RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9Y5_LEIMA

TriTrypDb:

LmjF.25.1080 , LMJLV39_250017400 , LMJSD75_250017300

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Y5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.422
CLV_NRD_NRD_1	294	296	PF00675	0.623
CLV_NRD_NRD_1	300	302	PF00675	0.677
CLV_NRD_NRD_1	453	455	PF00675	0.632
CLV_PCSK_FUR_1	153	157	PF00082	0.533
CLV_PCSK_KEX2_1	155	157	PF00082	0.496
CLV_PCSK_KEX2_1	294	296	PF00082	0.623
CLV_PCSK_KEX2_1	300	302	PF00082	0.677
CLV_PCSK_KEX2_1	453	455	PF00082	0.632
CLV_PCSK_SKI1_1	201	205	PF00082	0.557
CLV_PCSK_SKI1_1	238	242	PF00082	0.690
CLV_PCSK_SKI1_1	49	53	PF00082	0.418
CLV_PCSK_SKI1_1	81	85	PF00082	0.633
DEG_APCC_DBOX_1	226	234	PF00400	0.553
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.415
DOC_MAPK_gen_1	153	161	PF00069	0.386
DOC_MAPK_gen_1	6	15	PF00069	0.510
DOC_MAPK_MEF2A_6	153	161	PF00069	0.386
DOC_PP2B_LxvP_1	88	91	PF13499	0.451
DOC_PP4_FxxP_1	279	282	PF00568	0.524
DOC_USP7_MATH_1	179	183	PF00917	0.648
DOC_USP7_MATH_1	368	372	PF00917	0.769
DOC_USP7_MATH_1	438	442	PF00917	0.718
DOC_USP7_MATH_1	74	78	PF00917	0.658
DOC_USP7_UBL2_3	45	49	PF12436	0.520
DOC_USP7_UBL2_3	7	11	PF12436	0.612
DOC_WW_Pin1_4	246	251	PF00397	0.579
DOC_WW_Pin1_4	258	263	PF00397	0.544
DOC_WW_Pin1_4	304	309	PF00397	0.732
DOC_WW_Pin1_4	373	378	PF00397	0.617
LIG_14-3-3_CanoR_1	100	109	PF00244	0.402
LIG_14-3-3_CanoR_1	300	308	PF00244	0.687
LIG_14-3-3_CanoR_1	406	410	PF00244	0.617
LIG_14-3-3_CanoR_1	9	14	PF00244	0.594
LIG_14-3-3_CterR_2	453	455	PF00244	0.632
LIG_BRCT_BRCA1_1	128	132	PF00533	0.400
LIG_deltaCOP1_diTrp_1	29	35	PF00928	0.671
LIG_EH_1	319	323	PF12763	0.654
LIG_FHA_1	10	16	PF00498	0.516
LIG_FHA_1	117	123	PF00498	0.379
LIG_FHA_1	140	146	PF00498	0.521
LIG_FHA_1	384	390	PF00498	0.530
LIG_FHA_1	71	77	PF00498	0.594
LIG_FHA_2	101	107	PF00498	0.282
LIG_FHA_2	82	88	PF00498	0.605
LIG_Integrin_isoDGR_2	380	382	PF01839	0.740
LIG_LIR_Apic_2	278	282	PF02991	0.534
LIG_LIR_Gen_1	105	116	PF02991	0.539
LIG_LIR_Gen_1	129	140	PF02991	0.342
LIG_LIR_Gen_1	56	65	PF02991	0.598
LIG_LIR_Nem_3	105	111	PF02991	0.536
LIG_LIR_Nem_3	129	135	PF02991	0.329
LIG_LIR_Nem_3	446	452	PF02991	0.588
LIG_LIR_Nem_3	56	60	PF02991	0.511
LIG_MYND_1	311	315	PF01753	0.601
LIG_PCNA_yPIPBox_3	164	178	PF02747	0.553
LIG_Pex14_2	108	112	PF04695	0.325
LIG_Pex14_2	92	96	PF04695	0.402
LIG_SH2_CRK	57	61	PF00017	0.580
LIG_SH2_NCK_1	57	61	PF00017	0.580
LIG_SH2_PTP2	158	161	PF00017	0.396
LIG_SH2_STAP1	57	61	PF00017	0.514
LIG_SH2_STAT5	158	161	PF00017	0.396
LIG_SH2_STAT5	22	25	PF00017	0.500
LIG_SH3_1	434	440	PF00018	0.642
LIG_SH3_3	210	216	PF00018	0.653
LIG_SH3_3	274	280	PF00018	0.622
LIG_SH3_3	302	308	PF00018	0.701
LIG_SH3_3	309	315	PF00018	0.701
LIG_SH3_3	434	440	PF00018	0.664
LIG_SUMO_SIM_par_1	141	146	PF11976	0.435
LIG_TRAF2_1	103	106	PF00917	0.431
MOD_CK1_1	217	223	PF00069	0.737
MOD_CK1_1	249	255	PF00069	0.646
MOD_CK1_1	261	267	PF00069	0.613
MOD_CK1_1	288	294	PF00069	0.748
MOD_CK1_1	323	329	PF00069	0.622
MOD_CK1_1	344	350	PF00069	0.690
MOD_CK1_1	375	381	PF00069	0.733
MOD_CK1_1	70	76	PF00069	0.647
MOD_CK2_1	100	106	PF00069	0.412
MOD_Cter_Amidation	153	156	PF01082	0.418
MOD_GlcNHglycan	136	139	PF01048	0.520
MOD_GlcNHglycan	242	245	PF01048	0.727
MOD_GlcNHglycan	302	305	PF01048	0.717
MOD_GlcNHglycan	322	325	PF01048	0.634
MOD_GlcNHglycan	341	346	PF01048	0.524
MOD_GlcNHglycan	370	373	PF01048	0.745
MOD_GlcNHglycan	412	416	PF01048	0.633
MOD_GlcNHglycan	419	423	PF01048	0.638
MOD_GlcNHglycan	426	430	PF01048	0.703
MOD_GlcNHglycan	433	437	PF01048	0.628
MOD_GlcNHglycan	440	443	PF01048	0.633
MOD_GSK3_1	139	146	PF00069	0.534
MOD_GSK3_1	219	226	PF00069	0.651
MOD_GSK3_1	300	307	PF00069	0.689
MOD_GSK3_1	349	356	PF00069	0.684
MOD_GSK3_1	368	375	PF00069	0.718
MOD_GSK3_1	70	77	PF00069	0.612
MOD_N-GLC_1	100	105	PF02516	0.405
MOD_N-GLC_1	368	373	PF02516	0.601
MOD_N-GLC_1	61	66	PF02516	0.664
MOD_NEK2_1	147	152	PF00069	0.384
MOD_NEK2_1	240	245	PF00069	0.679
MOD_NEK2_1	299	304	PF00069	0.810
MOD_PIKK_1	160	166	PF00454	0.501
MOD_PKA_1	300	306	PF00069	0.748
MOD_PKA_2	172	178	PF00069	0.634
MOD_PKA_2	299	305	PF00069	0.715
MOD_PKA_2	383	389	PF00069	0.590
MOD_PKA_2	405	411	PF00069	0.608
MOD_Plk_1	147	153	PF00069	0.430
MOD_Plk_1	288	294	PF00069	0.615
MOD_Plk_1	341	347	PF00069	0.636
MOD_Plk_1	55	61	PF00069	0.591
MOD_Plk_2-3	357	363	PF00069	0.629
MOD_Plk_4	107	113	PF00069	0.549
MOD_ProDKin_1	246	252	PF00069	0.579
MOD_ProDKin_1	258	264	PF00069	0.546
MOD_ProDKin_1	304	310	PF00069	0.728
MOD_ProDKin_1	373	379	PF00069	0.614
MOD_SUMO_for_1	338	341	PF00179	0.661
MOD_SUMO_rev_2	351	360	PF00179	0.681
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.382
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.567
TRG_ENDOCYTIC_2	158	161	PF00928	0.396
TRG_ENDOCYTIC_2	57	60	PF00928	0.595
TRG_ER_diArg_1	153	156	PF00400	0.569
TRG_ER_diArg_1	299	301	PF00400	0.693
TRG_ER_diArg_1	452	454	PF00400	0.566
TRG_NLS_MonoExtN_4	4	10	PF00514	0.528
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	183	188	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F7	Leptomonas seymouri	73%	100%
A0A0S4IKR5	Bodo saltans	36%	100%
A0A1X0NLV4	Trypanosomatidae	45%	100%
A0A3R7KUR5	Trypanosoma rangeli	49%	100%
A0A3S7WZ21	Leishmania donovani	95%	100%
A4HE44	Leishmania braziliensis	81%	100%
A4I1F0	Leishmania infantum	95%	100%
C9ZJX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AXI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BKV0	Trypanosoma cruzi	50%	100%