Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA10_LEIMA

TriTrypDb:

LmjF.25.0840 , LMJLV39_250014700 , LMJSD75_250014600

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.457
CLV_NRD_NRD_1	123	125	PF00675	0.545
CLV_NRD_NRD_1	178	180	PF00675	0.665
CLV_NRD_NRD_1	210	212	PF00675	0.590
CLV_NRD_NRD_1	222	224	PF00675	0.621
CLV_NRD_NRD_1	258	260	PF00675	0.598
CLV_NRD_NRD_1	283	285	PF00675	0.566
CLV_NRD_NRD_1	359	361	PF00675	0.750
CLV_NRD_NRD_1	9	11	PF00675	0.553
CLV_PCSK_KEX2_1	125	127	PF00082	0.466
CLV_PCSK_KEX2_1	178	180	PF00082	0.665
CLV_PCSK_KEX2_1	183	185	PF00082	0.652
CLV_PCSK_KEX2_1	210	212	PF00082	0.550
CLV_PCSK_KEX2_1	221	223	PF00082	0.562
CLV_PCSK_KEX2_1	283	285	PF00082	0.591
CLV_PCSK_KEX2_1	291	293	PF00082	0.572
CLV_PCSK_KEX2_1	52	54	PF00082	0.616
CLV_PCSK_KEX2_1	8	10	PF00082	0.569
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.456
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.587
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.596
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.715
CLV_PCSK_PC7_1	179	185	PF00082	0.637
CLV_PCSK_PC7_1	206	212	PF00082	0.412
CLV_PCSK_SKI1_1	10	14	PF00082	0.601
CLV_PCSK_SKI1_1	102	106	PF00082	0.587
CLV_PCSK_SKI1_1	126	130	PF00082	0.446
CLV_PCSK_SKI1_1	178	182	PF00082	0.597
CLV_PCSK_SKI1_1	222	226	PF00082	0.616
CLV_PCSK_SKI1_1	36	40	PF00082	0.475
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DOC_CYCLIN_RxL_1	123	133	PF00134	0.517
DOC_CYCLIN_RxL_1	206	218	PF00134	0.580
DOC_MAPK_gen_1	124	131	PF00069	0.435
DOC_MAPK_gen_1	206	214	PF00069	0.411
DOC_USP7_MATH_1	303	307	PF00917	0.693
DOC_USP7_MATH_1	371	375	PF00917	0.617
DOC_USP7_MATH_1	77	81	PF00917	0.666
DOC_USP7_UBL2_3	249	253	PF12436	0.575
DOC_USP7_UBL2_3	357	361	PF12436	0.700
DOC_WW_Pin1_4	132	137	PF00397	0.582
DOC_WW_Pin1_4	267	272	PF00397	0.754
LIG_14-3-3_CanoR_1	178	187	PF00244	0.698
LIG_14-3-3_CanoR_1	222	232	PF00244	0.529
LIG_14-3-3_CanoR_1	259	269	PF00244	0.649
LIG_14-3-3_CanoR_1	292	302	PF00244	0.533
LIG_14-3-3_CanoR_1	332	342	PF00244	0.769
LIG_APCC_ABBA_1	192	197	PF00400	0.484
LIG_BRCT_BRCA1_1	262	266	PF00533	0.554
LIG_BRCT_BRCA1_1	337	341	PF00533	0.683
LIG_CtBP_PxDLS_1	326	332	PF00389	0.532
LIG_FHA_1	153	159	PF00498	0.567
LIG_FHA_1	189	195	PF00498	0.687
LIG_FHA_1	224	230	PF00498	0.628
LIG_FHA_1	295	301	PF00498	0.602
LIG_FHA_1	96	102	PF00498	0.694
LIG_FHA_2	103	109	PF00498	0.469
LIG_FHA_2	200	206	PF00498	0.519
LIG_FHA_2	225	231	PF00498	0.544
LIG_FHA_2	313	319	PF00498	0.728
LIG_GBD_Chelix_1	261	269	PF00786	0.560
LIG_HCF-1_HBM_1	174	177	PF13415	0.497
LIG_LIR_Apic_2	193	198	PF02991	0.576
LIG_LIR_Gen_1	263	274	PF02991	0.658
LIG_LIR_Nem_3	112	118	PF02991	0.467
LIG_LIR_Nem_3	143	148	PF02991	0.608
LIG_LIR_Nem_3	174	180	PF02991	0.662
LIG_LIR_Nem_3	263	269	PF02991	0.606
LIG_LIR_Nem_3	45	49	PF02991	0.562
LIG_Pex14_1	7	11	PF04695	0.511
LIG_Pex14_2	116	120	PF04695	0.470
LIG_SH2_CRK	177	181	PF00017	0.659
LIG_SH2_NCK_1	11	15	PF00017	0.383
LIG_SH2_SRC	195	198	PF00017	0.628
LIG_SH2_STAT5	115	118	PF00017	0.425
LIG_SH2_STAT5	127	130	PF00017	0.553
LIG_SH2_STAT5	139	142	PF00017	0.443
LIG_SH2_STAT5	145	148	PF00017	0.379
LIG_SH2_STAT5	195	198	PF00017	0.639
LIG_SH2_STAT5	63	66	PF00017	0.546
LIG_SH3_2	74	79	PF14604	0.673
LIG_SH3_3	268	274	PF00018	0.635
LIG_SH3_3	71	77	PF00018	0.597
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.419
LIG_SUMO_SIM_par_1	127	133	PF11976	0.491
LIG_SxIP_EBH_1	39	53	PF03271	0.541
LIG_TRAF2_1	119	122	PF00917	0.482
LIG_TRAF2_1	254	257	PF00917	0.564
LIG_WRC_WIRS_1	131	136	PF05994	0.362
LIG_WW_3	280	284	PF00397	0.557
MOD_CK1_1	190	196	PF00069	0.633
MOD_CK1_1	239	245	PF00069	0.689
MOD_CK1_1	276	282	PF00069	0.611
MOD_CK1_1	333	339	PF00069	0.700
MOD_CK1_1	97	103	PF00069	0.644
MOD_CK2_1	116	122	PF00069	0.489
MOD_CK2_1	199	205	PF00069	0.520
MOD_CK2_1	251	257	PF00069	0.617
MOD_CK2_1	261	267	PF00069	0.688
MOD_CK2_1	325	331	PF00069	0.683
MOD_CK2_1	87	93	PF00069	0.641
MOD_GlcNHglycan	243	246	PF01048	0.608
MOD_GlcNHglycan	306	309	PF01048	0.820
MOD_GlcNHglycan	335	338	PF01048	0.725
MOD_GlcNHglycan	353	356	PF01048	0.665
MOD_GlcNHglycan	66	71	PF01048	0.667
MOD_GlcNHglycan	85	88	PF01048	0.724
MOD_GSK3_1	183	190	PF00069	0.646
MOD_GSK3_1	239	246	PF00069	0.569
MOD_GSK3_1	312	319	PF00069	0.809
MOD_GSK3_1	371	378	PF00069	0.643
MOD_GSK3_1	83	90	PF00069	0.555
MOD_GSK3_1	93	100	PF00069	0.592
MOD_N-GLC_2	109	111	PF02516	0.543
MOD_NEK2_1	130	135	PF00069	0.492
MOD_NEK2_2	372	377	PF00069	0.587
MOD_PIKK_1	335	341	PF00454	0.513
MOD_PKA_1	178	184	PF00069	0.672
MOD_PKA_1	284	290	PF00069	0.548
MOD_PKA_2	178	184	PF00069	0.672
MOD_PKA_2	304	310	PF00069	0.671
MOD_PKB_1	221	229	PF00069	0.566
MOD_Plk_1	285	291	PF00069	0.722
MOD_Plk_4	109	115	PF00069	0.574
MOD_Plk_4	141	147	PF00069	0.535
MOD_Plk_4	183	189	PF00069	0.691
MOD_Plk_4	190	196	PF00069	0.578
MOD_Plk_4	261	267	PF00069	0.696
MOD_Plk_4	28	34	PF00069	0.638
MOD_Plk_4	42	48	PF00069	0.537
MOD_ProDKin_1	132	138	PF00069	0.583
MOD_ProDKin_1	267	273	PF00069	0.760
MOD_SUMO_for_1	274	277	PF00179	0.806
MOD_SUMO_for_1	363	366	PF00179	0.606
MOD_SUMO_rev_2	103	112	PF00179	0.449
TRG_ENDOCYTIC_2	113	116	PF00928	0.452
TRG_ENDOCYTIC_2	127	130	PF00928	0.553
TRG_ENDOCYTIC_2	145	148	PF00928	0.423
TRG_ENDOCYTIC_2	177	180	PF00928	0.659
TRG_ER_diArg_1	124	127	PF00400	0.513
TRG_ER_diArg_1	177	179	PF00400	0.663
TRG_ER_diArg_1	209	211	PF00400	0.603
TRG_ER_diArg_1	221	223	PF00400	0.623
TRG_ER_diArg_1	282	284	PF00400	0.562
TRG_ER_diArg_1	7	10	PF00400	0.610
TRG_NLS_MonoExtC_3	50	56	PF00514	0.616
TRG_NLS_MonoExtN_4	48	55	PF00514	0.588
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI8	Leptomonas seymouri	52%	92%
A0A1X0P4C2	Trypanosomatidae	29%	100%
A0A3S7WYY8	Leishmania donovani	84%	100%
A0A422MPP3	Trypanosoma rangeli	31%	100%
A4HE19	Leishmania braziliensis	64%	90%
A4I1C6	Leishmania infantum	84%	100%
E9AXG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5BXG5	Trypanosoma cruzi	31%	100%