SLBP_RNA_bind domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histone RNA hairpin-binding protein RNA-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QA02_LEIMA

TriTrypDb:

LmjF.25.0920 , LMJLV39_250015500 , LMJSD75_250015400

Length:

871

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0071204	histone pre-mRNA 3'end processing complex	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QA02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA02

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	8	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0008152	metabolic process	1	2
GO:0008334	histone mRNA metabolic process	7	2
GO:0009987	cellular process	1	2
GO:0015931	nucleobase-containing compound transport	5	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0031123	RNA 3'-end processing	7	2
GO:0031124	mRNA 3'-end processing	8	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050657	nucleic acid transport	6	2
GO:0050658	RNA transport	4	2
GO:0051028	mRNA transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051236	establishment of RNA localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003729	mRNA binding	5	7
GO:0005488	binding	1	7
GO:0036002	pre-mRNA binding	5	2
GO:0071207	histone pre-mRNA stem-loop binding	6	2
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.690
CLV_NRD_NRD_1	165	167	PF00675	0.260
CLV_NRD_NRD_1	220	222	PF00675	0.346
CLV_NRD_NRD_1	224	226	PF00675	0.346
CLV_NRD_NRD_1	252	254	PF00675	0.556
CLV_NRD_NRD_1	411	413	PF00675	0.733
CLV_NRD_NRD_1	450	452	PF00675	0.555
CLV_NRD_NRD_1	581	583	PF00675	0.574
CLV_NRD_NRD_1	700	702	PF00675	0.676
CLV_NRD_NRD_1	78	80	PF00675	0.692
CLV_NRD_NRD_1	94	96	PF00675	0.755
CLV_PCSK_KEX2_1	164	166	PF00082	0.306
CLV_PCSK_KEX2_1	186	188	PF00082	0.419
CLV_PCSK_KEX2_1	213	215	PF00082	0.309
CLV_PCSK_KEX2_1	224	226	PF00082	0.346
CLV_PCSK_KEX2_1	252	254	PF00082	0.657
CLV_PCSK_KEX2_1	411	413	PF00082	0.702
CLV_PCSK_KEX2_1	581	583	PF00082	0.574
CLV_PCSK_KEX2_1	675	677	PF00082	0.680
CLV_PCSK_KEX2_1	700	702	PF00082	0.668
CLV_PCSK_KEX2_1	78	80	PF00082	0.692
CLV_PCSK_KEX2_1	94	96	PF00082	0.755
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.419
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.309
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.680
CLV_PCSK_PC7_1	671	677	PF00082	0.589
CLV_PCSK_SKI1_1	224	228	PF00082	0.346
CLV_PCSK_SKI1_1	296	300	PF00082	0.545
CLV_PCSK_SKI1_1	582	586	PF00082	0.776
CLV_PCSK_SKI1_1	804	808	PF00082	0.655
CLV_Separin_Metazoa	262	266	PF03568	0.669
DEG_COP1_1	379	387	PF00400	0.707
DEG_Nend_UBRbox_3	1	3	PF02207	0.788
DEG_SCF_FBW7_1	798	805	PF00400	0.651
DEG_SIAH_1	523	531	PF03145	0.548
DOC_CKS1_1	834	839	PF01111	0.856
DOC_CYCLIN_RxL_1	801	809	PF00134	0.679
DOC_CYCLIN_yCln2_LP_2	775	781	PF00134	0.563
DOC_MAPK_gen_1	164	175	PF00069	0.546
DOC_MAPK_gen_1	210	220	PF00069	0.544
DOC_MAPK_gen_1	265	273	PF00069	0.563
DOC_MAPK_gen_1	411	417	PF00069	0.695
DOC_MAPK_gen_1	790	800	PF00069	0.798
DOC_MAPK_MEF2A_6	265	273	PF00069	0.563
DOC_PP1_RVXF_1	169	176	PF00149	0.546
DOC_PP2B_LxvP_1	203	206	PF13499	0.546
DOC_PP2B_LxvP_1	382	385	PF13499	0.562
DOC_PP2B_LxvP_1	415	418	PF13499	0.695
DOC_PP2B_LxvP_1	492	495	PF13499	0.680
DOC_PP2B_LxvP_1	504	507	PF13499	0.646
DOC_PP2B_LxvP_1	560	563	PF13499	0.743
DOC_PP2B_LxvP_1	645	648	PF13499	0.675
DOC_PP2B_LxvP_1	775	778	PF13499	0.560
DOC_PP4_FxxP_1	510	513	PF00568	0.697
DOC_USP7_MATH_1	121	125	PF00917	0.773
DOC_USP7_MATH_1	284	288	PF00917	0.608
DOC_USP7_MATH_1	416	420	PF00917	0.718
DOC_USP7_MATH_1	421	425	PF00917	0.654
DOC_USP7_MATH_1	460	464	PF00917	0.728
DOC_USP7_MATH_1	495	499	PF00917	0.789
DOC_USP7_MATH_1	52	56	PF00917	0.598
DOC_USP7_MATH_1	546	550	PF00917	0.685
DOC_USP7_MATH_1	619	623	PF00917	0.742
DOC_USP7_MATH_1	691	695	PF00917	0.755
DOC_USP7_MATH_1	708	712	PF00917	0.599
DOC_WW_Pin1_4	102	107	PF00397	0.850
DOC_WW_Pin1_4	139	144	PF00397	0.663
DOC_WW_Pin1_4	151	156	PF00397	0.713
DOC_WW_Pin1_4	201	206	PF00397	0.546
DOC_WW_Pin1_4	28	33	PF00397	0.698
DOC_WW_Pin1_4	323	328	PF00397	0.632
DOC_WW_Pin1_4	404	409	PF00397	0.703
DOC_WW_Pin1_4	417	422	PF00397	0.724
DOC_WW_Pin1_4	43	48	PF00397	0.669
DOC_WW_Pin1_4	436	441	PF00397	0.464
DOC_WW_Pin1_4	444	449	PF00397	0.636
DOC_WW_Pin1_4	511	516	PF00397	0.791
DOC_WW_Pin1_4	526	531	PF00397	0.680
DOC_WW_Pin1_4	54	59	PF00397	0.819
DOC_WW_Pin1_4	635	640	PF00397	0.757
DOC_WW_Pin1_4	70	75	PF00397	0.596
DOC_WW_Pin1_4	712	717	PF00397	0.676
DOC_WW_Pin1_4	726	731	PF00397	0.679
DOC_WW_Pin1_4	798	803	PF00397	0.697
DOC_WW_Pin1_4	829	834	PF00397	0.819
LIG_14-3-3_CanoR_1	164	173	PF00244	0.489
LIG_14-3-3_CanoR_1	253	263	PF00244	0.649
LIG_14-3-3_CanoR_1	281	289	PF00244	0.475
LIG_14-3-3_CanoR_1	355	360	PF00244	0.674
LIG_14-3-3_CanoR_1	476	481	PF00244	0.815
LIG_14-3-3_CanoR_1	61	70	PF00244	0.737
LIG_14-3-3_CanoR_1	685	691	PF00244	0.730
LIG_14-3-3_CanoR_1	700	707	PF00244	0.540
LIG_14-3-3_CanoR_1	725	730	PF00244	0.671
LIG_14-3-3_CanoR_1	738	744	PF00244	0.664
LIG_14-3-3_CanoR_1	79	85	PF00244	0.565
LIG_Actin_WH2_2	181	198	PF00022	0.546
LIG_Actin_WH2_2	282	298	PF00022	0.687
LIG_BRCT_BRCA1_1	256	260	PF00533	0.563
LIG_BRCT_BRCA1_1	457	461	PF00533	0.569
LIG_CSL_BTD_1	521	524	PF09270	0.693
LIG_CtBP_PxDLS_1	403	407	PF00389	0.720
LIG_DLG_GKlike_1	476	484	PF00625	0.571
LIG_EVH1_2	506	510	PF00568	0.662
LIG_FHA_1	243	249	PF00498	0.442
LIG_FHA_1	498	504	PF00498	0.797
LIG_FHA_1	635	641	PF00498	0.632
LIG_FHA_1	756	762	PF00498	0.672
LIG_FHA_1	807	813	PF00498	0.731
LIG_FHA_1	842	848	PF00498	0.739
LIG_FHA_2	432	438	PF00498	0.566
LIG_Integrin_RGD_1	114	116	PF01839	0.763
LIG_LIR_Gen_1	179	190	PF02991	0.546
LIG_LIR_Gen_1	231	239	PF02991	0.522
LIG_LIR_Gen_1	257	267	PF02991	0.599
LIG_LIR_Gen_1	302	313	PF02991	0.574
LIG_LIR_Gen_1	678	688	PF02991	0.777
LIG_LIR_Gen_1	7	15	PF02991	0.765
LIG_LIR_Nem_3	231	235	PF02991	0.492
LIG_LIR_Nem_3	302	308	PF02991	0.551
LIG_LIR_Nem_3	7	11	PF02991	0.760
LIG_PDZ_Class_3	866	871	PF00595	0.661
LIG_Pex14_2	230	234	PF04695	0.566
LIG_PTAP_UEV_1	384	389	PF05743	0.692
LIG_SH2_GRB2like	182	185	PF00017	0.546
LIG_SH2_PTP2	232	235	PF00017	0.503
LIG_SH2_STAT5	177	180	PF00017	0.562
LIG_SH2_STAT5	182	185	PF00017	0.529
LIG_SH2_STAT5	232	235	PF00017	0.482
LIG_SH3_3	199	205	PF00018	0.546
LIG_SH3_3	382	388	PF00018	0.709
LIG_SH3_3	407	413	PF00018	0.661
LIG_SH3_3	415	421	PF00018	0.655
LIG_SH3_3	423	429	PF00018	0.626
LIG_SH3_3	46	52	PF00018	0.707
LIG_SH3_3	500	506	PF00018	0.720
LIG_SH3_3	581	587	PF00018	0.706
LIG_SH3_3	604	610	PF00018	0.664
LIG_SH3_3	633	639	PF00018	0.693
LIG_SH3_3	771	777	PF00018	0.629
LIG_SH3_3	82	88	PF00018	0.727
LIG_SH3_3	848	854	PF00018	0.716
LIG_SUMO_SIM_par_1	401	407	PF11976	0.719
LIG_TRAF2_1	290	293	PF00917	0.634
LIG_WW_2	413	416	PF00397	0.817
MOD_CDC14_SPxK_1	409	412	PF00782	0.726
MOD_CDK_SPK_2	106	111	PF00069	0.613
MOD_CDK_SPK_2	406	411	PF00069	0.706
MOD_CDK_SPxK_1	406	412	PF00069	0.712
MOD_CDK_SPxK_1	436	442	PF00069	0.694
MOD_CDK_SPxK_1	70	76	PF00069	0.772
MOD_CDK_SPxK_1	798	804	PF00069	0.699
MOD_CDK_SPxxK_3	404	411	PF00069	0.706
MOD_CDK_SPxxK_3	444	451	PF00069	0.687
MOD_CDK_SPxxK_3	54	61	PF00069	0.767
MOD_CDK_SPxxK_3	833	840	PF00069	0.852
MOD_CK1_1	109	115	PF00069	0.725
MOD_CK1_1	156	162	PF00069	0.719
MOD_CK1_1	307	313	PF00069	0.560
MOD_CK1_1	315	321	PF00069	0.573
MOD_CK1_1	419	425	PF00069	0.743
MOD_CK1_1	427	433	PF00069	0.629
MOD_CK1_1	463	469	PF00069	0.685
MOD_CK1_1	529	535	PF00069	0.583
MOD_CK1_1	549	555	PF00069	0.646
MOD_CK1_1	622	628	PF00069	0.731
MOD_CK1_1	665	671	PF00069	0.779
MOD_CK1_1	686	692	PF00069	0.760
MOD_CK1_1	755	761	PF00069	0.642
MOD_CK2_1	156	162	PF00069	0.642
MOD_CK2_1	164	170	PF00069	0.411
MOD_CK2_1	19	25	PF00069	0.643
MOD_CK2_1	323	329	PF00069	0.632
MOD_CK2_1	431	437	PF00069	0.728
MOD_CK2_1	726	732	PF00069	0.678
MOD_Cter_Amidation	698	701	PF01082	0.591
MOD_DYRK1A_RPxSP_1	43	47	PF00069	0.722
MOD_GlcNHglycan	121	124	PF01048	0.754
MOD_GlcNHglycan	155	158	PF01048	0.781
MOD_GlcNHglycan	196	199	PF01048	0.411
MOD_GlcNHglycan	282	285	PF01048	0.655
MOD_GlcNHglycan	314	317	PF01048	0.617
MOD_GlcNHglycan	338	341	PF01048	0.578
MOD_GlcNHglycan	385	388	PF01048	0.769
MOD_GlcNHglycan	462	465	PF01048	0.750
MOD_GlcNHglycan	470	473	PF01048	0.768
MOD_GlcNHglycan	480	483	PF01048	0.774
MOD_GlcNHglycan	497	500	PF01048	0.543
MOD_GlcNHglycan	531	534	PF01048	0.606
MOD_GlcNHglycan	58	61	PF01048	0.727
MOD_GlcNHglycan	603	606	PF01048	0.684
MOD_GlcNHglycan	685	688	PF01048	0.723
MOD_GlcNHglycan	710	713	PF01048	0.663
MOD_GlcNHglycan	739	742	PF01048	0.771
MOD_GlcNHglycan	745	748	PF01048	0.674
MOD_GlcNHglycan	750	753	PF01048	0.623
MOD_GlcNHglycan	754	757	PF01048	0.586
MOD_GlcNHglycan	779	782	PF01048	0.611
MOD_GlcNHglycan	795	798	PF01048	0.741
MOD_GlcNHglycan	837	840	PF01048	0.776
MOD_GSK3_1	102	109	PF00069	0.692
MOD_GSK3_1	176	183	PF00069	0.513
MOD_GSK3_1	280	287	PF00069	0.593
MOD_GSK3_1	39	46	PF00069	0.702
MOD_GSK3_1	416	423	PF00069	0.677
MOD_GSK3_1	427	434	PF00069	0.602
MOD_GSK3_1	456	463	PF00069	0.587
MOD_GSK3_1	476	483	PF00069	0.805
MOD_GSK3_1	50	57	PF00069	0.731
MOD_GSK3_1	536	543	PF00069	0.628
MOD_GSK3_1	679	686	PF00069	0.767
MOD_GSK3_1	708	715	PF00069	0.693
MOD_GSK3_1	748	755	PF00069	0.628
MOD_GSK3_1	798	805	PF00069	0.680
MOD_GSK3_1	829	836	PF00069	0.846
MOD_NEK2_1	194	199	PF00069	0.411
MOD_NEK2_1	39	44	PF00069	0.804
MOD_NEK2_1	480	485	PF00069	0.781
MOD_NEK2_1	497	502	PF00069	0.730
MOD_NEK2_1	791	796	PF00069	0.808
MOD_NEK2_1	806	811	PF00069	0.622
MOD_NEK2_2	304	309	PF00069	0.517
MOD_NEK2_2	802	807	PF00069	0.633
MOD_PIKK_1	164	170	PF00454	0.370
MOD_PIKK_1	470	476	PF00454	0.703
MOD_PIKK_1	61	67	PF00454	0.859
MOD_PIKK_1	665	671	PF00454	0.784
MOD_PIKK_1	791	797	PF00454	0.707
MOD_PIKK_1	80	86	PF00454	0.581
MOD_PKA_1	164	170	PF00069	0.389
MOD_PKA_1	700	706	PF00069	0.798
MOD_PKA_2	164	170	PF00069	0.389
MOD_PKA_2	280	286	PF00069	0.528
MOD_PKA_2	354	360	PF00069	0.572
MOD_PKA_2	450	456	PF00069	0.760
MOD_PKA_2	670	676	PF00069	0.727
MOD_PKA_2	700	706	PF00069	0.726
MOD_PKA_2	724	730	PF00069	0.697
MOD_PKA_2	737	743	PF00069	0.679
MOD_PKA_2	841	847	PF00069	0.758
MOD_Plk_1	802	808	PF00069	0.635
MOD_Plk_4	603	609	PF00069	0.564
MOD_ProDKin_1	102	108	PF00069	0.852
MOD_ProDKin_1	139	145	PF00069	0.664
MOD_ProDKin_1	151	157	PF00069	0.712
MOD_ProDKin_1	201	207	PF00069	0.411
MOD_ProDKin_1	28	34	PF00069	0.698
MOD_ProDKin_1	323	329	PF00069	0.632
MOD_ProDKin_1	404	410	PF00069	0.700
MOD_ProDKin_1	417	423	PF00069	0.723
MOD_ProDKin_1	43	49	PF00069	0.669
MOD_ProDKin_1	436	442	PF00069	0.465
MOD_ProDKin_1	444	450	PF00069	0.628
MOD_ProDKin_1	511	517	PF00069	0.794
MOD_ProDKin_1	526	532	PF00069	0.681
MOD_ProDKin_1	54	60	PF00069	0.819
MOD_ProDKin_1	635	641	PF00069	0.758
MOD_ProDKin_1	70	76	PF00069	0.598
MOD_ProDKin_1	712	718	PF00069	0.678
MOD_ProDKin_1	726	732	PF00069	0.682
MOD_ProDKin_1	798	804	PF00069	0.699
MOD_ProDKin_1	829	835	PF00069	0.821
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.411
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.411
TRG_ENDOCYTIC_2	182	185	PF00928	0.411
TRG_ENDOCYTIC_2	232	235	PF00928	0.503
TRG_ENDOCYTIC_2	305	308	PF00928	0.512
TRG_ENDOCYTIC_2	570	573	PF00928	0.792
TRG_ENDOCYTIC_2	641	644	PF00928	0.688
TRG_ER_diArg_1	164	166	PF00400	0.411
TRG_ER_diArg_1	223	225	PF00400	0.404
TRG_ER_diArg_1	410	412	PF00400	0.727
TRG_ER_diArg_1	78	80	PF00400	0.649
TRG_NLS_MonoExtC_3	220	225	PF00514	0.411
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7C9	Leptomonas seymouri	40%	100%
A0A3Q8IF88	Leishmania donovani	88%	100%
A4HE27	Leishmania braziliensis	63%	100%
A4I1D3	Leishmania infantum	88%	100%
E9AXH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%