Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania major

UniProt:

Q4Q9Z3_LEIMA

TriTrypDb:

LmjF.25.1010 , LMJLV39_250016500 , LMJSD75_250016400

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Z3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.562
CLV_C14_Caspase3-7	305	309	PF00656	0.494
CLV_C14_Caspase3-7	417	421	PF00656	0.637
CLV_NRD_NRD_1	139	141	PF00675	0.493
CLV_NRD_NRD_1	159	161	PF00675	0.453
CLV_NRD_NRD_1	289	291	PF00675	0.592
CLV_PCSK_KEX2_1	139	141	PF00082	0.493
CLV_PCSK_KEX2_1	159	161	PF00082	0.327
CLV_PCSK_KEX2_1	248	250	PF00082	0.411
CLV_PCSK_KEX2_1	289	291	PF00082	0.592
CLV_PCSK_KEX2_1	80	82	PF00082	0.620
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.411
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.620
CLV_PCSK_SKI1_1	291	295	PF00082	0.620
CLV_PCSK_SKI1_1	311	315	PF00082	0.411
CLV_PCSK_SKI1_1	381	385	PF00082	0.339
CLV_PCSK_SKI1_1	49	53	PF00082	0.346
CLV_PCSK_SKI1_1	60	64	PF00082	0.286
DEG_APCC_DBOX_1	8	16	PF00400	0.442
DEG_MDM2_SWIB_1	364	372	PF02201	0.281
DEG_Nend_Nbox_1	1	3	PF02207	0.653
DOC_CDC14_PxL_1	347	355	PF14671	0.266
DOC_MAPK_gen_1	159	167	PF00069	0.476
DOC_MAPK_gen_1	266	273	PF00069	0.592
DOC_MAPK_MEF2A_6	344	352	PF00069	0.393
DOC_PP1_RVXF_1	58	64	PF00149	0.332
DOC_PP4_FxxP_1	395	398	PF00568	0.302
DOC_USP7_MATH_1	175	179	PF00917	0.687
DOC_USP7_MATH_1	418	422	PF00917	0.608
DOC_USP7_MATH_1	75	79	PF00917	0.624
DOC_USP7_MATH_2	94	100	PF00917	0.394
DOC_WW_Pin1_4	373	378	PF00397	0.281
DOC_WW_Pin1_4	90	95	PF00397	0.388
DOC_WW_Pin1_4	99	104	PF00397	0.376
LIG_14-3-3_CanoR_1	214	222	PF00244	0.341
LIG_BRCT_BRCA1_1	390	394	PF00533	0.266
LIG_FHA_1	293	299	PF00498	0.637
LIG_FHA_1	312	318	PF00498	0.305
LIG_FHA_1	323	329	PF00498	0.224
LIG_FHA_1	367	373	PF00498	0.328
LIG_FHA_2	317	323	PF00498	0.305
LIG_FHA_2	48	54	PF00498	0.401
LIG_HCF-1_HBM_1	36	39	PF13415	0.474
LIG_LIR_Gen_1	150	157	PF02991	0.484
LIG_LIR_Gen_1	346	353	PF02991	0.308
LIG_LIR_Gen_1	36	47	PF02991	0.487
LIG_LIR_Nem_3	104	109	PF02991	0.346
LIG_LIR_Nem_3	240	245	PF02991	0.395
LIG_LIR_Nem_3	346	350	PF02991	0.334
LIG_LIR_Nem_3	36	42	PF02991	0.482
LIG_LIR_Nem_3	391	397	PF02991	0.266
LIG_LYPXL_yS_3	258	261	PF13949	0.386
LIG_MYND_3	350	354	PF01753	0.360
LIG_Pex14_2	190	194	PF04695	0.470
LIG_Pex14_2	364	368	PF04695	0.266
LIG_SH2_CRK	110	114	PF00017	0.360
LIG_SH2_CRK	347	351	PF00017	0.403
LIG_SH2_CRK	39	43	PF00017	0.288
LIG_SH2_STAP1	202	206	PF00017	0.354
LIG_SH2_STAT3	142	145	PF00017	0.496
LIG_SH2_STAT3	257	260	PF00017	0.419
LIG_SH2_STAT5	112	115	PF00017	0.416
LIG_SH2_STAT5	153	156	PF00017	0.420
LIG_SH2_STAT5	206	209	PF00017	0.451
LIG_SH2_STAT5	241	244	PF00017	0.395
LIG_SH2_STAT5	39	42	PF00017	0.283
LIG_SH2_STAT5	66	69	PF00017	0.332
LIG_SH3_3	129	135	PF00018	0.386
LIG_SH3_3	221	227	PF00018	0.468
LIG_SUMO_SIM_anti_2	324	330	PF11976	0.298
LIG_SUMO_SIM_par_1	324	330	PF11976	0.411
LIG_WRC_WIRS_1	242	247	PF05994	0.390
MOD_CDK_SPxK_1	373	379	PF00069	0.266
MOD_CK1_1	155	161	PF00069	0.434
MOD_CK1_1	231	237	PF00069	0.555
MOD_CK1_1	324	330	PF00069	0.290
MOD_CK1_1	388	394	PF00069	0.287
MOD_CK1_1	99	105	PF00069	0.373
MOD_CK2_1	90	96	PF00069	0.399
MOD_GlcNHglycan	103	106	PF01048	0.411
MOD_GlcNHglycan	115	118	PF01048	0.420
MOD_GlcNHglycan	175	178	PF01048	0.589
MOD_GlcNHglycan	24	27	PF01048	0.524
MOD_GlcNHglycan	277	280	PF01048	0.606
MOD_GSK3_1	148	155	PF00069	0.519
MOD_GSK3_1	169	176	PF00069	0.566
MOD_GSK3_1	20	27	PF00069	0.419
MOD_GSK3_1	384	391	PF00069	0.348
MOD_N-GLC_1	20	25	PF02516	0.400
MOD_N-GLC_1	87	92	PF02516	0.503
MOD_NEK2_1	2	7	PF00069	0.483
MOD_NEK2_1	204	209	PF00069	0.468
MOD_NEK2_1	298	303	PF00069	0.641
MOD_NEK2_1	30	35	PF00069	0.371
MOD_NEK2_2	241	246	PF00069	0.384
MOD_NEK2_2	75	80	PF00069	0.628
MOD_PIKK_1	292	298	PF00454	0.633
MOD_PIKK_1	327	333	PF00454	0.411
MOD_PIKK_1	87	93	PF00454	0.423
MOD_PKA_2	2	8	PF00069	0.475
MOD_PKA_2	222	228	PF00069	0.441
MOD_PKA_2	388	394	PF00069	0.271
MOD_Plk_1	311	317	PF00069	0.340
MOD_Plk_1	321	327	PF00069	0.293
MOD_Plk_1	87	93	PF00069	0.423
MOD_Plk_4	152	158	PF00069	0.533
MOD_Plk_4	2	8	PF00069	0.489
MOD_Plk_4	343	349	PF00069	0.287
MOD_Plk_4	388	394	PF00069	0.266
MOD_Plk_4	418	424	PF00069	0.577
MOD_Plk_4	47	53	PF00069	0.427
MOD_ProDKin_1	373	379	PF00069	0.281
MOD_ProDKin_1	90	96	PF00069	0.382
MOD_ProDKin_1	99	105	PF00069	0.378
MOD_SUMO_rev_2	188	197	PF00179	0.486
MOD_SUMO_rev_2	338	346	PF00179	0.281
TRG_AP2beta_CARGO_1	240	249	PF09066	0.476
TRG_DiLeu_BaEn_1	354	359	PF01217	0.360
TRG_DiLeu_BaEn_4	149	155	PF01217	0.522
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.426
TRG_ENDOCYTIC_2	110	113	PF00928	0.409
TRG_ENDOCYTIC_2	153	156	PF00928	0.451
TRG_ENDOCYTIC_2	201	204	PF00928	0.338
TRG_ENDOCYTIC_2	258	261	PF00928	0.419
TRG_ENDOCYTIC_2	347	350	PF00928	0.300
TRG_ENDOCYTIC_2	39	42	PF00928	0.283
TRG_ER_diArg_1	138	140	PF00400	0.475
TRG_ER_diArg_1	288	290	PF00400	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U5	Leptomonas seymouri	83%	99%
A0A0S4JVQ8	Bodo saltans	46%	100%
A0A1X0NLX7	Trypanosomatidae	58%	100%
A0A3Q8IBQ1	Leishmania donovani	97%	100%
A0A422NXL7	Trypanosoma rangeli	62%	100%
A4HE36	Leishmania braziliensis	92%	100%
A4I1E2	Leishmania infantum	97%	100%
C9ZJV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AXH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5BGC6	Trypanosoma cruzi	65%	100%