LeishMANIAdb
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MGT2 magnesium transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MGT2 magnesium transporter
Gene product:
magnesium transporter protein 2
Species:
Leishmania major
UniProt:
Q4Q9Y4_LEIMA
TriTrypDb:
LmjF.25.1090 , LMJLV39_250017500 , LMJSD75_250017400
Length:
413

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 2
GO:0016020 membrane 2 16
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 16

Expansion

Sequence features

Q4Q9Y4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Y4

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 8
GO:0006811 monoatomic ion transport 4 8
GO:0006812 monoatomic cation transport 5 8
GO:0051179 localization 1 8
GO:0051234 establishment of localization 2 8
GO:0015693 magnesium ion transport 7 6
GO:0030001 metal ion transport 6 6
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 16
GO:0008324 monoatomic cation transmembrane transporter activity 4 16
GO:0015075 monoatomic ion transmembrane transporter activity 3 16
GO:0015095 magnesium ion transmembrane transporter activity 6 10
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 16
GO:0015562 efflux transmembrane transporter activity 3 2
GO:0022857 transmembrane transporter activity 2 16
GO:0022890 inorganic cation transmembrane transporter activity 4 16
GO:0046583 monoatomic cation efflux transmembrane transporter activity 4 2
GO:0046873 metal ion transmembrane transporter activity 5 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 4 8 PF00656 0.825
CLV_NRD_NRD_1 244 246 PF00675 0.324
CLV_NRD_NRD_1 251 253 PF00675 0.324
CLV_NRD_NRD_1 41 43 PF00675 0.491
CLV_NRD_NRD_1 70 72 PF00675 0.390
CLV_PCSK_KEX2_1 165 167 PF00082 0.428
CLV_PCSK_KEX2_1 244 246 PF00082 0.329
CLV_PCSK_KEX2_1 250 252 PF00082 0.331
CLV_PCSK_KEX2_1 70 72 PF00082 0.383
CLV_PCSK_PC1ET2_1 165 167 PF00082 0.433
CLV_PCSK_SKI1_1 165 169 PF00082 0.377
CLV_PCSK_SKI1_1 245 249 PF00082 0.360
CLV_PCSK_SKI1_1 257 261 PF00082 0.337
CLV_PCSK_SKI1_1 27 31 PF00082 0.432
CLV_PCSK_SKI1_1 292 296 PF00082 0.343
CLV_PCSK_SKI1_1 309 313 PF00082 0.255
CLV_PCSK_SKI1_1 397 401 PF00082 0.475
CLV_PCSK_SKI1_1 71 75 PF00082 0.336
CLV_Separin_Metazoa 172 176 PF03568 0.582
DEG_APCC_DBOX_1 70 78 PF00400 0.544
DOC_CKS1_1 193 198 PF01111 0.578
DOC_CKS1_1 270 275 PF01111 0.627
DOC_PP2B_LxvP_1 231 234 PF13499 0.571
DOC_USP7_MATH_1 205 209 PF00917 0.612
DOC_USP7_MATH_1 94 98 PF00917 0.620
DOC_WW_Pin1_4 17 22 PF00397 0.777
DOC_WW_Pin1_4 192 197 PF00397 0.606
DOC_WW_Pin1_4 269 274 PF00397 0.610
DOC_WW_Pin1_4 63 68 PF00397 0.617
DOC_WW_Pin1_4 7 12 PF00397 0.802
LIG_14-3-3_CanoR_1 250 260 PF00244 0.548
LIG_14-3-3_CanoR_1 27 32 PF00244 0.659
LIG_14-3-3_CanoR_1 326 336 PF00244 0.582
LIG_APCC_ABBA_1 288 293 PF00400 0.627
LIG_BRCT_BRCA1_1 196 200 PF00533 0.578
LIG_BRCT_BRCA1_1 36 40 PF00533 0.682
LIG_DLG_GKlike_1 252 259 PF00625 0.627
LIG_eIF4E_1 261 267 PF01652 0.571
LIG_FHA_1 126 132 PF00498 0.636
LIG_FHA_1 153 159 PF00498 0.618
LIG_FHA_1 184 190 PF00498 0.633
LIG_FHA_1 193 199 PF00498 0.606
LIG_FHA_1 214 220 PF00498 0.555
LIG_FHA_1 55 61 PF00498 0.624
LIG_FHA_1 8 14 PF00498 0.845
LIG_FHA_2 122 128 PF00498 0.606
LIG_FHA_2 159 165 PF00498 0.627
LIG_FHA_2 64 70 PF00498 0.607
LIG_FHA_2 93 99 PF00498 0.592
LIG_GBD_Chelix_1 173 181 PF00786 0.350
LIG_LIR_Gen_1 197 206 PF02991 0.621
LIG_LIR_Gen_1 56 67 PF02991 0.581
LIG_LIR_Nem_3 164 170 PF02991 0.573
LIG_LIR_Nem_3 197 203 PF02991 0.609
LIG_LIR_Nem_3 254 259 PF02991 0.627
LIG_LIR_Nem_3 56 62 PF02991 0.545
LIG_PTB_Apo_2 116 123 PF02174 0.621
LIG_PTB_Phospho_1 116 122 PF10480 0.621
LIG_Rb_pABgroove_1 116 124 PF01858 0.550
LIG_SH2_SRC 109 112 PF00017 0.561
LIG_SH2_STAP1 206 210 PF00017 0.610
LIG_SH2_STAT5 28 31 PF00017 0.675
LIG_SH3_3 190 196 PF00018 0.626
LIG_SH3_3 78 84 PF00018 0.609
LIG_SH3_3 88 94 PF00018 0.571
LIG_SUMO_SIM_anti_2 226 233 PF11976 0.557
LIG_SUMO_SIM_anti_2 342 348 PF11976 0.528
LIG_SUMO_SIM_par_1 155 161 PF11976 0.577
LIG_TRAF2_1 66 69 PF00917 0.606
LIG_UBA3_1 158 165 PF00899 0.611
LIG_UBA3_1 259 265 PF00899 0.633
LIG_WRC_WIRS_1 253 258 PF05994 0.610
MOD_CDK_SPxxK_3 269 276 PF00069 0.610
MOD_CDK_SPxxK_3 63 70 PF00069 0.633
MOD_CK1_1 192 198 PF00069 0.585
MOD_CK1_1 328 334 PF00069 0.555
MOD_CK1_1 34 40 PF00069 0.686
MOD_CK1_1 392 398 PF00069 0.519
MOD_CK1_1 53 59 PF00069 0.427
MOD_CK2_1 121 127 PF00069 0.579
MOD_CK2_1 63 69 PF00069 0.579
MOD_GlcNHglycan 136 139 PF01048 0.436
MOD_GlcNHglycan 33 36 PF01048 0.478
MOD_GlcNHglycan 330 333 PF01048 0.352
MOD_GlcNHglycan 84 87 PF01048 0.435
MOD_GSK3_1 121 128 PF00069 0.563
MOD_GSK3_1 148 155 PF00069 0.548
MOD_GSK3_1 185 192 PF00069 0.580
MOD_GSK3_1 213 220 PF00069 0.575
MOD_GSK3_1 27 34 PF00069 0.692
MOD_GSK3_1 271 278 PF00069 0.565
MOD_GSK3_1 321 328 PF00069 0.574
MOD_GSK3_1 50 57 PF00069 0.692
MOD_N-GLC_1 134 139 PF02516 0.433
MOD_N-GLC_1 31 36 PF02516 0.503
MOD_NEK2_1 1 6 PF00069 0.816
MOD_NEK2_1 158 163 PF00069 0.561
MOD_NEK2_1 184 189 PF00069 0.628
MOD_NEK2_1 275 280 PF00069 0.535
MOD_NEK2_1 325 330 PF00069 0.552
MOD_NEK2_1 353 358 PF00069 0.459
MOD_NEK2_1 389 394 PF00069 0.498
MOD_PIKK_1 325 331 PF00454 0.568
MOD_PIKK_1 339 345 PF00454 0.389
MOD_PIKK_1 50 56 PF00454 0.690
MOD_PKA_1 251 257 PF00069 0.568
MOD_PKA_2 251 257 PF00069 0.550
MOD_PKA_2 275 281 PF00069 0.544
MOD_PKA_2 325 331 PF00069 0.578
MOD_PKA_2 92 98 PF00069 0.602
MOD_PKB_1 25 33 PF00069 0.693
MOD_PKB_1 250 258 PF00069 0.595
MOD_Plk_1 184 190 PF00069 0.616
MOD_Plk_1 54 60 PF00069 0.611
MOD_Plk_2-3 127 133 PF00069 0.587
MOD_Plk_4 148 154 PF00069 0.554
MOD_Plk_4 189 195 PF00069 0.612
MOD_Plk_4 199 205 PF00069 0.545
MOD_Plk_4 214 220 PF00069 0.489
MOD_Plk_4 275 281 PF00069 0.535
MOD_Plk_4 35 41 PF00069 0.697
MOD_Plk_4 353 359 PF00069 0.431
MOD_Plk_4 54 60 PF00069 0.606
MOD_ProDKin_1 17 23 PF00069 0.775
MOD_ProDKin_1 192 198 PF00069 0.606
MOD_ProDKin_1 269 275 PF00069 0.610
MOD_ProDKin_1 63 69 PF00069 0.617
MOD_ProDKin_1 7 13 PF00069 0.802
MOD_SUMO_rev_2 330 338 PF00179 0.573
TRG_DiLeu_BaEn_1 227 232 PF01217 0.541
TRG_DiLeu_BaEn_3 68 74 PF01217 0.628
TRG_ENDOCYTIC_2 28 31 PF00928 0.675
TRG_ER_diArg_1 243 245 PF00400 0.524
TRG_ER_diArg_1 249 252 PF00400 0.524
TRG_ER_diArg_1 25 28 PF00400 0.723
TRG_Pf-PMV_PEXEL_1 166 171 PF00026 0.433
TRG_Pf-PMV_PEXEL_1 265 269 PF00026 0.364

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3I5 Leptomonas seymouri 73% 100%
A0A1X0NLW5 Trypanosomatidae 44% 96%
A0A1X0NUD3 Trypanosomatidae 30% 100%
A0A3Q8IND2 Leishmania donovani 97% 100%
A0A3R7KXL6 Trypanosoma rangeli 36% 100%
A0A3R7R8A9 Trypanosoma rangeli 42% 97%
A0A422N320 Trypanosoma rangeli 28% 76%
A4HE45 Leishmania braziliensis 84% 100%
A4I1F1 Leishmania infantum 97% 100%
C9ZK17 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZK26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 97%
C9ZXP3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AXI8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5B7S4 Trypanosoma cruzi 41% 100%
V5D3L0 Trypanosoma cruzi 43% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS