GPN-loop GTPase 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

GPN-loop GTPase 3

Gene product:

Conserved hypothetical ATP binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q9V4_LEIMA

TriTrypDb:

LmjF.25.1390 , LMJLV39_250020900 , LMJSD75_250020700

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9V4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	2
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.529
CLV_C14_Caspase3-7	262	266	PF00656	0.674
CLV_PCSK_SKI1_1	181	185	PF00082	0.304
DEG_APCC_KENBOX_2	183	187	PF00400	0.529
DEG_SCF_TRCP1_1	147	153	PF00400	0.529
DOC_PP2B_PxIxI_1	167	173	PF00149	0.529
DOC_PP4_FxxP_1	165	168	PF00568	0.454
DOC_USP7_MATH_1	11	15	PF00917	0.454
LIG_14-3-3_CanoR_1	32	39	PF00244	0.443
LIG_BRCT_BRCA1_1	147	151	PF00533	0.529
LIG_BRCT_BRCA1_1	179	183	PF00533	0.529
LIG_Clathr_ClatBox_1	57	61	PF01394	0.443
LIG_FHA_1	131	137	PF00498	0.529
LIG_FHA_1	247	253	PF00498	0.496
LIG_FHA_2	142	148	PF00498	0.529
LIG_FHA_2	172	178	PF00498	0.454
LIG_LIR_Gen_1	129	139	PF02991	0.465
LIG_LIR_Gen_1	166	173	PF02991	0.443
LIG_LIR_Gen_1	196	207	PF02991	0.453
LIG_LIR_Gen_1	221	231	PF02991	0.438
LIG_LIR_Gen_1	99	107	PF02991	0.444
LIG_LIR_Nem_3	129	135	PF02991	0.463
LIG_LIR_Nem_3	166	172	PF02991	0.443
LIG_LIR_Nem_3	196	202	PF02991	0.453
LIG_LIR_Nem_3	221	226	PF02991	0.433
LIG_LIR_Nem_3	227	231	PF02991	0.434
LIG_LIR_Nem_3	99	104	PF02991	0.444
LIG_Pex14_2	165	169	PF04695	0.454
LIG_SH2_CRK	132	136	PF00017	0.470
LIG_SH2_CRK	4	8	PF00017	0.335
LIG_SH2_SRC	48	51	PF00017	0.484
LIG_SH2_STAP1	132	136	PF00017	0.529
LIG_SH2_STAP1	4	8	PF00017	0.335
LIG_SH2_STAP1	97	101	PF00017	0.529
LIG_SH2_STAT5	132	135	PF00017	0.512
LIG_SH2_STAT5	137	140	PF00017	0.515
LIG_SH2_STAT5	238	241	PF00017	0.443
LIG_SH2_STAT5	81	84	PF00017	0.443
LIG_SH3_3	101	107	PF00018	0.461
LIG_SH3_3	114	120	PF00018	0.401
LIG_SH3_3	44	50	PF00018	0.468
LIG_SUMO_SIM_par_1	229	235	PF11976	0.546
LIG_SUMO_SIM_par_1	56	62	PF11976	0.443
LIG_WRC_WIRS_1	225	230	PF05994	0.454
LIG_WW_3	205	209	PF00397	0.510
MOD_CK1_1	14	20	PF00069	0.454
MOD_CK1_1	158	164	PF00069	0.504
MOD_GlcNHglycan	13	16	PF01048	0.254
MOD_GlcNHglycan	147	150	PF01048	0.271
MOD_GlcNHglycan	152	155	PF01048	0.225
MOD_GSK3_1	11	18	PF00069	0.454
MOD_GSK3_1	141	148	PF00069	0.528
MOD_GSK3_1	237	244	PF00069	0.488
MOD_GSK3_1	26	33	PF00069	0.454
MOD_GSK3_1	81	88	PF00069	0.529
MOD_N-GLC_2	241	243	PF02516	0.254
MOD_NEK2_1	157	162	PF00069	0.443
MOD_NEK2_1	200	205	PF00069	0.478
MOD_NEK2_1	246	251	PF00069	0.529
MOD_NEK2_1	30	35	PF00069	0.494
MOD_PIKK_1	88	94	PF00454	0.497
MOD_PKA_2	31	37	PF00069	0.443
MOD_PKB_1	208	216	PF00069	0.529
MOD_Plk_1	200	206	PF00069	0.528
MOD_Plk_1	246	252	PF00069	0.495
MOD_Plk_2-3	56	62	PF00069	0.454
MOD_Plk_4	131	137	PF00069	0.520
MOD_Plk_4	158	164	PF00069	0.454
MOD_Plk_4	241	247	PF00069	0.509
MOD_Plk_4	85	91	PF00069	0.529
MOD_SUMO_rev_2	59	69	PF00179	0.443
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.468
TRG_ENDOCYTIC_2	132	135	PF00928	0.470
TRG_ENDOCYTIC_2	199	202	PF00928	0.510
TRG_ENDOCYTIC_2	27	30	PF00928	0.529
TRG_ENDOCYTIC_2	4	7	PF00928	0.335
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Y6	Leptomonas seymouri	31%	81%
A0A0N1I1L3	Leptomonas seymouri	27%	78%
A0A0N1PCL7	Leptomonas seymouri	94%	100%
A0A0S4IQ77	Bodo saltans	63%	100%
A0A0S4IST9	Bodo saltans	25%	77%
A0A0S4JJ66	Bodo saltans	28%	100%
A0A1X0NNN3	Trypanosomatidae	72%	94%
A0A1X0NSR0	Trypanosomatidae	33%	82%
A0A3S5H7F7	Leishmania donovani	28%	82%
A0A3S7WSM7	Leishmania donovani	30%	81%
A0A3S7WZ40	Leishmania donovani	98%	100%
A0A422NVI7	Trypanosoma rangeli	26%	82%
A0A422P226	Trypanosoma rangeli	70%	94%
A4FUD1	Bos taurus	27%	71%
A4H7B1	Leishmania braziliensis	28%	88%
A4HEQ4	Leishmania braziliensis	28%	80%
A4HVQ6	Leishmania infantum	30%	81%
A4I1I3	Leishmania infantum	98%	100%
A4I1Y3	Leishmania infantum	28%	82%
A6H7F2	Bos taurus	33%	86%
C9ZJY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	95%
C9ZS35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	83%
D4A7C0	Rattus norvegicus	32%	86%
E9APF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	81%
E9AXL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AY30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	82%
O14443	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	96%
O42906	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	72%
P0CN94	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	38%	93%
P0CN95	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	38%	93%
P46577	Caenorhabditis elegans	27%	75%
P47122	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	69%
Q06543	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	98%
Q08726	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	77%
Q0P5E2	Bos taurus	36%	94%
Q28I42	Xenopus tropicalis	36%	93%
Q4IQT8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	33%	88%
Q4PF70	Ustilago maydis (strain 521 / FGSC 9021)	38%	95%
Q4Q9E3	Leishmania major	28%	82%
Q4QG26	Leishmania major	31%	81%
Q4R579	Macaca fascicularis	33%	86%
Q4V7Z0	Xenopus laevis	36%	93%
Q4WT40	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	33%	91%
Q54C25	Dictyostelium discoideum	30%	67%
Q54NK8	Dictyostelium discoideum	40%	93%
Q54TE7	Dictyostelium discoideum	34%	84%
Q56XY2	Arabidopsis thaliana	35%	89%
Q58DD9	Sus scrofa	33%	86%
Q5A0W6	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	97%
Q5BJ53	Xenopus tropicalis	35%	88%
Q66KF6	Xenopus laevis	35%	84%
Q6BI59	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	37%	97%
Q6CBB5	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	98%
Q6CQA6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	39%	98%
Q6FSS0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	38%	98%
Q6PUR6	Danio rerio	36%	86%
Q6R518	Rattus norvegicus	35%	94%
Q6ZM63	Danio rerio	36%	93%
Q750Q9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	37%	98%
Q8VCE2	Mus musculus	28%	72%
Q8VEJ1	Mus musculus	34%	86%
Q8W586	Arabidopsis thaliana	28%	70%
Q9D3W4	Mus musculus	36%	94%
Q9H9Y4	Homo sapiens	33%	86%
Q9HCN4	Homo sapiens	29%	71%
Q9UHW5	Homo sapiens	36%	94%
Q9UTL7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	84%
Q9UYR9	Pyrococcus abyssi (strain GE5 / Orsay)	30%	100%
V5A2Y8	Trypanosoma cruzi	29%	80%
V5B835	Trypanosoma cruzi	69%	95%
V5DR44	Trypanosoma cruzi	29%	82%