Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9Z0_LEIMA

TriTrypDb:

LmjF.25.1030 , LMJLV39_250016900 , LMJSD75_250016800

Length:

758

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.614
CLV_C14_Caspase3-7	712	716	PF00656	0.591
CLV_NRD_NRD_1	117	119	PF00675	0.514
CLV_NRD_NRD_1	188	190	PF00675	0.529
CLV_NRD_NRD_1	29	31	PF00675	0.383
CLV_NRD_NRD_1	685	687	PF00675	0.557
CLV_PCSK_KEX2_1	117	119	PF00082	0.514
CLV_PCSK_KEX2_1	188	190	PF00082	0.543
CLV_PCSK_KEX2_1	29	31	PF00082	0.383
CLV_PCSK_KEX2_1	460	462	PF00082	0.661
CLV_PCSK_KEX2_1	632	634	PF00082	0.405
CLV_PCSK_KEX2_1	685	687	PF00082	0.557
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.574
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.405
CLV_PCSK_PC7_1	628	634	PF00082	0.386
CLV_PCSK_SKI1_1	109	113	PF00082	0.393
CLV_PCSK_SKI1_1	166	170	PF00082	0.695
CLV_PCSK_SKI1_1	632	636	PF00082	0.405
CLV_PCSK_SKI1_1	685	689	PF00082	0.524
CLV_Separin_Metazoa	454	458	PF03568	0.559
DEG_APCC_DBOX_1	165	173	PF00400	0.502
DEG_APCC_DBOX_1	29	37	PF00400	0.450
DEG_APCC_DBOX_1	702	710	PF00400	0.515
DEG_SCF_FBW7_1	376	383	PF00400	0.450
DEG_SCF_FBW7_2	493	498	PF00400	0.661
DEG_SPOP_SBC_1	384	388	PF00917	0.641
DOC_CKS1_1	377	382	PF01111	0.450
DOC_CYCLIN_RxL_1	105	114	PF00134	0.415
DOC_CYCLIN_RxL_1	26	37	PF00134	0.496
DOC_CYCLIN_RxL_1	683	693	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	153	159	PF00134	0.569
DOC_MAPK_gen_1	29	38	PF00069	0.460
DOC_MAPK_HePTP_8	26	38	PF00069	0.439
DOC_MAPK_MEF2A_6	249	257	PF00069	0.588
DOC_MAPK_MEF2A_6	29	38	PF00069	0.580
DOC_MAPK_MEF2A_6	474	482	PF00069	0.545
DOC_PP1_RVXF_1	107	113	PF00149	0.428
DOC_PP1_RVXF_1	525	531	PF00149	0.595
DOC_SPAK_OSR1_1	240	244	PF12202	0.586
DOC_USP7_MATH_1	164	168	PF00917	0.696
DOC_USP7_MATH_1	217	221	PF00917	0.698
DOC_USP7_MATH_1	312	316	PF00917	0.621
DOC_USP7_MATH_1	366	370	PF00917	0.630
DOC_USP7_MATH_1	380	384	PF00917	0.584
DOC_USP7_MATH_1	385	389	PF00917	0.625
DOC_USP7_MATH_1	44	48	PF00917	0.579
DOC_USP7_MATH_1	53	57	PF00917	0.416
DOC_WW_Pin1_4	189	194	PF00397	0.603
DOC_WW_Pin1_4	376	381	PF00397	0.530
DOC_WW_Pin1_4	491	496	PF00397	0.602
DOC_WW_Pin1_4	575	580	PF00397	0.650
LIG_14-3-3_CanoR_1	213	222	PF00244	0.710
LIG_14-3-3_CanoR_1	289	293	PF00244	0.656
LIG_14-3-3_CanoR_1	321	330	PF00244	0.665
LIG_14-3-3_CanoR_1	334	340	PF00244	0.504
LIG_14-3-3_CanoR_1	396	402	PF00244	0.487
LIG_14-3-3_CanoR_1	461	467	PF00244	0.595
LIG_14-3-3_CanoR_1	598	602	PF00244	0.548
LIG_14-3-3_CanoR_1	662	672	PF00244	0.520
LIG_14-3-3_CanoR_1	685	691	PF00244	0.502
LIG_14-3-3_CanoR_1	703	707	PF00244	0.537
LIG_Actin_WH2_2	710	725	PF00022	0.472
LIG_APCC_ABBA_1	493	498	PF00400	0.661
LIG_BRCT_BRCA1_1	569	573	PF00533	0.620
LIG_DLG_GKlike_1	686	694	PF00625	0.487
LIG_EH1_1	604	612	PF00400	0.318
LIG_eIF4E_1	605	611	PF01652	0.420
LIG_FHA_1	105	111	PF00498	0.490
LIG_FHA_1	202	208	PF00498	0.612
LIG_FHA_1	222	228	PF00498	0.483
LIG_FHA_1	269	275	PF00498	0.577
LIG_FHA_1	278	284	PF00498	0.455
LIG_FHA_1	429	435	PF00498	0.548
LIG_FHA_1	614	620	PF00498	0.450
LIG_FHA_1	637	643	PF00498	0.603
LIG_FHA_2	359	365	PF00498	0.584
LIG_FHA_2	370	376	PF00498	0.444
LIG_FHA_2	398	404	PF00498	0.458
LIG_FHA_2	624	630	PF00498	0.517
LIG_FHA_2	727	733	PF00498	0.642
LIG_GBD_Chelix_1	411	419	PF00786	0.428
LIG_GBD_Chelix_1	607	615	PF00786	0.397
LIG_LIR_Apic_2	290	295	PF02991	0.632
LIG_LIR_Apic_2	529	533	PF02991	0.599
LIG_LIR_Apic_2	667	673	PF02991	0.496
LIG_LIR_Gen_1	124	131	PF02991	0.597
LIG_LIR_Gen_1	369	378	PF02991	0.546
LIG_LIR_Gen_1	431	441	PF02991	0.419
LIG_LIR_Gen_1	604	613	PF02991	0.421
LIG_LIR_Nem_3	114	119	PF02991	0.627
LIG_LIR_Nem_3	124	129	PF02991	0.553
LIG_LIR_Nem_3	192	197	PF02991	0.595
LIG_LIR_Nem_3	238	244	PF02991	0.594
LIG_LIR_Nem_3	369	373	PF02991	0.527
LIG_LIR_Nem_3	431	436	PF02991	0.421
LIG_LIR_Nem_3	604	608	PF02991	0.402
LIG_MAD2	195	203	PF02301	0.632
LIG_MYND_1	674	678	PF01753	0.556
LIG_NRBOX	372	378	PF00104	0.529
LIG_NRBOX	56	62	PF00104	0.504
LIG_NRBOX	610	616	PF00104	0.290
LIG_PDZ_Class_3	753	758	PF00595	0.566
LIG_Pex14_1	194	198	PF04695	0.592
LIG_Rb_LxCxE_1	136	152	PF01857	0.467
LIG_SH2_CRK	250	254	PF00017	0.560
LIG_SH2_CRK	577	581	PF00017	0.487
LIG_SH2_CRK	605	609	PF00017	0.364
LIG_SH2_CRK	621	625	PF00017	0.433
LIG_SH2_CRK	670	674	PF00017	0.519
LIG_SH2_NCK_1	126	130	PF00017	0.604
LIG_SH2_NCK_1	605	609	PF00017	0.311
LIG_SH2_PTP2	370	373	PF00017	0.548
LIG_SH2_SRC	621	624	PF00017	0.467
LIG_SH2_STAP1	304	308	PF00017	0.586
LIG_SH2_STAT5	304	307	PF00017	0.583
LIG_SH2_STAT5	349	352	PF00017	0.520
LIG_SH2_STAT5	370	373	PF00017	0.627
LIG_SH2_STAT5	417	420	PF00017	0.535
LIG_SH2_STAT5	550	553	PF00017	0.708
LIG_SH2_STAT5	623	626	PF00017	0.395
LIG_SH2_STAT5	721	724	PF00017	0.488
LIG_SH3_1	671	677	PF00018	0.553
LIG_SH3_3	208	214	PF00018	0.584
LIG_SH3_3	671	677	PF00018	0.566
LIG_SH3_3	88	94	PF00018	0.613
LIG_SUMO_SIM_par_1	224	230	PF11976	0.564
LIG_SUMO_SIM_par_1	32	37	PF11976	0.461
LIG_SUMO_SIM_par_1	349	355	PF11976	0.620
LIG_SUMO_SIM_par_1	475	486	PF11976	0.627
LIG_SUMO_SIM_par_1	610	616	PF11976	0.290
LIG_TRAF2_1	168	171	PF00917	0.683
LIG_TRAF2_1	317	320	PF00917	0.515
LIG_TRAF2_1	501	504	PF00917	0.681
LIG_TRAF2_1	742	745	PF00917	0.728
LIG_TYR_ITIM	196	201	PF00017	0.623
LIG_TYR_ITIM	619	624	PF00017	0.454
MOD_CDC14_SPxK_1	192	195	PF00782	0.608
MOD_CDK_SPxK_1	189	195	PF00069	0.605
MOD_CDK_SPxxK_3	575	582	PF00069	0.542
MOD_CK1_1	124	130	PF00069	0.604
MOD_CK1_1	315	321	PF00069	0.647
MOD_CK1_1	337	343	PF00069	0.737
MOD_CK1_1	369	375	PF00069	0.589
MOD_CK1_1	383	389	PF00069	0.611
MOD_CK1_1	465	471	PF00069	0.664
MOD_CK1_1	481	487	PF00069	0.704
MOD_CK1_1	650	656	PF00069	0.693
MOD_CK1_1	664	670	PF00069	0.525
MOD_CK2_1	133	139	PF00069	0.432
MOD_CK2_1	157	163	PF00069	0.690
MOD_CK2_1	164	170	PF00069	0.681
MOD_CK2_1	397	403	PF00069	0.383
MOD_CK2_1	498	504	PF00069	0.719
MOD_CK2_1	540	546	PF00069	0.634
MOD_CK2_1	623	629	PF00069	0.526
MOD_CK2_1	650	656	PF00069	0.618
MOD_CK2_1	70	76	PF00069	0.636
MOD_CMANNOS	120	123	PF00535	0.529
MOD_GlcNHglycan	113	116	PF01048	0.407
MOD_GlcNHglycan	159	162	PF01048	0.682
MOD_GlcNHglycan	165	169	PF01048	0.636
MOD_GlcNHglycan	215	218	PF01048	0.747
MOD_GlcNHglycan	219	222	PF01048	0.700
MOD_GlcNHglycan	323	326	PF01048	0.664
MOD_GlcNHglycan	354	357	PF01048	0.612
MOD_GlcNHglycan	364	367	PF01048	0.584
MOD_GlcNHglycan	382	385	PF01048	0.511
MOD_GlcNHglycan	387	390	PF01048	0.613
MOD_GlcNHglycan	467	470	PF01048	0.794
MOD_GlcNHglycan	485	488	PF01048	0.514
MOD_GlcNHglycan	514	517	PF01048	0.642
MOD_GlcNHglycan	560	563	PF01048	0.641
MOD_GlcNHglycan	645	648	PF01048	0.740
MOD_GlcNHglycan	652	655	PF01048	0.669
MOD_GlcNHglycan	740	743	PF01048	0.627
MOD_GlcNHglycan	76	79	PF01048	0.517
MOD_GSK3_1	133	140	PF00069	0.437
MOD_GSK3_1	213	220	PF00069	0.669
MOD_GSK3_1	311	318	PF00069	0.705
MOD_GSK3_1	358	365	PF00069	0.606
MOD_GSK3_1	376	383	PF00069	0.610
MOD_GSK3_1	419	426	PF00069	0.613
MOD_GSK3_1	428	435	PF00069	0.457
MOD_GSK3_1	474	481	PF00069	0.719
MOD_GSK3_1	49	56	PF00069	0.432
MOD_GSK3_1	540	547	PF00069	0.686
MOD_GSK3_1	558	565	PF00069	0.518
MOD_GSK3_1	597	604	PF00069	0.422
MOD_GSK3_1	643	650	PF00069	0.677
MOD_GSK3_1	686	693	PF00069	0.620
MOD_GSK3_1	70	77	PF00069	0.642
MOD_GSK3_1	705	712	PF00069	0.537
MOD_LATS_1	472	478	PF00433	0.670
MOD_N-GLC_1	643	648	PF02516	0.640
MOD_N-GLC_2	682	684	PF02516	0.509
MOD_NEK2_1	111	116	PF00069	0.538
MOD_NEK2_1	157	162	PF00069	0.679
MOD_NEK2_1	358	363	PF00069	0.651
MOD_NEK2_1	49	54	PF00069	0.527
MOD_NEK2_1	642	647	PF00069	0.684
MOD_NEK2_1	663	668	PF00069	0.451
MOD_NEK2_1	690	695	PF00069	0.536
MOD_NEK2_1	70	75	PF00069	0.468
MOD_NEK2_1	702	707	PF00069	0.395
MOD_NEK2_2	121	126	PF00069	0.585
MOD_NEK2_2	562	567	PF00069	0.586
MOD_OFUCOSY	293	300	PF10250	0.600
MOD_PIKK_1	268	274	PF00454	0.641
MOD_PIKK_1	44	50	PF00454	0.573
MOD_PIKK_1	664	670	PF00454	0.539
MOD_PIKK_1	690	696	PF00454	0.534
MOD_PK_1	133	139	PF00069	0.374
MOD_PKA_2	288	294	PF00069	0.657
MOD_PKA_2	473	479	PF00069	0.723
MOD_PKA_2	552	558	PF00069	0.676
MOD_PKA_2	597	603	PF00069	0.509
MOD_PKA_2	661	667	PF00069	0.492
MOD_PKA_2	702	708	PF00069	0.551
MOD_Plk_1	133	139	PF00069	0.501
MOD_Plk_1	164	170	PF00069	0.596
MOD_Plk_1	474	480	PF00069	0.563
MOD_Plk_1	528	534	PF00069	0.704
MOD_Plk_1	562	568	PF00069	0.582
MOD_Plk_2-3	726	732	PF00069	0.601
MOD_Plk_4	366	372	PF00069	0.644
MOD_Plk_4	462	468	PF00069	0.575
MOD_ProDKin_1	189	195	PF00069	0.605
MOD_ProDKin_1	376	382	PF00069	0.545
MOD_ProDKin_1	491	497	PF00069	0.601
MOD_ProDKin_1	575	581	PF00069	0.663
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.430
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.570
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.600
TRG_ENDOCYTIC_2	103	106	PF00928	0.581
TRG_ENDOCYTIC_2	116	119	PF00928	0.463
TRG_ENDOCYTIC_2	126	129	PF00928	0.605
TRG_ENDOCYTIC_2	198	201	PF00928	0.604
TRG_ENDOCYTIC_2	250	253	PF00928	0.568
TRG_ENDOCYTIC_2	370	373	PF00928	0.548
TRG_ENDOCYTIC_2	605	608	PF00928	0.409
TRG_ENDOCYTIC_2	621	624	PF00928	0.342
TRG_ER_diArg_1	116	118	PF00400	0.511
TRG_ER_diArg_1	28	30	PF00400	0.383
TRG_ER_diArg_1	566	569	PF00400	0.662
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	686	691	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUQ4	Leptomonas seymouri	41%	89%
A0A3S7WZ43	Leishmania donovani	87%	98%
A4HE39	Leishmania braziliensis	67%	87%
A4I1E5	Leishmania infantum	87%	91%
C9ZJW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AXI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	87%