Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9X1_LEIMA

TriTrypDb:

LmjF.25.1220 , LMJLV39_250019100 , LMJSD75_250018900

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005846	nuclear cap binding complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0034518	RNA cap binding complex	2	12
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	12

Expansion

Sequence features

Q4Q9X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9X1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	370	374	PF00656	0.363
CLV_C14_Caspase3-7	470	474	PF00656	0.490
CLV_C14_Caspase3-7	504	508	PF00656	0.435
CLV_NRD_NRD_1	124	126	PF00675	0.490
CLV_NRD_NRD_1	175	177	PF00675	0.328
CLV_NRD_NRD_1	308	310	PF00675	0.395
CLV_NRD_NRD_1	366	368	PF00675	0.337
CLV_NRD_NRD_1	424	426	PF00675	0.375
CLV_NRD_NRD_1	44	46	PF00675	0.367
CLV_NRD_NRD_1	90	92	PF00675	0.419
CLV_PCSK_FUR_1	42	46	PF00082	0.392
CLV_PCSK_KEX2_1	177	179	PF00082	0.297
CLV_PCSK_KEX2_1	308	310	PF00082	0.398
CLV_PCSK_KEX2_1	366	368	PF00082	0.352
CLV_PCSK_KEX2_1	424	426	PF00082	0.393
CLV_PCSK_KEX2_1	44	46	PF00082	0.388
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.287
CLV_PCSK_PC7_1	173	179	PF00082	0.421
CLV_PCSK_PC7_1	362	368	PF00082	0.421
CLV_PCSK_SKI1_1	114	118	PF00082	0.489
CLV_PCSK_SKI1_1	199	203	PF00082	0.323
CLV_PCSK_SKI1_1	209	213	PF00082	0.421
CLV_PCSK_SKI1_1	308	312	PF00082	0.421
CLV_PCSK_SKI1_1	349	353	PF00082	0.433
CLV_PCSK_SKI1_1	362	366	PF00082	0.374
CLV_PCSK_SKI1_1	437	441	PF00082	0.329
CLV_PCSK_SKI1_1	44	48	PF00082	0.280
CLV_PCSK_SKI1_1	596	600	PF00082	0.364
DEG_APCC_DBOX_1	348	356	PF00400	0.313
DEG_APCC_DBOX_1	595	603	PF00400	0.340
DEG_Nend_UBRbox_1	1	4	PF02207	0.421
DEG_SPOP_SBC_1	381	385	PF00917	0.449
DOC_CKS1_1	523	528	PF01111	0.365
DOC_CYCLIN_RxL_1	196	206	PF00134	0.420
DOC_CYCLIN_RxL_1	39	51	PF00134	0.297
DOC_MAPK_gen_1	39	48	PF00069	0.440
DOC_MAPK_gen_1	91	98	PF00069	0.365
DOC_MAPK_MEF2A_6	394	402	PF00069	0.386
DOC_MAPK_MEF2A_6	91	100	PF00069	0.320
DOC_PP2B_LxvP_1	406	409	PF13499	0.295
DOC_PP2B_LxvP_1	559	562	PF13499	0.421
DOC_USP7_MATH_1	242	246	PF00917	0.307
DOC_USP7_MATH_1	280	284	PF00917	0.382
DOC_USP7_MATH_1	381	385	PF00917	0.458
DOC_USP7_MATH_1	446	450	PF00917	0.412
DOC_WW_Pin1_4	210	215	PF00397	0.435
DOC_WW_Pin1_4	321	326	PF00397	0.280
DOC_WW_Pin1_4	387	392	PF00397	0.466
DOC_WW_Pin1_4	522	527	PF00397	0.369
DOC_WW_Pin1_4	541	546	PF00397	0.450
DOC_WW_Pin1_4	82	87	PF00397	0.340
LIG_14-3-3_CanoR_1	189	197	PF00244	0.210
LIG_14-3-3_CanoR_1	289	293	PF00244	0.422
LIG_14-3-3_CanoR_1	344	352	PF00244	0.427
LIG_14-3-3_CanoR_1	378	387	PF00244	0.453
LIG_14-3-3_CanoR_1	437	445	PF00244	0.311
LIG_14-3-3_CanoR_1	489	498	PF00244	0.376
LIG_APCC_ABBA_1	56	61	PF00400	0.330
LIG_BRCT_BRCA1_1	282	286	PF00533	0.413
LIG_CtBP_PxDLS_1	134	140	PF00389	0.295
LIG_eIF4E_1	433	439	PF01652	0.421
LIG_FHA_1	130	136	PF00498	0.391
LIG_FHA_1	330	336	PF00498	0.442
LIG_FHA_1	397	403	PF00498	0.368
LIG_FHA_1	414	420	PF00498	0.250
LIG_FHA_1	479	485	PF00498	0.314
LIG_FHA_1	523	529	PF00498	0.313
LIG_FHA_2	322	328	PF00498	0.280
LIG_FHA_2	502	508	PF00498	0.351
LIG_Integrin_RGD_1	564	566	PF01839	0.313
LIG_LIR_Gen_1	259	267	PF02991	0.365
LIG_LIR_Gen_1	3	12	PF02991	0.283
LIG_LIR_Gen_1	37	48	PF02991	0.280
LIG_LIR_Gen_1	554	563	PF02991	0.308
LIG_LIR_Nem_3	110	116	PF02991	0.439
LIG_LIR_Nem_3	155	161	PF02991	0.365
LIG_LIR_Nem_3	221	227	PF02991	0.376
LIG_LIR_Nem_3	259	263	PF02991	0.365
LIG_LIR_Nem_3	285	290	PF02991	0.392
LIG_LIR_Nem_3	3	7	PF02991	0.287
LIG_LIR_Nem_3	37	43	PF02991	0.280
LIG_LIR_Nem_3	554	559	PF02991	0.328
LIG_LYPXL_yS_3	93	96	PF13949	0.374
LIG_NRBOX	42	48	PF00104	0.295
LIG_PCNA_PIPBox_1	194	203	PF02747	0.313
LIG_PDZ_Class_3	602	607	PF00595	0.313
LIG_SH2_CRK	260	264	PF00017	0.365
LIG_SH2_CRK	433	437	PF00017	0.421
LIG_SH2_CRK	556	560	PF00017	0.421
LIG_SH2_PTP2	224	227	PF00017	0.340
LIG_SH2_PTP2	590	593	PF00017	0.315
LIG_SH2_SRC	224	227	PF00017	0.364
LIG_SH2_STAP1	331	335	PF00017	0.365
LIG_SH2_STAP1	556	560	PF00017	0.366
LIG_SH2_STAP1	65	69	PF00017	0.280
LIG_SH2_STAT5	224	227	PF00017	0.351
LIG_SH2_STAT5	331	334	PF00017	0.421
LIG_SH2_STAT5	407	410	PF00017	0.421
LIG_SH2_STAT5	418	421	PF00017	0.352
LIG_SH2_STAT5	590	593	PF00017	0.315
LIG_SH3_1	103	109	PF00018	0.421
LIG_SH3_2	86	91	PF14604	0.365
LIG_SH3_3	103	109	PF00018	0.319
LIG_SH3_3	520	526	PF00018	0.348
LIG_SH3_3	531	537	PF00018	0.441
LIG_SH3_3	83	89	PF00018	0.374
LIG_Sin3_3	448	455	PF02671	0.402
LIG_SUMO_SIM_anti_2	51	58	PF11976	0.340
LIG_SUMO_SIM_par_1	536	542	PF11976	0.398
LIG_TRAF2_1	228	231	PF00917	0.421
LIG_TRAF2_1	475	478	PF00917	0.365
LIG_TRAF2_1	549	552	PF00917	0.306
LIG_TRFH_1	13	17	PF08558	0.295
LIG_TYR_ITIM	38	43	PF00017	0.421
LIG_UBA3_1	14	23	PF00899	0.421
LIG_UBA3_1	55	63	PF00899	0.421
LIG_WRC_WIRS_1	1	6	PF05994	0.340
LIG_WRPW_2	113	116	PF00400	0.313
MOD_CDK_SPxxK_3	321	328	PF00069	0.280
MOD_CDK_SPxxK_3	387	394	PF00069	0.309
MOD_CDK_SPxxK_3	541	548	PF00069	0.365
MOD_CK1_1	301	307	PF00069	0.461
MOD_CK1_1	382	388	PF00069	0.382
MOD_CK1_1	390	396	PF00069	0.349
MOD_CK1_1	490	496	PF00069	0.400
MOD_CK1_1	554	560	PF00069	0.427
MOD_CK1_1	571	577	PF00069	0.145
MOD_CK1_1	592	598	PF00069	0.317
MOD_CK2_1	200	206	PF00069	0.470
MOD_CK2_1	225	231	PF00069	0.315
MOD_CK2_1	321	327	PF00069	0.284
MOD_CK2_1	594	600	PF00069	0.439
MOD_CK2_1	69	75	PF00069	0.312
MOD_Cter_Amidation	306	309	PF01082	0.365
MOD_Cter_Amidation	422	425	PF01082	0.421
MOD_Cter_Amidation	89	92	PF01082	0.365
MOD_GlcNHglycan	203	206	PF01048	0.313
MOD_GlcNHglycan	227	230	PF01048	0.365
MOD_GlcNHglycan	24	28	PF01048	0.340
MOD_GlcNHglycan	244	247	PF01048	0.346
MOD_GlcNHglycan	346	349	PF01048	0.445
MOD_GlcNHglycan	440	443	PF01048	0.370
MOD_GlcNHglycan	446	449	PF01048	0.392
MOD_GlcNHglycan	469	472	PF01048	0.314
MOD_GlcNHglycan	492	495	PF01048	0.384
MOD_GlcNHglycan	51	54	PF01048	0.304
MOD_GlcNHglycan	541	544	PF01048	0.425
MOD_GlcNHglycan	570	573	PF01048	0.327
MOD_GSK3_1	376	383	PF00069	0.436
MOD_GSK3_1	386	393	PF00069	0.224
MOD_GSK3_1	440	447	PF00069	0.389
MOD_GSK3_1	501	508	PF00069	0.391
MOD_GSK3_1	551	558	PF00069	0.431
MOD_N-GLC_2	343	345	PF02516	0.421
MOD_NEK2_1	129	134	PF00069	0.300
MOD_NEK2_1	159	164	PF00069	0.348
MOD_NEK2_1	355	360	PF00069	0.421
MOD_NEK2_1	438	443	PF00069	0.340
MOD_NEK2_1	444	449	PF00069	0.340
MOD_NEK2_1	487	492	PF00069	0.473
MOD_NEK2_1	555	560	PF00069	0.454
MOD_NEK2_1	568	573	PF00069	0.291
MOD_NEK2_1	594	599	PF00069	0.398
MOD_NEK2_2	589	594	PF00069	0.325
MOD_OFUCOSY	157	163	PF10250	0.340
MOD_PIKK_1	233	239	PF00454	0.313
MOD_PIKK_1	329	335	PF00454	0.421
MOD_PIKK_1	582	588	PF00454	0.421
MOD_PKA_1	366	372	PF00069	0.440
MOD_PKA_2	188	194	PF00069	0.378
MOD_PKA_2	288	294	PF00069	0.423
MOD_PKA_2	366	372	PF00069	0.452
MOD_Plk_1	220	226	PF00069	0.334
MOD_Plk_1	298	304	PF00069	0.298
MOD_Plk_1	413	419	PF00069	0.309
MOD_Plk_1	551	557	PF00069	0.316
MOD_Plk_1	579	585	PF00069	0.372
MOD_Plk_4	220	226	PF00069	0.425
MOD_Plk_4	282	288	PF00069	0.360
MOD_Plk_4	440	446	PF00069	0.421
MOD_Plk_4	536	542	PF00069	0.354
MOD_Plk_4	551	557	PF00069	0.355
MOD_ProDKin_1	210	216	PF00069	0.435
MOD_ProDKin_1	321	327	PF00069	0.280
MOD_ProDKin_1	387	393	PF00069	0.466
MOD_ProDKin_1	522	528	PF00069	0.369
MOD_ProDKin_1	541	547	PF00069	0.450
MOD_ProDKin_1	82	88	PF00069	0.340
TRG_DiLeu_BaEn_1	230	235	PF01217	0.349
TRG_DiLeu_BaEn_4	230	236	PF01217	0.365
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.405
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.374
TRG_ENDOCYTIC_2	113	116	PF00928	0.145
TRG_ENDOCYTIC_2	224	227	PF00928	0.340
TRG_ENDOCYTIC_2	260	263	PF00928	0.394
TRG_ENDOCYTIC_2	40	43	PF00928	0.286
TRG_ENDOCYTIC_2	433	436	PF00928	0.421
TRG_ENDOCYTIC_2	465	468	PF00928	0.374
TRG_ENDOCYTIC_2	556	559	PF00928	0.421
TRG_ENDOCYTIC_2	590	593	PF00928	0.297
TRG_ENDOCYTIC_2	93	96	PF00928	0.340
TRG_ER_diArg_1	139	142	PF00400	0.333
TRG_ER_diArg_1	175	178	PF00400	0.293
TRG_ER_diArg_1	308	310	PF00400	0.330
TRG_ER_diArg_1	311	314	PF00400	0.312
TRG_ER_diArg_1	365	367	PF00400	0.351
TRG_ER_diArg_1	42	45	PF00400	0.367
TRG_ER_diArg_1	424	427	PF00400	0.434
TRG_ER_diArg_1	96	99	PF00400	0.336
TRG_NLS_MonoCore_2	176	181	PF00514	0.295
TRG_NLS_MonoExtC_3	175	180	PF00514	0.316
TRG_NLS_MonoExtN_4	173	180	PF00514	0.349
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	548	552	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II50	Leptomonas seymouri	57%	92%
A0A0S4J8F6	Bodo saltans	33%	100%
A0A1X0NNM1	Trypanosomatidae	38%	97%
A0A3Q8IDG9	Leishmania donovani	93%	99%
A0A422P1X4	Trypanosoma rangeli	42%	100%
A4HE65	Leishmania braziliensis	81%	97%
A4I1G5	Leishmania infantum	93%	99%
C9ZK06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AXK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5D8Y9	Trypanosoma cruzi	43%	100%