Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QA04_LEIMA

TriTrypDb:

LmjF.25.0900 , LMJLV39_250015300 , LMJSD75_250015200

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QA04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.802
CLV_NRD_NRD_1	171	173	PF00675	0.789
CLV_NRD_NRD_1	252	254	PF00675	0.346
CLV_NRD_NRD_1	35	37	PF00675	0.578
CLV_PCSK_KEX2_1	170	172	PF00082	0.791
CLV_PCSK_KEX2_1	252	254	PF00082	0.346
CLV_PCSK_KEX2_1	35	37	PF00082	0.619
CLV_PCSK_KEX2_1	45	47	PF00082	0.645
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.659
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.680
CLV_PCSK_PC7_1	167	173	PF00082	0.736
CLV_PCSK_SKI1_1	93	97	PF00082	0.336
DEG_APCC_DBOX_1	252	260	PF00400	0.504
DEG_SCF_FBW7_1	237	244	PF00400	0.767
DEG_SPOP_SBC_1	285	289	PF00917	0.489
DOC_ANK_TNKS_1	233	240	PF00023	0.779
DOC_MAPK_gen_1	252	259	PF00069	0.546
DOC_MAPK_MEF2A_6	252	261	PF00069	0.563
DOC_PP4_FxxP_1	127	130	PF00568	0.506
DOC_USP7_MATH_1	162	166	PF00917	0.519
DOC_USP7_MATH_1	241	245	PF00917	0.766
DOC_USP7_MATH_1	290	294	PF00917	0.572
DOC_USP7_UBL2_3	181	185	PF12436	0.420
DOC_USP7_UBL2_3	89	93	PF12436	0.745
DOC_WW_Pin1_4	126	131	PF00397	0.525
DOC_WW_Pin1_4	150	155	PF00397	0.592
DOC_WW_Pin1_4	223	228	PF00397	0.823
DOC_WW_Pin1_4	237	242	PF00397	0.694
DOC_WW_Pin1_4	274	279	PF00397	0.509
LIG_14-3-3_CanoR_1	252	257	PF00244	0.530
LIG_14-3-3_CanoR_1	311	316	PF00244	0.615
LIG_14-3-3_CanoR_1	46	54	PF00244	0.532
LIG_14-3-3_CanoR_1	9	15	PF00244	0.619
LIG_APCC_ABBA_1	233	238	PF00400	0.784
LIG_BIR_III_2	275	279	PF00653	0.434
LIG_DLG_GKlike_1	252	259	PF00625	0.563
LIG_eIF4E_1	67	73	PF01652	0.436
LIG_FHA_1	186	192	PF00498	0.568
LIG_FHA_1	74	80	PF00498	0.408
LIG_FHA_2	316	322	PF00498	0.456
LIG_LIR_Gen_1	13	22	PF02991	0.459
LIG_LIR_Gen_1	201	210	PF02991	0.345
LIG_LIR_Gen_1	66	75	PF02991	0.339
LIG_LIR_Nem_3	13	18	PF02991	0.459
LIG_LIR_Nem_3	201	205	PF02991	0.508
LIG_LIR_Nem_3	66	70	PF02991	0.346
LIG_NRBOX	68	74	PF00104	0.312
LIG_SH2_CRK	112	116	PF00017	0.375
LIG_SH2_PTP2	108	111	PF00017	0.436
LIG_SH2_PTP2	67	70	PF00017	0.436
LIG_SH2_STAP1	15	19	PF00017	0.411
LIG_SH2_STAT5	108	111	PF00017	0.411
LIG_SH2_STAT5	26	29	PF00017	0.465
LIG_SH2_STAT5	67	70	PF00017	0.341
LIG_SH3_3	221	227	PF00018	0.679
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.436
LIG_SUMO_SIM_par_1	18	23	PF11976	0.418
LIG_TYR_ITIM	106	111	PF00017	0.394
LIG_TYR_ITIM	200	205	PF00017	0.573
MOD_CK1_1	277	283	PF00069	0.567
MOD_CK1_1	48	54	PF00069	0.478
MOD_CK2_1	198	204	PF00069	0.517
MOD_CMANNOS	28	31	PF00535	0.603
MOD_Cter_Amidation	168	171	PF01082	0.733
MOD_GlcNHglycan	103	106	PF01048	0.504
MOD_GlcNHglycan	15	18	PF01048	0.436
MOD_GlcNHglycan	164	167	PF01048	0.685
MOD_GlcNHglycan	182	185	PF01048	0.755
MOD_GlcNHglycan	192	195	PF01048	0.706
MOD_GlcNHglycan	279	282	PF01048	0.805
MOD_GlcNHglycan	288	291	PF01048	0.704
MOD_GlcNHglycan	292	295	PF01048	0.799
MOD_GlcNHglycan	313	316	PF01048	0.763
MOD_GlcNHglycan	329	332	PF01048	0.634
MOD_GlcNHglycan	49	53	PF01048	0.656
MOD_GlcNHglycan	61	64	PF01048	0.649
MOD_GlcNHglycan	89	92	PF01048	0.545
MOD_GSK3_1	237	244	PF00069	0.787
MOD_GSK3_1	286	293	PF00069	0.600
MOD_GSK3_1	311	318	PF00069	0.576
MOD_GSK3_1	41	48	PF00069	0.514
MOD_N-GLC_1	150	155	PF02516	0.650
MOD_NEK2_1	1	6	PF00069	0.682
MOD_NEK2_1	101	106	PF00069	0.404
MOD_NEK2_1	264	269	PF00069	0.435
MOD_NEK2_1	286	291	PF00069	0.525
MOD_NEK2_1	41	46	PF00069	0.514
MOD_NEK2_1	59	64	PF00069	0.388
MOD_NEK2_1	73	78	PF00069	0.411
MOD_NEK2_2	10	15	PF00069	0.299
MOD_NEK2_2	292	297	PF00069	0.546
MOD_PIKK_1	140	146	PF00454	0.586
MOD_PKA_1	252	258	PF00069	0.530
MOD_PKA_1	45	51	PF00069	0.483
MOD_PKA_2	252	258	PF00069	0.534
MOD_PKA_2	45	51	PF00069	0.540
MOD_Plk_2-3	198	204	PF00069	0.492
MOD_Plk_4	10	16	PF00069	0.409
MOD_Plk_4	252	258	PF00069	0.530
MOD_Plk_4	264	270	PF00069	0.389
MOD_ProDKin_1	126	132	PF00069	0.526
MOD_ProDKin_1	150	156	PF00069	0.590
MOD_ProDKin_1	223	229	PF00069	0.826
MOD_ProDKin_1	237	243	PF00069	0.693
MOD_ProDKin_1	274	280	PF00069	0.510
TRG_ENDOCYTIC_2	108	111	PF00928	0.411
TRG_ENDOCYTIC_2	112	115	PF00928	0.411
TRG_ENDOCYTIC_2	15	18	PF00928	0.411
TRG_ENDOCYTIC_2	202	205	PF00928	0.501
TRG_ENDOCYTIC_2	67	70	PF00928	0.411
TRG_ER_diArg_1	251	253	PF00400	0.669
TRG_ER_diArg_1	296	299	PF00400	0.599
TRG_ER_diArg_1	35	37	PF00400	0.378
TRG_ER_diLys_1	337	340	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE40	Leptomonas seymouri	40%	100%
A0A3Q8ICA7	Leishmania donovani	89%	100%
A4HE25	Leishmania braziliensis	57%	100%
A4I1D1	Leishmania infantum	89%	100%
E9AXG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%