Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PRP38 family, putative

Species:

Leishmania major

UniProt:

Q4Q9W3_LEIMA

TriTrypDb:

LmjF.25.1300 , LMJLV39_250019900 , LMJSD75_250019700

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	4
GO:1990904	ribonucleoprotein complex	2	4
GO:0071011	precatalytic spliceosome	4	2

Expansion

Sequence features

Q4Q9W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9W3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	4
GO:0006397	mRNA processing	7	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008380	RNA splicing	7	4
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.400
CLV_C14_Caspase3-7	52	56	PF00656	0.649
CLV_C14_Caspase3-7	583	587	PF00656	0.644
CLV_NRD_NRD_1	114	116	PF00675	0.491
CLV_NRD_NRD_1	122	124	PF00675	0.501
CLV_NRD_NRD_1	366	368	PF00675	0.284
CLV_NRD_NRD_1	537	539	PF00675	0.599
CLV_NRD_NRD_1	629	631	PF00675	0.620
CLV_NRD_NRD_1	645	647	PF00675	0.483
CLV_NRD_NRD_1	649	651	PF00675	0.365
CLV_NRD_NRD_1	96	98	PF00675	0.450
CLV_PCSK_KEX2_1	114	116	PF00082	0.491
CLV_PCSK_KEX2_1	122	124	PF00082	0.501
CLV_PCSK_KEX2_1	261	263	PF00082	0.502
CLV_PCSK_KEX2_1	366	368	PF00082	0.284
CLV_PCSK_KEX2_1	435	437	PF00082	0.442
CLV_PCSK_KEX2_1	535	537	PF00082	0.594
CLV_PCSK_KEX2_1	610	612	PF00082	0.591
CLV_PCSK_KEX2_1	629	631	PF00082	0.614
CLV_PCSK_KEX2_1	645	647	PF00082	0.483
CLV_PCSK_KEX2_1	96	98	PF00082	0.450
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.502
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.442
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.636
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.639
CLV_PCSK_SKI1_1	129	133	PF00082	0.564
CLV_PCSK_SKI1_1	262	266	PF00082	0.381
CLV_PCSK_SKI1_1	302	306	PF00082	0.552
CLV_PCSK_SKI1_1	315	319	PF00082	0.450
CLV_PCSK_SKI1_1	417	421	PF00082	0.400
CLV_PCSK_SKI1_1	509	513	PF00082	0.563
CLV_PCSK_SKI1_1	603	607	PF00082	0.609
CLV_PCSK_SKI1_1	646	650	PF00082	0.525
CLV_Separin_Metazoa	263	267	PF03568	0.433
DEG_Nend_UBRbox_2	1	3	PF02207	0.580
DEG_SPOP_SBC_1	179	183	PF00917	0.688
DEG_SPOP_SBC_1	199	203	PF00917	0.550
DOC_ANK_TNKS_1	493	500	PF00023	0.604
DOC_CKS1_1	389	394	PF01111	0.366
DOC_CYCLIN_RxL_1	259	267	PF00134	0.447
DOC_CYCLIN_RxL_1	413	424	PF00134	0.400
DOC_CYCLIN_yClb1_LxF_4	601	606	PF00134	0.536
DOC_MAPK_gen_1	366	376	PF00069	0.284
DOC_MAPK_gen_1	435	443	PF00069	0.481
DOC_MAPK_gen_1	618	625	PF00069	0.634
DOC_MAPK_gen_1	629	640	PF00069	0.588
DOC_MAPK_MEF2A_6	367	376	PF00069	0.284
DOC_MAPK_MEF2A_6	633	642	PF00069	0.601
DOC_MAPK_NFAT4_5	633	641	PF00069	0.599
DOC_MAPK_RevD_3	522	538	PF00069	0.591
DOC_PP1_RVXF_1	601	607	PF00149	0.609
DOC_PP2B_LxvP_1	13	16	PF13499	0.348
DOC_PP4_FxxP_1	389	392	PF00568	0.284
DOC_PP4_FxxP_1	6	9	PF00568	0.431
DOC_USP7_MATH_1	177	181	PF00917	0.509
DOC_USP7_MATH_1	186	190	PF00917	0.674
DOC_USP7_MATH_1	192	196	PF00917	0.621
DOC_USP7_MATH_1	200	204	PF00917	0.557
DOC_USP7_MATH_1	467	471	PF00917	0.695
DOC_USP7_MATH_1	587	591	PF00917	0.638
DOC_USP7_MATH_2	164	170	PF00917	0.429
DOC_WW_Pin1_4	193	198	PF00397	0.656
DOC_WW_Pin1_4	335	340	PF00397	0.284
DOC_WW_Pin1_4	388	393	PF00397	0.366
LIG_14-3-3_CanoR_1	282	288	PF00244	0.530
LIG_14-3-3_CanoR_1	349	355	PF00244	0.344
LIG_14-3-3_CanoR_1	378	382	PF00244	0.284
LIG_14-3-3_CanoR_1	645	649	PF00244	0.567
LIG_Actin_WH2_2	215	230	PF00022	0.409
LIG_APCC_ABBA_1	572	577	PF00400	0.678
LIG_BIR_III_4	586	590	PF00653	0.667
LIG_BRCT_BRCA1_1	477	481	PF00533	0.643
LIG_Clathr_ClatBox_1	573	577	PF01394	0.637
LIG_CSL_BTD_1	428	431	PF09270	0.284
LIG_CtBP_PxDLS_1	116	122	PF00389	0.401
LIG_FHA_1	157	163	PF00498	0.641
LIG_FHA_1	205	211	PF00498	0.430
LIG_FHA_1	282	288	PF00498	0.483
LIG_FHA_1	389	395	PF00498	0.284
LIG_FHA_1	590	596	PF00498	0.545
LIG_FHA_1	637	643	PF00498	0.555
LIG_FHA_1	90	96	PF00498	0.395
LIG_FHA_2	303	309	PF00498	0.536
LIG_FHA_2	351	357	PF00498	0.284
LIG_FHA_2	419	425	PF00498	0.400
LIG_FHA_2	45	51	PF00498	0.770
LIG_GBD_Chelix_1	342	350	PF00786	0.400
LIG_GBD_Chelix_1	368	376	PF00786	0.312
LIG_LIR_Gen_1	150	158	PF02991	0.517
LIG_LIR_Gen_1	207	213	PF02991	0.457
LIG_LIR_Gen_1	384	394	PF02991	0.400
LIG_LIR_Gen_1	653	659	PF02991	0.532
LIG_LIR_Nem_3	150	156	PF02991	0.514
LIG_LIR_Nem_3	207	211	PF02991	0.465
LIG_LIR_Nem_3	274	279	PF02991	0.353
LIG_LIR_Nem_3	384	389	PF02991	0.400
LIG_LIR_Nem_3	427	432	PF02991	0.368
LIG_LIR_Nem_3	505	511	PF02991	0.627
LIG_LIR_Nem_3	653	659	PF02991	0.648
LIG_PAM2_1	267	279	PF00658	0.407
LIG_PCNA_PIPBox_1	354	363	PF02747	0.400
LIG_PDZ_Class_2	654	659	PF00595	0.534
LIG_PTAP_UEV_1	196	201	PF05743	0.600
LIG_PTAP_UEV_1	41	46	PF05743	0.527
LIG_PTB_Apo_2	566	573	PF02174	0.466
LIG_PTB_Apo_2	82	89	PF02174	0.439
LIG_PTB_Phospho_1	82	88	PF10480	0.433
LIG_Rb_LxCxE_1	396	416	PF01857	0.346
LIG_SH2_CRK	327	331	PF00017	0.400
LIG_SH2_GRB2like	567	570	PF00017	0.463
LIG_SH2_NCK_1	379	383	PF00017	0.284
LIG_SH2_PTP2	231	234	PF00017	0.437
LIG_SH2_STAT3	320	323	PF00017	0.320
LIG_SH2_STAT5	208	211	PF00017	0.442
LIG_SH2_STAT5	231	234	PF00017	0.470
LIG_SH2_STAT5	243	246	PF00017	0.503
LIG_SH2_STAT5	320	323	PF00017	0.284
LIG_SH2_STAT5	375	378	PF00017	0.298
LIG_SH2_STAT5	379	382	PF00017	0.271
LIG_SH2_STAT5	386	389	PF00017	0.262
LIG_SH2_STAT5	656	659	PF00017	0.570
LIG_SH3_3	141	147	PF00018	0.480
LIG_SH3_3	191	197	PF00018	0.586
LIG_SH3_3	31	37	PF00018	0.549
LIG_SH3_3	39	45	PF00018	0.497
LIG_SH3_3	438	444	PF00018	0.476
LIG_SH3_3	521	527	PF00018	0.515
LIG_SH3_3	621	627	PF00018	0.583
LIG_Sin3_3	31	38	PF02671	0.486
LIG_SUMO_SIM_anti_2	557	566	PF11976	0.629
LIG_SUMO_SIM_anti_2	639	644	PF11976	0.548
LIG_TRAF2_1	26	29	PF00917	0.506
LIG_TRFH_1	379	383	PF08558	0.400
LIG_TYR_ITIM	325	330	PF00017	0.308
MOD_CK1_1	180	186	PF00069	0.564
MOD_CK1_1	195	201	PF00069	0.609
MOD_CK1_1	204	210	PF00069	0.479
MOD_CK1_1	281	287	PF00069	0.494
MOD_CK1_1	48	54	PF00069	0.767
MOD_CK1_1	529	535	PF00069	0.549
MOD_CK1_1	59	65	PF00069	0.620
MOD_CK2_1	23	29	PF00069	0.600
MOD_CK2_1	302	308	PF00069	0.508
MOD_CK2_1	44	50	PF00069	0.755
MOD_CK2_1	507	513	PF00069	0.638
MOD_Cter_Amidation	643	646	PF01082	0.617
MOD_GlcNHglycan	139	142	PF01048	0.683
MOD_GlcNHglycan	182	185	PF01048	0.571
MOD_GlcNHglycan	188	191	PF01048	0.577
MOD_GlcNHglycan	197	200	PF01048	0.505
MOD_GlcNHglycan	203	206	PF01048	0.386
MOD_GlcNHglycan	25	28	PF01048	0.605
MOD_GlcNHglycan	292	295	PF01048	0.477
MOD_GlcNHglycan	41	45	PF01048	0.654
MOD_GlcNHglycan	47	50	PF01048	0.778
MOD_GlcNHglycan	588	592	PF01048	0.741
MOD_GlcNHglycan	619	623	PF01048	0.670
MOD_GlcNHglycan	62	65	PF01048	0.648
MOD_GlcNHglycan	77	80	PF01048	0.515
MOD_GSK3_1	132	139	PF00069	0.652
MOD_GSK3_1	166	173	PF00069	0.505
MOD_GSK3_1	178	185	PF00069	0.599
MOD_GSK3_1	195	202	PF00069	0.702
MOD_GSK3_1	331	338	PF00069	0.215
MOD_GSK3_1	40	47	PF00069	0.739
MOD_GSK3_1	463	470	PF00069	0.614
MOD_GSK3_1	471	478	PF00069	0.633
MOD_GSK3_1	55	62	PF00069	0.679
MOD_N-GLC_1	55	60	PF02516	0.735
MOD_NEK2_1	170	175	PF00069	0.461
MOD_NEK2_1	244	249	PF00069	0.617
MOD_NEK2_1	264	269	PF00069	0.420
MOD_NEK2_1	448	453	PF00069	0.434
MOD_NEK2_1	636	641	PF00069	0.540
MOD_NEK2_2	644	649	PF00069	0.519
MOD_PIKK_1	253	259	PF00454	0.500
MOD_PIKK_1	467	473	PF00454	0.607
MOD_PIKK_1	475	481	PF00454	0.576
MOD_PKA_2	281	287	PF00069	0.413
MOD_PKA_2	377	383	PF00069	0.334
MOD_PKA_2	644	650	PF00069	0.624
MOD_PKA_2	75	81	PF00069	0.594
MOD_Plk_4	204	210	PF00069	0.508
MOD_Plk_4	529	535	PF00069	0.542
MOD_Plk_4	638	644	PF00069	0.547
MOD_ProDKin_1	193	199	PF00069	0.656
MOD_ProDKin_1	335	341	PF00069	0.284
MOD_ProDKin_1	388	394	PF00069	0.366
TRG_DiLeu_BaEn_3	335	341	PF01217	0.400
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.455
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.502
TRG_ENDOCYTIC_2	208	211	PF00928	0.459
TRG_ENDOCYTIC_2	231	234	PF00928	0.437
TRG_ENDOCYTIC_2	327	330	PF00928	0.284
TRG_ENDOCYTIC_2	386	389	PF00928	0.400
TRG_ENDOCYTIC_2	656	659	PF00928	0.662
TRG_ER_diArg_1	113	115	PF00400	0.503
TRG_ER_diArg_1	122	124	PF00400	0.494
TRG_ER_diArg_1	365	367	PF00400	0.308
TRG_ER_diArg_1	536	538	PF00400	0.651
TRG_ER_diArg_1	629	631	PF00400	0.614
TRG_ER_diArg_1	95	97	PF00400	0.445
TRG_NLS_MonoCore_2	534	539	PF00514	0.635
TRG_NLS_MonoExtC_3	609	615	PF00514	0.573
TRG_NLS_MonoExtN_4	607	614	PF00514	0.661
TRG_Pf-PMV_PEXEL_1	509	513	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	523	528	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	538	542	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP9	Leptomonas seymouri	62%	100%
A0A1X0NM33	Trypanosomatidae	34%	100%
A0A3Q8IDC3	Leishmania donovani	93%	100%
A0A422P1Y9	Trypanosoma rangeli	33%	100%
A4HE72	Leishmania braziliensis	83%	99%
A4I1H4	Leishmania infantum	93%	100%
C9ZJZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AXK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%