NPL4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NPL4 family, putative

Species:

Leishmania major

UniProt:

Q4Q9W4_LEIMA

TriTrypDb:

LmjF.25.1290 , LMJLV39_250019800 , LMJSD75_250019600

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9W4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006511	ubiquitin-dependent protein catabolic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019941	modification-dependent protein catabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043632	modification-dependent macromolecule catabolic process	5	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0051603	proteolysis involved in protein catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0031625	ubiquitin protein ligase binding	5	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2
GO:0044389	ubiquitin-like protein ligase binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.673
CLV_NRD_NRD_1	216	218	PF00675	0.507
CLV_NRD_NRD_1	230	232	PF00675	0.639
CLV_NRD_NRD_1	371	373	PF00675	0.312
CLV_NRD_NRD_1	568	570	PF00675	0.538
CLV_NRD_NRD_1	76	78	PF00675	0.470
CLV_NRD_NRD_1	95	97	PF00675	0.494
CLV_PCSK_KEX2_1	215	217	PF00082	0.519
CLV_PCSK_KEX2_1	222	224	PF00082	0.526
CLV_PCSK_KEX2_1	371	373	PF00082	0.312
CLV_PCSK_KEX2_1	568	570	PF00082	0.484
CLV_PCSK_KEX2_1	75	77	PF00082	0.473
CLV_PCSK_KEX2_1	95	97	PF00082	0.493
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.565
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.484
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.473
CLV_PCSK_PC7_1	211	217	PF00082	0.562
CLV_PCSK_SKI1_1	363	367	PF00082	0.399
CLV_PCSK_SKI1_1	392	396	PF00082	0.417
CLV_PCSK_SKI1_1	511	515	PF00082	0.542
CLV_PCSK_SKI1_1	524	528	PF00082	0.324
CLV_PCSK_SKI1_1	541	545	PF00082	0.339
CLV_PCSK_SKI1_1	608	612	PF00082	0.583
DEG_APCC_DBOX_1	290	298	PF00400	0.480
DEG_SPOP_SBC_1	270	274	PF00917	0.617
DOC_MAPK_gen_1	360	370	PF00069	0.612
DOC_MAPK_gen_1	568	574	PF00069	0.527
DOC_MAPK_gen_1	79	88	PF00069	0.509
DOC_MAPK_MEF2A_6	382	391	PF00069	0.473
DOC_MAPK_RevD_3	356	372	PF00069	0.533
DOC_PP1_RVXF_1	282	288	PF00149	0.457
DOC_PP2B_PxIxI_1	447	453	PF00149	0.515
DOC_PP4_FxxP_1	51	54	PF00568	0.410
DOC_PP4_FxxP_1	535	538	PF00568	0.492
DOC_PP4_MxPP_1	552	555	PF00568	0.484
DOC_USP7_MATH_1	119	123	PF00917	0.406
DOC_USP7_MATH_1	158	162	PF00917	0.476
DOC_USP7_MATH_1	203	207	PF00917	0.552
DOC_USP7_MATH_1	417	421	PF00917	0.617
DOC_USP7_MATH_1	434	438	PF00917	0.701
DOC_USP7_MATH_1	439	443	PF00917	0.689
DOC_WW_Pin1_4	107	112	PF00397	0.598
DOC_WW_Pin1_4	151	156	PF00397	0.483
DOC_WW_Pin1_4	21	26	PF00397	0.412
DOC_WW_Pin1_4	224	229	PF00397	0.584
DOC_WW_Pin1_4	457	462	PF00397	0.448
DOC_WW_Pin1_4	472	477	PF00397	0.468
DOC_WW_Pin1_4	50	55	PF00397	0.449
DOC_WW_Pin1_4	534	539	PF00397	0.490
LIG_14-3-3_CanoR_1	105	114	PF00244	0.456
LIG_14-3-3_CanoR_1	30	39	PF00244	0.420
LIG_14-3-3_CanoR_1	524	530	PF00244	0.409
LIG_14-3-3_CanoR_1	561	567	PF00244	0.527
LIG_14-3-3_CanoR_1	569	575	PF00244	0.461
LIG_Actin_WH2_2	137	154	PF00022	0.424
LIG_Actin_WH2_2	357	373	PF00022	0.550
LIG_BRCT_BRCA1_1	145	149	PF00533	0.628
LIG_BRCT_BRCA1_1	248	252	PF00533	0.557
LIG_BRCT_BRCA1_1	4	8	PF00533	0.440
LIG_BRCT_BRCA1_1	570	574	PF00533	0.493
LIG_BRCT_BRCA1_1	93	97	PF00533	0.514
LIG_Clathr_ClatBox_1	294	298	PF01394	0.410
LIG_EH_1	37	41	PF12763	0.406
LIG_FHA_1	225	231	PF00498	0.647
LIG_FHA_1	265	271	PF00498	0.541
LIG_FHA_1	290	296	PF00498	0.438
LIG_FHA_1	328	334	PF00498	0.510
LIG_FHA_1	447	453	PF00498	0.609
LIG_FHA_1	492	498	PF00498	0.524
LIG_FHA_1	525	531	PF00498	0.393
LIG_FHA_2	500	506	PF00498	0.570
LIG_FHA_2	517	523	PF00498	0.500
LIG_FHA_2	575	581	PF00498	0.511
LIG_FHA_2	591	597	PF00498	0.374
LIG_LIR_Apic_2	49	54	PF02991	0.410
LIG_LIR_Gen_1	249	260	PF02991	0.527
LIG_LIR_Gen_1	527	535	PF02991	0.420
LIG_LIR_Gen_1	580	588	PF02991	0.380
LIG_LIR_Gen_1	84	93	PF02991	0.469
LIG_LIR_Nem_3	150	156	PF02991	0.476
LIG_LIR_Nem_3	249	255	PF02991	0.505
LIG_LIR_Nem_3	347	353	PF02991	0.599
LIG_LIR_Nem_3	523	529	PF02991	0.415
LIG_LIR_Nem_3	580	584	PF02991	0.378
LIG_LIR_Nem_3	84	88	PF02991	0.473
LIG_NRBOX	583	589	PF00104	0.506
LIG_Pex14_1	525	529	PF04695	0.416
LIG_Pex14_2	149	153	PF04695	0.408
LIG_Rb_pABgroove_1	320	328	PF01858	0.599
LIG_SH2_CRK	319	323	PF00017	0.550
LIG_SH2_CRK	617	621	PF00017	0.555
LIG_SH2_NCK_1	326	330	PF00017	0.512
LIG_SH2_PTP2	529	532	PF00017	0.419
LIG_SH2_SRC	326	329	PF00017	0.599
LIG_SH2_STAP1	173	177	PF00017	0.447
LIG_SH2_STAP1	241	245	PF00017	0.525
LIG_SH2_STAP1	319	323	PF00017	0.599
LIG_SH2_STAT5	173	176	PF00017	0.519
LIG_SH2_STAT5	177	180	PF00017	0.537
LIG_SH2_STAT5	348	351	PF00017	0.555
LIG_SH2_STAT5	529	532	PF00017	0.419
LIG_SH2_STAT5	563	566	PF00017	0.432
LIG_SH2_STAT5	586	589	PF00017	0.441
LIG_SH2_STAT5	599	602	PF00017	0.459
LIG_SH3_3	108	114	PF00018	0.451
LIG_SH3_3	127	133	PF00018	0.463
LIG_SH3_3	33	39	PF00018	0.521
LIG_SH3_3	335	341	PF00018	0.490
LIG_SH3_3	547	553	PF00018	0.536
LIG_SH3_3	77	83	PF00018	0.538
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.417
LIG_SUMO_SIM_par_1	41	47	PF11976	0.417
LIG_SUMO_SIM_par_1	447	453	PF11976	0.609
LIG_SxIP_EBH_1	19	32	PF03271	0.414
LIG_TYR_ITSM	525	532	PF00017	0.413
LIG_UBA3_1	251	259	PF00899	0.580
LIG_WRC_WIRS_1	305	310	PF05994	0.408
MOD_CDC14_SPxK_1	53	56	PF00782	0.408
MOD_CDK_SPxK_1	50	56	PF00069	0.414
MOD_CDK_SPxxK_3	224	231	PF00069	0.646
MOD_CDK_SPxxK_3	50	57	PF00069	0.453
MOD_CDK_SPxxK_3	534	541	PF00069	0.490
MOD_CK1_1	147	153	PF00069	0.647
MOD_CK1_1	264	270	PF00069	0.513
MOD_CK1_1	346	352	PF00069	0.604
MOD_CK1_1	420	426	PF00069	0.599
MOD_CK1_1	442	448	PF00069	0.671
MOD_CK2_1	151	157	PF00069	0.440
MOD_CK2_1	570	576	PF00069	0.481
MOD_CK2_1	591	597	PF00069	0.487
MOD_Cter_Amidation	255	258	PF01082	0.390
MOD_DYRK1A_RPxSP_1	107	111	PF00069	0.461
MOD_GlcNHglycan	201	204	PF01048	0.605
MOD_GlcNHglycan	248	251	PF01048	0.506
MOD_GlcNHglycan	422	425	PF01048	0.708
MOD_GlcNHglycan	427	430	PF01048	0.729
MOD_GlcNHglycan	436	439	PF01048	0.549
MOD_GlcNHglycan	441	444	PF01048	0.476
MOD_GlcNHglycan	476	479	PF01048	0.423
MOD_GlcNHglycan	505	509	PF01048	0.572
MOD_GSK3_1	143	150	PF00069	0.676
MOD_GSK3_1	167	174	PF00069	0.534
MOD_GSK3_1	177	184	PF00069	0.507
MOD_GSK3_1	187	194	PF00069	0.566
MOD_GSK3_1	199	206	PF00069	0.387
MOD_GSK3_1	261	268	PF00069	0.466
MOD_GSK3_1	420	427	PF00069	0.628
MOD_GSK3_1	434	441	PF00069	0.682
MOD_GSK3_1	442	449	PF00069	0.583
MOD_GSK3_1	46	53	PF00069	0.420
MOD_GSK3_1	511	518	PF00069	0.524
MOD_GSK3_1	520	527	PF00069	0.423
MOD_GSK3_1	570	577	PF00069	0.480
MOD_GSK3_1	586	593	PF00069	0.503
MOD_GSK3_1	600	607	PF00069	0.485
MOD_GSK3_1	87	94	PF00069	0.511
MOD_LATS_1	509	515	PF00433	0.598
MOD_N-GLC_1	199	204	PF02516	0.570
MOD_N-GLC_2	244	246	PF02516	0.530
MOD_NEK2_1	165	170	PF00069	0.463
MOD_NEK2_1	28	33	PF00069	0.441
MOD_NEK2_1	44	49	PF00069	0.469
MOD_NEK2_1	545	550	PF00069	0.472
MOD_NEK2_1	574	579	PF00069	0.433
MOD_NEK2_2	46	51	PF00069	0.465
MOD_NEK2_2	58	63	PF00069	0.429
MOD_OFUCOSY	10	16	PF10250	0.419
MOD_OFUCOSY	121	128	PF10250	0.417
MOD_PIKK_1	105	111	PF00454	0.510
MOD_PIKK_1	187	193	PF00454	0.435
MOD_PIKK_1	271	277	PF00454	0.612
MOD_PIKK_1	289	295	PF00454	0.375
MOD_PIKK_1	586	592	PF00454	0.452
MOD_PKA_1	56	62	PF00069	0.427
MOD_PKA_1	568	574	PF00069	0.495
MOD_PKA_1	608	614	PF00069	0.374
MOD_PKA_1	81	87	PF00069	0.470
MOD_PKA_2	117	123	PF00069	0.543
MOD_PKA_2	144	150	PF00069	0.717
MOD_PKA_2	545	551	PF00069	0.467
MOD_PKA_2	568	574	PF00069	0.495
MOD_Plk_1	203	209	PF00069	0.549
MOD_Plk_1	280	286	PF00069	0.459
MOD_Plk_1	399	405	PF00069	0.412
MOD_Plk_4	144	150	PF00069	0.615
MOD_Plk_4	160	166	PF00069	0.458
MOD_Plk_4	261	267	PF00069	0.464
MOD_Plk_4	304	310	PF00069	0.410
MOD_Plk_4	446	452	PF00069	0.628
MOD_Plk_4	46	52	PF00069	0.586
MOD_Plk_4	525	531	PF00069	0.416
MOD_Plk_4	81	87	PF00069	0.470
MOD_ProDKin_1	107	113	PF00069	0.596
MOD_ProDKin_1	151	157	PF00069	0.487
MOD_ProDKin_1	21	27	PF00069	0.414
MOD_ProDKin_1	224	230	PF00069	0.581
MOD_ProDKin_1	457	463	PF00069	0.446
MOD_ProDKin_1	472	478	PF00069	0.469
MOD_ProDKin_1	50	56	PF00069	0.452
MOD_ProDKin_1	534	540	PF00069	0.485
MOD_SUMO_for_1	221	224	PF00179	0.507
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.435
TRG_ENDOCYTIC_2	319	322	PF00928	0.550
TRG_ENDOCYTIC_2	529	532	PF00928	0.408
TRG_ENDOCYTIC_2	617	620	PF00928	0.443
TRG_ER_diArg_1	215	217	PF00400	0.485
TRG_ER_diArg_1	29	32	PF00400	0.442
TRG_ER_diArg_1	370	372	PF00400	0.512
TRG_ER_diArg_1	62	65	PF00400	0.501
TRG_ER_diArg_1	76	79	PF00400	0.466
TRG_ER_diArg_1	95	97	PF00400	0.485
TRG_NES_CRM1_1	385	400	PF08389	0.444
TRG_NES_CRM1_1	576	590	PF08389	0.445
TRG_NLS_MonoExtC_3	74	79	PF00514	0.468
TRG_NLS_MonoExtN_4	567	572	PF00514	0.533
TRG_NLS_MonoExtN_4	72	79	PF00514	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4H2	Leptomonas seymouri	72%	100%
A0A3S7WZ51	Leishmania donovani	96%	100%
A4HE71	Leishmania braziliensis	88%	100%
C9ZK00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AXK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%