Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9Z9_LEIMA

TriTrypDb:

LmjF.25.0950 , LMJLV39_250015800 , LMJSD75_250015700

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.556
CLV_NRD_NRD_1	215	217	PF00675	0.606
CLV_NRD_NRD_1	277	279	PF00675	0.585
CLV_NRD_NRD_1	29	31	PF00675	0.490
CLV_NRD_NRD_1	325	327	PF00675	0.639
CLV_NRD_NRD_1	354	356	PF00675	0.585
CLV_NRD_NRD_1	414	416	PF00675	0.584
CLV_NRD_NRD_1	456	458	PF00675	0.571
CLV_NRD_NRD_1	98	100	PF00675	0.526
CLV_PCSK_KEX2_1	215	217	PF00082	0.656
CLV_PCSK_KEX2_1	277	279	PF00082	0.585
CLV_PCSK_KEX2_1	29	31	PF00082	0.490
CLV_PCSK_KEX2_1	325	327	PF00082	0.639
CLV_PCSK_KEX2_1	354	356	PF00082	0.585
CLV_PCSK_KEX2_1	414	416	PF00082	0.584
CLV_PCSK_KEX2_1	456	458	PF00082	0.646
CLV_PCSK_KEX2_1	98	100	PF00082	0.526
CLV_PCSK_PC7_1	452	458	PF00082	0.580
CLV_PCSK_SKI1_1	142	146	PF00082	0.456
CLV_PCSK_SKI1_1	157	161	PF00082	0.525
CLV_PCSK_SKI1_1	342	346	PF00082	0.534
CLV_PCSK_SKI1_1	98	102	PF00082	0.433
DEG_Nend_UBRbox_1	1	4	PF02207	0.465
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.466
DOC_MAPK_gen_1	372	381	PF00069	0.708
DOC_MAPK_gen_1	421	429	PF00069	0.429
DOC_MAPK_MEF2A_6	2	10	PF00069	0.448
DOC_MAPK_MEF2A_6	423	431	PF00069	0.416
DOC_PP1_RVXF_1	155	162	PF00149	0.432
DOC_PP2B_LxvP_1	296	299	PF13499	0.553
DOC_PP2B_LxvP_1	316	319	PF13499	0.475
DOC_PP4_FxxP_1	90	93	PF00568	0.478
DOC_USP7_MATH_1	170	174	PF00917	0.719
DOC_USP7_MATH_1	211	215	PF00917	0.560
DOC_USP7_MATH_1	265	269	PF00917	0.528
DOC_USP7_MATH_1	337	341	PF00917	0.738
DOC_USP7_MATH_1	361	365	PF00917	0.566
DOC_USP7_MATH_1	71	75	PF00917	0.651
DOC_WW_Pin1_4	299	304	PF00397	0.645
DOC_WW_Pin1_4	50	55	PF00397	0.509
LIG_14-3-3_CanoR_1	119	124	PF00244	0.485
LIG_14-3-3_CanoR_1	142	147	PF00244	0.359
LIG_14-3-3_CanoR_1	196	202	PF00244	0.624
LIG_14-3-3_CanoR_1	262	271	PF00244	0.551
LIG_14-3-3_CanoR_1	294	299	PF00244	0.643
LIG_14-3-3_CanoR_1	314	319	PF00244	0.485
LIG_14-3-3_CanoR_1	342	350	PF00244	0.554
LIG_Actin_RPEL_3	416	435	PF02755	0.539
LIG_Actin_WH2_2	127	144	PF00022	0.528
LIG_DLG_GKlike_1	423	431	PF00625	0.522
LIG_EH1_1	37	45	PF00400	0.451
LIG_FHA_1	154	160	PF00498	0.481
LIG_FHA_1	202	208	PF00498	0.454
LIG_FHA_1	270	276	PF00498	0.762
LIG_FHA_1	311	317	PF00498	0.674
LIG_FHA_1	477	483	PF00498	0.476
LIG_FHA_2	233	239	PF00498	0.506
LIG_LIR_Apic_2	88	93	PF02991	0.566
LIG_LIR_Gen_1	117	128	PF02991	0.434
LIG_LIR_Gen_1	156	164	PF02991	0.500
LIG_LIR_Gen_1	219	228	PF02991	0.528
LIG_LIR_Nem_3	117	123	PF02991	0.451
LIG_LIR_Nem_3	156	161	PF02991	0.477
LIG_LIR_Nem_3	20	26	PF02991	0.522
LIG_LIR_Nem_3	219	224	PF02991	0.630
LIG_NRBOX	249	255	PF00104	0.610
LIG_NRBOX	340	346	PF00104	0.635
LIG_PCNA_PIPBox_1	289	298	PF02747	0.520
LIG_PCNA_yPIPBox_3	287	296	PF02747	0.558
LIG_SH2_CRK	221	225	PF00017	0.527
LIG_SH2_CRK	413	417	PF00017	0.465
LIG_SH2_SRC	217	220	PF00017	0.627
LIG_SH2_STAP1	256	260	PF00017	0.539
LIG_SH2_STAP1	478	482	PF00017	0.369
LIG_SH2_STAT5	139	142	PF00017	0.416
LIG_SH2_STAT5	158	161	PF00017	0.519
LIG_SH2_STAT5	405	408	PF00017	0.483
LIG_SH2_STAT5	478	481	PF00017	0.435
LIG_SH3_3	112	118	PF00018	0.442
LIG_SH3_3	18	24	PF00018	0.435
LIG_SH3_3	377	383	PF00018	0.796
LIG_SH3_3	62	68	PF00018	0.593
LIG_SUMO_SIM_par_1	76	83	PF11976	0.486
LIG_UBA3_1	51	59	PF00899	0.470
LIG_WRC_WIRS_1	120	125	PF05994	0.411
MOD_CK1_1	124	130	PF00069	0.432
MOD_CK1_1	269	275	PF00069	0.761
MOD_CK1_1	301	307	PF00069	0.638
MOD_CK1_1	346	352	PF00069	0.714
MOD_CK1_1	364	370	PF00069	0.579
MOD_CK1_1	371	377	PF00069	0.644
MOD_CK1_1	439	445	PF00069	0.537
MOD_CK1_1	74	80	PF00069	0.573
MOD_CK1_1	88	94	PF00069	0.404
MOD_CK2_1	160	166	PF00069	0.500
MOD_CK2_1	202	208	PF00069	0.626
MOD_CK2_1	232	238	PF00069	0.550
MOD_CK2_1	346	352	PF00069	0.509
MOD_Cter_Amidation	323	326	PF01082	0.571
MOD_Cter_Amidation	96	99	PF01082	0.371
MOD_GlcNHglycan	123	126	PF01048	0.452
MOD_GlcNHglycan	208	212	PF01048	0.612
MOD_GlcNHglycan	229	232	PF01048	0.704
MOD_GlcNHglycan	296	299	PF01048	0.623
MOD_GlcNHglycan	316	319	PF01048	0.530
MOD_GlcNHglycan	33	36	PF01048	0.481
MOD_GlcNHglycan	363	366	PF01048	0.654
MOD_GlcNHglycan	385	388	PF01048	0.521
MOD_GlcNHglycan	61	64	PF01048	0.610
MOD_GlcNHglycan	72	76	PF01048	0.525
MOD_GlcNHglycan	87	90	PF01048	0.416
MOD_GSK3_1	119	126	PF00069	0.445
MOD_GSK3_1	149	156	PF00069	0.501
MOD_GSK3_1	160	167	PF00069	0.465
MOD_GSK3_1	197	204	PF00069	0.508
MOD_GSK3_1	207	214	PF00069	0.569
MOD_GSK3_1	265	272	PF00069	0.669
MOD_GSK3_1	294	301	PF00069	0.782
MOD_GSK3_1	310	317	PF00069	0.578
MOD_GSK3_1	361	368	PF00069	0.560
MOD_GSK3_1	423	430	PF00069	0.406
MOD_GSK3_1	67	74	PF00069	0.738
MOD_N-GLC_1	299	304	PF02516	0.565
MOD_NEK2_1	123	128	PF00069	0.452
MOD_NEK2_1	147	152	PF00069	0.592
MOD_NEK2_1	160	165	PF00069	0.437
MOD_NEK2_1	227	232	PF00069	0.695
MOD_NEK2_1	356	361	PF00069	0.576
MOD_NEK2_1	406	411	PF00069	0.421
MOD_NEK2_1	427	432	PF00069	0.510
MOD_NEK2_1	43	48	PF00069	0.545
MOD_NEK2_1	80	85	PF00069	0.544
MOD_NEK2_2	337	342	PF00069	0.658
MOD_OFUCOSY	329	335	PF10250	0.630
MOD_PIKK_1	266	272	PF00454	0.674
MOD_PIKK_1	318	324	PF00454	0.580
MOD_PIKK_1	441	447	PF00454	0.492
MOD_PKA_1	476	482	PF00069	0.422
MOD_PKA_2	31	37	PF00069	0.480
MOD_PKA_2	331	337	PF00069	0.615
MOD_PKA_2	371	377	PF00069	0.711
MOD_PKB_1	421	429	PF00069	0.429
MOD_Plk_1	202	208	PF00069	0.696
MOD_Plk_1	337	343	PF00069	0.588
MOD_Plk_4	142	148	PF00069	0.406
MOD_Plk_4	197	203	PF00069	0.618
MOD_Plk_4	423	429	PF00069	0.422
MOD_ProDKin_1	299	305	PF00069	0.644
MOD_ProDKin_1	50	56	PF00069	0.509
MOD_SUMO_rev_2	481	488	PF00179	0.618
TRG_DiLeu_BaEn_1	454	459	PF01217	0.560
TRG_DiLeu_BaEn_1	483	488	PF01217	0.554
TRG_DiLeu_BaEn_2	290	296	PF01217	0.567
TRG_DiLeu_BaEn_4	483	489	PF01217	0.556
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.391
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.511
TRG_DiLeu_LyEn_5	76	81	PF01217	0.439
TRG_ENDOCYTIC_2	120	123	PF00928	0.407
TRG_ENDOCYTIC_2	158	161	PF00928	0.519
TRG_ENDOCYTIC_2	221	224	PF00928	0.630
TRG_ENDOCYTIC_2	413	416	PF00928	0.463
TRG_ER_diArg_1	179	182	PF00400	0.696
TRG_ER_diArg_1	215	217	PF00400	0.606
TRG_ER_diArg_1	276	278	PF00400	0.666
TRG_ER_diArg_1	29	32	PF00400	0.493
TRG_ER_diArg_1	354	356	PF00400	0.580
TRG_ER_diArg_1	393	396	PF00400	0.649
TRG_ER_diArg_1	413	415	PF00400	0.598
TRG_ER_diArg_1	456	458	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU1	Leptomonas seymouri	44%	100%
A4HE30	Leishmania braziliensis	69%	100%
E9AXH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%