39S ribosomal protein L23, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA05_LEIMA

TriTrypDb:

LmjF.25.0890 , LMJLV39_250015200 , LMJSD75_250015100

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	2
GO:0005737	cytoplasm	2	2
GO:0005762	mitochondrial large ribosomal subunit	3	2
GO:0015934	large ribosomal subunit	4	2
GO:0032991	protein-containing complex	1	11
GO:0044391	ribosomal subunit	3	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005840	ribosome	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9

Expansion

Sequence features

Q4QA05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA05

PDB structure(s): 7aih_N , 7am2_N , 7ane_N

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0032543	mitochondrial translation	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.552
CLV_NRD_NRD_1	113	115	PF00675	0.440
CLV_NRD_NRD_1	132	134	PF00675	0.471
CLV_NRD_NRD_1	203	205	PF00675	0.448
CLV_PCSK_FUR_1	201	205	PF00082	0.426
CLV_PCSK_KEX2_1	132	134	PF00082	0.471
CLV_PCSK_KEX2_1	2	4	PF00082	0.534
CLV_PCSK_KEX2_1	203	205	PF00082	0.446
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.665
CLV_PCSK_SKI1_1	152	156	PF00082	0.416
CLV_PCSK_SKI1_1	165	169	PF00082	0.242
CLV_PCSK_SKI1_1	203	207	PF00082	0.545
CLV_PCSK_SKI1_1	234	238	PF00082	0.508
DEG_APCC_DBOX_1	151	159	PF00400	0.399
DEG_Nend_UBRbox_1	1	4	PF02207	0.683
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.381
DOC_MAPK_MEF2A_6	144	153	PF00069	0.507
DOC_PP4_FxxP_1	168	171	PF00568	0.393
DOC_PP4_FxxP_1	48	51	PF00568	0.521
DOC_PP4_FxxP_1	87	90	PF00568	0.456
DOC_WW_Pin1_4	131	136	PF00397	0.486
DOC_WW_Pin1_4	224	229	PF00397	0.410
DOC_WW_Pin1_4	239	244	PF00397	0.479
DOC_WW_Pin1_4	35	40	PF00397	0.598
LIG_14-3-3_CanoR_1	3	11	PF00244	0.571
LIG_BRCT_BRCA1_1	142	146	PF00533	0.477
LIG_BRCT_BRCA1_1	20	24	PF00533	0.498
LIG_BRCT_BRCA1_1	229	233	PF00533	0.486
LIG_BRCT_BRCA1_1	37	41	PF00533	0.435
LIG_deltaCOP1_diTrp_1	117	121	PF00928	0.429
LIG_FHA_1	162	168	PF00498	0.474
LIG_FHA_1	35	41	PF00498	0.649
LIG_FHA_2	70	76	PF00498	0.496
LIG_LIR_Apic_2	117	122	PF02991	0.415
LIG_LIR_Nem_3	134	140	PF02991	0.375
LIG_LIR_Nem_3	143	149	PF02991	0.386
LIG_LIR_Nem_3	21	27	PF02991	0.502
LIG_LIR_Nem_3	230	236	PF02991	0.493
LIG_LIR_Nem_3	99	105	PF02991	0.439
LIG_MLH1_MIPbox_1	142	146	PF16413	0.510
LIG_Pex14_2	138	142	PF04695	0.380
LIG_REV1ctd_RIR_1	138	146	PF16727	0.381
LIG_SH2_CRK	49	53	PF00017	0.504
LIG_SH2_STAT5	137	140	PF00017	0.387
LIG_SH2_STAT5	145	148	PF00017	0.368
LIG_SH2_STAT5	182	185	PF00017	0.382
LIG_SH2_STAT5	95	98	PF00017	0.423
LIG_SUMO_SIM_anti_2	226	233	PF11976	0.520
LIG_SUMO_SIM_par_1	221	227	PF11976	0.350
LIG_TRAF2_1	175	178	PF00917	0.477
MOD_CDK_SPxxK_3	239	246	PF00069	0.570
MOD_CK1_1	227	233	PF00069	0.494
MOD_CK1_1	32	38	PF00069	0.673
MOD_CK2_1	172	178	PF00069	0.400
MOD_CK2_1	69	75	PF00069	0.553
MOD_CMANNOS	71	74	PF00535	0.453
MOD_Cter_Amidation	201	204	PF01082	0.419
MOD_GlcNHglycan	15	18	PF01048	0.652
MOD_GSK3_1	15	22	PF00069	0.624
MOD_GSK3_1	30	37	PF00069	0.638
MOD_N-GLC_1	160	165	PF02516	0.412
MOD_NEK2_1	140	145	PF00069	0.520
MOD_NEK2_1	59	64	PF00069	0.662
MOD_NEK2_1	96	101	PF00069	0.418
MOD_PKA_1	2	8	PF00069	0.608
MOD_PKA_2	2	8	PF00069	0.616
MOD_Plk_2-3	211	217	PF00069	0.518
MOD_Plk_4	154	160	PF00069	0.389
MOD_Plk_4	227	233	PF00069	0.521
MOD_ProDKin_1	131	137	PF00069	0.475
MOD_ProDKin_1	224	230	PF00069	0.412
MOD_ProDKin_1	239	245	PF00069	0.484
MOD_ProDKin_1	35	41	PF00069	0.596
MOD_SUMO_for_1	205	208	PF00179	0.552
MOD_SUMO_rev_2	208	215	PF00179	0.439
MOD_SUMO_rev_2	240	248	PF00179	0.661
TRG_ENDOCYTIC_2	137	140	PF00928	0.425
TRG_ENDOCYTIC_2	49	52	PF00928	0.510
TRG_ER_diArg_1	131	133	PF00400	0.481
TRG_ER_diArg_1	193	196	PF00400	0.420
TRG_ER_diArg_1	200	203	PF00400	0.448
TRG_ER_diArg_1	45	48	PF00400	0.532
TRG_ER_diArg_1	60	63	PF00400	0.485
TRG_ER_diArg_1	98	101	PF00400	0.449
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Z4	Leptomonas seymouri	78%	98%
A0A0S4J3V0	Bodo saltans	57%	100%
A0A1X0P4M1	Trypanosomatidae	73%	100%
A0A3Q8IGI5	Leishmania donovani	94%	98%
A0A422NTM0	Trypanosoma rangeli	71%	100%
A4HE24	Leishmania braziliensis	87%	98%
A4I1D0	Leishmania infantum	95%	98%
D0A5M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AXG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%