Modification methylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

modification methylase-like protein

Species:

Leishmania major

UniProt:

Q4Q9X3_LEIMA

TriTrypDb:

LmjF.25.1200 , LMJLV39_250018900 , LMJSD75_250018700

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9X3

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	5	6
GO:0008168	methyltransferase activity	4	8
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	6
GO:0009008	DNA-methyltransferase activity	4	6
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0140097	catalytic activity, acting on DNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.752
CLV_C14_Caspase3-7	152	156	PF00656	0.651
CLV_C14_Caspase3-7	210	214	PF00656	0.847
CLV_C14_Caspase3-7	53	57	PF00656	0.661
CLV_C14_Caspase3-7	622	626	PF00656	0.481
CLV_C14_Caspase3-7	785	789	PF00656	0.798
CLV_NRD_NRD_1	234	236	PF00675	0.608
CLV_NRD_NRD_1	255	257	PF00675	0.718
CLV_NRD_NRD_1	35	37	PF00675	0.571
CLV_NRD_NRD_1	547	549	PF00675	0.323
CLV_NRD_NRD_1	670	672	PF00675	0.327
CLV_PCSK_KEX2_1	234	236	PF00082	0.608
CLV_PCSK_KEX2_1	255	257	PF00082	0.718
CLV_PCSK_KEX2_1	35	37	PF00082	0.640
CLV_PCSK_KEX2_1	374	376	PF00082	0.758
CLV_PCSK_KEX2_1	549	551	PF00082	0.322
CLV_PCSK_KEX2_1	670	672	PF00082	0.327
CLV_PCSK_KEX2_1	838	840	PF00082	0.580
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.671
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.379
CLV_PCSK_SKI1_1	147	151	PF00082	0.676
CLV_PCSK_SKI1_1	196	200	PF00082	0.697
CLV_PCSK_SKI1_1	256	260	PF00082	0.695
CLV_PCSK_SKI1_1	339	343	PF00082	0.295
CLV_PCSK_SKI1_1	35	39	PF00082	0.579
CLV_PCSK_SKI1_1	383	387	PF00082	0.735
CLV_PCSK_SKI1_1	41	45	PF00082	0.588
CLV_PCSK_SKI1_1	615	619	PF00082	0.305
CLV_PCSK_SKI1_1	691	695	PF00082	0.356
CLV_PCSK_SKI1_1	822	826	PF00082	0.366
CLV_Separin_Metazoa	475	479	PF03568	0.517
DEG_APCC_DBOX_1	329	337	PF00400	0.517
DEG_APCC_DBOX_1	82	90	PF00400	0.683
DEG_SCF_FBW7_2	519	525	PF00400	0.551
DEG_SCF_SKP2-CKS1_1	723	730	PF00560	0.524
DEG_SIAH_1	792	800	PF03145	0.619
DEG_SPOP_SBC_1	640	644	PF00917	0.524
DOC_ANK_TNKS_1	153	160	PF00023	0.633
DOC_CKS1_1	519	524	PF01111	0.550
DOC_CKS1_1	628	633	PF01111	0.524
DOC_CKS1_1	660	665	PF01111	0.505
DOC_CYCLIN_RxL_1	612	622	PF00134	0.468
DOC_CYCLIN_RxL_1	688	696	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	512	518	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	607	613	PF00134	0.551
DOC_MAPK_gen_1	35	45	PF00069	0.605
DOC_PP1_RVXF_1	547	554	PF00149	0.556
DOC_PP2B_LxvP_1	166	169	PF13499	0.698
DOC_PP2B_LxvP_1	368	371	PF13499	0.687
DOC_PP2B_LxvP_1	618	621	PF13499	0.542
DOC_PP4_FxxP_1	346	349	PF00568	0.556
DOC_PP4_FxxP_1	577	580	PF00568	0.533
DOC_PP4_FxxP_1	774	777	PF00568	0.556
DOC_USP7_MATH_1	136	140	PF00917	0.792
DOC_USP7_MATH_1	153	157	PF00917	0.474
DOC_USP7_MATH_1	220	224	PF00917	0.654
DOC_USP7_MATH_1	402	406	PF00917	0.640
DOC_USP7_MATH_1	452	456	PF00917	0.517
DOC_USP7_MATH_1	650	654	PF00917	0.586
DOC_USP7_MATH_1	709	713	PF00917	0.545
DOC_USP7_MATH_1	740	744	PF00917	0.571
DOC_USP7_MATH_1	78	82	PF00917	0.796
DOC_USP7_MATH_1	830	834	PF00917	0.557
DOC_USP7_UBL2_3	726	730	PF12436	0.524
DOC_WW_Pin1_4	222	227	PF00397	0.698
DOC_WW_Pin1_4	273	278	PF00397	0.760
DOC_WW_Pin1_4	311	316	PF00397	0.682
DOC_WW_Pin1_4	518	523	PF00397	0.491
DOC_WW_Pin1_4	541	546	PF00397	0.517
DOC_WW_Pin1_4	606	611	PF00397	0.607
DOC_WW_Pin1_4	627	632	PF00397	0.548
DOC_WW_Pin1_4	659	664	PF00397	0.468
DOC_WW_Pin1_4	724	729	PF00397	0.601
DOC_WW_Pin1_4	788	793	PF00397	0.674
LIG_14-3-3_CanoR_1	137	141	PF00244	0.669
LIG_14-3-3_CanoR_1	297	301	PF00244	0.812
LIG_14-3-3_CanoR_1	41	46	PF00244	0.591
LIG_14-3-3_CanoR_1	514	522	PF00244	0.530
LIG_14-3-3_CanoR_1	557	564	PF00244	0.468
LIG_14-3-3_CanoR_1	566	571	PF00244	0.424
LIG_14-3-3_CanoR_1	61	67	PF00244	0.544
LIG_14-3-3_CanoR_1	670	676	PF00244	0.534
LIG_14-3-3_CanoR_1	689	694	PF00244	0.492
LIG_14-3-3_CanoR_1	698	702	PF00244	0.512
LIG_14-3-3_CanoR_1	822	831	PF00244	0.270
LIG_Actin_WH2_2	24	40	PF00022	0.594
LIG_Actin_WH2_2	715	732	PF00022	0.579
LIG_APCC_ABBAyCdc20_2	469	475	PF00400	0.517
LIG_BIR_III_4	461	465	PF00653	0.607
LIG_BRCT_BRCA1_1	313	317	PF00533	0.514
LIG_BRCT_BRCA1_1	319	323	PF00533	0.508
LIG_BRCT_BRCA1_1	424	428	PF00533	0.661
LIG_BRCT_BRCA1_1	437	441	PF00533	0.479
LIG_Clathr_ClatBox_1	496	500	PF01394	0.607
LIG_deltaCOP1_diTrp_1	468	473	PF00928	0.556
LIG_DLG_GKlike_1	566	574	PF00625	0.524
LIG_EH1_1	716	724	PF00400	0.524
LIG_eIF4E_1	145	151	PF01652	0.519
LIG_EVH1_2	754	758	PF00568	0.517
LIG_FHA_1	255	261	PF00498	0.661
LIG_FHA_1	380	386	PF00498	0.718
LIG_FHA_1	441	447	PF00498	0.565
LIG_FHA_1	484	490	PF00498	0.517
LIG_FHA_1	771	777	PF00498	0.587
LIG_FHA_1	778	784	PF00498	0.544
LIG_FHA_2	150	156	PF00498	0.674
LIG_FHA_2	208	214	PF00498	0.800
LIG_FHA_2	316	322	PF00498	0.376
LIG_FHA_2	42	48	PF00498	0.735
LIG_FHA_2	521	527	PF00498	0.607
LIG_FHA_2	713	719	PF00498	0.522
LIG_FHA_2	91	97	PF00498	0.711
LIG_GBD_Chelix_1	54	62	PF00786	0.682
LIG_LIR_Apic_2	345	349	PF02991	0.556
LIG_LIR_Apic_2	625	631	PF02991	0.524
LIG_LIR_Apic_2	771	777	PF02991	0.556
LIG_LIR_Gen_1	160	169	PF02991	0.648
LIG_LIR_Gen_1	318	326	PF02991	0.506
LIG_LIR_Gen_1	49	58	PF02991	0.742
LIG_LIR_Nem_3	160	165	PF02991	0.674
LIG_LIR_Nem_3	176	181	PF02991	0.668
LIG_LIR_Nem_3	314	319	PF02991	0.458
LIG_LIR_Nem_3	320	326	PF02991	0.496
LIG_LIR_Nem_3	468	474	PF02991	0.519
LIG_LIR_Nem_3	49	54	PF02991	0.696
LIG_LIR_Nem_3	6	10	PF02991	0.689
LIG_LIR_Nem_3	608	614	PF02991	0.558
LIG_LIR_Nem_3	699	704	PF02991	0.495
LIG_LIR_Nem_3	705	710	PF02991	0.488
LIG_LYPXL_SIV_4	610	618	PF13949	0.607
LIG_LYPXL_yS_3	7	10	PF13949	0.510
LIG_MLH1_MIPbox_1	313	317	PF16413	0.572
LIG_MLH1_MIPbox_1	437	441	PF16413	0.542
LIG_MYND_1	8	12	PF01753	0.511
LIG_NRP_CendR_1	838	840	PF00754	0.574
LIG_PCNA_yPIPBox_3	109	122	PF02747	0.564
LIG_PCNA_yPIPBox_3	714	723	PF02747	0.599
LIG_Pex14_2	319	323	PF04695	0.517
LIG_Pex14_2	342	346	PF04695	0.556
LIG_REV1ctd_RIR_1	551	561	PF16727	0.556
LIG_REV1ctd_RIR_1	756	766	PF16727	0.556
LIG_RPA_C_Fungi	588	600	PF08784	0.385
LIG_SH2_CRK	611	615	PF00017	0.430
LIG_SH2_CRK	628	632	PF00017	0.430
LIG_SH2_CRK	812	816	PF00017	0.472
LIG_SH2_NCK_1	628	632	PF00017	0.503
LIG_SH2_STAP1	145	149	PF00017	0.518
LIG_SH2_STAP1	704	708	PF00017	0.341
LIG_SH2_STAT3	531	534	PF00017	0.462
LIG_SH2_STAT5	229	232	PF00017	0.739
LIG_SH2_STAT5	552	555	PF00017	0.376
LIG_SH2_STAT5	834	837	PF00017	0.488
LIG_SH3_2	752	757	PF14604	0.385
LIG_SH3_3	236	242	PF00018	0.591
LIG_SH3_3	274	280	PF00018	0.582
LIG_SH3_3	6	12	PF00018	0.686
LIG_SH3_3	725	731	PF00018	0.513
LIG_SH3_3	743	749	PF00018	0.292
LIG_SUMO_SIM_anti_2	160	167	PF11976	0.758
LIG_SUMO_SIM_par_1	494	501	PF11976	0.501
LIG_SxIP_EBH_1	791	804	PF03271	0.485
LIG_TRAF2_1	20	23	PF00917	0.607
LIG_TYR_ITIM	472	477	PF00017	0.376
LIG_WRC_WIRS_1	316	321	PF05994	0.498
LIG_WW_1	8	11	PF00397	0.662
MOD_CDC14_SPxK_1	609	612	PF00782	0.501
MOD_CDK_SPxK_1	606	612	PF00069	0.501
MOD_CDK_SPxK_1	724	730	PF00069	0.385
MOD_CDK_SPxxK_3	541	548	PF00069	0.376
MOD_CDK_SPxxK_3	627	634	PF00069	0.418
MOD_CK1_1	125	131	PF00069	0.769
MOD_CK1_1	201	207	PF00069	0.789
MOD_CK1_1	209	215	PF00069	0.744
MOD_CK1_1	282	288	PF00069	0.737
MOD_CK1_1	291	297	PF00069	0.711
MOD_CK1_1	3	9	PF00069	0.702
MOD_CK1_1	517	523	PF00069	0.396
MOD_CK1_1	606	612	PF00069	0.444
MOD_CK1_1	627	633	PF00069	0.426
MOD_CK1_1	696	702	PF00069	0.350
MOD_CK1_1	712	718	PF00069	0.306
MOD_CK2_1	124	130	PF00069	0.563
MOD_CK2_1	17	23	PF00069	0.656
MOD_CK2_1	315	321	PF00069	0.376
MOD_CK2_1	328	334	PF00069	0.376
MOD_CK2_1	62	68	PF00069	0.658
MOD_CK2_1	641	647	PF00069	0.371
MOD_CK2_1	712	718	PF00069	0.377
MOD_CK2_1	78	84	PF00069	0.745
MOD_CK2_1	90	96	PF00069	0.698
MOD_GlcNHglycan	112	115	PF01048	0.790
MOD_GlcNHglycan	138	141	PF01048	0.644
MOD_GlcNHglycan	2	5	PF01048	0.747
MOD_GlcNHglycan	204	207	PF01048	0.686
MOD_GlcNHglycan	248	251	PF01048	0.658
MOD_GlcNHglycan	290	293	PF01048	0.790
MOD_GlcNHglycan	298	301	PF01048	0.744
MOD_GlcNHglycan	330	333	PF01048	0.444
MOD_GlcNHglycan	395	398	PF01048	0.738
MOD_GlcNHglycan	400	403	PF01048	0.708
MOD_GlcNHglycan	404	407	PF01048	0.713
MOD_GlcNHglycan	437	440	PF01048	0.424
MOD_GlcNHglycan	516	519	PF01048	0.414
MOD_GlcNHglycan	559	562	PF01048	0.402
MOD_GlcNHglycan	586	590	PF01048	0.365
MOD_GlcNHglycan	62	65	PF01048	0.785
MOD_GlcNHglycan	647	651	PF01048	0.449
MOD_GlcNHglycan	653	656	PF01048	0.398
MOD_GlcNHglycan	785	788	PF01048	0.747
MOD_GlcNHglycan	807	810	PF01048	0.549
MOD_GSK3_1	103	110	PF00069	0.777
MOD_GSK3_1	121	128	PF00069	0.751
MOD_GSK3_1	149	156	PF00069	0.682
MOD_GSK3_1	190	197	PF00069	0.657
MOD_GSK3_1	198	205	PF00069	0.749
MOD_GSK3_1	282	289	PF00069	0.725
MOD_GSK3_1	291	298	PF00069	0.663
MOD_GSK3_1	311	318	PF00069	0.532
MOD_GSK3_1	398	405	PF00069	0.640
MOD_GSK3_1	431	438	PF00069	0.345
MOD_GSK3_1	514	521	PF00069	0.439
MOD_GSK3_1	620	627	PF00069	0.362
MOD_GSK3_1	646	653	PF00069	0.419
MOD_GSK3_1	689	696	PF00069	0.395
MOD_GSK3_1	708	715	PF00069	0.233
MOD_GSK3_1	777	784	PF00069	0.497
MOD_GSK3_1	78	85	PF00069	0.701
MOD_LATS_1	88	94	PF00433	0.711
MOD_N-GLC_1	41	46	PF02516	0.614
MOD_NEK2_1	221	226	PF00069	0.795
MOD_NEK2_1	254	259	PF00069	0.648
MOD_NEK2_1	295	300	PF00069	0.776
MOD_NEK2_1	328	333	PF00069	0.501
MOD_NEK2_1	480	485	PF00069	0.393
MOD_NEK2_1	62	67	PF00069	0.681
MOD_NEK2_1	693	698	PF00069	0.366
MOD_NEK2_1	82	87	PF00069	0.709
MOD_NEK2_2	78	83	PF00069	0.562
MOD_PIKK_1	101	107	PF00454	0.806
MOD_PIKK_1	384	390	PF00454	0.761
MOD_PIKK_1	712	718	PF00454	0.501
MOD_PIKK_1	778	784	PF00454	0.444
MOD_PKA_2	136	142	PF00069	0.687
MOD_PKA_2	153	159	PF00069	0.454
MOD_PKA_2	254	260	PF00069	0.649
MOD_PKA_2	296	302	PF00069	0.815
MOD_PKA_2	483	489	PF00069	0.505
MOD_PKA_2	60	66	PF00069	0.675
MOD_PKA_2	669	675	PF00069	0.399
MOD_PKA_2	697	703	PF00069	0.417
MOD_PKA_2	82	88	PF00069	0.753
MOD_PKA_2	89	95	PF00069	0.685
MOD_PKB_1	393	401	PF00069	0.664
MOD_Plk_1	41	47	PF00069	0.590
MOD_Plk_1	624	630	PF00069	0.462
MOD_Plk_1	770	776	PF00069	0.470
MOD_Plk_1	778	784	PF00069	0.400
MOD_Plk_4	161	167	PF00069	0.684
MOD_Plk_4	41	47	PF00069	0.647
MOD_Plk_4	770	776	PF00069	0.424
MOD_Plk_4	793	799	PF00069	0.503
MOD_Plk_4	82	88	PF00069	0.794
MOD_Plk_4	830	836	PF00069	0.568
MOD_ProDKin_1	222	228	PF00069	0.687
MOD_ProDKin_1	273	279	PF00069	0.761
MOD_ProDKin_1	311	317	PF00069	0.660
MOD_ProDKin_1	518	524	PF00069	0.339
MOD_ProDKin_1	541	547	PF00069	0.376
MOD_ProDKin_1	606	612	PF00069	0.501
MOD_ProDKin_1	627	633	PF00069	0.419
MOD_ProDKin_1	659	665	PF00069	0.307
MOD_ProDKin_1	724	730	PF00069	0.493
MOD_ProDKin_1	788	794	PF00069	0.668
MOD_SUMO_for_1	373	376	PF00179	0.736
TRG_DiLeu_BaEn_1	146	151	PF01217	0.666
TRG_DiLeu_BaEn_1	161	166	PF01217	0.709
TRG_DiLeu_BaEn_1	771	776	PF01217	0.501
TRG_DiLeu_BaEn_1	96	101	PF01217	0.721
TRG_DiLeu_BaEn_2	157	163	PF01217	0.640
TRG_ENDOCYTIC_2	474	477	PF00928	0.376
TRG_ENDOCYTIC_2	611	614	PF00928	0.399
TRG_ENDOCYTIC_2	7	10	PF00928	0.510
TRG_ENDOCYTIC_2	704	707	PF00928	0.341
TRG_ENDOCYTIC_2	812	815	PF00928	0.478
TRG_ER_diArg_1	233	235	PF00400	0.606
TRG_ER_diArg_1	254	256	PF00400	0.717
TRG_ER_diArg_1	35	37	PF00400	0.659
TRG_ER_diArg_1	548	551	PF00400	0.378
TRG_ER_diArg_1	669	671	PF00400	0.390
TRG_ER_diArg_1	838	840	PF00400	0.574
TRG_NLS_MonoExtN_4	545	552	PF00514	0.462
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.675
TRG_Pf-PMV_PEXEL_1	383	388	PF00026	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHE0	Leptomonas seymouri	48%	100%
A0A3S5H7E7	Leishmania donovani	94%	100%
A4HE63	Leishmania braziliensis	74%	100%
A4I1G3	Leishmania infantum	95%	100%
C9ZK08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AXJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%