_GlcNHglycan	728	731	PF01048	0.626
MOD_GlcNHglycan	733	736	PF01048	0.664
MOD_GlcNHglycan	820	823	PF01048	0.748
MOD_GlcNHglycan	825	828	PF01048	0.732
MOD_GlcNHglycan	900	904	PF01048	0.564
MOD_GlcNHglycan	95	99	PF01048	0.760
MOD_GlcNHglycan	970	973	PF01048	0.761
MOD_GSK3_1	201	208	PF00069	0.574
MOD_GSK3_1	211	218	PF00069	0.612
MOD_GSK3_1	240	247	PF00069	0.616
MOD_GSK3_1	265	272	PF00069	0.542
MOD_GSK3_1	275	282	PF00069	0.616
MOD_GSK3_1	288	295	PF00069	0.520
MOD_GSK3_1	303	310	PF00069	0.545
MOD_GSK3_1	317	324	PF00069	0.646
MOD_GSK3_1	327	334	PF00069	0.667
MOD_GSK3_1	335	342	PF00069	0.710
MOD_GSK3_1	353	360	PF00069	0.756
MOD_GSK3_1	367	374	PF00069	0.610
MOD_GSK3_1	586	593	PF00069	0.426
MOD_GSK3_1	623	630	PF00069	0.409
MOD_GSK3_1	633	640	PF00069	0.493
MOD_GSK3_1	721	728	PF00069	0.573
MOD_GSK3_1	731	738	PF00069	0.687
MOD_GSK3_1	79	86	PF00069	0.686
MOD_GSK3_1	817	824	PF00069	0.690
MOD_GSK3_1	870	877	PF00069	0.755
MOD_GSK3_1	943	950	PF00069	0.683
MOD_GSK3_1	951	958	PF00069	0.703
MOD_GSK3_1	967	974	PF00069	0.635
MOD_GSK3_1	99	106	PF00069	0.728
MOD_N-GLC_1	247	252	PF02516	0.532
MOD_N-GLC_1	317	322	PF02516	0.614
MOD_NEK2_1	111	116	PF00069	0.702
MOD_NEK2_1	120	125	PF00069	0.644
MOD_NEK2_1	163	168	PF00069	0.447
MOD_NEK2_1	170	175	PF00069	0.483
MOD_NEK2_1	229	234	PF00069	0.622
MOD_NEK2_1	269	274	PF00069	0.540
MOD_NEK2_1	275	280	PF00069	0.583
MOD_NEK2_1	294	299	PF00069	0.612
MOD_NEK2_1	302	307	PF00069	0.582
MOD_NEK2_1	428	433	PF00069	0.526
MOD_NEK2_1	520	525	PF00069	0.538
MOD_NEK2_1	539	544	PF00069	0.709
MOD_NEK2_1	566	571	PF00069	0.347
MOD_NEK2_1	625	630	PF00069	0.435
MOD_NEK2_1	633	638	PF00069	0.480
MOD_NEK2_1	830	835	PF00069	0.600
MOD_NEK2_1	847	852	PF00069	0.494
MOD_NEK2_1	870	875	PF00069	0.601
MOD_PIKK_1	123	129	PF00454	0.724
MOD_PIKK_1	333	339	PF00454	0.693
MOD_PIKK_1	414	420	PF00454	0.456
MOD_PIKK_1	555	561	PF00454	0.340
MOD_PKA_2	1002	1008	PF00069	0.521
MOD_PKA_2	111	117	PF00069	0.659
MOD_PKA_2	21	27	PF00069	0.547
MOD_PKA_2	340	346	PF00069	0.599
MOD_PKA_2	523	529	PF00069	0.633
MOD_PKA_2	818	824	PF00069	0.627
MOD_PKA_2	870	876	PF00069	0.607
MOD_PKA_2	896	902	PF00069	0.556
MOD_PKB_1	242	250	PF00069	0.548
MOD_PKB_1	339	347	PF00069	0.622
MOD_PKB_1	444	452	PF00069	0.374
MOD_PKB_1	704	712	PF00069	0.382
MOD_PKB_1	834	842	PF00069	0.543
MOD_PKB_1	976	984	PF00069	0.638
MOD_Plk_1	247	253	PF00069	0.530
MOD_Plk_1	429	435	PF00069	0.541
MOD_Plk_1	836	842	PF00069	0.554
MOD_Plk_1	885	891	PF00069	0.498
MOD_Plk_2-3	405	411	PF00069	0.472
MOD_Plk_4	327	333	PF00069	0.632
MOD_Plk_4	405	411	PF00069	0.723
MOD_Plk_4	429	435	PF00069	0.510
MOD_Plk_4	552	558	PF00069	0.429
MOD_Plk_4	613	619	PF00069	0.377
MOD_Plk_4	885	891	PF00069	0.509
MOD_ProDKin_1	100	106	PF00069	0.721
MOD_ProDKin_1	181	187	PF00069	0.571
MOD_ProDKin_1	371	377	PF00069	0.611
MOD_ProDKin_1	689	695	PF00069	0.516
MOD_ProDKin_1	736	742	PF00069	0.610
MOD_ProDKin_1	767	773	PF00069	0.407
MOD_ProDKin_1	916	922	PF00069	0.619
MOD_ProDKin_1	943	949	PF00069	0.549
MOD_ProDKin_1	971	977	PF00069	0.751
MOD_SUMO_rev_2	754	760	PF00179	0.642
TRG_DiLeu_BaEn_1	178	183	PF01217	0.493
TRG_DiLeu_BaEn_1	601	606	PF01217	0.358
TRG_DiLeu_BaEn_1	886	891	PF01217	0.477
TRG_DiLeu_BaEn_2	551	557	PF01217	0.391
TRG_DiLeu_BaEn_3	594	600	PF01217	0.448
TRG_DiLeu_BaEn_4	848	854	PF01217	0.658
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.508
TRG_DiLeu_BaLyEn_6	642	647	PF01217	0.519
TRG_ENDOCYTIC_2	1014	1017	PF00928	0.522
TRG_ENDOCYTIC_2	168	171	PF00928	0.452
TRG_ENDOCYTIC_2	180	183	PF00928	0.495
TRG_ENDOCYTIC_2	477	480	PF00928	0.330
TRG_ENDOCYTIC_2	634	637	PF00928	0.558
TRG_ENDOCYTIC_2	881	884	PF00928	0.528
TRG_ER_diArg_1	1000	1003	PF00400	0.410
TRG_ER_diArg_1	219	221	PF00400	0.486
TRG_ER_diArg_1	425	427	PF00400	0.464
TRG_ER_diArg_1	442	444	PF00400	0.400
TRG_ER_diArg_1	577	580	PF00400	0.448
TRG_ER_diArg_1	644	646	PF00400	0.523
TRG_ER_diArg_1	703	706	PF00400	0.398
TRG_ER_diArg_1	740	743	PF00400	0.584
TRG_ER_diArg_1	834	836	PF00400	0.668
TRG_ER_diArg_1	975	978	PF00400	0.640
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	455	460	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	882	886	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7D6	Leptomonas seymouri	52%	98%
A0A3Q8ID75	Leishmania donovani	92%	100%
A4HE16	Leishmania braziliensis	80%	100%
A4I1C3	Leishmania infantum	93%	100%
E9AXF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%