ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (many copies), putative

Species:

Leishmania major

UniProt:

Q4QA01_LEIMA

TriTrypDb:

LmjF.25.0930 , LMJLV39_250015600 , LMJSD75_250015500

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	165	169	PF00082	0.409
DEG_APCC_DBOX_1	238	246	PF00400	0.520
DEG_APCC_DBOX_1	38	46	PF00400	0.193
DEG_SPOP_SBC_1	118	122	PF00917	0.611
DOC_CDC14_PxL_1	1	9	PF14671	0.535
DOC_CKS1_1	95	100	PF01111	0.514
DOC_CYCLIN_RxL_1	162	170	PF00134	0.408
DOC_MAPK_MEF2A_6	39	46	PF00069	0.401
DOC_MAPK_NFAT4_5	39	47	PF00069	0.193
DOC_PP4_FxxP_1	95	98	PF00568	0.456
DOC_USP7_MATH_1	101	105	PF00917	0.625
DOC_USP7_MATH_1	118	122	PF00917	0.674
DOC_USP7_MATH_1	142	146	PF00917	0.192
DOC_USP7_MATH_1	211	215	PF00917	0.535
DOC_USP7_MATH_1	254	258	PF00917	0.485
DOC_USP7_MATH_1	85	89	PF00917	0.317
DOC_WW_Pin1_4	114	119	PF00397	0.732
DOC_WW_Pin1_4	123	128	PF00397	0.456
DOC_WW_Pin1_4	147	152	PF00397	0.266
DOC_WW_Pin1_4	26	31	PF00397	0.479
DOC_WW_Pin1_4	94	99	PF00397	0.454
LIG_14-3-3_CanoR_1	39	45	PF00244	0.295
LIG_14-3-3_CanoR_1	53	61	PF00244	0.298
LIG_14-3-3_CanoR_1	63	68	PF00244	0.375
LIG_14-3-3_CanoR_1	80	90	PF00244	0.396
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_FHA_1	11	17	PF00498	0.421
LIG_FHA_1	54	60	PF00498	0.339
LIG_FHA_2	182	188	PF00498	0.350
LIG_LIR_Gen_1	227	237	PF02991	0.535
LIG_LIR_Nem_3	227	232	PF02991	0.538
LIG_PCNA_PIPBox_1	160	169	PF02747	0.321
LIG_SH2_PTP2	229	232	PF00017	0.533
LIG_SH2_SRC	229	232	PF00017	0.592
LIG_SH2_STAT5	166	169	PF00017	0.399
LIG_SH2_STAT5	229	232	PF00017	0.539
LIG_SH2_STAT5	35	38	PF00017	0.438
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.193
LIG_SUMO_SIM_par_1	126	131	PF11976	0.359
LIG_TYR_ITIM	164	169	PF00017	0.321
MOD_CK1_1	121	127	PF00069	0.616
MOD_GlcNHglycan	104	107	PF01048	0.647
MOD_GlcNHglycan	123	126	PF01048	0.673
MOD_GlcNHglycan	144	147	PF01048	0.375
MOD_GlcNHglycan	157	160	PF01048	0.391
MOD_GlcNHglycan	20	24	PF01048	0.472
MOD_GlcNHglycan	213	216	PF01048	0.579
MOD_GlcNHglycan	224	227	PF01048	0.482
MOD_GlcNHglycan	83	86	PF01048	0.389
MOD_GlcNHglycan	99	102	PF01048	0.478
MOD_GSK3_1	110	117	PF00069	0.627
MOD_GSK3_1	119	126	PF00069	0.658
MOD_GSK3_1	177	184	PF00069	0.358
MOD_GSK3_1	218	225	PF00069	0.579
MOD_GSK3_1	3	10	PF00069	0.556
MOD_GSK3_1	59	66	PF00069	0.412
MOD_GSK3_1	81	88	PF00069	0.370
MOD_GSK3_1	93	100	PF00069	0.388
MOD_N-GLC_1	26	31	PF02516	0.505
MOD_N-GLC_1	33	38	PF02516	0.450
MOD_NEK2_1	102	107	PF00069	0.508
MOD_NEK2_1	128	133	PF00069	0.437
MOD_NEK2_1	167	172	PF00069	0.398
MOD_NEK2_1	59	64	PF00069	0.356
MOD_NEK2_1	7	12	PF00069	0.490
MOD_PIKK_1	10	16	PF00454	0.396
MOD_PIKK_1	219	225	PF00454	0.554
MOD_PIKK_1	54	60	PF00454	0.321
MOD_PKA_2	110	116	PF00069	0.571
MOD_PKA_2	177	183	PF00069	0.397
MOD_PKA_2	40	46	PF00069	0.296
MOD_Plk_1	19	25	PF00069	0.512
MOD_Plk_1	254	260	PF00069	0.513
MOD_Plk_1	85	91	PF00069	0.193
MOD_Plk_4	40	46	PF00069	0.280
MOD_Plk_4	85	91	PF00069	0.219
MOD_ProDKin_1	114	120	PF00069	0.728
MOD_ProDKin_1	123	129	PF00069	0.451
MOD_ProDKin_1	147	153	PF00069	0.266
MOD_ProDKin_1	26	32	PF00069	0.472
MOD_ProDKin_1	94	100	PF00069	0.464
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.404
TRG_ENDOCYTIC_2	166	169	PF00928	0.321
TRG_ENDOCYTIC_2	229	232	PF00928	0.543
TRG_NES_CRM1_1	187	200	PF08389	0.384
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I922	Leptomonas seymouri	62%	100%
A0A0S4IMZ1	Bodo saltans	29%	100%
A0A0S4IRG3	Bodo saltans	29%	100%
A0A1X0NNH1	Trypanosomatidae	37%	100%
A0A3Q8ICG2	Leishmania donovani	93%	100%
A0A422NXA4	Trypanosoma rangeli	37%	100%
A2AS55	Mus musculus	27%	73%
A4HE28	Leishmania braziliensis	81%	100%
A4I1D4	Leishmania infantum	93%	100%
C9ZKX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AXH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q6P6B7	Homo sapiens	28%	73%
V5BBP8	Trypanosoma cruzi	37%	100%