JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9Z4_LEIMA

TriTrypDb:

LmjF.25.1000 , LMJLV39_250016400 , LMJSD75_250016300

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Z4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.647
CLV_C14_Caspase3-7	456	460	PF00656	0.592
CLV_C14_Caspase3-7	49	53	PF00656	0.603
CLV_C14_Caspase3-7	581	585	PF00656	0.603
CLV_C14_Caspase3-7	780	784	PF00656	0.546
CLV_C14_Caspase3-7	92	96	PF00656	0.647
CLV_NRD_NRD_1	451	453	PF00675	0.664
CLV_NRD_NRD_1	507	509	PF00675	0.624
CLV_NRD_NRD_1	517	519	PF00675	0.563
CLV_NRD_NRD_1	600	602	PF00675	0.541
CLV_NRD_NRD_1	708	710	PF00675	0.436
CLV_NRD_NRD_1	712	714	PF00675	0.433
CLV_PCSK_KEX2_1	451	453	PF00082	0.664
CLV_PCSK_KEX2_1	507	509	PF00082	0.624
CLV_PCSK_KEX2_1	516	518	PF00082	0.506
CLV_PCSK_KEX2_1	600	602	PF00082	0.712
CLV_PCSK_KEX2_1	701	703	PF00082	0.488
CLV_PCSK_KEX2_1	708	710	PF00082	0.432
CLV_PCSK_KEX2_1	712	714	PF00082	0.387
CLV_PCSK_KEX2_1	754	756	PF00082	0.557
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.638
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.488
CLV_PCSK_PC1ET2_1	754	756	PF00082	0.557
CLV_PCSK_PC7_1	708	714	PF00082	0.438
CLV_PCSK_SKI1_1	600	604	PF00082	0.623
CLV_PCSK_SKI1_1	607	611	PF00082	0.540
CLV_PCSK_SKI1_1	766	770	PF00082	0.484
DEG_APCC_DBOX_1	17	25	PF00400	0.558
DEG_APCC_DBOX_1	599	607	PF00400	0.552
DEG_Nend_Nbox_1	1	3	PF02207	0.660
DEG_SPOP_SBC_1	105	109	PF00917	0.594
DEG_SPOP_SBC_1	296	300	PF00917	0.589
DEG_SPOP_SBC_1	648	652	PF00917	0.581
DOC_CKS1_1	102	107	PF01111	0.644
DOC_CKS1_1	293	298	PF01111	0.645
DOC_CKS1_1	48	53	PF01111	0.604
DOC_CKS1_1	608	613	PF01111	0.620
DOC_CYCLIN_RxL_1	551	561	PF00134	0.544
DOC_CYCLIN_RxL_1	597	605	PF00134	0.537
DOC_PP1_RVXF_1	196	202	PF00149	0.584
DOC_PP1_RVXF_1	387	393	PF00149	0.576
DOC_PP1_SILK_1	731	736	PF00149	0.455
DOC_USP7_MATH_1	105	109	PF00917	0.601
DOC_USP7_MATH_1	124	128	PF00917	0.564
DOC_USP7_MATH_1	135	139	PF00917	0.601
DOC_USP7_MATH_1	192	196	PF00917	0.645
DOC_USP7_MATH_1	257	261	PF00917	0.632
DOC_USP7_MATH_1	281	285	PF00917	0.608
DOC_USP7_MATH_1	296	300	PF00917	0.591
DOC_USP7_MATH_1	315	319	PF00917	0.565
DOC_USP7_MATH_1	326	330	PF00917	0.596
DOC_USP7_MATH_1	383	387	PF00917	0.778
DOC_USP7_MATH_1	450	454	PF00917	0.657
DOC_USP7_MATH_1	46	50	PF00917	0.674
DOC_USP7_MATH_1	500	504	PF00917	0.616
DOC_USP7_MATH_1	536	540	PF00917	0.587
DOC_USP7_MATH_1	623	627	PF00917	0.628
DOC_USP7_MATH_1	631	635	PF00917	0.571
DOC_USP7_MATH_1	648	652	PF00917	0.496
DOC_USP7_MATH_1	729	733	PF00917	0.490
DOC_USP7_MATH_1	774	778	PF00917	0.573
DOC_USP7_MATH_1	90	94	PF00917	0.631
DOC_USP7_UBL2_3	750	754	PF12436	0.523
DOC_WW_Pin1_4	101	106	PF00397	0.645
DOC_WW_Pin1_4	127	132	PF00397	0.602
DOC_WW_Pin1_4	144	149	PF00397	0.587
DOC_WW_Pin1_4	188	193	PF00397	0.642
DOC_WW_Pin1_4	214	219	PF00397	0.654
DOC_WW_Pin1_4	292	297	PF00397	0.646
DOC_WW_Pin1_4	318	323	PF00397	0.601
DOC_WW_Pin1_4	335	340	PF00397	0.589
DOC_WW_Pin1_4	379	384	PF00397	0.633
DOC_WW_Pin1_4	4	9	PF00397	0.615
DOC_WW_Pin1_4	405	410	PF00397	0.638
DOC_WW_Pin1_4	47	52	PF00397	0.603
DOC_WW_Pin1_4	544	549	PF00397	0.621
DOC_WW_Pin1_4	607	612	PF00397	0.619
DOC_WW_Pin1_4	619	624	PF00397	0.610
LIG_14-3-3_CanoR_1	472	480	PF00244	0.591
LIG_14-3-3_CanoR_1	507	515	PF00244	0.626
LIG_14-3-3_CanoR_1	537	543	PF00244	0.658
LIG_Actin_WH2_2	515	532	PF00022	0.607
LIG_BIR_III_2	286	290	PF00653	0.647
LIG_BIR_III_2	95	99	PF00653	0.649
LIG_BRCT_BRCA1_1	212	216	PF00533	0.579
LIG_BRCT_BRCA1_1	403	407	PF00533	0.572
LIG_FHA_1	162	168	PF00498	0.654
LIG_FHA_1	353	359	PF00498	0.658
LIG_FHA_1	650	656	PF00498	0.633
LIG_FHA_2	209	215	PF00498	0.573
LIG_FHA_2	247	253	PF00498	0.665
LIG_FHA_2	400	406	PF00498	0.566
LIG_FHA_2	438	444	PF00498	0.622
LIG_FHA_2	573	579	PF00498	0.621
LIG_FHA_2	608	614	PF00498	0.651
LIG_GBD_Chelix_1	13	21	PF00786	0.556
LIG_LIR_Apic_2	686	692	PF02991	0.586
LIG_LIR_Apic_2	756	761	PF02991	0.498
LIG_LIR_Nem_3	213	219	PF02991	0.579
LIG_LIR_Nem_3	404	410	PF02991	0.585
LIG_LIR_Nem_3	705	710	PF02991	0.473
LIG_LIR_Nem_3	711	717	PF02991	0.415
LIG_LIR_Nem_3	762	768	PF02991	0.490
LIG_SH2_CRK	169	173	PF00017	0.654
LIG_SH2_CRK	360	364	PF00017	0.839
LIG_SH2_CRK	689	693	PF00017	0.693
LIG_SH2_CRK	714	718	PF00017	0.432
LIG_SH2_NCK_1	169	173	PF00017	0.654
LIG_SH2_NCK_1	360	364	PF00017	0.649
LIG_SH2_NCK_1	689	693	PF00017	0.538
LIG_SH2_SRC	557	560	PF00017	0.548
LIG_SH2_STAP1	710	714	PF00017	0.457
LIG_SH2_STAT5	557	560	PF00017	0.614
LIG_SH2_STAT5	689	692	PF00017	0.587
LIG_SH3_1	39	45	PF00018	0.615
LIG_SH3_3	261	267	PF00018	0.678
LIG_SH3_3	39	45	PF00018	0.615
LIG_SH3_3	522	528	PF00018	0.644
LIG_SH3_3	547	553	PF00018	0.652
LIG_SH3_3	56	62	PF00018	0.586
LIG_SH3_3	605	611	PF00018	0.614
LIG_SH3_3	70	76	PF00018	0.612
LIG_SH3_4	750	757	PF00018	0.530
LIG_SUMO_SIM_anti_2	34	39	PF11976	0.526
LIG_SUMO_SIM_anti_2	669	674	PF11976	0.563
LIG_SUMO_SIM_par_1	666	671	PF11976	0.590
LIG_TRAF2_1	267	270	PF00917	0.647
LIG_TRAF2_1	76	79	PF00917	0.630
MOD_CDC14_SPxK_1	217	220	PF00782	0.625
MOD_CDC14_SPxK_1	408	411	PF00782	0.605
MOD_CDK_SPK_2	607	612	PF00069	0.619
MOD_CDK_SPxK_1	214	220	PF00069	0.656
MOD_CDK_SPxK_1	405	411	PF00069	0.639
MOD_CDK_SPxxK_3	47	54	PF00069	0.606
MOD_CK1_1	127	133	PF00069	0.601
MOD_CK1_1	188	194	PF00069	0.641
MOD_CK1_1	204	210	PF00069	0.530
MOD_CK1_1	236	242	PF00069	0.586
MOD_CK1_1	3	9	PF00069	0.619
MOD_CK1_1	318	324	PF00069	0.637
MOD_CK1_1	379	385	PF00069	0.633
MOD_CK1_1	395	401	PF00069	0.728
MOD_CK1_1	427	433	PF00069	0.572
MOD_CK1_1	47	53	PF00069	0.677
MOD_CK1_1	626	632	PF00069	0.589
MOD_CK1_1	777	783	PF00069	0.545
MOD_CK2_1	222	228	PF00069	0.629
MOD_CK2_1	246	252	PF00069	0.663
MOD_CK2_1	413	419	PF00069	0.614
MOD_CK2_1	437	443	PF00069	0.627
MOD_CK2_1	450	456	PF00069	0.581
MOD_CK2_1	572	578	PF00069	0.612
MOD_CK2_1	607	613	PF00069	0.649
MOD_CK2_1	753	759	PF00069	0.510
MOD_DYRK1A_RPxSP_1	607	611	PF00069	0.572
MOD_GlcNHglycan	126	129	PF01048	0.681
MOD_GlcNHglycan	172	175	PF01048	0.600
MOD_GlcNHglycan	187	190	PF01048	0.546
MOD_GlcNHglycan	201	204	PF01048	0.562
MOD_GlcNHglycan	224	227	PF01048	0.618
MOD_GlcNHglycan	239	242	PF01048	0.604
MOD_GlcNHglycan	283	286	PF01048	0.602
MOD_GlcNHglycan	317	320	PF01048	0.838
MOD_GlcNHglycan	363	366	PF01048	0.595
MOD_GlcNHglycan	378	381	PF01048	0.642
MOD_GlcNHglycan	392	395	PF01048	0.657
MOD_GlcNHglycan	415	418	PF01048	0.623
MOD_GlcNHglycan	430	433	PF01048	0.587
MOD_GlcNHglycan	489	492	PF01048	0.764
MOD_GlcNHglycan	502	505	PF01048	0.585
MOD_GlcNHglycan	519	522	PF01048	0.582
MOD_GlcNHglycan	538	541	PF01048	0.512
MOD_GlcNHglycan	580	583	PF01048	0.585
MOD_GlcNHglycan	631	634	PF01048	0.624
MOD_GlcNHglycan	660	663	PF01048	0.538
MOD_GlcNHglycan	692	695	PF01048	0.552
MOD_GlcNHglycan	719	723	PF01048	0.446
MOD_GlcNHglycan	92	95	PF01048	0.633
MOD_GSK3_1	101	108	PF00069	0.643
MOD_GSK3_1	144	151	PF00069	0.635
MOD_GSK3_1	184	191	PF00069	0.645
MOD_GSK3_1	20	27	PF00069	0.491
MOD_GSK3_1	201	208	PF00069	0.530
MOD_GSK3_1	210	217	PF00069	0.576
MOD_GSK3_1	233	240	PF00069	0.599
MOD_GSK3_1	292	299	PF00069	0.642
MOD_GSK3_1	335	342	PF00069	0.645
MOD_GSK3_1	375	382	PF00069	0.644
MOD_GSK3_1	392	399	PF00069	0.620
MOD_GSK3_1	401	408	PF00069	0.610
MOD_GSK3_1	424	431	PF00069	0.584
MOD_GSK3_1	619	626	PF00069	0.632
MOD_GSK3_1	632	639	PF00069	0.546
MOD_GSK3_1	683	690	PF00069	0.513
MOD_GSK3_1	729	736	PF00069	0.642
MOD_N-GLC_1	199	204	PF02516	0.653
MOD_N-GLC_1	237	242	PF02516	0.588
MOD_N-GLC_1	390	395	PF02516	0.790
MOD_N-GLC_1	428	433	PF02516	0.573
MOD_N-GLC_1	616	621	PF02516	0.573
MOD_NEK2_1	114	119	PF00069	0.638
MOD_NEK2_1	185	190	PF00069	0.647
MOD_NEK2_1	201	206	PF00069	0.542
MOD_NEK2_1	305	310	PF00069	0.748
MOD_NEK2_1	376	381	PF00069	0.646
MOD_NEK2_1	392	397	PF00069	0.635
MOD_NEK2_1	489	494	PF00069	0.595
MOD_NEK2_1	590	595	PF00069	0.579
MOD_NEK2_1	649	654	PF00069	0.595
MOD_NEK2_1	687	692	PF00069	0.513
MOD_NEK2_2	192	197	PF00069	0.647
MOD_NEK2_2	383	388	PF00069	0.780
MOD_PIKK_1	122	128	PF00454	0.667
MOD_PIKK_1	136	142	PF00454	0.579
MOD_PIKK_1	201	207	PF00454	0.645
MOD_PIKK_1	313	319	PF00454	0.665
MOD_PIKK_1	327	333	PF00454	0.571
MOD_PIKK_1	392	398	PF00454	0.799
MOD_PIKK_1	473	479	PF00454	0.589
MOD_PKA_1	507	513	PF00069	0.626
MOD_PKA_1	517	523	PF00069	0.555
MOD_PKA_1	708	714	PF00069	0.428
MOD_PKA_2	219	225	PF00069	0.655
MOD_PKA_2	410	416	PF00069	0.639
MOD_PKA_2	450	456	PF00069	0.657
MOD_PKA_2	507	513	PF00069	0.626
MOD_PKA_2	517	523	PF00069	0.575
MOD_PKA_2	536	542	PF00069	0.716
MOD_PKA_2	708	714	PF00069	0.468
MOD_Plk_1	114	120	PF00069	0.639
MOD_Plk_1	136	142	PF00069	0.598
MOD_Plk_1	192	198	PF00069	0.650
MOD_Plk_1	305	311	PF00069	0.645
MOD_Plk_1	327	333	PF00069	0.590
MOD_Plk_1	383	389	PF00069	0.713
MOD_Plk_1	572	578	PF00069	0.623
MOD_Plk_1	702	708	PF00069	0.471
MOD_Plk_1	718	724	PF00069	0.339
MOD_Plk_4	33	39	PF00069	0.523
MOD_Plk_4	475	481	PF00069	0.637
MOD_Plk_4	591	597	PF00069	0.559
MOD_Plk_4	702	708	PF00069	0.446
MOD_Plk_4	729	735	PF00069	0.602
MOD_ProDKin_1	101	107	PF00069	0.644
MOD_ProDKin_1	127	133	PF00069	0.603
MOD_ProDKin_1	144	150	PF00069	0.586
MOD_ProDKin_1	188	194	PF00069	0.641
MOD_ProDKin_1	214	220	PF00069	0.656
MOD_ProDKin_1	292	298	PF00069	0.645
MOD_ProDKin_1	318	324	PF00069	0.600
MOD_ProDKin_1	335	341	PF00069	0.585
MOD_ProDKin_1	379	385	PF00069	0.633
MOD_ProDKin_1	4	10	PF00069	0.613
MOD_ProDKin_1	405	411	PF00069	0.639
MOD_ProDKin_1	47	53	PF00069	0.603
MOD_ProDKin_1	544	550	PF00069	0.618
MOD_ProDKin_1	607	613	PF00069	0.619
MOD_ProDKin_1	619	625	PF00069	0.610
MOD_SUMO_rev_2	283	289	PF00179	0.646
MOD_SUMO_rev_2	745	752	PF00179	0.520
MOD_SUMO_rev_2	92	98	PF00179	0.647
TRG_DiLeu_BaEn_2	585	591	PF01217	0.587
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.537
TRG_ENDOCYTIC_2	714	717	PF00928	0.441
TRG_ER_diArg_1	450	452	PF00400	0.660
TRG_ER_diArg_1	507	509	PF00400	0.624
TRG_ER_diArg_1	517	519	PF00400	0.563
TRG_ER_diArg_1	600	602	PF00400	0.541
TRG_ER_diArg_1	707	709	PF00400	0.482
TRG_ER_diArg_1	712	714	PF00400	0.427
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	574	578	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	715	719	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	767	771	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WZ10	Leishmania donovani	83%	81%
A4I1E1	Leishmania infantum	81%	100%
E9AXH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%