Ubiquitinyl hydrolase 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9Y7_LEIMA

TriTrypDb:

LmjF.25.1060 , LMJLV39_250017200 , LMJSD75_250017100

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.651
CLV_C14_Caspase3-7	370	374	PF00656	0.456
CLV_C14_Caspase3-7	41	45	PF00656	0.485
CLV_C14_Caspase3-7	681	685	PF00656	0.696
CLV_C14_Caspase3-7	718	722	PF00656	0.655
CLV_NRD_NRD_1	617	619	PF00675	0.630
CLV_NRD_NRD_1	64	66	PF00675	0.475
CLV_NRD_NRD_1	663	665	PF00675	0.763
CLV_PCSK_KEX2_1	344	346	PF00082	0.480
CLV_PCSK_KEX2_1	364	366	PF00082	0.527
CLV_PCSK_KEX2_1	483	485	PF00082	0.644
CLV_PCSK_KEX2_1	64	66	PF00082	0.475
CLV_PCSK_KEX2_1	663	665	PF00082	0.763
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.480
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.527
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.644
CLV_PCSK_SKI1_1	245	249	PF00082	0.727
CLV_PCSK_SKI1_1	266	270	PF00082	0.747
CLV_PCSK_SKI1_1	480	484	PF00082	0.684
CLV_PCSK_SKI1_1	508	512	PF00082	0.690
CLV_PCSK_SKI1_1	513	517	PF00082	0.694
DEG_APCC_DBOX_1	507	515	PF00400	0.541
DEG_SCF_FBW7_1	324	331	PF00400	0.639
DEG_SPOP_SBC_1	165	169	PF00917	0.587
DOC_CDC14_PxL_1	516	524	PF14671	0.613
DOC_CKS1_1	260	265	PF01111	0.697
DOC_CKS1_1	325	330	PF01111	0.768
DOC_CKS1_1	523	528	PF01111	0.656
DOC_MAPK_gen_1	607	617	PF00069	0.635
DOC_MAPK_gen_1	666	675	PF00069	0.710
DOC_MAPK_MEF2A_6	171	178	PF00069	0.587
DOC_MAPK_MEF2A_6	517	524	PF00069	0.639
DOC_MAPK_MEF2A_6	610	617	PF00069	0.638
DOC_MAPK_NFAT4_5	171	179	PF00069	0.584
DOC_PP2B_LxvP_1	235	238	PF13499	0.636
DOC_PP2B_LxvP_1	3	6	PF13499	0.568
DOC_USP7_MATH_1	165	169	PF00917	0.643
DOC_USP7_MATH_1	183	187	PF00917	0.540
DOC_USP7_MATH_1	38	42	PF00917	0.507
DOC_USP7_MATH_1	453	457	PF00917	0.693
DOC_USP7_MATH_1	538	542	PF00917	0.683
DOC_USP7_MATH_1	699	703	PF00917	0.695
DOC_USP7_UBL2_3	513	517	PF12436	0.582
DOC_WW_Pin1_4	249	254	PF00397	0.806
DOC_WW_Pin1_4	259	264	PF00397	0.733
DOC_WW_Pin1_4	299	304	PF00397	0.695
DOC_WW_Pin1_4	315	320	PF00397	0.666
DOC_WW_Pin1_4	324	329	PF00397	0.563
DOC_WW_Pin1_4	522	527	PF00397	0.653
DOC_WW_Pin1_4	530	535	PF00397	0.610
DOC_WW_Pin1_4	567	572	PF00397	0.699
DOC_WW_Pin1_4	583	588	PF00397	0.542
DOC_WW_Pin1_4	666	671	PF00397	0.675
LIG_14-3-3_CanoR_1	254	260	PF00244	0.748
LIG_14-3-3_CanoR_1	264	272	PF00244	0.672
LIG_14-3-3_CanoR_1	563	571	PF00244	0.665
LIG_14-3-3_CanoR_1	598	602	PF00244	0.663
LIG_14-3-3_CanoR_1	610	616	PF00244	0.566
LIG_BIR_III_4	373	377	PF00653	0.481
LIG_BIR_III_4	721	725	PF00653	0.539
LIG_BRCT_BRCA1_1	7	11	PF00533	0.667
LIG_EH_1	751	755	PF12763	0.639
LIG_FHA_1	393	399	PF00498	0.455
LIG_FHA_1	421	427	PF00498	0.478
LIG_FHA_1	523	529	PF00498	0.620
LIG_FHA_1	555	561	PF00498	0.653
LIG_FHA_1	573	579	PF00498	0.543
LIG_FHA_1	656	662	PF00498	0.720
LIG_FHA_1	711	717	PF00498	0.651
LIG_FHA_2	167	173	PF00498	0.668
LIG_FHA_2	197	203	PF00498	0.651
LIG_FHA_2	205	211	PF00498	0.622
LIG_FHA_2	279	285	PF00498	0.655
LIG_FHA_2	405	411	PF00498	0.512
LIG_FHA_2	423	429	PF00498	0.340
LIG_FHA_2	485	491	PF00498	0.580
LIG_FHA_2	736	742	PF00498	0.651
LIG_LIR_Apic_2	269	275	PF02991	0.682
LIG_LIR_Gen_1	27	34	PF02991	0.496
LIG_LIR_Gen_1	350	360	PF02991	0.477
LIG_LIR_Gen_1	378	389	PF02991	0.482
LIG_LIR_Gen_1	49	56	PF02991	0.471
LIG_LIR_Gen_1	707	716	PF02991	0.615
LIG_LIR_Gen_1	71	78	PF02991	0.456
LIG_LIR_Nem_3	27	32	PF02991	0.495
LIG_LIR_Nem_3	350	355	PF02991	0.464
LIG_LIR_Nem_3	378	384	PF02991	0.487
LIG_LIR_Nem_3	49	54	PF02991	0.467
LIG_LIR_Nem_3	591	595	PF02991	0.582
LIG_LIR_Nem_3	71	76	PF02991	0.494
LIG_PTAP_UEV_1	586	591	PF05743	0.638
LIG_SH2_CRK	272	276	PF00017	0.681
LIG_SH2_CRK	531	535	PF00017	0.646
LIG_SH2_CRK	592	596	PF00017	0.661
LIG_SH2_GRB2like	157	160	PF00017	0.608
LIG_SH2_GRB2like	648	651	PF00017	0.657
LIG_SH2_NCK_1	736	740	PF00017	0.693
LIG_SH2_PTP2	381	384	PF00017	0.506
LIG_SH2_SRC	157	160	PF00017	0.608
LIG_SH2_SRC	549	552	PF00017	0.650
LIG_SH2_STAP1	157	161	PF00017	0.690
LIG_SH2_STAP1	420	424	PF00017	0.595
LIG_SH2_STAP1	564	568	PF00017	0.619
LIG_SH2_STAT5	233	236	PF00017	0.574
LIG_SH2_STAT5	381	384	PF00017	0.506
LIG_SH2_STAT5	549	552	PF00017	0.650
LIG_SH2_STAT5	709	712	PF00017	0.650
LIG_SH3_3	257	263	PF00018	0.693
LIG_SH3_3	584	590	PF00018	0.643
LIG_SH3_3	598	604	PF00018	0.537
LIG_SH3_3	743	749	PF00018	0.641
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.483
LIG_SUMO_SIM_par_1	421	428	PF11976	0.508
LIG_TRAF2_1	121	124	PF00917	0.498
LIG_TRAF2_1	143	146	PF00917	0.582
LIG_TRAF2_1	148	151	PF00917	0.620
LIG_TRAF2_1	207	210	PF00917	0.770
LIG_TRAF2_1	281	284	PF00917	0.667
LIG_TRAF2_1	33	36	PF00917	0.514
LIG_TRAF2_1	55	58	PF00917	0.502
LIG_TRAF2_1	686	689	PF00917	0.750
LIG_TRAF2_1	77	80	PF00917	0.549
LIG_TRAF2_1	99	102	PF00917	0.498
LIG_TRFH_1	233	237	PF08558	0.648
LIG_UBA3_1	510	517	PF00899	0.563
LIG_WRC_WIRS_1	26	31	PF05994	0.507
LIG_WRC_WIRS_1	48	53	PF05994	0.474
LIG_WRC_WIRS_1	70	75	PF05994	0.457
MOD_CDK_SPK_2	249	254	PF00069	0.719
MOD_CDK_SPK_2	259	264	PF00069	0.619
MOD_CDK_SPK_2	522	527	PF00069	0.653
MOD_CDK_SPK_2	530	535	PF00069	0.610
MOD_CDK_SPxK_1	567	573	PF00069	0.663
MOD_CDK_SPxxK_3	259	266	PF00069	0.715
MOD_CK1_1	116	122	PF00069	0.576
MOD_CK1_1	138	144	PF00069	0.749
MOD_CK1_1	160	166	PF00069	0.715
MOD_CK1_1	186	192	PF00069	0.697
MOD_CK1_1	219	225	PF00069	0.636
MOD_CK1_1	240	246	PF00069	0.755
MOD_CK1_1	255	261	PF00069	0.799
MOD_CK1_1	267	273	PF00069	0.721
MOD_CK1_1	28	34	PF00069	0.575
MOD_CK1_1	292	298	PF00069	0.667
MOD_CK1_1	299	305	PF00069	0.705
MOD_CK1_1	4	10	PF00069	0.782
MOD_CK1_1	448	454	PF00069	0.740
MOD_CK1_1	493	499	PF00069	0.670
MOD_CK1_1	50	56	PF00069	0.555
MOD_CK1_1	562	568	PF00069	0.674
MOD_CK1_1	588	594	PF00069	0.686
MOD_CK1_1	662	668	PF00069	0.722
MOD_CK1_1	72	78	PF00069	0.555
MOD_CK1_1	94	100	PF00069	0.556
MOD_CK2_1	118	124	PF00069	0.571
MOD_CK2_1	140	146	PF00069	0.622
MOD_CK2_1	181	187	PF00069	0.650
MOD_CK2_1	204	210	PF00069	0.704
MOD_CK2_1	278	284	PF00069	0.674
MOD_CK2_1	292	298	PF00069	0.646
MOD_CK2_1	30	36	PF00069	0.614
MOD_CK2_1	404	410	PF00069	0.524
MOD_CK2_1	453	459	PF00069	0.695
MOD_CK2_1	484	490	PF00069	0.581
MOD_CK2_1	52	58	PF00069	0.564
MOD_CK2_1	74	80	PF00069	0.645
MOD_CK2_1	96	102	PF00069	0.571
MOD_Cter_Amidation	62	65	PF01082	0.495
MOD_DYRK1A_RPxSP_1	666	670	PF00069	0.674
MOD_GlcNHglycan	257	260	PF01048	0.823
MOD_GlcNHglycan	266	269	PF01048	0.727
MOD_GlcNHglycan	294	297	PF01048	0.693
MOD_GlcNHglycan	298	301	PF01048	0.650
MOD_GlcNHglycan	3	6	PF01048	0.682
MOD_GlcNHglycan	331	334	PF01048	0.619
MOD_GlcNHglycan	455	458	PF01048	0.628
MOD_GlcNHglycan	492	495	PF01048	0.673
MOD_GlcNHglycan	505	508	PF01048	0.536
MOD_GlcNHglycan	566	569	PF01048	0.671
MOD_GlcNHglycan	587	590	PF01048	0.632
MOD_GlcNHglycan	643	646	PF01048	0.805
MOD_GlcNHglycan	680	683	PF01048	0.782
MOD_GlcNHglycan	699	702	PF01048	0.755
MOD_GSK3_1	1	8	PF00069	0.781
MOD_GSK3_1	160	167	PF00069	0.619
MOD_GSK3_1	255	262	PF00069	0.815
MOD_GSK3_1	264	271	PF00069	0.707
MOD_GSK3_1	292	299	PF00069	0.738
MOD_GSK3_1	324	331	PF00069	0.659
MOD_GSK3_1	351	358	PF00069	0.469
MOD_GSK3_1	392	399	PF00069	0.546
MOD_GSK3_1	499	506	PF00069	0.647
MOD_GSK3_1	554	561	PF00069	0.717
MOD_GSK3_1	563	570	PF00069	0.625
MOD_GSK3_1	572	579	PF00069	0.643
MOD_GSK3_1	581	588	PF00069	0.597
MOD_GSK3_1	593	600	PF00069	0.585
MOD_GSK3_1	655	662	PF00069	0.699
MOD_GSK3_1	676	683	PF00069	0.691
MOD_N-GLC_1	165	170	PF02516	0.667
MOD_N-GLC_1	368	373	PF02516	0.504
MOD_N-GLC_1	490	495	PF02516	0.670
MOD_N-GLC_1	581	586	PF02516	0.666
MOD_N-GLC_1	641	646	PF02516	0.573
MOD_NEK2_1	204	209	PF00069	0.687
MOD_NEK2_1	216	221	PF00069	0.607
MOD_NEK2_1	697	702	PF00069	0.819
MOD_PIKK_1	204	210	PF00454	0.667
MOD_PIKK_1	240	246	PF00454	0.701
MOD_PIKK_1	376	382	PF00454	0.498
MOD_PIKK_1	448	454	PF00454	0.671
MOD_PIKK_1	484	490	PF00454	0.554
MOD_PIKK_1	710	716	PF00454	0.614
MOD_PK_1	351	357	PF00069	0.485
MOD_PK_1	593	599	PF00069	0.630
MOD_PKA_2	202	208	PF00069	0.649
MOD_PKA_2	216	222	PF00069	0.570
MOD_PKA_2	240	246	PF00069	0.782
MOD_PKA_2	562	568	PF00069	0.661
MOD_PKA_2	572	578	PF00069	0.587
MOD_PKA_2	597	603	PF00069	0.686
MOD_PKA_2	633	639	PF00069	0.652
MOD_PKA_2	662	668	PF00069	0.716
MOD_PKB_1	264	272	PF00069	0.726
MOD_Plk_1	157	163	PF00069	0.662
MOD_Plk_1	186	192	PF00069	0.697
MOD_Plk_1	396	402	PF00069	0.399
MOD_Plk_1	420	426	PF00069	0.466
MOD_Plk_1	538	544	PF00069	0.657
MOD_Plk_2-3	684	690	PF00069	0.729
MOD_Plk_4	289	295	PF00069	0.582
MOD_Plk_4	351	357	PF00069	0.462
MOD_Plk_4	543	549	PF00069	0.690
MOD_ProDKin_1	249	255	PF00069	0.807
MOD_ProDKin_1	259	265	PF00069	0.733
MOD_ProDKin_1	299	305	PF00069	0.697
MOD_ProDKin_1	315	321	PF00069	0.668
MOD_ProDKin_1	324	330	PF00069	0.563
MOD_ProDKin_1	522	528	PF00069	0.654
MOD_ProDKin_1	530	536	PF00069	0.612
MOD_ProDKin_1	567	573	PF00069	0.703
MOD_ProDKin_1	583	589	PF00069	0.541
MOD_ProDKin_1	666	672	PF00069	0.677
MOD_SUMO_rev_2	105	114	PF00179	0.535
MOD_SUMO_rev_2	127	136	PF00179	0.517
MOD_SUMO_rev_2	17	26	PF00179	0.575
MOD_SUMO_rev_2	39	48	PF00179	0.544
MOD_SUMO_rev_2	410	416	PF00179	0.525
MOD_SUMO_rev_2	61	70	PF00179	0.549
MOD_SUMO_rev_2	83	92	PF00179	0.534
TRG_DiLeu_BaEn_1	289	294	PF01217	0.580
TRG_DiLeu_BaEn_4	150	156	PF01217	0.649
TRG_ENDOCYTIC_2	381	384	PF00928	0.506
TRG_ENDOCYTIC_2	592	595	PF00928	0.664
TRG_ENDOCYTIC_2	709	712	PF00928	0.650
TRG_ER_diArg_1	263	266	PF00400	0.726
TRG_ER_diArg_1	663	666	PF00400	0.693
TRG_NLS_MonoExtC_3	479	484	PF00514	0.688
TRG_NLS_MonoExtN_4	479	484	PF00514	0.687
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF98	Leishmania donovani	81%	89%
A4HE42	Leishmania braziliensis	38%	100%
A4I1E8	Leishmania infantum	80%	89%
E9AXI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	81%