Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9Y6_LEIMA

TriTrypDb:

LmjF.25.1070 , LMJLV39_250017300 , LMJSD75_250017200

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Y6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.593
CLV_C14_Caspase3-7	263	267	PF00656	0.607
CLV_C14_Caspase3-7	595	599	PF00656	0.489
CLV_C14_Caspase3-7	777	781	PF00656	0.448
CLV_NRD_NRD_1	104	106	PF00675	0.691
CLV_NRD_NRD_1	328	330	PF00675	0.625
CLV_NRD_NRD_1	331	333	PF00675	0.599
CLV_NRD_NRD_1	357	359	PF00675	0.632
CLV_NRD_NRD_1	385	387	PF00675	0.674
CLV_NRD_NRD_1	56	58	PF00675	0.663
CLV_NRD_NRD_1	629	631	PF00675	0.575
CLV_NRD_NRD_1	637	639	PF00675	0.682
CLV_NRD_NRD_1	725	727	PF00675	0.599
CLV_NRD_NRD_1	856	858	PF00675	0.499
CLV_PCSK_FUR_1	329	333	PF00082	0.611
CLV_PCSK_FUR_1	54	58	PF00082	0.664
CLV_PCSK_KEX2_1	104	106	PF00082	0.691
CLV_PCSK_KEX2_1	328	330	PF00082	0.625
CLV_PCSK_KEX2_1	331	333	PF00082	0.599
CLV_PCSK_KEX2_1	355	357	PF00082	0.531
CLV_PCSK_KEX2_1	384	386	PF00082	0.684
CLV_PCSK_KEX2_1	416	418	PF00082	0.626
CLV_PCSK_KEX2_1	512	514	PF00082	0.489
CLV_PCSK_KEX2_1	56	58	PF00082	0.663
CLV_PCSK_KEX2_1	629	631	PF00082	0.575
CLV_PCSK_KEX2_1	637	639	PF00082	0.501
CLV_PCSK_KEX2_1	725	727	PF00082	0.566
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.531
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.684
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.626
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.489
CLV_PCSK_PC7_1	380	386	PF00082	0.619
CLV_PCSK_SKI1_1	187	191	PF00082	0.548
CLV_PCSK_SKI1_1	306	310	PF00082	0.500
CLV_PCSK_SKI1_1	385	389	PF00082	0.677
CLV_PCSK_SKI1_1	509	513	PF00082	0.585
CLV_PCSK_SKI1_1	552	556	PF00082	0.515
CLV_PCSK_SKI1_1	615	619	PF00082	0.443
CLV_PCSK_SKI1_1	659	663	PF00082	0.565
CLV_PCSK_SKI1_1	747	751	PF00082	0.508
CLV_PCSK_SKI1_1	754	758	PF00082	0.402
DEG_APCC_DBOX_1	479	487	PF00400	0.471
DEG_APCC_DBOX_1	746	754	PF00400	0.387
DEG_ODPH_VHL_1	145	156	PF01847	0.603
DEG_SCF_FBW7_1	833	839	PF00400	0.552
DOC_CKS1_1	255	260	PF01111	0.575
DOC_CKS1_1	452	457	PF01111	0.527
DOC_CKS1_1	833	838	PF01111	0.555
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.502
DOC_MAPK_gen_1	310	318	PF00069	0.487
DOC_MAPK_gen_1	491	500	PF00069	0.508
DOC_MAPK_gen_1	805	815	PF00069	0.585
DOC_MAPK_HePTP_8	554	566	PF00069	0.499
DOC_MAPK_MEF2A_6	131	139	PF00069	0.634
DOC_MAPK_MEF2A_6	557	566	PF00069	0.560
DOC_MAPK_MEF2A_6	808	817	PF00069	0.610
DOC_PP1_RVXF_1	628	635	PF00149	0.466
DOC_PP2B_LxvP_1	459	462	PF13499	0.433
DOC_PP2B_LxvP_1	538	541	PF13499	0.600
DOC_PP4_FxxP_1	452	455	PF00568	0.512
DOC_USP7_MATH_1	372	376	PF00917	0.714
DOC_USP7_MATH_1	405	409	PF00917	0.616
DOC_USP7_MATH_1	721	725	PF00917	0.486
DOC_USP7_MATH_1	823	827	PF00917	0.618
DOC_USP7_MATH_1	842	846	PF00917	0.717
DOC_USP7_MATH_2	50	56	PF00917	0.626
DOC_USP7_UBL2_3	306	310	PF12436	0.465
DOC_USP7_UBL2_3	512	516	PF12436	0.445
DOC_WW_Pin1_4	11	16	PF00397	0.684
DOC_WW_Pin1_4	113	118	PF00397	0.632
DOC_WW_Pin1_4	20	25	PF00397	0.556
DOC_WW_Pin1_4	254	259	PF00397	0.597
DOC_WW_Pin1_4	368	373	PF00397	0.615
DOC_WW_Pin1_4	385	390	PF00397	0.561
DOC_WW_Pin1_4	427	432	PF00397	0.571
DOC_WW_Pin1_4	435	440	PF00397	0.614
DOC_WW_Pin1_4	451	456	PF00397	0.523
DOC_WW_Pin1_4	555	560	PF00397	0.553
DOC_WW_Pin1_4	806	811	PF00397	0.589
DOC_WW_Pin1_4	819	824	PF00397	0.645
DOC_WW_Pin1_4	832	837	PF00397	0.641
DOC_WW_Pin1_4	88	93	PF00397	0.624
LIG_14-3-3_CanoR_1	109	113	PF00244	0.707
LIG_14-3-3_CanoR_1	187	195	PF00244	0.552
LIG_14-3-3_CanoR_1	220	224	PF00244	0.621
LIG_14-3-3_CanoR_1	235	242	PF00244	0.538
LIG_14-3-3_CanoR_1	319	326	PF00244	0.590
LIG_14-3-3_CanoR_1	33	42	PF00244	0.571
LIG_14-3-3_CanoR_1	542	550	PF00244	0.712
LIG_14-3-3_CanoR_1	552	561	PF00244	0.563
LIG_14-3-3_CanoR_1	586	591	PF00244	0.626
LIG_14-3-3_CanoR_1	808	814	PF00244	0.582
LIG_14-3-3_CanoR_1	824	828	PF00244	0.597
LIG_14-3-3_CanoR_1	840	850	PF00244	0.578
LIG_APCC_ABBA_1	562	567	PF00400	0.579
LIG_BRCT_BRCA1_1	150	154	PF00533	0.616
LIG_BRCT_BRCA1_1	164	168	PF00533	0.628
LIG_BRCT_BRCA1_1	182	186	PF00533	0.612
LIG_BRCT_BRCA1_1	221	225	PF00533	0.609
LIG_FHA_1	124	130	PF00498	0.679
LIG_FHA_1	255	261	PF00498	0.641
LIG_FHA_1	556	562	PF00498	0.680
LIG_FHA_1	6	12	PF00498	0.640
LIG_FHA_1	810	816	PF00498	0.625
LIG_FHA_2	331	337	PF00498	0.654
LIG_FHA_2	404	410	PF00498	0.611
LIG_FHA_2	44	50	PF00498	0.668
LIG_FHA_2	500	506	PF00498	0.383
LIG_FHA_2	660	666	PF00498	0.549
LIG_LIR_Gen_1	313	320	PF02991	0.488
LIG_LIR_Gen_1	443	452	PF02991	0.510
LIG_LIR_Gen_1	848	856	PF02991	0.577
LIG_LIR_Nem_3	183	189	PF02991	0.570
LIG_LIR_Nem_3	313	318	PF02991	0.517
LIG_LIR_Nem_3	443	447	PF02991	0.519
LIG_LIR_Nem_3	848	854	PF02991	0.556
LIG_PTAP_UEV_1	438	443	PF05743	0.582
LIG_Rb_LxCxE_1	464	476	PF01857	0.452
LIG_SH2_CRK	315	319	PF00017	0.536
LIG_SH2_CRK	673	677	PF00017	0.464
LIG_SH2_NCK_1	77	81	PF00017	0.639
LIG_SH2_STAP1	576	580	PF00017	0.562
LIG_SH2_STAP1	604	608	PF00017	0.509
LIG_SH2_STAP1	673	677	PF00017	0.464
LIG_SH2_STAP1	697	701	PF00017	0.515
LIG_SH2_STAP1	732	736	PF00017	0.452
LIG_SH2_STAT3	565	568	PF00017	0.522
LIG_SH2_STAT5	565	568	PF00017	0.548
LIG_SH3_1	436	442	PF00018	0.631
LIG_SH3_1	77	83	PF00018	0.635
LIG_SH3_3	129	135	PF00018	0.611
LIG_SH3_3	250	256	PF00018	0.633
LIG_SH3_3	436	442	PF00018	0.591
LIG_SH3_3	77	83	PF00018	0.614
LIG_SUMO_SIM_par_1	586	595	PF11976	0.602
LIG_TRAF2_1	179	182	PF00917	0.597
LIG_TRAF2_1	300	303	PF00917	0.475
LIG_TRAF2_1	432	435	PF00917	0.592
LIG_TRAF2_1	742	745	PF00917	0.525
LIG_TRAF2_1	770	773	PF00917	0.443
LIG_WW_3	101	105	PF00397	0.678
MOD_CDK_SPK_2	113	118	PF00069	0.632
MOD_CDK_SPK_2	819	824	PF00069	0.647
MOD_CDK_SPK_2	88	93	PF00069	0.630
MOD_CDK_SPxxK_3	254	261	PF00069	0.572
MOD_CDK_SPxxK_3	88	95	PF00069	0.655
MOD_CK1_1	108	114	PF00069	0.634
MOD_CK1_1	148	154	PF00069	0.718
MOD_CK1_1	16	22	PF00069	0.649
MOD_CK1_1	237	243	PF00069	0.797
MOD_CK1_1	334	340	PF00069	0.623
MOD_CK1_1	36	42	PF00069	0.649
MOD_CK1_1	371	377	PF00069	0.681
MOD_CK1_1	391	397	PF00069	0.727
MOD_CK1_1	426	432	PF00069	0.611
MOD_CK1_1	43	49	PF00069	0.620
MOD_CK1_1	543	549	PF00069	0.620
MOD_CK1_1	589	595	PF00069	0.554
MOD_CK1_1	809	815	PF00069	0.798
MOD_CK2_1	319	325	PF00069	0.599
MOD_CK2_1	330	336	PF00069	0.593
MOD_CK2_1	403	409	PF00069	0.607
MOD_CK2_1	429	435	PF00069	0.570
MOD_CK2_1	43	49	PF00069	0.680
MOD_CK2_1	499	505	PF00069	0.586
MOD_CK2_1	589	595	PF00069	0.578
MOD_CK2_1	596	602	PF00069	0.443
MOD_CK2_1	659	665	PF00069	0.509
MOD_CK2_1	711	717	PF00069	0.614
MOD_CK2_1	739	745	PF00069	0.577
MOD_CK2_1	767	773	PF00069	0.504
MOD_DYRK1A_RPxSP_1	819	823	PF00069	0.656
MOD_GlcNHglycan	26	29	PF01048	0.811
MOD_GlcNHglycan	266	270	PF01048	0.601
MOD_GlcNHglycan	336	339	PF01048	0.588
MOD_GlcNHglycan	368	371	PF01048	0.655
MOD_GlcNHglycan	376	379	PF01048	0.632
MOD_GlcNHglycan	390	393	PF01048	0.547
MOD_GlcNHglycan	651	654	PF01048	0.551
MOD_GlcNHglycan	714	717	PF01048	0.595
MOD_GlcNHglycan	741	744	PF01048	0.634
MOD_GlcNHglycan	768	772	PF01048	0.573
MOD_GSK3_1	1	8	PF00069	0.593
MOD_GSK3_1	141	148	PF00069	0.599
MOD_GSK3_1	158	165	PF00069	0.601
MOD_GSK3_1	199	206	PF00069	0.618
MOD_GSK3_1	20	27	PF00069	0.602
MOD_GSK3_1	214	221	PF00069	0.597
MOD_GSK3_1	310	317	PF00069	0.457
MOD_GSK3_1	33	40	PF00069	0.622
MOD_GSK3_1	330	337	PF00069	0.529
MOD_GSK3_1	364	371	PF00069	0.604
MOD_GSK3_1	372	379	PF00069	0.623
MOD_GSK3_1	423	430	PF00069	0.617
MOD_GSK3_1	540	547	PF00069	0.630
MOD_GSK3_1	553	560	PF00069	0.523
MOD_GSK3_1	645	652	PF00069	0.560
MOD_GSK3_1	659	666	PF00069	0.646
MOD_GSK3_1	815	822	PF00069	0.634
MOD_GSK3_1	823	830	PF00069	0.652
MOD_GSK3_1	832	839	PF00069	0.705
MOD_GSK3_1	9	16	PF00069	0.648
MOD_LATS_1	838	844	PF00433	0.636
MOD_N-GLC_1	177	182	PF02516	0.640
MOD_N-GLC_1	235	240	PF02516	0.647
MOD_N-GLC_1	372	377	PF02516	0.690
MOD_N-GLC_1	827	832	PF02516	0.671
MOD_NEK2_1	1	6	PF00069	0.557
MOD_NEK2_1	234	239	PF00069	0.546
MOD_NEK2_1	314	319	PF00069	0.506
MOD_NEK2_1	703	708	PF00069	0.545
MOD_NEK2_1	767	772	PF00069	0.536
MOD_NEK2_1	815	820	PF00069	0.565
MOD_PIKK_1	138	144	PF00454	0.627
MOD_PIKK_1	16	22	PF00454	0.657
MOD_PIKK_1	203	209	PF00454	0.624
MOD_PIKK_1	33	39	PF00454	0.670
MOD_PIKK_1	645	651	PF00454	0.551
MOD_PIKK_1	97	103	PF00454	0.665
MOD_PK_1	557	563	PF00069	0.560
MOD_PK_1	586	592	PF00069	0.623
MOD_PKA_1	331	337	PF00069	0.590
MOD_PKA_1	637	643	PF00069	0.517
MOD_PKA_2	108	114	PF00069	0.618
MOD_PKA_2	219	225	PF00069	0.697
MOD_PKA_2	234	240	PF00069	0.523
MOD_PKA_2	330	336	PF00069	0.594
MOD_PKA_2	37	43	PF00069	0.570
MOD_PKA_2	637	643	PF00069	0.520
MOD_PKA_2	823	829	PF00069	0.743
MOD_PKA_2	852	858	PF00069	0.590
MOD_PKB_1	329	337	PF00069	0.595
MOD_PKB_1	491	499	PF00069	0.428
MOD_PKB_1	95	103	PF00069	0.651
MOD_Plk_1	148	154	PF00069	0.607
MOD_Plk_1	180	186	PF00069	0.605
MOD_Plk_1	199	205	PF00069	0.577
MOD_Plk_1	235	241	PF00069	0.634
MOD_Plk_1	310	316	PF00069	0.544
MOD_Plk_1	493	499	PF00069	0.550
MOD_Plk_1	505	511	PF00069	0.440
MOD_Plk_1	697	703	PF00069	0.461
MOD_Plk_1	803	809	PF00069	0.482
MOD_Plk_2-3	594	600	PF00069	0.473
MOD_Plk_2-3	745	751	PF00069	0.444
MOD_Plk_4	1	7	PF00069	0.562
MOD_Plk_4	124	130	PF00069	0.654
MOD_Plk_4	13	19	PF00069	0.627
MOD_Plk_4	162	168	PF00069	0.619
MOD_Plk_4	557	563	PF00069	0.682
MOD_Plk_4	586	592	PF00069	0.558
MOD_ProDKin_1	11	17	PF00069	0.687
MOD_ProDKin_1	113	119	PF00069	0.632
MOD_ProDKin_1	20	26	PF00069	0.557
MOD_ProDKin_1	254	260	PF00069	0.600
MOD_ProDKin_1	368	374	PF00069	0.619
MOD_ProDKin_1	385	391	PF00069	0.564
MOD_ProDKin_1	427	433	PF00069	0.569
MOD_ProDKin_1	435	441	PF00069	0.614
MOD_ProDKin_1	451	457	PF00069	0.522
MOD_ProDKin_1	555	561	PF00069	0.554
MOD_ProDKin_1	806	812	PF00069	0.593
MOD_ProDKin_1	819	825	PF00069	0.647
MOD_ProDKin_1	832	838	PF00069	0.643
MOD_ProDKin_1	88	94	PF00069	0.625
MOD_SUMO_for_1	275	278	PF00179	0.579
MOD_SUMO_rev_2	248	254	PF00179	0.637
MOD_SUMO_rev_2	614	623	PF00179	0.464
TRG_DiLeu_BaEn_1	621	626	PF01217	0.438
TRG_DiLeu_BaEn_1	745	750	PF01217	0.464
TRG_DiLeu_BaEn_2	12	18	PF01217	0.625
TRG_DiLeu_BaEn_2	447	453	PF01217	0.609
TRG_ENDOCYTIC_2	315	318	PF00928	0.490
TRG_ENDOCYTIC_2	575	578	PF00928	0.507
TRG_ENDOCYTIC_2	673	676	PF00928	0.470
TRG_ER_diArg_1	103	105	PF00400	0.608
TRG_ER_diArg_1	328	331	PF00400	0.594
TRG_ER_diArg_1	356	358	PF00400	0.524
TRG_ER_diArg_1	385	387	PF00400	0.607
TRG_ER_diArg_1	490	493	PF00400	0.441
TRG_ER_diArg_1	54	57	PF00400	0.666
TRG_ER_diArg_1	636	638	PF00400	0.487
TRG_ER_diArg_1	92	95	PF00400	0.683
TRG_NLS_MonoExtN_4	383	388	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	527	532	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	630	635	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	747	751	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT63	Leptomonas seymouri	42%	89%
A0A3Q8ICH3	Leishmania donovani	88%	100%
A4HE43	Leishmania braziliensis	59%	97%
A4I1E9	Leishmania infantum	89%	100%
E9AXI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%