Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q9X9_LEIMA

TriTrypDb:

LmjF.25.1140 , LMJLV39_250018000 , LMJSD75_250017900

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	522	526	PF00656	0.806
CLV_NRD_NRD_1	12	14	PF00675	0.542
CLV_NRD_NRD_1	176	178	PF00675	0.739
CLV_PCSK_FUR_1	174	178	PF00082	0.719
CLV_PCSK_KEX2_1	12	14	PF00082	0.542
CLV_PCSK_KEX2_1	176	178	PF00082	0.739
CLV_PCSK_SKI1_1	527	531	PF00082	0.794
DEG_SCF_FBW7_1	242	249	PF00400	0.754
DEG_SCF_FBW7_2	346	353	PF00400	0.675
DEG_SPOP_SBC_1	109	113	PF00917	0.712
DEG_SPOP_SBC_1	116	120	PF00917	0.656
DOC_CDC14_PxL_1	182	190	PF14671	0.611
DOC_CKS1_1	243	248	PF01111	0.708
DOC_CKS1_1	389	394	PF01111	0.584
DOC_CKS1_1	53	58	PF01111	0.524
DOC_PP2B_LxvP_1	313	316	PF13499	0.680
DOC_PP2B_LxvP_1	74	77	PF13499	0.683
DOC_PP2B_PxIxI_1	361	367	PF00149	0.602
DOC_PP4_FxxP_1	212	215	PF00568	0.726
DOC_USP7_MATH_1	103	107	PF00917	0.699
DOC_USP7_MATH_1	138	142	PF00917	0.720
DOC_USP7_MATH_1	150	154	PF00917	0.690
DOC_USP7_MATH_1	234	238	PF00917	0.761
DOC_USP7_MATH_1	241	245	PF00917	0.697
DOC_USP7_MATH_1	246	250	PF00917	0.645
DOC_USP7_MATH_1	327	331	PF00917	0.755
DOC_USP7_MATH_1	338	342	PF00917	0.654
DOC_USP7_MATH_1	408	412	PF00917	0.805
DOC_USP7_MATH_1	532	536	PF00917	0.747
DOC_USP7_MATH_1	8	12	PF00917	0.648
DOC_USP7_MATH_1	93	97	PF00917	0.746
DOC_USP7_UBL2_3	136	140	PF12436	0.743
DOC_WW_Pin1_4	236	241	PF00397	0.729
DOC_WW_Pin1_4	242	247	PF00397	0.740
DOC_WW_Pin1_4	278	283	PF00397	0.775
DOC_WW_Pin1_4	287	292	PF00397	0.609
DOC_WW_Pin1_4	342	347	PF00397	0.825
DOC_WW_Pin1_4	388	393	PF00397	0.691
DOC_WW_Pin1_4	412	417	PF00397	0.809
DOC_WW_Pin1_4	422	427	PF00397	0.671
DOC_WW_Pin1_4	512	517	PF00397	0.717
DOC_WW_Pin1_4	52	57	PF00397	0.531
DOC_WW_Pin1_4	528	533	PF00397	0.647
LIG_14-3-3_CanoR_1	47	53	PF00244	0.608
LIG_14-3-3_CanoR_1	527	532	PF00244	0.706
LIG_Actin_WH2_2	462	480	PF00022	0.552
LIG_BIR_III_2	393	397	PF00653	0.708
LIG_BRCT_BRCA1_1	410	414	PF00533	0.752
LIG_EVH1_1	212	216	PF00568	0.764
LIG_EVH1_2	429	433	PF00568	0.782
LIG_FHA_1	26	32	PF00498	0.517
LIG_FHA_1	284	290	PF00498	0.597
LIG_FHA_1	486	492	PF00498	0.682
LIG_FHA_1	5	11	PF00498	0.571
LIG_FHA_1	507	513	PF00498	0.793
LIG_FHA_1	531	537	PF00498	0.703
LIG_FHA_2	216	222	PF00498	0.823
LIG_FHA_2	520	526	PF00498	0.809
LIG_FHA_2	53	59	PF00498	0.518
LIG_FHA_2	67	73	PF00498	0.598
LIG_LIR_Apic_2	209	215	PF02991	0.705
LIG_LIR_Apic_2	224	229	PF02991	0.727
LIG_LIR_Apic_2	330	334	PF02991	0.738
LIG_LIR_Gen_1	436	447	PF02991	0.511
LIG_LIR_Gen_1	464	473	PF02991	0.628
LIG_LIR_Gen_1	69	78	PF02991	0.670
LIG_LIR_Nem_3	298	303	PF02991	0.620
LIG_LIR_Nem_3	436	442	PF02991	0.504
LIG_LIR_Nem_3	464	469	PF02991	0.533
LIG_LIR_Nem_3	471	476	PF02991	0.483
LIG_LIR_Nem_3	69	74	PF02991	0.647
LIG_MAD2	304	312	PF02301	0.480
LIG_MYND_1	311	315	PF01753	0.656
LIG_NRBOX	58	64	PF00104	0.592
LIG_NRP_CendR_1	541	543	PF00754	0.785
LIG_PTAP_UEV_1	129	134	PF05743	0.787
LIG_SH2_CRK	303	307	PF00017	0.592
LIG_SH2_CRK	331	335	PF00017	0.740
LIG_SH2_CRK	452	456	PF00017	0.459
LIG_SH2_PTP2	359	362	PF00017	0.610
LIG_SH2_SRC	359	362	PF00017	0.610
LIG_SH2_STAT3	61	64	PF00017	0.495
LIG_SH2_STAT5	18	21	PF00017	0.503
LIG_SH2_STAT5	198	201	PF00017	0.483
LIG_SH2_STAT5	29	32	PF00017	0.488
LIG_SH2_STAT5	359	362	PF00017	0.560
LIG_SH2_STAT5	439	442	PF00017	0.518
LIG_SH2_STAT5	476	479	PF00017	0.496
LIG_SH2_STAT5	61	64	PF00017	0.461
LIG_SH3_2	426	431	PF14604	0.804
LIG_SH3_3	127	133	PF00018	0.796
LIG_SH3_3	180	186	PF00018	0.633
LIG_SH3_3	210	216	PF00018	0.757
LIG_SH3_3	237	243	PF00018	0.783
LIG_SH3_3	245	251	PF00018	0.693
LIG_SH3_3	308	314	PF00018	0.734
LIG_SH3_3	386	392	PF00018	0.733
LIG_SH3_3	423	429	PF00018	0.749
LIG_SH3_3	50	56	PF00018	0.548
LIG_SH3_3	513	519	PF00018	0.721
LIG_SH3_3	87	93	PF00018	0.770
LIG_WW_2	240	243	PF00397	0.566
LIG_WW_2	311	314	PF00397	0.524
MOD_CDC14_SPxK_1	415	418	PF00782	0.734
MOD_CDC14_SPxK_1	428	431	PF00782	0.573
MOD_CDK_SPK_2	242	247	PF00069	0.754
MOD_CDK_SPxK_1	412	418	PF00069	0.734
MOD_CDK_SPxK_1	425	431	PF00069	0.598
MOD_CK1_1	108	114	PF00069	0.727
MOD_CK1_1	190	196	PF00069	0.628
MOD_CK1_1	253	259	PF00069	0.751
MOD_CK1_1	281	287	PF00069	0.799
MOD_CK1_1	295	301	PF00069	0.443
MOD_CK1_1	317	323	PF00069	0.726
MOD_CK1_1	341	347	PF00069	0.769
MOD_CK1_1	412	418	PF00069	0.781
MOD_CK1_1	510	516	PF00069	0.680
MOD_CK1_1	531	537	PF00069	0.725
MOD_CK2_1	483	489	PF00069	0.517
MOD_CK2_1	52	58	PF00069	0.511
MOD_CK2_1	66	72	PF00069	0.568
MOD_GlcNHglycan	105	108	PF01048	0.770
MOD_GlcNHglycan	122	125	PF01048	0.729
MOD_GlcNHglycan	140	143	PF01048	0.680
MOD_GlcNHglycan	271	274	PF01048	0.808
MOD_GlcNHglycan	283	286	PF01048	0.562
MOD_GlcNHglycan	300	303	PF01048	0.406
MOD_GlcNHglycan	319	322	PF01048	0.547
MOD_GlcNHglycan	386	389	PF01048	0.689
MOD_GlcNHglycan	522	525	PF01048	0.733
MOD_GlcNHglycan	83	86	PF01048	0.749
MOD_GlcNHglycan	95	98	PF01048	0.639
MOD_GSK3_1	105	112	PF00069	0.787
MOD_GSK3_1	116	123	PF00069	0.645
MOD_GSK3_1	134	141	PF00069	0.756
MOD_GSK3_1	187	194	PF00069	0.606
MOD_GSK3_1	232	239	PF00069	0.744
MOD_GSK3_1	242	249	PF00069	0.756
MOD_GSK3_1	265	272	PF00069	0.771
MOD_GSK3_1	283	290	PF00069	0.588
MOD_GSK3_1	337	344	PF00069	0.839
MOD_GSK3_1	384	391	PF00069	0.586
MOD_GSK3_1	4	11	PF00069	0.682
MOD_GSK3_1	408	415	PF00069	0.804
MOD_GSK3_1	464	471	PF00069	0.556
MOD_GSK3_1	479	486	PF00069	0.529
MOD_GSK3_1	48	55	PF00069	0.658
MOD_GSK3_1	506	513	PF00069	0.707
MOD_GSK3_1	527	534	PF00069	0.802
MOD_GSK3_1	66	73	PF00069	0.472
MOD_GSK3_1	77	84	PF00069	0.705
MOD_GSK3_1	93	100	PF00069	0.682
MOD_N-GLC_1	507	512	PF02516	0.640
MOD_N-GLC_1	66	71	PF02516	0.547
MOD_NEK2_1	158	163	PF00069	0.630
MOD_NEK2_1	188	193	PF00069	0.581
MOD_NEK2_1	376	381	PF00069	0.630
MOD_NEK2_1	433	438	PF00069	0.642
MOD_NEK2_1	48	53	PF00069	0.608
MOD_NEK2_2	18	23	PF00069	0.570
MOD_PIKK_1	158	164	PF00454	0.671
MOD_PIKK_1	232	238	PF00454	0.811
MOD_PKA_2	384	390	PF00069	0.724
MOD_PKA_2	48	54	PF00069	0.604
MOD_Plk_1	409	415	PF00069	0.770
MOD_Plk_1	483	489	PF00069	0.517
MOD_Plk_1	507	513	PF00069	0.570
MOD_Plk_2-3	483	489	PF00069	0.517
MOD_Plk_4	295	301	PF00069	0.567
MOD_Plk_4	532	538	PF00069	0.562
MOD_ProDKin_1	236	242	PF00069	0.731
MOD_ProDKin_1	278	284	PF00069	0.775
MOD_ProDKin_1	287	293	PF00069	0.602
MOD_ProDKin_1	342	348	PF00069	0.822
MOD_ProDKin_1	388	394	PF00069	0.690
MOD_ProDKin_1	412	418	PF00069	0.814
MOD_ProDKin_1	422	428	PF00069	0.668
MOD_ProDKin_1	512	518	PF00069	0.713
MOD_ProDKin_1	52	58	PF00069	0.524
MOD_ProDKin_1	528	534	PF00069	0.648
MOD_SUMO_rev_2	436	445	PF00179	0.550
TRG_DiLeu_BaEn_1	58	63	PF01217	0.587
TRG_DiLeu_BaEn_2	153	159	PF01217	0.623
TRG_ENDOCYTIC_2	303	306	PF00928	0.610
TRG_ENDOCYTIC_2	439	442	PF00928	0.526
TRG_ENDOCYTIC_2	452	455	PF00928	0.459
TRG_ER_diArg_1	12	14	PF00400	0.542
TRG_ER_diArg_1	173	176	PF00400	0.728
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z7	Leptomonas seymouri	52%	100%
A0A3Q8ID95	Leishmania donovani	91%	100%
A4HE58	Leishmania braziliensis	71%	95%
A4I1F6	Leishmania infantum	91%	100%
E9AXJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%