Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9W6_LEIMA

TriTrypDb:

LmjF.25.1270 , LMJLV39_250019600 , LMJSD75_250019400

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9W6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.537
CLV_C14_Caspase3-7	179	183	PF00656	0.523
CLV_NRD_NRD_1	135	137	PF00675	0.743
CLV_NRD_NRD_1	184	186	PF00675	0.636
CLV_NRD_NRD_1	195	197	PF00675	0.563
CLV_NRD_NRD_1	253	255	PF00675	0.539
CLV_NRD_NRD_1	388	390	PF00675	0.456
CLV_NRD_NRD_1	62	64	PF00675	0.514
CLV_NRD_NRD_1	99	101	PF00675	0.532
CLV_PCSK_KEX2_1	135	137	PF00082	0.743
CLV_PCSK_KEX2_1	161	163	PF00082	0.362
CLV_PCSK_KEX2_1	184	186	PF00082	0.673
CLV_PCSK_KEX2_1	195	197	PF00082	0.580
CLV_PCSK_KEX2_1	253	255	PF00082	0.540
CLV_PCSK_KEX2_1	308	310	PF00082	0.603
CLV_PCSK_KEX2_1	387	389	PF00082	0.461
CLV_PCSK_KEX2_1	62	64	PF00082	0.514
CLV_PCSK_KEX2_1	99	101	PF00082	0.532
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.362
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.603
CLV_PCSK_PC7_1	384	390	PF00082	0.549
CLV_PCSK_SKI1_1	238	242	PF00082	0.442
CLV_PCSK_SKI1_1	309	313	PF00082	0.570
CLV_PCSK_SKI1_1	80	84	PF00082	0.450
DEG_Nend_Nbox_1	1	3	PF02207	0.489
DEG_SCF_FBW7_1	278	284	PF00400	0.682
DEG_SCF_FBW7_1	408	414	PF00400	0.605
DEG_SPOP_SBC_1	481	485	PF00917	0.799
DOC_ANK_TNKS_1	124	131	PF00023	0.628
DOC_ANK_TNKS_1	195	202	PF00023	0.550
DOC_CKS1_1	278	283	PF01111	0.680
DOC_CKS1_1	408	413	PF01111	0.601
DOC_CKS1_1	417	422	PF01111	0.500
DOC_CKS1_1	442	447	PF01111	0.653
DOC_MAPK_gen_1	384	393	PF00069	0.531
DOC_PP2B_LxvP_1	126	129	PF13499	0.625
DOC_USP7_MATH_1	120	124	PF00917	0.551
DOC_USP7_MATH_1	15	19	PF00917	0.522
DOC_USP7_MATH_1	173	177	PF00917	0.653
DOC_USP7_MATH_1	214	218	PF00917	0.646
DOC_USP7_MATH_1	262	266	PF00917	0.628
DOC_USP7_MATH_1	273	277	PF00917	0.622
DOC_USP7_MATH_1	279	283	PF00917	0.516
DOC_USP7_MATH_1	324	328	PF00917	0.560
DOC_USP7_MATH_1	411	415	PF00917	0.672
DOC_USP7_MATH_1	435	439	PF00917	0.682
DOC_USP7_MATH_1	450	454	PF00917	0.680
DOC_USP7_MATH_1	481	485	PF00917	0.711
DOC_USP7_MATH_1	91	95	PF00917	0.392
DOC_USP7_UBL2_3	109	113	PF12436	0.483
DOC_WW_Pin1_4	115	120	PF00397	0.688
DOC_WW_Pin1_4	129	134	PF00397	0.710
DOC_WW_Pin1_4	169	174	PF00397	0.692
DOC_WW_Pin1_4	177	182	PF00397	0.525
DOC_WW_Pin1_4	200	205	PF00397	0.719
DOC_WW_Pin1_4	215	220	PF00397	0.652
DOC_WW_Pin1_4	221	226	PF00397	0.657
DOC_WW_Pin1_4	268	273	PF00397	0.784
DOC_WW_Pin1_4	277	282	PF00397	0.656
DOC_WW_Pin1_4	407	412	PF00397	0.626
DOC_WW_Pin1_4	416	421	PF00397	0.539
DOC_WW_Pin1_4	441	446	PF00397	0.639
DOC_WW_Pin1_4	459	464	PF00397	0.689
DOC_WW_Pin1_4	87	92	PF00397	0.470
LIG_14-3-3_CanoR_1	135	139	PF00244	0.693
LIG_14-3-3_CanoR_1	162	167	PF00244	0.346
LIG_14-3-3_CanoR_1	184	190	PF00244	0.614
LIG_14-3-3_CanoR_1	213	219	PF00244	0.829
LIG_14-3-3_CanoR_1	227	236	PF00244	0.357
LIG_14-3-3_CanoR_1	242	248	PF00244	0.423
LIG_14-3-3_CanoR_1	290	300	PF00244	0.790
LIG_14-3-3_CanoR_1	309	318	PF00244	0.413
LIG_Actin_WH2_2	233	249	PF00022	0.303
LIG_BRCT_BRCA1_1	19	23	PF00533	0.531
LIG_BRCT_BRCA1_1	5	9	PF00533	0.527
LIG_CaM_IQ_9	376	391	PF13499	0.557
LIG_FHA_1	342	348	PF00498	0.565
LIG_FHA_1	68	74	PF00498	0.500
LIG_FHA_2	110	116	PF00498	0.576
LIG_FHA_2	293	299	PF00498	0.644
LIG_FHA_2	417	423	PF00498	0.610
LIG_FHA_2	486	492	PF00498	0.713
LIG_FHA_2	495	501	PF00498	0.701
LIG_Integrin_RGD_1	37	39	PF01839	0.605
LIG_LIR_Apic_2	68	74	PF02991	0.442
LIG_LIR_Gen_1	154	163	PF02991	0.463
LIG_LIR_Gen_1	297	307	PF02991	0.599
LIG_LIR_Gen_1	499	509	PF02991	0.573
LIG_LIR_Gen_1	6	16	PF02991	0.498
LIG_LIR_Nem_3	147	153	PF02991	0.509
LIG_LIR_Nem_3	154	158	PF02991	0.474
LIG_LIR_Nem_3	20	26	PF02991	0.483
LIG_LIR_Nem_3	233	239	PF02991	0.403
LIG_LIR_Nem_3	297	303	PF02991	0.623
LIG_LIR_Nem_3	6	12	PF02991	0.459
LIG_Pex14_2	12	16	PF04695	0.516
LIG_PTAP_UEV_1	274	279	PF05743	0.616
LIG_REV1ctd_RIR_1	233	242	PF16727	0.365
LIG_SH2_CRK	163	167	PF00017	0.421
LIG_SH2_CRK	71	75	PF00017	0.476
LIG_SH2_SRC	26	29	PF00017	0.533
LIG_SH2_STAT5	239	242	PF00017	0.389
LIG_SH2_STAT5	26	29	PF00017	0.579
LIG_SH2_STAT5	71	74	PF00017	0.392
LIG_SH3_1	71	77	PF00018	0.442
LIG_SH3_3	135	141	PF00018	0.682
LIG_SH3_3	213	219	PF00018	0.632
LIG_SH3_3	269	275	PF00018	0.768
LIG_SH3_3	414	420	PF00018	0.650
LIG_SH3_3	439	445	PF00018	0.719
LIG_SH3_3	460	466	PF00018	0.682
LIG_SH3_3	71	77	PF00018	0.480
LIG_TRAF2_1	144	147	PF00917	0.477
LIG_TYR_ITIM	153	158	PF00017	0.527
MOD_CDK_SPK_2	169	174	PF00069	0.549
MOD_CDK_SPxK_1	129	135	PF00069	0.645
MOD_CDK_SPxK_1	221	227	PF00069	0.714
MOD_CDK_SPxxK_3	129	136	PF00069	0.819
MOD_CDK_SPxxK_3	177	184	PF00069	0.686
MOD_CDK_SPxxK_3	416	423	PF00069	0.648
MOD_CK1_1	172	178	PF00069	0.661
MOD_CK1_1	217	223	PF00069	0.788
MOD_CK1_1	263	269	PF00069	0.706
MOD_CK1_1	271	277	PF00069	0.722
MOD_CK1_1	291	297	PF00069	0.501
MOD_CK1_1	3	9	PF00069	0.537
MOD_CK1_1	327	333	PF00069	0.597
MOD_CK1_1	334	340	PF00069	0.632
MOD_CK1_1	427	433	PF00069	0.638
MOD_CK1_1	454	460	PF00069	0.641
MOD_CK1_1	479	485	PF00069	0.798
MOD_CK1_1	494	500	PF00069	0.488
MOD_CK1_1	90	96	PF00069	0.411
MOD_CK2_1	109	115	PF00069	0.677
MOD_CK2_1	228	234	PF00069	0.464
MOD_CK2_1	334	340	PF00069	0.617
MOD_CK2_1	416	422	PF00069	0.611
MOD_CK2_1	504	510	PF00069	0.619
MOD_GlcNHglycan	122	125	PF01048	0.657
MOD_GlcNHglycan	19	22	PF01048	0.486
MOD_GlcNHglycan	220	223	PF01048	0.781
MOD_GlcNHglycan	262	265	PF01048	0.614
MOD_GlcNHglycan	266	269	PF01048	0.591
MOD_GlcNHglycan	275	278	PF01048	0.551
MOD_GlcNHglycan	314	317	PF01048	0.485
MOD_GlcNHglycan	336	339	PF01048	0.586
MOD_GlcNHglycan	394	397	PF01048	0.635
MOD_GlcNHglycan	414	417	PF01048	0.749
MOD_GlcNHglycan	453	456	PF01048	0.668
MOD_GlcNHglycan	459	462	PF01048	0.605
MOD_GlcNHglycan	488	491	PF01048	0.730
MOD_GlcNHglycan	493	496	PF01048	0.662
MOD_GlcNHglycan	507	510	PF01048	0.689
MOD_GSK3_1	111	118	PF00069	0.735
MOD_GSK3_1	169	176	PF00069	0.658
MOD_GSK3_1	214	221	PF00069	0.679
MOD_GSK3_1	260	267	PF00069	0.671
MOD_GSK3_1	273	280	PF00069	0.580
MOD_GSK3_1	288	295	PF00069	0.770
MOD_GSK3_1	3	10	PF00069	0.513
MOD_GSK3_1	327	334	PF00069	0.579
MOD_GSK3_1	341	348	PF00069	0.695
MOD_GSK3_1	407	414	PF00069	0.628
MOD_GSK3_1	450	457	PF00069	0.599
MOD_GSK3_1	476	483	PF00069	0.718
MOD_GSK3_1	494	501	PF00069	0.596
MOD_GSK3_1	87	94	PF00069	0.388
MOD_NEK2_1	241	246	PF00069	0.381
MOD_PIKK_1	241	247	PF00454	0.396
MOD_PIKK_1	248	254	PF00454	0.481
MOD_PIKK_1	3	9	PF00454	0.542
MOD_PKA_2	134	140	PF00069	0.685
MOD_PKA_2	173	179	PF00069	0.644
MOD_PKA_2	228	234	PF00069	0.448
MOD_PKA_2	241	247	PF00069	0.360
MOD_PKA_2	291	297	PF00069	0.741
MOD_PKA_2	334	340	PF00069	0.588
MOD_PKA_2	435	441	PF00069	0.634
MOD_PKB_1	290	298	PF00069	0.635
MOD_Plk_1	145	151	PF00069	0.401
MOD_Plk_1	424	430	PF00069	0.668
MOD_Plk_1	498	504	PF00069	0.605
MOD_Plk_1	67	73	PF00069	0.553
MOD_Plk_2-3	345	351	PF00069	0.629
MOD_Plk_4	162	168	PF00069	0.505
MOD_Plk_4	324	330	PF00069	0.523
MOD_Plk_4	371	377	PF00069	0.434
MOD_Plk_4	498	504	PF00069	0.630
MOD_ProDKin_1	115	121	PF00069	0.688
MOD_ProDKin_1	129	135	PF00069	0.711
MOD_ProDKin_1	169	175	PF00069	0.699
MOD_ProDKin_1	177	183	PF00069	0.524
MOD_ProDKin_1	200	206	PF00069	0.716
MOD_ProDKin_1	215	221	PF00069	0.650
MOD_ProDKin_1	268	274	PF00069	0.786
MOD_ProDKin_1	277	283	PF00069	0.659
MOD_ProDKin_1	407	413	PF00069	0.631
MOD_ProDKin_1	416	422	PF00069	0.540
MOD_ProDKin_1	441	447	PF00069	0.640
MOD_ProDKin_1	459	465	PF00069	0.689
MOD_ProDKin_1	87	93	PF00069	0.462
MOD_SUMO_for_1	16	19	PF00179	0.526
MOD_SUMO_rev_2	349	359	PF00179	0.710
TRG_DiLeu_BaEn_2	18	24	PF01217	0.532
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.388
TRG_ENDOCYTIC_2	155	158	PF00928	0.513
TRG_ENDOCYTIC_2	163	166	PF00928	0.393
TRG_ER_diArg_1	184	186	PF00400	0.677
TRG_ER_diArg_1	227	230	PF00400	0.576
TRG_ER_diArg_1	387	389	PF00400	0.500
TRG_ER_diArg_1	61	63	PF00400	0.519
TRG_ER_diArg_1	98	100	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC05	Leptomonas seymouri	46%	94%
A0A1X0NLY0	Trypanosomatidae	26%	100%
A0A3R7NU60	Trypanosoma rangeli	28%	100%
A0A3S7WZ41	Leishmania donovani	92%	100%
A4HE69	Leishmania braziliensis	67%	100%
A4I1H1	Leishmania infantum	92%	100%
E9AXK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%