Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9Y9_LEIMA

TriTrypDb:

LmjF.25.1040 , LMJLV39_250017000 , LMJSD75_250016900

Length:

733

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Y9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.568
CLV_C14_Caspase3-7	529	533	PF00656	0.626
CLV_C14_Caspase3-7	560	564	PF00656	0.667
CLV_C14_Caspase3-7	638	642	PF00656	0.676
CLV_C14_Caspase3-7	98	102	PF00656	0.486
CLV_NRD_NRD_1	307	309	PF00675	0.507
CLV_NRD_NRD_1	322	324	PF00675	0.454
CLV_NRD_NRD_1	365	367	PF00675	0.629
CLV_NRD_NRD_1	446	448	PF00675	0.685
CLV_NRD_NRD_1	481	483	PF00675	0.686
CLV_NRD_NRD_1	513	515	PF00675	0.658
CLV_NRD_NRD_1	548	550	PF00675	0.553
CLV_NRD_NRD_1	582	584	PF00675	0.620
CLV_NRD_NRD_1	601	603	PF00675	0.643
CLV_NRD_NRD_1	650	652	PF00675	0.697
CLV_NRD_NRD_1	654	656	PF00675	0.681
CLV_NRD_NRD_1	730	732	PF00675	0.461
CLV_PCSK_FUR_1	510	514	PF00082	0.666
CLV_PCSK_KEX2_1	112	114	PF00082	0.493
CLV_PCSK_KEX2_1	307	309	PF00082	0.507
CLV_PCSK_KEX2_1	322	324	PF00082	0.454
CLV_PCSK_KEX2_1	364	366	PF00082	0.536
CLV_PCSK_KEX2_1	480	482	PF00082	0.685
CLV_PCSK_KEX2_1	512	514	PF00082	0.664
CLV_PCSK_KEX2_1	548	550	PF00082	0.535
CLV_PCSK_KEX2_1	582	584	PF00082	0.620
CLV_PCSK_KEX2_1	601	603	PF00082	0.643
CLV_PCSK_KEX2_1	649	651	PF00082	0.833
CLV_PCSK_KEX2_1	654	656	PF00082	0.782
CLV_PCSK_KEX2_1	701	703	PF00082	0.741
CLV_PCSK_KEX2_1	730	732	PF00082	0.501
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.607
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.669
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.598
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.741
CLV_PCSK_PC7_1	477	483	PF00082	0.653
CLV_PCSK_PC7_1	650	656	PF00082	0.696
CLV_PCSK_SKI1_1	134	138	PF00082	0.431
CLV_PCSK_SKI1_1	141	145	PF00082	0.431
CLV_PCSK_SKI1_1	209	213	PF00082	0.651
CLV_PCSK_SKI1_1	352	356	PF00082	0.574
CLV_PCSK_SKI1_1	377	381	PF00082	0.608
CLV_PCSK_SKI1_1	513	517	PF00082	0.614
CLV_PCSK_SKI1_1	678	682	PF00082	0.473
CLV_Separin_Metazoa	675	679	PF03568	0.486
DEG_APCC_DBOX_1	512	520	PF00400	0.673
DEG_APCC_DBOX_1	677	685	PF00400	0.479
DEG_SPOP_SBC_1	13	17	PF00917	0.601
DEG_SPOP_SBC_1	573	577	PF00917	0.700
DEG_SPOP_SBC_1	615	619	PF00917	0.557
DOC_ANK_TNKS_1	527	534	PF00023	0.688
DOC_CYCLIN_RxL_1	675	685	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	391	397	PF00134	0.668
DOC_MAPK_gen_1	134	142	PF00069	0.429
DOC_PP2B_LxvP_1	277	280	PF13499	0.660
DOC_PP2B_LxvP_1	4	7	PF13499	0.637
DOC_PP2B_LxvP_1	535	538	PF13499	0.664
DOC_PP4_FxxP_1	508	511	PF00568	0.563
DOC_USP7_MATH_1	11	15	PF00917	0.654
DOC_USP7_MATH_1	303	307	PF00917	0.651
DOC_USP7_MATH_1	35	39	PF00917	0.664
DOC_USP7_MATH_1	488	492	PF00917	0.726
DOC_USP7_MATH_1	518	522	PF00917	0.728
DOC_USP7_MATH_1	573	577	PF00917	0.700
DOC_USP7_MATH_1	596	600	PF00917	0.578
DOC_USP7_MATH_1	616	620	PF00917	0.601
DOC_USP7_MATH_1	624	628	PF00917	0.595
DOC_USP7_MATH_1	705	709	PF00917	0.675
DOC_USP7_UBL2_3	137	141	PF12436	0.417
DOC_WW_Pin1_4	201	206	PF00397	0.622
DOC_WW_Pin1_4	232	237	PF00397	0.571
DOC_WW_Pin1_4	275	280	PF00397	0.664
DOC_WW_Pin1_4	390	395	PF00397	0.757
DOC_WW_Pin1_4	423	428	PF00397	0.731
DOC_WW_Pin1_4	441	446	PF00397	0.522
DOC_WW_Pin1_4	47	52	PF00397	0.650
DOC_WW_Pin1_4	539	544	PF00397	0.583
LIG_14-3-3_CanoR_1	105	114	PF00244	0.351
LIG_14-3-3_CanoR_1	24	30	PF00244	0.748
LIG_14-3-3_CanoR_1	268	277	PF00244	0.704
LIG_14-3-3_CanoR_1	55	62	PF00244	0.716
LIG_14-3-3_CanoR_1	601	605	PF00244	0.625
LIG_14-3-3_CanoR_1	614	623	PF00244	0.558
LIG_14-3-3_CanoR_1	635	640	PF00244	0.689
LIG_14-3-3_CanoR_1	704	710	PF00244	0.668
LIG_14-3-3_CanoR_1	89	94	PF00244	0.480
LIG_BIR_III_4	255	259	PF00653	0.562
LIG_BRCT_BRCA1_1	150	154	PF00533	0.452
LIG_FHA_1	595	601	PF00498	0.648
LIG_FHA_2	269	275	PF00498	0.699
LIG_FHA_2	353	359	PF00498	0.555
LIG_FHA_2	469	475	PF00498	0.611
LIG_FHA_2	527	533	PF00498	0.685
LIG_FHA_2	616	622	PF00498	0.566
LIG_FHA_2	636	642	PF00498	0.514
LIG_FHA_2	710	716	PF00498	0.525
LIG_FHA_2	75	81	PF00498	0.487
LIG_HCF-1_HBM_1	406	409	PF13415	0.622
LIG_LIR_Apic_2	406	412	PF02991	0.688
LIG_LIR_Apic_2	507	511	PF02991	0.564
LIG_LIR_Gen_1	228	239	PF02991	0.671
LIG_LIR_Gen_1	603	610	PF02991	0.538
LIG_LIR_Nem_3	228	233	PF02991	0.602
LIG_LIR_Nem_3	603	609	PF02991	0.540
LIG_LYPXL_SIV_4	309	317	PF13949	0.470
LIG_NRBOX	399	405	PF00104	0.537
LIG_NRBOX	676	682	PF00104	0.554
LIG_Rb_pABgroove_1	91	99	PF01858	0.449
LIG_RPA_C_Fungi	597	609	PF08784	0.544
LIG_SH2_CRK	130	134	PF00017	0.525
LIG_SH2_CRK	409	413	PF00017	0.794
LIG_SH2_GRB2like	338	341	PF00017	0.578
LIG_SH2_NCK_1	541	545	PF00017	0.489
LIG_SH2_PTP2	146	149	PF00017	0.429
LIG_SH2_STAP1	225	229	PF00017	0.602
LIG_SH2_STAP1	338	342	PF00017	0.485
LIG_SH2_STAP1	606	610	PF00017	0.573
LIG_SH2_STAP1	71	75	PF00017	0.475
LIG_SH2_STAT5	146	149	PF00017	0.429
LIG_SH3_1	415	421	PF00018	0.695
LIG_SH3_2	418	423	PF14604	0.664
LIG_SH3_2	645	650	PF14604	0.682
LIG_SH3_3	230	236	PF00018	0.576
LIG_SH3_3	415	421	PF00018	0.695
LIG_SH3_3	428	434	PF00018	0.577
LIG_SH3_3	439	445	PF00018	0.630
LIG_SH3_3	642	648	PF00018	0.680
LIG_SH3_3	694	700	PF00018	0.711
LIG_SUMO_SIM_par_1	283	290	PF11976	0.591
LIG_SUMO_SIM_par_1	323	328	PF11976	0.463
LIG_TYR_ITIM	604	609	PF00017	0.541
LIG_WW_3	432	436	PF00397	0.602
MOD_CDC14_SPxK_1	444	447	PF00782	0.646
MOD_CDK_SPxK_1	441	447	PF00069	0.653
MOD_CDK_SPxxK_3	441	448	PF00069	0.653
MOD_CK1_1	12	18	PF00069	0.750
MOD_CK1_1	152	158	PF00069	0.462
MOD_CK1_1	244	250	PF00069	0.684
MOD_CK1_1	38	44	PF00069	0.656
MOD_CK1_1	422	428	PF00069	0.747
MOD_CK1_1	465	471	PF00069	0.721
MOD_CK1_1	50	56	PF00069	0.615
MOD_CK1_1	521	527	PF00069	0.697
MOD_CK1_1	575	581	PF00069	0.743
MOD_CK1_1	627	633	PF00069	0.578
MOD_CK1_1	679	685	PF00069	0.475
MOD_CK2_1	268	274	PF00069	0.699
MOD_CK2_1	296	302	PF00069	0.578
MOD_CK2_1	352	358	PF00069	0.555
MOD_CK2_1	46	52	PF00069	0.661
MOD_CK2_1	615	621	PF00069	0.563
MOD_CK2_1	679	685	PF00069	0.475
MOD_CK2_1	74	80	PF00069	0.488
MOD_GlcNHglycan	11	14	PF01048	0.745
MOD_GlcNHglycan	171	174	PF01048	0.560
MOD_GlcNHglycan	189	192	PF01048	0.602
MOD_GlcNHglycan	243	246	PF01048	0.754
MOD_GlcNHglycan	299	302	PF01048	0.597
MOD_GlcNHglycan	466	471	PF01048	0.686
MOD_GlcNHglycan	490	493	PF01048	0.783
MOD_GlcNHglycan	523	526	PF01048	0.648
MOD_GlcNHglycan	578	581	PF01048	0.714
MOD_GlcNHglycan	618	621	PF01048	0.649
MOD_GlcNHglycan	626	629	PF01048	0.620
MOD_GlcNHglycan	657	660	PF01048	0.648
MOD_GSK3_1	148	155	PF00069	0.434
MOD_GSK3_1	197	204	PF00069	0.549
MOD_GSK3_1	219	226	PF00069	0.673
MOD_GSK3_1	240	247	PF00069	0.649
MOD_GSK3_1	283	290	PF00069	0.681
MOD_GSK3_1	35	42	PF00069	0.603
MOD_GSK3_1	375	382	PF00069	0.763
MOD_GSK3_1	419	426	PF00069	0.746
MOD_GSK3_1	458	465	PF00069	0.802
MOD_GSK3_1	46	53	PF00069	0.658
MOD_GSK3_1	468	475	PF00069	0.610
MOD_GSK3_1	488	495	PF00069	0.827
MOD_GSK3_1	572	579	PF00069	0.758
MOD_GSK3_1	596	603	PF00069	0.672
MOD_GSK3_1	610	617	PF00069	0.550
MOD_GSK3_1	627	634	PF00069	0.573
MOD_GSK3_1	7	14	PF00069	0.692
MOD_GSK3_1	70	77	PF00069	0.559
MOD_GSK3_1	705	712	PF00069	0.729
MOD_LATS_1	612	618	PF00433	0.654
MOD_N-GLC_1	103	108	PF02516	0.543
MOD_N-GLC_1	152	157	PF02516	0.406
MOD_N-GLC_1	472	477	PF02516	0.634
MOD_N-GLC_1	521	526	PF02516	0.571
MOD_N-GLC_2	264	266	PF02516	0.553
MOD_NEK2_1	129	134	PF00069	0.527
MOD_NEK2_1	149	154	PF00069	0.279
MOD_NEK2_1	296	301	PF00069	0.499
MOD_NEK2_1	327	332	PF00069	0.496
MOD_NEK2_1	610	615	PF00069	0.685
MOD_NEK2_1	676	681	PF00069	0.534
MOD_NEK2_2	596	601	PF00069	0.621
MOD_PIKK_1	15	21	PF00454	0.742
MOD_PIKK_1	219	225	PF00454	0.676
MOD_PIKK_1	244	250	PF00454	0.634
MOD_PIKK_1	35	41	PF00454	0.609
MOD_PIKK_1	563	569	PF00454	0.625
MOD_PIKK_1	705	711	PF00454	0.691
MOD_PKA_1	649	655	PF00069	0.644
MOD_PKA_2	182	188	PF00069	0.604
MOD_PKA_2	197	203	PF00069	0.546
MOD_PKA_2	23	29	PF00069	0.726
MOD_PKA_2	267	273	PF00069	0.644
MOD_PKA_2	504	510	PF00069	0.667
MOD_PKA_2	600	606	PF00069	0.626
MOD_PKA_2	649	655	PF00069	0.839
MOD_PKB_1	113	121	PF00069	0.485
MOD_PKB_1	633	641	PF00069	0.691
MOD_Plk_1	103	109	PF00069	0.543
MOD_Plk_1	352	358	PF00069	0.481
MOD_Plk_4	504	510	PF00069	0.560
MOD_ProDKin_1	201	207	PF00069	0.623
MOD_ProDKin_1	232	238	PF00069	0.576
MOD_ProDKin_1	275	281	PF00069	0.667
MOD_ProDKin_1	390	396	PF00069	0.745
MOD_ProDKin_1	423	429	PF00069	0.731
MOD_ProDKin_1	441	447	PF00069	0.522
MOD_ProDKin_1	47	53	PF00069	0.647
MOD_ProDKin_1	539	545	PF00069	0.574
MOD_SUMO_for_1	136	139	PF00179	0.425
MOD_SUMO_for_1	356	359	PF00179	0.569
MOD_SUMO_rev_2	109	114	PF00179	0.545
MOD_SUMO_rev_2	708	714	PF00179	0.656
TRG_DiLeu_BaEn_1	292	297	PF01217	0.601
TRG_ENDOCYTIC_2	130	133	PF00928	0.432
TRG_ENDOCYTIC_2	146	149	PF00928	0.429
TRG_ENDOCYTIC_2	310	313	PF00928	0.477
TRG_ENDOCYTIC_2	606	609	PF00928	0.541
TRG_ENDOCYTIC_2	97	100	PF00928	0.455
TRG_ER_diArg_1	322	324	PF00400	0.556
TRG_ER_diArg_1	364	366	PF00400	0.596
TRG_ER_diArg_1	480	482	PF00400	0.684
TRG_ER_diArg_1	513	515	PF00400	0.642
TRG_ER_diArg_1	548	550	PF00400	0.615
TRG_ER_diArg_1	582	585	PF00400	0.681
TRG_ER_diArg_1	600	602	PF00400	0.471
TRG_ER_diArg_1	633	636	PF00400	0.762
TRG_ER_diArg_1	702	705	PF00400	0.686
TRG_NES_CRM1_1	148	163	PF08389	0.527
TRG_NLS_MonoExtC_3	700	705	PF00514	0.684
TRG_NLS_MonoExtN_4	510	516	PF00514	0.641
TRG_NLS_MonoExtN_4	648	653	PF00514	0.581
TRG_NLS_MonoExtN_4	698	705	PF00514	0.675
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	602	607	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T6	Leptomonas seymouri	39%	92%
A0A3Q8ICB6	Leishmania donovani	86%	100%
A4HE40	Leishmania braziliensis	60%	81%
A4I1E6	Leishmania infantum	86%	76%
E9AXI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%