Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Atypical serine/threonine protein kinase BUD32, putative

Species:

Leishmania major

UniProt:

Q4QA07_LEIMA

TriTrypDb:

LmjF.25.0870 , LMJLV39_250015000 , LMJSD75_250014900

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000408	EKC/KEOPS complex	2	2
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA07

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006468	protein phosphorylation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0070525	tRNA threonylcarbamoyladenosine metabolic process	6	2
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.704
CLV_NRD_NRD_1	276	278	PF00675	0.435
CLV_NRD_NRD_1	285	287	PF00675	0.446
CLV_NRD_NRD_1	68	70	PF00675	0.524
CLV_PCSK_FUR_1	66	70	PF00082	0.551
CLV_PCSK_KEX2_1	276	278	PF00082	0.463
CLV_PCSK_KEX2_1	287	289	PF00082	0.485
CLV_PCSK_KEX2_1	51	53	PF00082	0.495
CLV_PCSK_KEX2_1	68	70	PF00082	0.425
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.537
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.495
CLV_PCSK_SKI1_1	108	112	PF00082	0.401
CLV_PCSK_SKI1_1	23	27	PF00082	0.534
CLV_PCSK_SKI1_1	48	52	PF00082	0.472
CLV_PCSK_SKI1_1	76	80	PF00082	0.495
CLV_Separin_Fungi	18	24	PF03568	0.461
DEG_SCF_FBW7_1	135	142	PF00400	0.722
DOC_CKS1_1	136	141	PF01111	0.736
DOC_PP1_RVXF_1	21	27	PF00149	0.478
DOC_USP7_MATH_1	12	16	PF00917	0.682
DOC_USP7_MATH_1	139	143	PF00917	0.757
DOC_USP7_MATH_1	201	205	PF00917	0.693
DOC_USP7_MATH_1	242	246	PF00917	0.359
DOC_WW_Pin1_4	135	140	PF00397	0.713
DOC_WW_Pin1_4	147	152	PF00397	0.446
DOC_WW_Pin1_4	203	208	PF00397	0.623
LIG_14-3-3_CanoR_1	241	250	PF00244	0.371
LIG_14-3-3_CanoR_1	286	291	PF00244	0.529
LIG_BIR_II_1	1	5	PF00653	0.727
LIG_eIF4E_1	92	98	PF01652	0.507
LIG_FHA_1	14	20	PF00498	0.559
LIG_FHA_1	151	157	PF00498	0.474
LIG_FHA_1	93	99	PF00498	0.470
LIG_FHA_2	104	110	PF00498	0.405
LIG_FHA_2	209	215	PF00498	0.497
LIG_FHA_2	65	71	PF00498	0.430
LIG_LIR_Gen_1	95	103	PF02991	0.445
LIG_LIR_Nem_3	219	223	PF02991	0.378
LIG_LIR_Nem_3	37	42	PF02991	0.356
LIG_SH2_CRK	39	43	PF00017	0.414
LIG_SH2_GRB2like	92	95	PF00017	0.501
LIG_SH2_STAT3	118	121	PF00017	0.518
LIG_SH2_STAT5	237	240	PF00017	0.361
LIG_SH2_STAT5	249	252	PF00017	0.384
LIG_SH2_STAT5	34	37	PF00017	0.373
LIG_SH2_STAT5	92	95	PF00017	0.501
LIG_SH3_3	204	210	PF00018	0.630
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.393
LIG_SUMO_SIM_par_1	213	219	PF11976	0.360
LIG_TRAF2_1	228	231	PF00917	0.363
LIG_WRC_WIRS_1	250	255	PF05994	0.280
LIG_WRC_WIRS_1	93	98	PF05994	0.477
MOD_CK1_1	15	21	PF00069	0.584
MOD_CK1_1	150	156	PF00069	0.493
MOD_CK1_1	252	258	PF00069	0.329
MOD_CK2_1	103	109	PF00069	0.445
MOD_CK2_1	225	231	PF00069	0.407
MOD_CK2_1	54	60	PF00069	0.459
MOD_CK2_1	64	70	PF00069	0.380
MOD_Cter_Amidation	284	287	PF01082	0.459
MOD_GlcNHglycan	128	131	PF01048	0.749
MOD_GlcNHglycan	141	144	PF01048	0.677
MOD_GlcNHglycan	263	266	PF01048	0.415
MOD_GSK3_1	120	127	PF00069	0.580
MOD_GSK3_1	135	142	PF00069	0.683
MOD_GSK3_1	221	228	PF00069	0.486
MOD_GSK3_1	248	255	PF00069	0.471
MOD_NEK2_1	1	6	PF00069	0.708
MOD_NEK2_1	156	161	PF00069	0.434
MOD_NEK2_1	177	182	PF00069	0.351
MOD_NEK2_1	202	207	PF00069	0.677
MOD_NEK2_2	34	39	PF00069	0.460
MOD_PIKK_1	61	67	PF00454	0.545
MOD_PKA_1	286	292	PF00069	0.537
MOD_PKB_1	284	292	PF00069	0.510
MOD_PKB_1	52	60	PF00069	0.549
MOD_Plk_4	34	40	PF00069	0.469
MOD_Plk_4	92	98	PF00069	0.406
MOD_ProDKin_1	135	141	PF00069	0.711
MOD_ProDKin_1	147	153	PF00069	0.434
MOD_ProDKin_1	203	209	PF00069	0.609
TRG_DiLeu_BaEn_1	20	25	PF01217	0.490
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.488
TRG_DiLeu_LyEn_5	20	25	PF01217	0.490
TRG_ENDOCYTIC_2	39	42	PF00928	0.426
TRG_ER_diArg_1	275	277	PF00400	0.450
TRG_ER_diArg_1	281	284	PF00400	0.369
TRG_ER_diArg_1	66	69	PF00400	0.509
TRG_NLS_Bipartite_1	269	290	PF00514	0.553
TRG_NLS_MonoExtN_4	284	290	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P733	Leptomonas seymouri	64%	96%
A0A0S4J0K1	Bodo saltans	38%	100%
A0A1X0P554	Trypanosomatidae	48%	100%
A0A3R7L6S7	Trypanosoma rangeli	45%	100%
A0A3S7WZ44	Leishmania donovani	96%	100%
A1CLD2	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	38%	100%
A4HE22	Leishmania braziliensis	83%	100%
A4I1C8	Leishmania infantum	96%	100%
D0A5M3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AXG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
P0CP72	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	33%	100%
P0CP73	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	33%	100%
P53323	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q1EBD3	Coccidioides immitis (strain RS)	35%	100%
Q2HGY8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	37%	100%
Q2U3T8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	35%	100%
Q4HYC1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
Q4WYU4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	100%
Q54W07	Dictyostelium discoideum	35%	100%
Q5AGC7	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	99%
Q5BAB7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	100%
Q6BHA8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	31%	100%
Q6C2A3	Yarrowia lipolytica (strain CLIB 122 / E 150)	35%	100%
Q6CXB9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	100%
Q6FTW0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	29%	100%
Q74Z75	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	100%
Q96S44	Homo sapiens	36%	100%
Q99PW4	Mus musculus	36%	100%
Q9P7N1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q9UYB9	Pyrococcus abyssi (strain GE5 / Orsay)	29%	100%
V5BXG1	Trypanosoma cruzi	47%	100%