Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA00_LEIMA

TriTrypDb:

LmjF.25.0940 , LMJLV39_250015700 , LMJSD75_250015600

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.769
CLV_NRD_NRD_1	153	155	PF00675	0.744
CLV_NRD_NRD_1	196	198	PF00675	0.724
CLV_NRD_NRD_1	201	203	PF00675	0.695
CLV_NRD_NRD_1	220	222	PF00675	0.538
CLV_NRD_NRD_1	417	419	PF00675	0.647
CLV_NRD_NRD_1	424	426	PF00675	0.567
CLV_NRD_NRD_1	436	438	PF00675	0.531
CLV_NRD_NRD_1	449	451	PF00675	0.539
CLV_NRD_NRD_1	523	525	PF00675	0.832
CLV_NRD_NRD_1	527	529	PF00675	0.785
CLV_NRD_NRD_1	602	604	PF00675	0.732
CLV_PCSK_FUR_1	519	523	PF00082	0.758
CLV_PCSK_KEX2_1	142	144	PF00082	0.725
CLV_PCSK_KEX2_1	195	197	PF00082	0.770
CLV_PCSK_KEX2_1	201	203	PF00082	0.755
CLV_PCSK_KEX2_1	220	222	PF00082	0.538
CLV_PCSK_KEX2_1	417	419	PF00082	0.647
CLV_PCSK_KEX2_1	426	428	PF00082	0.539
CLV_PCSK_KEX2_1	449	451	PF00082	0.779
CLV_PCSK_KEX2_1	521	523	PF00082	0.820
CLV_PCSK_KEX2_1	527	529	PF00082	0.758
CLV_PCSK_KEX2_1	639	641	PF00082	0.681
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.725
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.657
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.674
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.762
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.674
CLV_PCSK_PC7_1	138	144	PF00082	0.723
CLV_PCSK_PC7_1	197	203	PF00082	0.701
CLV_PCSK_PC7_1	519	525	PF00082	0.762
CLV_PCSK_PC7_1	635	641	PF00082	0.655
CLV_PCSK_SKI1_1	143	147	PF00082	0.723
CLV_PCSK_SKI1_1	540	544	PF00082	0.688
CLV_Separin_Metazoa	331	335	PF03568	0.621
DEG_APCC_DBOX_1	320	328	PF00400	0.589
DEG_COP1_1	563	570	PF00400	0.748
DEG_SCF_FBW7_1	372	377	PF00400	0.693
DOC_ANK_TNKS_1	449	456	PF00023	0.714
DOC_CKS1_1	278	283	PF01111	0.728
DOC_CKS1_1	511	516	PF01111	0.692
DOC_CKS1_1	597	602	PF01111	0.692
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.526
DOC_MAPK_gen_1	318	327	PF00069	0.599
DOC_MAPK_HePTP_8	380	392	PF00069	0.534
DOC_MAPK_MEF2A_6	383	392	PF00069	0.612
DOC_PP1_RVXF_1	633	639	PF00149	0.628
DOC_PP2B_LxvP_1	472	475	PF13499	0.762
DOC_PP4_FxxP_1	32	35	PF00568	0.491
DOC_USP7_MATH_1	108	112	PF00917	0.634
DOC_USP7_MATH_1	161	165	PF00917	0.750
DOC_USP7_MATH_1	287	291	PF00917	0.770
DOC_USP7_MATH_1	439	443	PF00917	0.721
DOC_USP7_MATH_1	45	49	PF00917	0.566
DOC_USP7_MATH_1	555	559	PF00917	0.693
DOC_USP7_MATH_1	561	565	PF00917	0.673
DOC_USP7_UBL2_3	434	438	PF12436	0.712
DOC_WW_Pin1_4	114	119	PF00397	0.784
DOC_WW_Pin1_4	123	128	PF00397	0.670
DOC_WW_Pin1_4	18	23	PF00397	0.464
DOC_WW_Pin1_4	277	282	PF00397	0.727
DOC_WW_Pin1_4	368	373	PF00397	0.741
DOC_WW_Pin1_4	37	42	PF00397	0.477
DOC_WW_Pin1_4	382	387	PF00397	0.546
DOC_WW_Pin1_4	510	515	PF00397	0.684
DOC_WW_Pin1_4	532	537	PF00397	0.732
DOC_WW_Pin1_4	593	598	PF00397	0.713
LIG_14-3-3_CanoR_1	143	148	PF00244	0.720
LIG_14-3-3_CanoR_1	154	160	PF00244	0.621
LIG_14-3-3_CanoR_1	270	278	PF00244	0.786
LIG_14-3-3_CanoR_1	321	325	PF00244	0.604
LIG_14-3-3_CanoR_1	417	423	PF00244	0.609
LIG_14-3-3_CanoR_1	427	433	PF00244	0.576
LIG_14-3-3_CanoR_1	437	444	PF00244	0.526
LIG_14-3-3_CanoR_1	540	548	PF00244	0.606
LIG_14-3-3_CanoR_1	608	616	PF00244	0.689
LIG_Actin_WH2_2	306	323	PF00022	0.661
LIG_BRCT_BRCA1_1	78	82	PF00533	0.554
LIG_deltaCOP1_diTrp_1	476	486	PF00928	0.769
LIG_eIF4E_1	12	18	PF01652	0.491
LIG_FHA_1	278	284	PF00498	0.794
LIG_FHA_1	371	377	PF00498	0.664
LIG_FHA_1	9	15	PF00498	0.489
LIG_FHA_2	295	301	PF00498	0.531
LIG_FHA_2	597	603	PF00498	0.692
LIG_FHA_2	84	90	PF00498	0.664
LIG_LIR_Gen_1	11	19	PF02991	0.476
LIG_LIR_Gen_1	551	561	PF02991	0.670
LIG_LIR_Gen_1	622	631	PF02991	0.626
LIG_LIR_Gen_1	65	76	PF02991	0.566
LIG_LIR_Gen_1	79	88	PF02991	0.506
LIG_LIR_Nem_3	11	15	PF02991	0.480
LIG_LIR_Nem_3	513	518	PF02991	0.701
LIG_LIR_Nem_3	551	556	PF02991	0.672
LIG_LIR_Nem_3	622	627	PF02991	0.639
LIG_LIR_Nem_3	65	71	PF02991	0.572
LIG_LIR_Nem_3	79	85	PF02991	0.509
LIG_Rb_LxCxE_1	569	584	PF01857	0.680
LIG_SH2_CRK	624	628	PF00017	0.626
LIG_SH2_SRC	402	405	PF00017	0.611
LIG_SH2_STAP1	410	414	PF00017	0.629
LIG_SH2_STAP1	606	610	PF00017	0.694
LIG_SH2_STAP1	624	628	PF00017	0.626
LIG_SH2_STAT5	402	405	PF00017	0.627
LIG_SH2_STAT5	430	433	PF00017	0.523
LIG_SH2_STAT5	609	612	PF00017	0.691
LIG_SH3_3	16	22	PF00018	0.491
LIG_SH3_3	275	281	PF00018	0.737
LIG_SH3_3	324	330	PF00018	0.580
LIG_SH3_3	38	44	PF00018	0.504
LIG_SH3_3	385	391	PF00018	0.675
LIG_SH3_3	477	483	PF00018	0.765
LIG_SH3_3	573	579	PF00018	0.775
LIG_SH3_3	591	597	PF00018	0.504
LIG_SH3_3	82	88	PF00018	0.569
LIG_Sin3_3	591	598	PF02671	0.735
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.478
LIG_SUMO_SIM_anti_2	589	596	PF11976	0.646
LIG_TRAF2_1	160	163	PF00917	0.713
LIG_TRAF2_1	297	300	PF00917	0.694
LIG_TRAF2_1	461	464	PF00917	0.643
LIG_TRAF2_1	599	602	PF00917	0.747
LIG_UBA3_1	389	394	PF00899	0.652
MOD_CDK_SPxK_1	510	516	PF00069	0.687
MOD_CDK_SPxxK_3	596	603	PF00069	0.699
MOD_CK1_1	136	142	PF00069	0.614
MOD_CK1_1	21	27	PF00069	0.460
MOD_CK1_1	273	279	PF00069	0.763
MOD_CK1_1	288	294	PF00069	0.565
MOD_CK1_1	37	43	PF00069	0.473
MOD_CK1_1	378	384	PF00069	0.580
MOD_CK1_1	442	448	PF00069	0.794
MOD_CK1_1	535	541	PF00069	0.709
MOD_CK1_1	554	560	PF00069	0.607
MOD_CK1_1	596	602	PF00069	0.541
MOD_CK1_1	75	81	PF00069	0.640
MOD_CK2_1	103	109	PF00069	0.775
MOD_CK2_1	183	189	PF00069	0.741
MOD_CK2_1	246	252	PF00069	0.787
MOD_CK2_1	294	300	PF00069	0.520
MOD_CK2_1	457	463	PF00069	0.720
MOD_CK2_1	596	602	PF00069	0.719
MOD_CK2_1	83	89	PF00069	0.667
MOD_CMANNOS	512	515	PF00535	0.716
MOD_Cter_Amidation	152	155	PF01082	0.741
MOD_Cter_Amidation	435	438	PF01082	0.715
MOD_GlcNHglycan	135	138	PF01048	0.710
MOD_GlcNHglycan	287	290	PF01048	0.776
MOD_GlcNHglycan	292	295	PF01048	0.754
MOD_GlcNHglycan	457	462	PF01048	0.630
MOD_GlcNHglycan	495	498	PF01048	0.722
MOD_GlcNHglycan	503	506	PF01048	0.601
MOD_GlcNHglycan	537	540	PF01048	0.761
MOD_GlcNHglycan	545	548	PF01048	0.713
MOD_GlcNHglycan	553	556	PF01048	0.632
MOD_GlcNHglycan	563	566	PF01048	0.572
MOD_GlcNHglycan	589	592	PF01048	0.734
MOD_GlcNHglycan	612	615	PF01048	0.698
MOD_GSK3_1	1	8	PF00069	0.462
MOD_GSK3_1	108	115	PF00069	0.738
MOD_GSK3_1	118	125	PF00069	0.720
MOD_GSK3_1	177	184	PF00069	0.617
MOD_GSK3_1	187	194	PF00069	0.668
MOD_GSK3_1	197	204	PF00069	0.566
MOD_GSK3_1	266	273	PF00069	0.780
MOD_GSK3_1	290	297	PF00069	0.605
MOD_GSK3_1	370	377	PF00069	0.718
MOD_GSK3_1	378	385	PF00069	0.650
MOD_GSK3_1	438	445	PF00069	0.709
MOD_GSK3_1	523	530	PF00069	0.769
MOD_GSK3_1	551	558	PF00069	0.758
MOD_GSK3_1	566	573	PF00069	0.614
MOD_GSK3_1	60	67	PF00069	0.586
MOD_GSK3_1	72	79	PF00069	0.556
MOD_N-GLC_1	112	117	PF02516	0.708
MOD_N-GLC_1	118	123	PF02516	0.659
MOD_N-GLC_1	83	88	PF02516	0.568
MOD_NEK2_1	320	325	PF00069	0.661
MOD_NEK2_1	375	380	PF00069	0.670
MOD_NEK2_1	626	631	PF00069	0.670
MOD_NEK2_1	83	88	PF00069	0.665
MOD_NEK2_2	10	15	PF00069	0.480
MOD_PIKK_1	183	189	PF00454	0.645
MOD_PIKK_1	312	318	PF00454	0.451
MOD_PIKK_1	362	368	PF00454	0.777
MOD_PIKK_1	416	422	PF00454	0.592
MOD_PKA_1	201	207	PF00069	0.706
MOD_PKA_1	437	443	PF00069	0.676
MOD_PKA_1	523	529	PF00069	0.769
MOD_PKA_2	148	154	PF00069	0.745
MOD_PKA_2	201	207	PF00069	0.615
MOD_PKA_2	320	326	PF00069	0.600
MOD_PKA_2	416	422	PF00069	0.601
MOD_PKA_2	428	434	PF00069	0.560
MOD_PKA_2	523	529	PF00069	0.807
MOD_PKA_2	72	78	PF00069	0.685
MOD_PKB_1	270	278	PF00069	0.786
MOD_Plk_1	161	167	PF00069	0.785
MOD_Plk_1	64	70	PF00069	0.578
MOD_Plk_1	83	89	PF00069	0.496
MOD_Plk_2-3	103	109	PF00069	0.743
MOD_Plk_4	10	16	PF00069	0.479
MOD_Plk_4	162	168	PF00069	0.787
MOD_Plk_4	21	27	PF00069	0.443
MOD_Plk_4	279	285	PF00069	0.640
MOD_Plk_4	320	326	PF00069	0.663
MOD_ProDKin_1	114	120	PF00069	0.785
MOD_ProDKin_1	123	129	PF00069	0.671
MOD_ProDKin_1	18	24	PF00069	0.467
MOD_ProDKin_1	277	283	PF00069	0.728
MOD_ProDKin_1	368	374	PF00069	0.740
MOD_ProDKin_1	37	43	PF00069	0.480
MOD_ProDKin_1	382	388	PF00069	0.537
MOD_ProDKin_1	510	516	PF00069	0.687
MOD_ProDKin_1	532	538	PF00069	0.732
MOD_ProDKin_1	593	599	PF00069	0.704
MOD_SUMO_rev_2	457	467	PF00179	0.676
TRG_DiLeu_BaEn_1	162	167	PF01217	0.786
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.530
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.679
TRG_ENDOCYTIC_2	12	15	PF00928	0.482
TRG_ENDOCYTIC_2	624	627	PF00928	0.631
TRG_ER_diArg_1	416	418	PF00400	0.644
TRG_ER_diArg_1	427	430	PF00400	0.520
TRG_ER_diArg_1	449	451	PF00400	0.719
TRG_ER_diArg_1	522	524	PF00400	0.833
TRG_ER_diArg_1	527	529	PF00400	0.769
TRG_NLS_Bipartite_1	140	158	PF00514	0.729
TRG_NLS_MonoCore_2	139	144	PF00514	0.721
TRG_NLS_MonoCore_2	520	525	PF00514	0.574
TRG_NLS_MonoExtC_3	153	159	PF00514	0.741
TRG_NLS_MonoExtC_3	424	429	PF00514	0.671
TRG_NLS_MonoExtN_4	138	145	PF00514	0.723
TRG_NLS_MonoExtN_4	425	430	PF00514	0.677
TRG_NLS_MonoExtN_4	519	525	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8INB5	Leishmania donovani	86%	100%
A4HE29	Leishmania braziliensis	68%	100%
A4I1D5	Leishmania infantum	86%	100%
E9AXH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	94%