SURP motif domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surp module, putative

Species:

Leishmania major

UniProt:

Q4Q9V3_LEIMA

TriTrypDb:

LmjF.25.1400 , LMJLV39_250021000 , LMJSD75_250020800

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	12
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005686	U2 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	12
GO:0071004	U2-type prespliceosome	5	2
GO:0071010	prespliceosome	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	12
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4Q9V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9V3

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0045292	mRNA cis splicing, via spliceosome	9	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.577
CLV_NRD_NRD_1	136	138	PF00675	0.631
CLV_NRD_NRD_1	150	152	PF00675	0.630
CLV_NRD_NRD_1	207	209	PF00675	0.353
CLV_NRD_NRD_1	215	217	PF00675	0.488
CLV_NRD_NRD_1	257	259	PF00675	0.459
CLV_NRD_NRD_1	33	35	PF00675	0.505
CLV_PCSK_KEX2_1	136	138	PF00082	0.554
CLV_PCSK_KEX2_1	215	217	PF00082	0.512
CLV_PCSK_KEX2_1	247	249	PF00082	0.504
CLV_PCSK_KEX2_1	256	258	PF00082	0.474
CLV_PCSK_KEX2_1	33	35	PF00082	0.516
CLV_PCSK_KEX2_1	380	382	PF00082	0.703
CLV_PCSK_KEX2_1	48	50	PF00082	0.546
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.395
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.703
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.584
CLV_PCSK_SKI1_1	215	219	PF00082	0.463
CLV_PCSK_SKI1_1	248	252	PF00082	0.449
CLV_PCSK_SKI1_1	258	262	PF00082	0.415
CLV_Separin_Metazoa	126	130	PF03568	0.584
DEG_Nend_UBRbox_2	1	3	PF02207	0.738
DEG_SCF_FBW7_2	10	16	PF00400	0.573
DEG_SPOP_SBC_1	165	169	PF00917	0.562
DEG_SPOP_SBC_1	315	319	PF00917	0.713
DOC_CKS1_1	10	15	PF01111	0.573
DOC_CYCLIN_RxL_1	213	224	PF00134	0.617
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.545
DOC_MAPK_gen_1	151	158	PF00069	0.591
DOC_MAPK_gen_1	48	55	PF00069	0.461
DOC_PP1_RVXF_1	214	221	PF00149	0.513
DOC_PP1_RVXF_1	268	274	PF00149	0.473
DOC_PP4_FxxP_1	311	314	PF00568	0.722
DOC_USP7_MATH_1	183	187	PF00917	0.498
DOC_USP7_MATH_1	315	319	PF00917	0.741
DOC_USP7_MATH_1	337	341	PF00917	0.725
DOC_USP7_MATH_1	358	362	PF00917	0.765
DOC_USP7_UBL2_3	175	179	PF12436	0.498
DOC_USP7_UBL2_3	247	251	PF12436	0.520
DOC_WW_Pin1_4	310	315	PF00397	0.713
DOC_WW_Pin1_4	356	361	PF00397	0.640
DOC_WW_Pin1_4	9	14	PF00397	0.553
LIG_14-3-3_CanoR_1	270	276	PF00244	0.591
LIG_14-3-3_CanoR_1	283	289	PF00244	0.627
LIG_14-3-3_CanoR_1	347	352	PF00244	0.702
LIG_AP2alpha_2	141	143	PF02296	0.548
LIG_BRCT_BRCA1_1	358	362	PF00533	0.743
LIG_BRCT_BRCA1_1	57	61	PF00533	0.534
LIG_CtBP_PxDLS_1	14	20	PF00389	0.502
LIG_eIF4E_1	366	372	PF01652	0.731
LIG_FHA_1	153	159	PF00498	0.550
LIG_FHA_1	279	285	PF00498	0.587
LIG_FHA_1	55	61	PF00498	0.548
LIG_FHA_2	129	135	PF00498	0.596
LIG_FHA_2	225	231	PF00498	0.552
LIG_FHA_2	239	245	PF00498	0.367
LIG_FHA_2	261	267	PF00498	0.461
LIG_FHA_2	323	329	PF00498	0.727
LIG_LIR_Gen_1	274	284	PF02991	0.450
LIG_LIR_Nem_3	205	210	PF02991	0.481
LIG_LIR_Nem_3	212	217	PF02991	0.522
LIG_LIR_Nem_3	274	279	PF02991	0.448
LIG_LIR_Nem_3	359	365	PF02991	0.752
LIG_LIR_Nem_3	58	64	PF02991	0.445
LIG_LYPXL_S_1	61	65	PF13949	0.389
LIG_MYND_1	76	80	PF01753	0.575
LIG_PCNA_yPIPBox_3	268	279	PF02747	0.588
LIG_Pex14_2	61	65	PF04695	0.412
LIG_PTB_Apo_2	188	195	PF02174	0.581
LIG_RPA_C_Fungi	22	34	PF08784	0.602
LIG_SH2_CRK	214	218	PF00017	0.411
LIG_SH2_NCK_1	249	253	PF00017	0.451
LIG_SH2_STAP1	172	176	PF00017	0.413
LIG_SH2_STAP1	249	253	PF00017	0.447
LIG_SH2_STAT5	138	141	PF00017	0.534
LIG_SH2_STAT5	172	175	PF00017	0.342
LIG_SH2_STAT5	237	240	PF00017	0.525
LIG_SH2_STAT5	64	67	PF00017	0.442
LIG_SH3_3	77	83	PF00018	0.747
LIG_SUMO_SIM_par_1	154	159	PF11976	0.564
LIG_TRAF2_1	263	266	PF00917	0.493
LIG_WRC_WIRS_1	279	284	PF05994	0.549
MOD_CK1_1	277	283	PF00069	0.600
MOD_CK1_1	67	73	PF00069	0.552
MOD_CK2_1	128	134	PF00069	0.624
MOD_CK2_1	224	230	PF00069	0.503
MOD_CK2_1	238	244	PF00069	0.403
MOD_CK2_1	260	266	PF00069	0.475
MOD_CK2_1	322	328	PF00069	0.750
MOD_Cter_Amidation	378	381	PF01082	0.776
MOD_GlcNHglycan	28	31	PF01048	0.485
MOD_GlcNHglycan	339	342	PF01048	0.673
MOD_GSK3_1	100	107	PF00069	0.659
MOD_GSK3_1	108	115	PF00069	0.617
MOD_GSK3_1	152	159	PF00069	0.610
MOD_GSK3_1	166	173	PF00069	0.449
MOD_GSK3_1	274	281	PF00069	0.544
MOD_GSK3_1	310	317	PF00069	0.676
MOD_GSK3_1	337	344	PF00069	0.730
MOD_NEK2_1	112	117	PF00069	0.694
MOD_NEK2_1	166	171	PF00069	0.348
MOD_NEK2_1	210	215	PF00069	0.336
MOD_NEK2_1	238	243	PF00069	0.559
MOD_NEK2_1	271	276	PF00069	0.587
MOD_NEK2_1	316	321	PF00069	0.770
MOD_NEK2_1	367	372	PF00069	0.630
MOD_NEK2_1	43	48	PF00069	0.538
MOD_NEK2_1	54	59	PF00069	0.383
MOD_PIKK_1	231	237	PF00454	0.599
MOD_PKA_2	128	134	PF00069	0.567
MOD_PKA_2	26	32	PF00069	0.574
MOD_PKA_2	282	288	PF00069	0.607
MOD_PKA_2	322	328	PF00069	0.610
MOD_Plk_1	156	162	PF00069	0.573
MOD_Plk_1	55	61	PF00069	0.442
MOD_Plk_4	233	239	PF00069	0.535
MOD_Plk_4	367	373	PF00069	0.649
MOD_Plk_4	6	12	PF00069	0.689
MOD_ProDKin_1	310	316	PF00069	0.716
MOD_ProDKin_1	356	362	PF00069	0.639
MOD_ProDKin_1	9	15	PF00069	0.552
MOD_SUMO_rev_2	148	153	PF00179	0.653
TRG_ENDOCYTIC_2	214	217	PF00928	0.404
TRG_ENDOCYTIC_2	62	65	PF00928	0.422
TRG_ER_diArg_1	136	138	PF00400	0.648
TRG_ER_diArg_1	214	216	PF00400	0.495
TRG_ER_diArg_1	256	258	PF00400	0.576
TRG_ER_diArg_1	267	270	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXM6	Leptomonas seymouri	70%	100%
A0A0S4IPX0	Bodo saltans	36%	86%
A0A1X0NNP0	Trypanosomatidae	43%	80%
A0A3R7KXN8	Trypanosoma rangeli	46%	88%
A0A3S7WZ46	Leishmania donovani	96%	100%
A4HEF0	Leishmania braziliensis	88%	100%
A4I1I4	Leishmania infantum	96%	100%
C9ZJY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AXL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BCN7	Trypanosoma cruzi	46%	81%